1Restricted © Siemens Healthcare GmbH, 2018Restricted © Siemens Healthcare GmbH, 2018

Julie Clark, TI TC Wien, Dezember 11, 2018

value

We enable healthcare providers toincrease

Unrestricted © Siemens Healthcare GmbH, 2018

A long story of success: Innovation is our Lifeblood

2

Digitalizing healthcare

Expanding precision medicine

Improving patient

experience

Transfor-ming care delivery

1896 Industrially manufactured medical X-ray

1956CLINISTIX − dry chemistry testing for glucose in urine

1967First real-time ultrasound scanner

1986First acridiniumester based chemilumin-escenceimmuno-assays

1983First Siemens MRI scanner

1999First intuitive medical IT platform from Siemens

2005First Dual Source CT scanner

2008Robotic-assisted angiography system

2011First integrated, simultaneous whole-body MRI and PET

2014 Cloud-based network: teamplay

1975First Siemens CT scanner

1998First Siemens track-based laboratory automation system

2001First PET/CT system from Siemens

2006Diagnostic analyzer integrating four technologies in one system

2009Multi-modality 3D imaging software

2008 Digital radiography, wireless flatpanel detector

2014“Free breathing” CT scanning with dual X-ray sources and detectors

2012Wireless transducers for ultrasound

2015First Twin Robotic X-ray for better patient care and productivity

2017Lab diagnostics solution for immu-noassay and clinical chemistry:Atellica® Solution

2015Wide-angle image acquisition breast tomosynthesis

2016Liquid biopsy

Future

1901Nobel prize

winners (Physics and Medicine)

Röntgen Von Behring

2017 MRI technology adapting to human nature: BioMatrix

2015The first research 7T MRI: MAGNETOM 7T

2017 A whole new world of precision: Biograph Vision

2017Mobile operations for closer patient interaction: SOMATOM go.platform

1997First in vitro whole-blood detector of platelet-function abnormalities

1977 First automated protein system launched

2015 First BTP assay to determine RRF and CSF leakage

2017FAST 3D Camera –automated precise patient positioning

2016Cinematic rendering for 3D medical imaging

1957Fully automated discrete chemistry analyzer for whole blood or serum

3Restricted © Siemens Healthcare GmbH, 2018

Who we are

1) Revenue P10 FY 2017 (not acc. to IFRS 15)2) AdvaMedDX, “A Policy Primer on Diagnostics”, June 2011, p. 3

of global top 100providers partner

with us

>90%

patient touch points

every hour

~240,000

Revenue1)

€13.8bn in developing countries

~1.3bnpeople

Access to care for

highly skilledemployees

>48,000

patentsIP base

18,000+

in majority of businesses

Marketleader

countries with direct presence

>70of critical clinical

decisions are influenced by the

type of technology we provide2)

>70%

installed base~600,000

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Generation of high quality imaging, laboratory and operational data.

Operationalization through simplified user experiences and support in change management.

Data analysis to generate actionable insights leveraging analytics and artificial intelligence.

Data aggregation for transpa-rency, system wide interopera-bility and knowledge sharing.

Generation of high quality imaging, laboratory and operational data.

Operationalization through simplified user experiences and support in change management.

Data analysis to generate actionable insights leveraging analytics and artificial intelligence.

Data aggregation for transpa-rency, system wide interopera-bility and knowledge sharing.

High quality data through intelligent medical devices

eHealth solutions technology used in ~70% of Austrian hospitals∏

Unified user experience with syngo® at the scanner and syngo.via for reading/reporting

Generate Aggregate Analyze Operationalize

Digitalizing healthcare

• ∏ Referring to the share of Austrian hospitals which use ELGA and are connected to ITH/SHS.Source for number of Austrian hospitals in total: https://www.spitalskompass.at/#/spitaeler (accessed September 12th 2018)Source for number of hospitals using ELGA: https://elga.gv.at/fileadmin/user_upload/Dokumente_PDF_MP4/Infomaterialien/gestartete_ELGA-GDA.pdf

Improve transparency, fleet utilization, and protocol standardization with teamplay

Page 5

Precision Medicine based on precise medical decision making

DX Portfolio(LD/MSV)

Imaging Portfolio

Health Records, Fitness-Tracker etc.

