Volume Contents

Volume 156, Number 1, January 1, 2005

Contents

Original articlesKaryotypic evolution and tumor progression in head and neck squamous cell carcinomas 1

Yuesheng Jin, Charlotte Jin, Mei Lv, Sai-Wah Tsao, Jingke Zhu, Johan Wennerberg, Fredrik Mertens, Yok-Lam Kwong

Cytogenetic abnormalities in hepatoblastoma: report of two new cases and review of the 8literature suggesting imbalance of chromosomal regions on chromosomes 1, 4, and 12

Toshihito Nagata, Masanori Nakamura, Hiroyuki Shichino, Motoaki Chin, Kiminobu Sugito, Taro Ikeda, Tsugumichi Koshinaga, Masahiro Fukuzawa, Mitsuru Inoue, Hideo Mugishima

Gene expression profile of an adenomyoepithelioma of the breast with a reciprocal 14translocation involving chromosomes 8 and 16

Zoran Gatalica Gopalrao Velagaleti, Helena Kuivaniemi, Gerard Tromp, Juan Palazzo, Kerry M. Graves, Michelle Guigneaux, Thomas Wood, Mala Sinha, Bruce Luxon

Chromosomal alterations detected by comparative genomic hybridization in nonfunctioning 23endocrine pancreatic tumors

Giovanna Floridia, Giulia Grilli, Marco Salvatore, Chiara Pescucci, Patrick S. Moore, Aldo Scarpa, Domenica Taruscio

Global hypomethylation is common in prostate cancer cells: a quantitative predictor for 31 clinical outcome?

Arthur R. Brothman, Gregory Swanson, Teresa M. Maxwell, Jiang Cui, Kelley J. Murphy, Jennifer Herrick, V.O. Speights, Jorge Isaac, L. Ralph Rohr

Molecular cytogenetic analysis of a human breast metastasis model: identification of 37phenotype-specific chromosomal rearrangements

Steve Goodison, Carrie Viars, Virginia Urquidi

Short communicationsPrimary effusion lymphoma of the pericardial cavity carrying t(1;22)(q21;q11) 49and t(14;17)(q32;q23)

Tohru Fujiwara, Ryo Ichinohasama, Ikuo Miura, Tomohiro Sugawara, Hideo Harigae, Hisayuki Yokoyama, Shinichiro Takahashi, Yasuo Tomiya, Minami Yamada, Kenichi Ishizawa, Junichi Kameoka, Takeshi Sasaki

Molecular cytogenetic study of instability at 1q21~q32 in adult acute lymphoblastic leukemia 54Giorgina Specchia, Francesco Albano, Luisa Anelli, Antonella Zagaria, Arcangelo Liso, Alessandra Pannunzio, Nicoletta Archidiacono, Vincenzo Liso, Mariano Rocchi

Re-analysis of the cell line NALM-1 karyotype by GTG-banding, spectral karyotyping, and 59whole chromosome painting

Antje-Friederike Pelz, Gisela Weilepp, Peter F. Wieacker

A case of myelodysplastic syndrome with acquired monosomy 7 in a child with 62a constitutional t(1;19) and a mosaicism for trisomy 21

Jie Hu, Sofia Shekhter-Levin, Peter H. Shaw, Carolyn Bay, Sally Kochmar, Urvashi Surti

Genetic polymorphisms of CYP2D6, GSTM1, and GSTT1 genes and bladder cancer risk in 68North India

R.C. Sobti, A.I. Al-Badran, S. Sharma, S.K. Sharma, A. Krishan, H. Mohan

Absence of mutations of the BRAF gene in malignant melanoma of soft parts 74 (clear cell sarcoma of tendons and aponeuroses)

Ioannis Panagopoulos, Fredrik Mertens, Margareth Isaksson, Nils Mandahl

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Hepatoblastoma in a patient with a partial trisomy 9p syndrome: a case report 77J. Marco Schnater, Antoinette Y.N. Schouten–van Meeteren, Yvonne M. Heins, Daniël C. Aronson

Cytogenetics of a pediatric unclassified sex cord-stromal tumor of the testis: a case report 80David T. Yang, Amy Lowichik, Jige Chen, Brent W. Snow, Thomas M. Ulbright, Zhong Chen

Monosomy 22 as a diagnostic aid in a case of late recurrence of adult granulosa cell tumor 83of the ovary

Samuel K. Caughron, Julia A. Bridge, Chhanda B. Bewtra, William J. Hunter, Marilu Nelson,Suganthi Soundararajan, Edibaldo Silva, Zoran Gatalica

A case of neurofibromatosis and breast cancer: loss of heterozygosity of NF1 in breast cancer 86Sefık Güran, Mükerrem Safali

Letters to the editorGranulocytic sarcoma associated with a der(7;12)(q10;q10) 89

Dennis B. Cornfield, Guoxian Sun, Basil Ahmed

No correlation between trisomy 13 and FLT3 duplication in acute myeloid leukemia 92Helen Powell, Ann Curtis, Nick Bown, Penny Taylor

Trisomy 8 in a newly diagnosed chronic lymphocytic leukemia 94Thein H. Oo

Forthcoming events 96

Volume 156, Number 2, January 15, 2005

Contents

Original articlesDeletion of 5q in myeloid leukemia cells HL-60: an L1 element-mediated instability 97

Daniel P. Hejlik, Lalitha Nagarajan

Characterization of gene expression in major types of salivary gland carcinomas 104with epithelial differentiation

Ilmo Leivo, Kowan Ja Jee, Kristiina Heikinheimo, Merja Laine, Juha Ollila, Balint Nagy, Sakari Knuutila

Frequent aberrations of chromosome 8 in aggressive B-cell non-Hodgkin lymphoma 114Barbara Pienkowska-Grela, Anna Witkowska, Beata Grygalewicz, Grzegorz Rymkiewicz, Jolanta Rygier, Renata Woroniecka, Jan Walewski

Recurrent genomic imbalances in B-cell splenic marginal-zone lymphoma revealed 122by comparative genomic hybridization

Claus L. Andersen, Alicja Gruszka-Westwood, Shayne Atkinson, Estella Matutes, Daniel Catovsky, Rikke K. Pedersen, Bjarne B. Pedersen, Stanislaw Pulczynski, Peter Hokland, Elisa Jacobsen, Jørn Koch

TEL-AML1 frequency in multi-ethnic Malaysian pediatric acute lymphoblastic leukemia 129Harvindar Kaur Gill, Ten Sew Keoh, Jasbir Singh Dhaliwal, Sarah Moore, Tan Sew Kim, Roshida Hassan, Faraiza Abdul Karim, Zubaidah Zakaria, Shahnaz Murad, Mahfuzah Mohamed, Caroline Mei Li Ho, Hishamshah Ibrahim, Eni Juraida Abdul Rahman

Increased frequency of multiradial chromosome structures in mouse embryonic 134fibroblasts lacking functional Werner syndrome protein and poly(ADP-ribose) polymerase-1

Josée Lavoie, Ronald Carter, Régen Drouin, Michel Lebel

Genetic polymorphisms of GSTs and their association with primary brain tumor incidence 144Hatice Pinarbasi, Yavuz Silig, Mustafa Gurelik

