We Still Don’t Know Everything about the Lac Operon

(But We are Getting Closer!)

Steve Brewer

Patrick Ehrman

Allen Koop

Lac Operon

Lac Promoter

Comparison of No ligand-bound Repressor to DNA-bound and Inducer-bound Repressor

• 1LBI no ligand; 1LBH inducer; 1LBG DNA

Comparison of Inducer-bound Repressor to DNA-bound and No ligand-bound Repressor

• 1LBH-inducer; 1LBG-DNA; 1LBI no ligand

Acknowledgements

• Slides 2-3 http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/L/LacOperon.html

• Slides 4-6, 8-9 NCBI structural program http://www.ncbi.nlm.nih.gov/

• Slide 7 http://www.webbooks.com/MoBio/Free/Ch4D3.htm