VolumeCheck

VolumeCheck Technology Overview

VolumeCheck

Sensor

Step#1: Sensor detects

meniscus

Step #2: VolumeCheck processes plate

based on calibration table

Step #3: Output data file

VolumeCheck Technology

VolumeCheck is a volume inspection

system utilizing a non-contact sensor to

measure the distance between the

sensor and the sample meniscus in a

tube or well plate

– Output data is the distance measured

between sensor and solution level

Sensor Measures:

Sensor-to-sample distance

Example: 15mm = 350uL

VolumeCheck Sensor

Well Plate Position

VolumeCheck Applications and Customers

• Typical Application

– Production monitoring system

– Quality control system

– Compound or sample library

volume/inventory management tool

• Typical Customers

– XL20 customers with no scale

– Reagent/Oligonucleotide Synthesis

– Compound sample laboratories

– Biobanks or Tissue banks

VolumeCheck Consumables

VolumeCheck operates

with SBS standard:

– 96 well

– 48 well

– 24 well

– 12 well

– Must be uncapped or

uncovered

VolumeCheck Hardware Features

Hardware Features

• One non-contact sensor

• Detects volume in uncapped well plates and

tube racks

• Works with water, alcohol, DMSO, and other

common laboratory solutions

• Labware needs to be greater than 41mm in

height – rack adapters available

Two Models

• VolumeCheck 100 - One minute per rack

• VolumeCheck 50 – 3 minutes per rack

VolumeCheck Hardware Features

• Accuracy: +/- 10mL in 1.4mL tube

• Accuracy: +/- 5mL in PCR plates

– Accuracy dependent on the type of consumable used

– The VolumeCheck sensor detects meniscus surface

– Conical and V-Shaped well plates will return accuracy ratings at smaller volumes

because less volume is needed to achieve a consistent meniscus.

Conical V-Shaped Flat-bottom

VolumeCheck Software Features

• Main Processing Screen

– Volume Data Displayed

– Graphical interface of

volume detected

• Entire Plate Map

• Inspection by Row

– Start and Stop anytime

– Load calibration table

– Select specific wells to

read

– Apply current data against

a different calibration table

VolumeCheck Software Features

• Display Settings Screen

– Control the visual representation of volume detected

– Up to 10 levels of volume intervals

• Project Based Workflow

– Save software settings as projects for different consumables and applications

– Project file includes error handling settings, display settings, and calibration tables in one project file

– Helpful for labs using multiple types of labware.

Report Feature

• Report Feature

– Outputs to computer’s default printer

– One page includes

– Plate map

– Scan data

– Rack ID

– Time and date

– Sample shown right

VolumeCheck – Output Files

Example of VolumeCheck Output file

• File format - .csv, .txt, or user defined

VolumeCheck Output File Options

• User-definable selection of data to output

• Customer determines content and order of data

VolumeCheck Calibration Curves

Plate Data Creator

Utility

– Calibration Curve data

collected

– Plate Maps

– Curve Fitting Tools

VolumeCheck Calibration

Distance from the sensor to the

sample corresponds to a known

volume level

– Curve represents data points of

known volumes vs. distance

measured

– Curve fitting tools help to fine-tune

data for best accuracy

VolumeCheck Calibration Curves

VolumeCheck system resolution

may be influenced by:

Differences in labware such as

conical, v-shaped, or flat-bottom

well plates and tubes

Droplets on the wall of a tube or

well

Air bubbles in sample

Plate-to-plate dimensional

variations

Curve should closely represent

the concentration of samples

VolumeCheck Rack Adapters

How to measure for correct adapter height:

Consumable Plate Height + Adapter Plate Height = 41-48mm

Examples of VolumeCheck Rack Adapters

VolumeCheck with Rack Adapter

Shallow Well Rack Adapter

Matrix 750uL Rack Adapter

2mL Screw Cap Tube Holder

See BioMicroLab Price Book for part numbers

Medium Well Rack Adapter

VolumeCheck Models

• VolumeCheck 50 – 3 minutes per rack

– Compatible with SBS formatted well plates and tube racks

– Research environment or labs with low throughput

– Consumables up to 52mm in height

• VolumeCheck 100 – One minute per rack

– Compatible with SBS formatted well plates and tube racks

– Production type environment with high throughput

– Consumables up to 52mm in height

• Price Includes – VolumeCheck robot, VolumeCheck software, VolumeCheck Manual, and Quick Start

Guide

• Rack adapters are quoted separately

• VolumeCheck ActiveX Tool Kit

VolumeCheck Specifications

• System Specifications

– VolumeCheck Dimensions: 10.5” H x 10.3” W x 17.0” D

– Weight: 27 lbs

– Electrical: 110-220 VAC 50/60Hz

• Computer Specifications

– Dell P4 with Windows XP/Vista/7

– 512MB RAM

– Optional: Linear Bar Code Scanner for scanning racks IDs

Contact Information

BioMicroLab, Inc.

Web: www.biomicrolab.com

Email: info@biomicrolab.com

Tel: (925) 689-1200 or Fax: (925) 689-1263

Mail: 2500-A Dean Lesher Drive

Concord, CA 94520 USA