Contents continued


Genomic aberrations in plasma cell leukemia shown by interphase fluorescence 150in situ hybridization

Hong Chang, Stephen Sloan, Dan Li, Bruce Patterson

Isochromosome of a deleted 20q: a rare but recurrent chromosome abnormality in 154myelodysplastic syndromes

K. Saunders, B. Czepulkowski, R. Sivalingam, J.P.L.A. Hayes, M. Aldouri, M. Sekhar, M. Cummins, A. Ho, G.J. Mufti

Allelic imbalance on chromosome 10 in rat endometrial adenocarcinomas 158Carola Nordlander, Afrouz Behboudi, Göran Levan, Karin Klinga Levan

Primary desmoplastic small round cell tumor of bone: report of a case with 167cytogenetic confirmation

Amanda Murphy, Raymond L. Stallings, Julie Howard, Maureen O’Sullivan, Roisin Hayes, Finn Breatnach, Michael B. McDermott

Short communicationsA reciprocal t(4;9)(q31;p22) in a solitary neurofibroma 172

Jeffrey R. Sawyer, Lewis G. Parr, Neriman Gokden, Richard W. Nicholas

Clonality analysis of cell lineages in acute myeloid leukemia with inversion 16 175Hong Chang, Rakash Nayar, Dan Li, D. Robert Sutherland

Mutational analysis of hSNF5/INI1 and TP53 genes in choroid plexus carcinomas 179Magdalena Zakrzewska, Izabela Wojcik, Krzysztof Zakrzewski, Lech Polis, Wieslawa Grajkowska, Marcin Roszkowski, Brian J. Augelli, Pawel P. Liberski, Piotr Rieske

Letters to the editorPLAG1-HAS2 fusion in lipoblastoma with masked 8q intrachromosomal rearrangement 183

Cristina Morerio, Annamaria Rapella, Cristina Rosanda, Elisa Tassano, Claudio Gambini, Giuseppe Romagnoli, Claudio Panarello

Trisomy 13 in a patient with idiopathic myelofibrosis 185Alessandro Gozzetti, Rosaria Crupi, Daniela Tozzuoli, Alberto Fabbri, Monica Bocchia, Francesco Lauria

Translocation (3;12)(q25;p11.2): a recurrent cytogenetic abnormality in 186acute myeloid leukemia

Roopal Shah, Brenda Rowland, Kathleen Richkind, Patricia Mowery-Rushton, Synthia Roherty, Rod Morgan, Martin Schlam

Erratum 188

Forthcoming Events 190

Volume 157, Number 1, February 2005

Contents

Lead articleGenomic alterations in primary cutaneous melanomas detected by metaphase 1comparative genomic hybridization with laser capture or manual microdissection: 6p gains may predict poor outcome

Takeshi Namiki, Shigeru Yanagawa, Toshiyuki Izumo, Masashi Ishikawa, Masayoshi Tachibana, Yutaka Kawakami, Hiroo Yokozeki, Kiyoshi Nishioka, Yasuhiko Kaneko

Contents continued


Original articlesVariant t(14;18) in malignant lymphoma: a report of seven cases 12

Gail Bentley, Margarita Palutke, Anwar N. Mohamed

Significance of mutations in TGFBR2 and BAX in neoplastic progression and patient 18outcome in sporadic colorectal tumors with high-frequency microsatellite instability

Antonia M. Fernández-Peralta, Nargisse Nejda, Soledad Oliart, Vicente Medina, Mariano Moreno Azcoita, Juan J. González-Aguilera

Cytogenetic instability in young patients with multiple primary cancers 25Ulrike Keller, Gerhard Grabenbauer, Alma Kuechler, Carl N. Sprung, Elisabeth Müller, Rolf Sauer, Luitpold Distel

Karyotyping, immunophenotyping, and apoptosis analyses on human hematopoietic 33precursor cells derived from umbilical cord blood following long-term ex vivo expansion

Hong Tian, Shiang Huang, Feili Gong, Lei Tian, Zhong Chen

Chromosomal imbalances in Korean intrahepatic cholangiocarcinoma by 37comparative genomic hybridization

Kyung-Ok Uhm, Young-Nyun Park, Ji-Young Lee, Dong-Seop Yoon, Sun-Hwa Park

Genetic abnormalities and HPV status in cervical and vulvar squamous cell carcinomas 42Fung Yu Huang, Yvonne K.Y. Kwok, Elizabeth T. Lau, Mary H.Y. Tang, Tong Yow Ng, Hextan Y.S. Ngan

A functional single nucleotide polymorphism site detected in nasopharyngeal 49carcinoma-associated transforming gene Tx

Wei Ren, Hui Zheng, Ming Li, Lin Deng, Xing-Li Li, Kai-feng Pan, You-yong Lu, Ya Cao

Additional clonal abnormalities in Philadelphia-positive ALL and CML demonstrate a 53different cytogenetic pattern at diagnosis and follow different pathways at progression

Ulrike Bacher, Torsten Haferlach, Wolfgang Hiddemann, Susanne Schnittger, Wolfgang Kern, Claudia Schoch

Short communicationsAcute leukemia with B-lymphoid and myeloid differentiation associated with an 62inv(5)(q13q33) in an adult patient

Brad W. Butcher, Kathleen S. Wilson, Steven H. Kroft, Robert H. Collins, Jr., Vikas Bhushan

Minimal interval defined on 7q in uterine leiomyoma 67Susan M. Sell, Christine Tullis, Darcy Stracner, Chun-Yan Song, John Gewin

Translocation (X;20)(q13;q13.3): a nonrandom abnormality in four patients with 70myeloid disorders

Kavita S. Reddy, Kathy Richkind, Micheal Ross, Rubin Seirra

Molecular and cytogenetic characterization of a novel rearrangement involving chromosomes 9, 12, and 17 resulting in ETV6 (TEL) and ABL fusion 74

C.A. Tirado, S. Sebastian, J.O. Moore, J.Z. Gong, B.K. Goodman

Development of a dual-color fluorescence in situ hybridization probe set on chromosome 6q toimprove cytogenetic diagnosis of lymphoid malignancies 78

Jessica A. Crowley, Melody S. Butler, Michael J. Ronnenburg, Candice N. Ament,Joann S. Meekins, Yi Ning

Defective mismatch-repair as a minor tumorigenic pathway in Barrett esophagus-associated adenocarcinoma 82

Dan Falkenback, Jan Johansson, Britta Halvarsson, Mef Nilbert

Letters to the editorAcute myelocytic leukemia with t(11;17)(q23;q12-q21) involves a fusion of MLL and AF17 87

Steven D.P. Moore, Sabine Strehl, Paola Dal Cin

Y-chromosome loss in acute promyelocytic leukemia 90Yafang Wu, Yongquan Xue, Jinlan Pan

Acute promyelocytic leukemia in late pregnancy with unusual secondary chromosomal change and its prognostic importance 92

Dae Dong Lee, Tae Sung Park, Dong Soon Lee, Eun Yup Lee

Contents continued


Acute biphenotypic leukemia and an acquired X chromosome 94Yutaka Tsutsumi, Junji Tanaka, Hiina Minami, Mio Musashi, Arata Fukushima, Nobuyuki Ehira, Hiroe Kanamori, Hiroaki Yamato, Jun Sasaki, Chiharu Funaki, Satoshi Hasegawa, Shinji Obara, Nobutaka Ogura, Masahiro Asaka, Masahiro Imamura, Nobuo Masauzi