Diseases…… originate and manifest on diverse (biological) levels … can be diagnosed more precisely by integration of multiple diagnostic modalities (lifestyle, imaging, molecular Dx)

Functional disease relevance relates to diagnosis and therapy / treatment

Can we extract more functionalinformation from diagnostic images?• PET MR/CT• MR-Spectroscopy or “in vivo NMR” (e.g. Metabolites)

https://radiopaedia.org/articles/mr-spectroscopy-1

Lifestyle

Organ

Tissue

Cell

Protein/DNA

Integration of diagnostic information

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Provides decision support for prediction, prevention, diagnosis, treatment selection and monitoring

Facilitates workflow optimization for operational efficiency

Ability to tailor solutions and evaluate comparative effectiveness

Imagine a „Digital Patient“…

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We enable healthcare providers to increase value by…

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Digitalizinghealthcare

Improvingpatient

experience

Expandingprecisionmedicine

Transformingcare

delivery

Restricted © Siemens Healthcare GmbH, 2017

Innovation distinguishes between a leader and a follower.

- Steve Jobs

Unrestricted © Siemens Healthcare GmbH, 2018

Motivations – to participate in public funded activities (grants)

• Benchmark with other R&D partners • Need for clearly defined project

plans and deliverables & use of results

• Jointly reduce time-to-market • Advance TRL• Aligns with SHS portfolio/roadmap

• Positioned as valued expert for policy makers/ministries

• Shape future R&D funding agenda • Participate in the development of

industry standards/guidelines & influence regulations

• New ideas – disruptive trends • Evaluation and learning of novel

technologies• Access to high-class innovation know-how • Shared risk R&D • Explore new application (use cases)

• Global access to new talents • Integration of young researchers • Position SHS as innovative employer • Establish international collaboration culture

within the own company

• Platform for pre-competitive cooperation with customers and partners

• Networking and creation of value for specific customers & suppliers

Joint Development

Influencing + Standardization

Joint Pre-Competitive Research

External Perception as Thought Leaders

Network driven Collaboration

External Perception as Thought

Leaders

Joint Development

Joint Pre-Competitive Research

Network driven

Collaboration

Influencing +

Standardi-zation

Unrestricted © Siemens Healthcare GmbH, 2018

European Research – LandscapeSiemens Healthineers

Unrestricted © Siemens Healthcare GmbH, 2018

Innovation – P3Stroke

https://eit.europa.eu/

>140 Core Partners

”activities” (projects, ...)

P3-Strokexyzabc”external”

Project Partner

annualfee

sub-granting

annualbudget

EIT funding

https://eithealth.eu/

FPA (Framework Partnership Agreement)Framework agreement between EIT and „KIC“ (Knowledge and Innovation Community)KIC Legal Entity = EIT HealthKIC Partners = EIT Health Core Partners

SGA (Specific Grant Agreement)Grant agreement between EIT and the „KIC“ = Annual Business Plan

PGA (Project Grant Agreement)Project specific agreement between KIC LE and KIC Partners

External Partner AgreementAgreement between ohne KIC Partner and one External Project Partner

“KIC”

Unrestricted © Siemens Healthcare GmbH, 2018

Innovation – FiBrUSFighting Breast Cancer with optimized workflow Ultrasound screening

Our motivation is to improve women’s health by addressing the issue with today’s routinemammography. Creating an easy to use multi-modality solution that combines X-ray based mammography(MAM) with ultrasound (US) offers better specificity and sensitivity.

Siemens Healthineers

TUM

IMEC

University Heidelberg

Unrestricted © Siemens Healthcare GmbH, 2018

Thank you!

Julie Clark

Siemens Healthineers GmbHTechnology & Innovation Center TI TC Karlheinz-Kaske-Straße 591052 Erlangen, Germany

P +49 (9131) 843527M +49 (172) 89 40 586E julie.a.clark@siemens-healthineers.com