Volume 157, Number 2, March 2005

Contents

Original articlesAssessment of allele dosage at polymorphic microsatellite loci displaying 97allelic imbalance in tumors by means of quantitative competitive-polymerase chain reaction

Åsa Sjöling, Anna Walentinsson, Carola Nordlander, Åsa Karlsson, Afrouz Behboudi, Emma Samuelson, Göran Levan, Dan Röhme

Clonal evolution with inv(11)(p15q22) and NUP98/DDX10 fusion gene in 104imatinib-resistant chronic myelogenous leukemia

Masahide Yamamoto, Kazuhiko Kakihana, Tetsuya Kurosu, Naomi Murakami, Osamu Miura

Pediatric pancreatoblastoma: histopathologic and cytogenetic characterization 109of tumor and derived cell line

Linda Barenboim-Stapleton, Xuezhong Yang, Maria Tsokos, Jon M. Wigginton, Hesed Padilla-Nash, Thomas Ried, Carol J. Thiele

Role of multiplex FISH in identifying chromosome involvement in myelodysplastic 118syndromes and acute myeloid leukemias with complex karyotypes: a report on 28 cases

Emmanuelle Barouk-Simonet, Valérie Soenen-Cornu, Christophe Roumier, Alain Cosson, Jean-Luc Laï, Pierre Fenaux, Claude Preudhomme

Chromosome mechanisms and INI1 inactivation in human and mouse 127rhabdoid tumors

Marie-Françoise Rousseau-Merck, Laurence Fiette, Agnes Klochendler-Yeivin, Olivier Delattre, Alain Aurias

Molecular cytogenetic characterization of rearrangements involving 12p in leukemia 134L. Vieira, B. Marques, C. Cavaleiro, A.P. Ambrósio, M. Jorge, A. Neto, J.M. Costa, E.C. Júnior, M.G. Boavida

Short communicationsConventional and array-based comparative genomic hybridization analysis 140of nasopharyngeal carcinomas from the Mediterranean area

S. Rodriguez, A. Khabir, C. Keryer, C. Perrot, M. Drira, A. Ghorbel, R. Jlidi, A. Bernheim, A. Valent, P. Busson

Primary myeloid sarcoma of the testicle with t(15;17) 148Shanti Gopal, Sandra Marcussen, Sheila M. Dobin, William Koss, Ludvik R. Donner

NUP98 is fused to HOXA9 in a variant complex t(7;11;13;17) in a patient with AML-M2 151Idoya Lahortiga, Elena Belloni, Iria Vázquez, Xabier Agirre, María J. Larrayoz, Jose L. Vizmanos, Mikel Valgañón, Isabel Zudaire, Borja Sáez, María C. Mateos, Pier Paolo Di Fiore, María J. Calasanz, María D. Odero

Jumping translocation of 1q in a BCR/ABL-positive acute lymphoblastic leukemia 157Antje-Friederike Pelz, Gerd Müller, Peter Wieacker

A clonal dic(16;21)(p13.1;p11.2)del(16)(q11.1), with gains of several chromosomes 160and monosomy 21, in a case of splenic hamartoma: evidence for its neoplastic, not hamartomatous, origin

Ludvik R. Donner, Sandra Marcussen, Sheila M. Dobin

Contents continued


A der(19)t(12;19)(q12;p13.3) in a case of pediatric acute leukemia with unusual 164immunophenotype

Elaine Leung, Ikuko Teshima, Charles Ye, Ron Grant, Mohamed Abdelhaleem

Rearrangement of the MLL gene in acute myeloblastic leukemia: report of two 169rare translocations

Nathalie Douet-Guilbert, Frédéric Morel, Marie-Josée Le Bris, Angèle Herry, Patrick Morice, Pascal Bourquard, Saïd Banzakour, Geneviève Le Calvez, Véronique Marion, Christian Berthou, Marc De Braekeleer

A complex translocation (9;22;16)(q34;q11.2;p13) in chronic myelocytic leukemia 175Juan Pablo Meza Espinoza, Verónica Judith Picos Cárdenas, Erika Alejandra Vásquez Jiménez, Melva Gutiérrez Angulo, María Amparo Esparza Flores, Juan Ramón González García

Cryptic 5� MLL gene insertion in an X-chromosome in acute myeloblastic leukemia 178Nathalie Douet-Guilbert, Bertrand Arnaud, Frédéric Morel, Marie-Josée Le Bris, Marc De Braekeleer

Analysis of somatic NF1 promoter methylation in plexiform neurofibromas 181and Schwann cells

Lauren Fishbein, Bonnie Eady, Nicholas Sanek, David Muir, Margaret R. Wallace

Letters to the editorA second case of myelodysplastic syndrome with t(9;12)(q22;p12) 187

Mandana Mahmoodi, Vanlila K. Swami, Emmanuel C. Besa, Hope H. Punnett

Standard mono- and dinucleotide repeats do not appear to be sensitive markers 189of microsatellite instability in the Ewing family of tumors

Martin Ebinger, Thomas Bock, Reinhard Kandolf, Karl Sotlar, Burkhard D. Bültmann, Johann Greil

Prenatal diagnosis history of a Li-Fraumeni syndrome family 191Sefik Güran, Yusuf Tunca


Volume 158, Number 1, April 1, 2005

Contents

Lead articlesUpdates on the cytogenetics and molecular genetics of bone and soft tissue tumors: 1leiomyoma

Avery A. Sandberg

The role of viral integration in the development of cervical cancer 27Tingxi Yu, Matthew J. Ferber, Tak Hong Cheung, Tong Kwok Hung Chung, Yick Fu Wong, David I. Smith

Original articlescDNA array analysis of cytobrush-collected normal and malignant cervical epithelial cells: 35a feasibility study

Gernot Hudelist, Klaus Czerwenka, Christian Singer, Kerstin Pischinger, Ernst Kubista, Mahmood Manavi

Identification of cell lineages involved by t(15;17) in acute promyelocytic leukemia by 43combined fluorescence activated cell sorting and FISH

Hong Chang, Xiao Ying Qi, D. Robert Sutherland

Contents continued


The effectiveness of high–resolution-comparative genomic hybridization in 49detecting the most common chromosomal abnormalities in pediatric myelodysplastic syndromes

Mariusz Babicz, Jerzy R. Kowalczyk, Dorota Winnicka, Anna Gaworczyk, Monika Lejman, Rafal Dmowski, Katarzyna Kaczanowska

Frequency and spectrum of K-RAS codons 12 and 13 mutations in colorectal 55adenocarcinomas from Taiwan

Chi-Ming Wu, Reiping Tang, Jeng-Yi Wang, Chung-Rong Changchien, Ling-Ling Hsieh

Short communicationsCharacterization of 3p, 5p, and 3q in two nasopharyngeal carcinoma cell lines, using 61region-specific multiplex fluorescence in situ hybridization probes

Wai Mui Tjia, Jonathan S.T. Sham, Liang Hu, Amy L.S. Tai, Xin-Yuan Guan

A clonal reciprocal t(2;7)(p13;p13) in plantar fibromatosis 67Jeffrey R. Sawyer, Gael Sammartino, Neriman Gokden, Richard W. Nicholas

Founder mutation in familial adenomatous polyposis (FAP) in the Balearic Islands 70Sara González, Ignacio Blanco, Olga Campos, María Julià, José Reyes, Alfred Llompart, Elena Cabeza, Josep Ramon Germa, Antoni Obrador, Gabriel Capellá

Oncogenetic tree models based on cytogenetic data: new insights into the development of 75epithelial tumors of the thymus

Ralf J. Rieker, Roland Penzel, Sebastian Aulmann, Hendrik Blaeker, Alicia Morresi-Hauf, Erich Hecker, Herwart F. Otto, Gunhild Mechtersheimer, Anja von Heydebreck

Translocation (X;20) involving the inactive X chromosome in a patient with 81myeloproliferative disorder

John O'Reilly, Julie Crawford, Joan Uzaraga, Paul Cannell

SKY and genetic fingerprinting reveal a cross-contamination of the putative normal colon 84epithelial cell line NCOL-1

Ralph Melcher, Stefanie Maisch, Sigrid Koehler, Martin Bauer, Claus Steinlein, Michael Schmid, Theodor Kudlich, Jürgen Schauber, Hardi Luehrs, Thomas Menzel, Wolfgang Scheppach

The value of fluorescence in situ hybridization in the diagnosis and prognosis of chronic 88lymphocytic leukemia

Armand B. Glassman, Kimberly J. Hayes

Letters to the editorA complex karyotype in promyelocytic-like blastic transformation of Ph-positive chronic 92myeloid leukemia

A.D. Panani, M. Stamouli, N. Harhalakis, M. Nikiforakis, Ch. Roussos

Translocation (1;4;12)(q25;q27;q15) in a childhood intramuscular lipoma 95Liming Bao, Lili Miles


Volume 158, Number 2, April 15, 2005

Contents

Lead articlesTargeting plasma cells improves detection of cytogenetic aberrations in multiple 99myeloma: phenotype/genotype fluorescence in situ hybridization

Marilyn L. Slovak, Victoria Bedell, Kristen Pagel, Karen L. Chang, David Smith, George Somlo

Contents continued


Characterization of quantitative chromosomal abnormalities in renal cell 110carcinomas by interphase four-color fluorescence in situ hybridization

Aline Ossard Receveur, Jérome Couturier, Vincent Molinié, Annick Vieillefond, François Desangles, Marine Guillaud-Bataille, Gisèle Danglot, Philippe Coullin, Alain Bernheim

Original articlesBRCA1 and pancreatic cancer: pedigree findings and their causal relationships 119

Henry T. Lynch, Carolyn A. Deters, Carrie L. Snyder, Jane F. Lynch, Pierre Villeneuve, Julie Silberstein, Holly Martin, Steven A. Narod, Randall E. Brand

Molecular analysis of primary and recurrent giant cell tumors of bone 126Uma N.M. Rao, Mark Goodman, Wen-Wei Chung, Patricia Swalski, Raj Pal, Sydney Finkelstein

Genetic analysis of susceptibility to endometrial adenocarcinoma in the BDII 137rat model

L. Roshani, P. Mallon, E. Sjostrand, D. Wedekind, J. Szpirer, C. Szpirer, H.J. Hedrich, K. Klinga-Levan

Allelic loss at 10q26 in osteosarcoma in the region of the BUB3 and FGFR2 genes 142Susana Mendoza, Heldi David, Grace M. Gaylord, Carl W. Miller

Methylation status of EXT1 and EXT2 promoters and two mutations of EXT2 148in chondrosarcoma

Takashi Tsuchiya, Toshihisa Osanai, Akira Ogose, Gen Tamura, Tokuhiro Chano, Yasuhiko Kaneko, Akira Ishikawa, Hiroshi Orui, Takuro Wada, Tatsuru Ikeda, Masayoshi Namba, Masaharu Takigawa, Hiroyuki Kawashima, Tetsuo Hotta, Atsushi Tsuchiya, Toshihiko Ogino, Teiichi Motoyama

Effects of degenerate oligonucleotide-primed polymerase chain reaction 156amplification and labeling methods on the sensitivity and specificity of metaphase- and array-based comparative genomic hybridization

Yasuhiro Tsubosa, Hiroyuki Sugihara, Ken-ichi Mukaisho, Sumihiro Kamitani, Dun-Fa Peng, Zhi-Qiang Ling, Tohru Tani, Takanori Hattori

Alterations of loci encoding PU.1, BOB1, and OCT2 transcription regulators 167do not correlate with their suppressed expression in Hodgkin lymphoma

Francesco Cavazzini, Chris De Wolf-Peeters, Iwona Wlodarska

Establishment of a cell line from a malignant rhabdoid tumor of the liver lacking 172the function of two tumor suppressor genes, hSNF5/INI1 and p16

Hiroshi Kuroda, Hiroshi Moritake, Kazumi Sawada, Yasumichi Kuwahara, Issei Imoto, Johji Inazawa, Tohru Sugimoto

Short communicationsMolecular cytogenetic characteristics of the human hepatocellular carcinoma 180cell line HCCLM3 with high metastatic potential: comparative genomic hybridization and multiplex fluorescence in situ hybridization

Jiong Yang, Lun-Xiu Qin, Yan Li, Sheng-Long Ye, Yin-Kun Liu, Dong-Mei Gao, Jie Chen, Zhao-You Tang

Chromosome 7 abnormalities in acute megakaryoblastic leukemia associated 184with Down syndrome

Ken-ichiro Kobayashi, Ikuya Usami, Masaru Kubota, Toshikazu Nishio, Naoki Kakazu

Inv(1)(p22q25) in chronic myeloproliferative disease: constitutional or clonal defect? 188K.F. Wong, W.C. Wong, W. Cheuk

Letter to the editorsPrecursor T-lymphoblastic leukemia with an inv(6)(p21.2q27) 192

K.F. Wong, Jennifer N.S. Leung

Multiple reciprocal translocations in carcinomas 194Wael M. Abdel-Rahman

Contents continued


Acquired Robertsonian translocations in leukemia: two more cases 196Daniel B. Herring, Kerry A. Harbert, Sharon L. Wenger, Solveig G. Ericson


Volume 159, Number 1, May 2005

Contents

Lead articleA combination of molecular cytogenetic analyses reveals complex genetic alterations in 1conventional renal cell carcinoma

Jon C. Strefford, Irina Stasevich, Tim M. Lane, Yong-Jie Lu, Tim Oliver, Bryan D. Young

Original articlesAURKA amplification, chromosome instability, and centrosome abnormality in 10human pancreatic carcinoma cells

Jijiang Zhu, James L. Abbruzzese, Julie Izzo, Walter N. Hittelman, Donghui Li

Molecular characterization of a consistent 4.5-megabase deletion at 4q28 in 18prostate cancer cells

Sei-Ichi Matsui, Jeffrey LaDuca, Michael R. Rossi, Norma J. Nowak, John K. Cowell

Microarray-based comparative genomic hybridization of pheochromocytoma 27cell lines from neurofibromatosis knockout mice reveals genetic alterations similar to those in human pheochromocytomas

James F. Powers, Arthur S. Tischler, Mansoor Mohammed, Rizwann Naeem

Evidence for telomeric fusions as a mechanism for recurring structural aberrations 32of chromosome 11 in giant cell tumor of bone

Jeffrey R. Sawyer, Linda S. Goosen, Regina Lichti Binz, Charles M. Swanson, Richard W. Nicholas

Frequent allelic loss of 21q11.1~q21.1 region in advanced stage oral squamous 37cell carcinoma

Lan Chen, Maria Pik Wong, Lim Kwong Cheung, Lakshman P. Samaranayake, Larry Baum, Nabil Samman

Association between the stages of cervical cancer and chromosome 1 aneusomy 44Elva I. Cortés-Gutiérrez, Martha I. Dávila-Rodríguez, Marycarmen Muraira-Rodríguez, Salvador Said-Fernández, Ricardo M. Cerda-Flores

Association of functional polymorphisms of SLC11A1 with risk of esophageal 48cancer in the South African Colored population

Monique G. Zaahl, Louise Warnich, Tommy C. Victor, Maritha J. Kotze

Mini-ReviewProgress in concurrent analysis of loss of heterozygosity and comparative genomic hybridization utilizing high density single nucleotide polymorphism arrays 53

Xiaofeng Zhou, Nagesh P. Rao, Steven W. Cole, Samuel C. Mok, Zugen Chen, David T. Wong

Short communicationsAcquisition of a Ph chromosome with minor BCR/ABL fusion in 58treatment-related myelodysplastic syndrome with chromosome 7 abnormalities in a patient treated for Hodgkin disease

Abraham Kneller, Ninette Cohen, Miriam Berkowicz, Malka Reichart, Esther Rosner, Maya Sokolovski, Arnon Nagler, Gideon Rechavi, Ninette Amariglio, Luba Trakhtenbrot

Cytogenetically unrelated clones in different histologic components of a Wilms tumor 63Michelle Dolan, Kristin Mascotti

Contents continued


A new variant t(6;15;17)(q25;q22;q21) in acute promyelocytic leukemia: fluorescence 69in situ hybridization confirmation

Virginie Eclache, Franck Viguie, Claudie Frocrain, Bruno Cassinat, Christine Chomienne, Florence Cymbalista, Pierre Fenaux

Burkitt-type acute leukemia in a patient with B-prolymphocytic leukemia: evidence 74for a common origin

Florence Nguyen-Khac, Frédéric Davi, Aline Receveur, Karim Maloum, Véronique Morel, Magali Le Garff-Tavernier, Jeanne Ong, Roland Berger, Véronique Leblond, Hélène Merle-Béral

A variant t(8;10;21) in a patient with pathological features mimicking atypical 79chronic myeloid leukemia

Jiyun Lee, William F. Kern, Joan B. Cain, John J. Mulvihill, Shibo Li

Genetic changes in localized prostate cancer of Japanese patients shown by 84comparative genomic hybridization

Kotaro Kasahara, Takahiro Taguchi, Ichiro Yamasaki, Masayuki Kamada, Taro Shuin

Copy number gains on 22q13 in adenoid cystic carcinoma of the salivary gland 89revealed by comparative genomic hybridization and tissue microarray analysis

Kolja Freier, Christa Flechtenmacher, Axel Walch, Sibylle Ohl, Frauke Devens, Bert Burke, Stefan Hassfeld, Peter Lichter, Stefan Joos, Christof Hofele

Letter to the editorVariant translocation t(2;21;8)(q36;q22;q22) with RUNX1/CBFA2T1 (AML1/ETO) 96transcript in a case of acute myelogenous leukemia

Hui-Hua Hsiao, Goro Sashida, Atsushi Kodama, Katsuhiro Fukutake, Kazuma Ohyashiki

Volume 159, Number 2, June 2005

Contents

Original articlesAnalysis of ameloblastomas by comparative genomic hybridization and fluorescence 99in situ hybridization

Makoto Toida, Margit Balázs, Andrea Treszl, Zsuzsa Rákosy, Keizo Kato, Yutaka Yamazaki, Toshiaki Matsui, Tatsuhiko Suwa, Daijiro Hatakeyama, Hiroki Makita, Sojiro Mori, Tomomi Yamashita, Toshiyuki Shibata, Róza Ádány

Genomic deletions in cell lines derived from primitive neuroectodermal tumors of the 105central nervous system

Peter B. Dallas, Philippa A. Terry, Ursula R. Kees

High-resolution methylation analysis of the BRCA1 promoter in ovarian tumors 114 Cathy B. Wilcox, Bora E. Baysal, Holly H. Gallion, Mary A. Strange, Julie A. DeLoia

Cytogenetic aberrations in spontaneous endometrial adenocarcinomas in the BDII rat 123model as revealed by chromosome banding and comparative genome hybridization

Ahmad Hamta, Tatjana Adamovic, Khalil Heloua, Göran Levan

Acute promyelocytic leukemia with PML-RARA fusion on i(17q) and therapy-related 129acute myeloid leukemia

Geok Yee Lee, Sivaswaren Christina, Sim Leng Tien, Anisah Bte Abdul Ghafar, William Hwang, Lay Cheng Lim, Tse Hui Lim

Contents continued


Short communicationsChromosomal abnormalities in bronchial epithelium from smokers, nonsmokers, 137and lung cancer patients

Robbert J.C. Slebos, Elizabeth Livanos, Hyeon-Woo Yim, Scott H. Randell, Alden M. Parsons, Frank C. Detterbeck, M. Patricia Rivera, Jack A. Taylor

TP53 codon 72 polymorphism and risk for cervical cancer in Portugal 143Alexandra M. Santos, Hugo Sousa, Raquel Catarino, Daniela Pinto, Deolinda Pereira, André Vasconcelos, Ana Matos, Carlos Lopes, Rui Medeiros

Genotoxicity and sister chromatid exchange in patients with myelodysplastic disorders 148Sükrü Öztürk, Sükrü Palanduz, Kıvanç Çefle, Gülçin Tutkan, Ali Uçur, Günçag Dinçol, Meliha Nalçacı, Melih Aktan, Selim Yavuz, Reyhan Diz Küçükkaya

Trisomy 8 as the sole cytogenetic abnormality in a case of extraskeletal mesenchymal 151chondrosarcoma

Ken M. Gatter, Susan Olson, Helen Lawce, Anne E. Rader

Identification of a transcriptionally active hVH-5 pseudogene on 10q22.2 155Ingemarie R. Berger, Marcus Buschbeck, Johannes Bange, Axel Ullrich

Cytogenetic characterization of Ewing tumors with high-ploidy 160David R. Betts, Pierino Avoledo, Nicolas von der Weid, Jeanette Greiner, Felix K. Niggli

BCR-ABL gene amplification and overexpression in a patient with chronic myeloid 164leukemia treated with imatinib

Dorothea Gadzicki, Nils von Neuhoff, Doris Steinemann, Marianne Just, Guntram Büsche, Hans Kreipe, Ludwig Wilkens, Brigitte Schlegelberger

Two cases of acute myeloid leukemia with t(11;17) associated with varying morphology 168and immunophenotype: rearrangement of the MLL gene and a region proximal to the RAR� gene

Loveleen C. Kang, Scott V. Smith, Kathleen Kaiser-Rogers, Kathleen Rao, Cherie H. Dunphy

Unique three-way translocation, t(3;14;18)(q27;q32;q21), in follicular lymphoma 174Akira Okano, Sonoko Nakano, Kyoko Namura, Noriko Yamada, Ryo Uchida, Shin-ichi Fuchida, Masashi Okamoto, Naoya Ochiai, Chihiro Shimazaki

Cytogenetic and molecular cytogenetic studies of a variant of t(21;22), 177ins(22;21)(q12;q21q22), with a deletion of the 3� EWSR1 gene in a patient with Ewing sarcoma

Jiyun Lee, Deborah J. Hopcus-Niccum, John J. Mulvihill, Shibo Li

Letters to the editorA case of infantile acute myelogenous leukemia with MLL-MLL10 fusion caused by 181insertion of 11q into 10p

Lydia Christiansen, Richard A. Allen, S. Terence Dunn, Daynna J. Wolff

A t(2;3)(q11;q27) involving the BCL6 gene in follicular lymphoma with dup(12q) 184and t(14;18)

Katsuya Yamamoto, Atsuo Okamura, Akio Hato, Shinichiro Nishikawa, Kimikazu Yakushijin, Toshimitsu Matsui

Biphenotypic expression in a case of acute leukemia with pericentric inv(6)(p12q24) 187Lily Kerketta, V. Babu Rao, Manisha Madkaiker, Kanjaksha Ghosh, Dipika Mohanty, Farah Jijina

Clonal abnormalities in a recurrent laryngeal papilloma 190Ahmed Soliman, Jasvir S. Khurana, Hope H. Punnett

Monosomy 22 and trisomy 14 in a granulosa tumor metastatic to the lung 20 years after 192the removal of the primary tumor

Asraa L. Namiq, Diane L. Persons, Jeffrey Piehler, Ivan Damjanov

Erratum 194

Contents continued


Volume 160, Number 1, July 1, 2005

Contents

Lead articlesMolecular cytogenetic analysis of chromosomes 1 and 19 in glioma cell lines 1

Mark E. Law, Kristen L. Templeton, Gaspar Kitange, Justin Smith, Anjan Misra, Burt G. Feuerstein, Robert B. Jenkins

Chromosome 7 abnormalities are common in chordomas 15Petter Brandal, Bodil Bjerkehagen, Håvard Danielsen, Sverre Heim

Original articlesCoexistence of different clonal populations harboring the b3a2 (p210) and e1a2 (p190) 22BCR-ABL1 fusion transcripts in chronic myelogenous leukemia resistant to imatinib

Xabier Agirre, José Román-Gómez, Iria Vázquez, Antonio Jiménez-Velasco, María J. Larráyoz, Idoya Lahortiga, Enrique J. Andreu, José Márquez, José M. Beltrán de Heredia, María D. Odero, Felipe Prósper, María J. Calasanz

Incidence of chromosomal anomalies detected with FISH and their clinical correlations 27in B-chronic lymphocytic leukemia

Lenka Sindelárová, Kyra Michalová, Zuzana Zemanová, Sárka Ransdorfová, Jana Brezinová, Sona Peková, Jirí Schwarz, Josef Karban, Eduard Cmunt

In silico chromosomal clustering of genes displaying altered expression patterns in 35ovarian cancer

Ofir Israeli, Ayala Goldring-Aviram, Shlomit Rienstein, Gilad Ben-Baruch, Jakob Korach,Boleslaow Goldman, Eitan Friedman

Allelic loss of 3p25 associated with alterations of 5q22.3~q23.2 may affect the prognosis of 43conventional renal cell carcinoma

Kazuhiro Nagao, Shiro Yamaguchi, Hideyasu Matsuyama, Yoshihito Korenaga, Hiroshi Hirata, Satoru Yoshihiro, Koji Fukunaga, Kazuo Oba, Katsusuke Naito

Increased risk of cervical cancer associated with cyclin D1 gene A870G polymorphism 49Raquel Catarino, Ana Matos, Daniela Pinto, Deolinda Pereira, Rogéria Craveiro, André Vasconcelos, Carlos Lopes, Rui Medeiros

Genetic polymorphism in the sulfotransferase SULT1A1 gene in cancer 55Wogelsanger O. Pereira, Aldair S. Paiva, José W. Queiroz, Leny Toma, Carl P. Dietrich, Helena B. Nader, Selma M.B. Jerônimo

Large genomic aberrations in MSH2 and MLH1 genes are frequent in Chinese 61colorectal cancer

Ming Zhu, Jintian Li, Xiaomei Zhang, Xiaorong Liu, Waltraut Friedl, Yuanying Zhang, Xiaoliu Wu, Peter Propping, Yaping Wang

Short communicationsHematological, immunophenotypic, and cytogenetic characteristics of acute myeloblastic 68leukemia with trisomy 11

Magdalena Sierra, Jesús M. Hernández, Juan L. García, Norma C. Gutiérrez, José J. Pérez, M. Belén Vidriales, Fernando Ramos, José M. Hernández, Mercedes Romero, M. Belén González, Josefina Galende, Jesús F. San Miguel

Chronic myelogenous leukemia occurring in two brothers diagnosed 26 years apart 73David S. Lessen, Amory V. Novoselac, Gerard Hellman, Alberto Tapia, Lynn H. Ratner, Vesna Najfeld

Acquired inv(9): what is its significance? 76Jaime L. Betz, Ahmed S. Behairy, Pedro Rabionet, Budi Tirtorahardjo, Mathew W. Moore, Philip D. Cotter

Telomere stability genes are not mutated in osteosarcoma cell lines 79Sharon A. Savage, Brian J. Stewart, Jason S. Liao, Lee J. Helman, Stephen J. Chanock

Contents continued


Aberrations of 11q13 in laryngeal squamous cell lines and their prognostic significance 82Malgorzata Jarmuz, Reidar Grenman, Wojciech Golusinski, Krzysztof Szyfter

A der(14)t(1;14)(q12;p11) in chronic myelomonocytic leukemia 89Vesna Djordjevic, Gradimir Jankovic, Nada Suvajdzic, Dragomir Marisavljevic, Milena Pantic, Andrija Bogdanovic, Dijana Sefer, Marija Dencic, Milica Colovic

Letter to the editorCryptic chromosomal anomaly in a patient with acute myeloid leukemia leading to 94AML1/ETO fusion with unfavorable prognostic factors

Yuko Ishii, Goro Sashida, Tomo-iku Takaku, Masahiko Sumi, Akihiro Nakajima, Kazuma Ohyashiki

Volume 160, Number 2, July 15, 2005

Contents

Original articlesPolysomy 8 defines a clinico-cytogenetic entity representing a subset of myeloid 97hematologic malignancies associated with a poor prognosis: report on a cohort of 12 patients and review of 105 published cases

Valérie Beyer, Dominique Mühlematter, Valérie Parlier, Christine Cabrol, Sandrine Bougeon-Mamin, Max Solenthaler, Andreas Tobler, Paul Pugin, Michael Gregor, Felicitas Hitz, Urs Hess, Bernard Chapuis, France Laurencet, Urs Schanz, Pierre-Michel Schmidt, Guy van Melle, Martine Jotterand

Losses of 1p and chromosome 14 in renal oncocytomas 120László Füzesi, Derk Frank, Christian Nguyen, Rolf-Hermann Ringert, Henning Bartels, Bastian Gunawan

Characterization of ABCG2 gene amplification manifesting as extrachromsomal 126DNA in mitoxantrone-selected SF295 human glioblastoma cells

V. Koneti Rao, Darawalee Wangsa, Robert W. Robey, Lyn Huff, Yasumasa Honjo, Jeffrey Hung, Turid Knutsen, Thomas Ried, Susan E. Bates

Complex CGH alterations on chromosome arm 8p at candidate tumor suppressor 134gene loci in breast cancer cell lines

Deon J. Venter, Susan J. Ramus, Fleur M.A. Hammet, Melanie de Silva, Anne-Marie Hutchins, Vida Petrovic, Gareth Price, Jane E. Armes

Genetic losses in breast cancer: toward an integrated molecular cytogenetic map 141Xin Mao, Rifat A. Hamoudi, Po Zhao, Michael Baudis

Chromosome alterations in colorectal cancer in Thai patients 152S. Poeaim, B. Rerkamnuaychoke, S. Jesdapatarakul, A. Campiranon

Short communicationsAn intronic variant in the TP53 gene in a Brazilian woman with breast cancer 160

Leandra Linhares Lacerda, Sergio Vicente Serrano, Angelo Mathes, Juan A. Rey, Maria Josefa Bello, Cacilda Casartelli

Hereditary breast cancer syndromes in a Turkish population. Results of molecular 164germline analysis

Sefik Güran, Ahmet Özet, Murat Dede, Johan J.P. Gille, Müfit Cemal Yenen

No evidence of INI1hSNF5 (SMARCB1) and PARVG point mutations in 169oligodendroglial neoplasms

M. Eva Alonso, M. Josefa Bello, Jose M. de Campos, Alberto Isla, Jesús Vaquero, Manuel Gutierrez, Jose L. Sarasa, Juan A. Rey

Identification of a ring chromosome with spectral karyotyping in a pleural 174synovial sarcoma

Jun Nishio, Hiroshi Iwasaki, Pamela A. Althof, Sabine Naumann, Masako Ishiguro, Seiji Haraoka, Akinori Iwashita, Akinori Iwasaki, Yoshio Kaku, Yasuhiko Kaneko, Masahiro Kikuchi, Julia A. Bridge

Contents continued


Gain of 9p due to an unbalanced rearrangement der(9;18): a recurrent clonal abnormality 179in chronic myeloproliferative disorders

Ulrike Bacher, Torsten Haferlach, Claudia Schoch

Deletions of the 3� BCR and 5� ABL regions in patients with Philadelphia-positive 184chronic myeloid leukemia: a one-step process occurring in about 10% of the cases without any evidence of genetic instability in the target cells

Mickaël Fournier, Stéphanie Lacrosse, Mauricette Jamar, Vincent Bours, Christian Herens

Prognostic significance of del(20q) in patients with hematological malignancies 188Jana Brezinová, Zuzana Zemanová, Sárka Ransdorfová, Lenka Sindelárová, Magda Sisková, Radana Neuwirtová, Jaroslav Cermák, Kyra Michalová

Volume 161, Number 1, August 2005

Contents

Lead articleUpdates on the cytogenetics and molecular genetics of bone and soft tissue tumors: 1leiomyosarcoma

Avery A. Sandberg

Original articlesLoss of DNA copy number of 10q is associated with aggressive behavior of 20leiomyosarcomas: a comparative genomic hybridization study

Jie Hu, Uma N.M. Rao, Suhagi Jasani, Vineesh Khanna, Kenneth Yaw, Urvashi Surti

Establishment and characterization of a novel myxofibrosarcoma cell line 28Hiroyuki Kawashima, Akira Ogose, Wenguang Gu, Jun Nishio, Naoko Kudo, Naoki Kondo, Tetsuo Hotta, Hajime Umezu, Tsuyoshi Tohyama, Hirokazu Nishijima, Hiroshi Iwasaki, Naoto Endo

Genome-wide aberrations in pancreatic adenocarcinoma 36Norma J. Nowak, Daniel Gaile, Jeffrey M. Conroy, Devin McQuaid, John Cowell, Randy Carter, Michael G. Goggins, Ralph H. Hruban, Anirban Maitra

Cytogenetic characterization of a BCR-ABL transduced mouse cell line 51Cornelia Rudolph, Ahmed N. Hegazy, Nils von Neuhoff, Doris Steinemann, Evelin Schröck, Renata Stripecke, Christoph Klein, Brigitte Schlegelberger

Analysis by comparative genomic hybridization of gastric cancer with peritoneal 57dissemination and/or positive peritoneal cytology

Koji Morohara, Kentaro Nakao, Yusuke Tajima, Nobukazu Nishino, Kimiyasu Yamazaki, Tsutomu Kaetsu, Satoshi Suzuki, Akira Tsunoda, Masatoshi Kawamura, Tadateru Aida, Tetsuhiko Tachikawa, Mitsuo Kusano

Short communicationsThe human ovarian teratocarcinoma cell line PA-1 demonstrates a single translocation: 63analysis with fluorescence in situ hybridization, spectral karyotyping, and bacterial artificial chromosome microarray

Shireen Sarraf, Raphael Tejada, Massih Abawi, Michael Oberst, Tom Dennis, Kelly Claire Simon, Jan Blancato

Variant acute promyelocytic leukemia translocation (15;17) originating from two 70subsequent balanced translocations involving the same chromosomes 15 and 17 while preserving the PML/RARA fusion

Carlos A. Tirado, Jennifer A. Jahn, Jay Scheerle, Maya Eid, Robert J. Meister, Robert J. Christie, Calvin D. Croft, Steven Wallingford, Deborah W. Heritage, Philip N. Mowrey, Aurelia M. Meloni-Ehrig

Contents continued


Chronic lymphocytic leukemia developing in a patient with chronic myeloid leukemia: 74evidence of distinct lineage-associated genomic events

Patricia Gargallo, Roberto Cacchione, Christian Chena, Juan Dupont, Guy Garay, Dardo Riveros, Irene Larripa, Irma Slavutsky

Acute myelogenous leukemia with tetrasomy 8 is a disease with a poor prognosis 78Panagiotis Tsirigotis, Sotirios Papageorgiou, Danai Abatzis, Sofia Athanatou, Constantinos Girkas, Vasiliki Pappa, Constantinos Pangalos, Efstathios Papageorgiou, John Dervenoulas, Sotirios Raptis

Isolated del(14)(q21) in a case of precursor B-cell acute lymphoblastic leukemia 82Aurelia M. Meloni-Ehrig, Carlos A. Tirado, Kuoping Chen, Jennifer Jahn, Stephany Suchan, Jay Scheerle, Maria Gabriela Crosby, Holly Meany, Nita Seibel, David Leitenberg, Deborah W. Heritage, Philip N. Mowrey

Frequent allelic imbalances at 8p and 11q22 in oral and oropharyngeal epithelial 86dysplastic lesions

Xiaofeng Zhou, Richard C.K. Jordan, Yang Li, Bau-Lin Huang, David T.W. Wong

Letters to the editorIs the cryptic interstitial deletion of 8q24 surrounding MYC a common mechanism in 90the formation of double minute chromosome?

Nicole C. Christacos, Leah Sherman, Alyssa Roy, Daniel J. DeAngelo, Paola Dal Cin

Absence of CHEK2 mutations in Spanish families with hereditary breast cancer 93Beatriz Bellosillo, Ignacio Tusquets, Raquel Longarón, Anna Pérez-Lezaun, Meritxell Bellet, Xavier Fabregat, Sergi Serrano, Francesc Solé

Volume 161, Number 2, September 2005

Contents

Original articlesIdentification of inactivating mutations in the JAK1, SYNJ2, and CLPTM1 genes in 97prostate cancer cells using inhibition of nonsense-mediated decay and microarray analysis

Michael R. Rossi, Lesleyann Hawthorn, Julie Platt, Tania Burkhardt, John K. Cowell, Yurij Ionov

Chromosomal aberrations in cell lines derived from thyroid tumors spontaneously 104developed in TR�PV/PV mice

Drazen B. Zimonjic, Yasuhito Kato, Hao Ying, Nicholas C. Popescu, Sheue-Yann Cheng

Screening by fluorescence in situ hybridization for MLL status at diagnosis in 239 110unselected patients with acute myeloblastic leukemia

Bertrand Arnaud, Nathalie Douet-Guilbert, Frédéric Morel, Marie-Josée Le Bris, Angèle Herry, Said Banzakour, Pascal Bourquard, Patrick Morice, Geneviève Le Calvez, Véronique Marion, Jean François Abgrall, Christian Berthou, Marc De Braekeleer

High incidence and intraclonal heterogeneity of chromosome 11 aberrations in patients 116with newly diagnosed multiple myeloma detected by multiprobe interphase FISH

Friedrich W. Cremer, Mutlu Kartal, Dirk Hose, Jelena Bila, Isabelle Buck, Frauke Bellos, Marc-Steffen Raab, Michaela Brough, Anke Moebus, Hans-Dieter Hager, Hartmut Goldschmidt, Marion Moos, Claus R. Bartram, Anna Jauch

Recurrent duplication of Xq27~qter in hematological malignancies revealed by multicolor 125fluorescence in situ hybridization and multicolor banding

Ruth N. MacKinnon, Adrian Zordan, Lynda J. Campbell

Cytogenetic findings, Trp53 mutations, and hormone responsiveness in 130a medroxyprogesterone acetate induced murine breast cancer model

Victoria T. Fabris, Fernando Benavides, Claudio Conti, Susana Merani, Claudia Lanari

Contents continued


Identification of oligodendroglioma specific chromosomal copy number changes in the 140glioblastoma MI-4 cell line by array-CGH and FISH analyses

Ivana Magnani, Ramona Frida Ramona, Gaia Roversi, Alessandro Beghini, Rolph Pfundt, Eric F. Schoenmakers, Lidia Larizza

Loss of 10p material in a child with human papillomavirus–positive 146disseminated bilateral retinoblastoma

Juan Pablo Meza Espinoza, Veronica Judith Picos Cardenas, Carlos Aguilar Luna, Hector Montoya Fuentes, Gonzalo Vazquez Camacho, Francisco Mendoza Carrera, Juan Ramon Gonzalez Garcia

THY-1 induction is associated with up-regulation of fibronectin and thrombospondin-1 151in human ovarian cancer

Harindra R. Abeysinghe, Li Qiong Li, Nedra L. Guckert, Jay Reeder, Nancy Wang

Jumping translocations in multiple myeloma 159Déborah Jamet, Youna Marzin, Nathalie Douet-Guilbert, Frédéric Morel, Marie-Josée Le Bris, Angèle Herry, Said Banzakour, Pascal Bourquard, Patrick Morice, Jean François Abgrall, Christian Berthou, Marc De Braekeleer

Genotype stability and clonal evolution of hepatocellular carcinoma assessed by 164autopsy-based genome-wide microsatellite analysis

Takafumi Nishimura, Naoshi Nishida, Toshiki Komeda, Yoshihiro Fukuda, Kazuwa Nakao

Short communicationsOvarian cancer is a heterogeneous disease 170

Vivian Wang, Cheng Li, Ming Lin, William Welch, Deborah Bell, Yuk-Fu Wong, Ross Berkowitz, Samuel C. Mok, Christina A. Bandera

Live cell catapulting and recultivation does not change the karyotype of HCT116 174tumor cells

Sabine Langer, Jochen B. Geigl, Susanne Ehnle, Rainer Gangnus, Michael R. Speicher

Karyotypic characterization of 64 nonmalignant thyroid goiters 178Mariola Iliszko, Alina Kuzniacka, Andrzej Lachinski, Malgorzata Babinska, Grazyna Kobierska-Gulida, Janusz Limon

Biallelic deletion and loss of expression analysis of genes at FRA2G common fragile site 181in tumor-derived cell lines

Zaira M. Limongi, Angela Curatolo, Franca Pelliccia, Angela Rocchi

Letter to the editorB-lymphoid or myeloid lineage identity of cell lines derived from chronic myeloid 187leukemia blast crisis

Bonaventure Ndikung Bejeng Soh, Florian Klein, Niklas Feldhahn, Markus Müschen

Volume 162, Number 1, October 1, 2005

Contents

Original articlesChromosome abnormalities in 10 lung cancer cell lines of the NCI-H series analyzed 1with spectral karyotyping

Mira Grigorova, Rachel C. Lyman, Carlos Caldas, Paul A.W. Edwards

Polymorphisms of the GSTM1, GSTP1, MPO, XRCC1, and NQO1 genes in 10Chinese patients with non-small cell lung cancers: relationship with aberrant promoter methylation of the CDKN2A and RARB genes

Eunice C. Chan, Shui Y. Lam, Kin H. Fu, Yok L. Kwong

Contents continued


Genetic abnormalities associated with the t(12;21) and their impact in the outcome 21of 56 patients with B-precursor acute lymphoblastic leukemia

Y. Alvarez, M.D. Coll, J.J. Ortega, P. Bastida, N. Dastugue, A. Robert, J. Cervera, A. Verdeguer, M. Tasso, A. Aventín, M. Guitart, M.R. Caballín

9q34 Rearrangements in BCR/ABL fusion-negative acute lymphoblastic leukemia 30Bhavana J. Dave, Michele Wiggins, Christine M. Higgins, Diane L. Pickering, Deborah Perry, Patricia Aoun, Minnie Abromowich, Marcel DeVetten, Warren G. Sanger

Chromosomal imbalances in a recurrent solitary fibrous tumor of the orbit 38Gro Oddveig Ness, Helle Lybæk, Jarle Arnes, Eyvind Rødahl

Leukemic recombinations involving heterochromatin in myeloproliferative 45disorders with t(1;9)

Constantina Sambani, Roberta La Starza, Valentina Pierini, Peter Vandenberghe, Juan J. Gonzales-Aguilera, Helen Rigana, Daphne Koumbi, Kalliopi N. Manola, Chryssa Stavropoulou, Vasileios N. Georgakakos, Maria Pagoni, Iwona Wlodarska, Cristina Mecucci

Epithelioid sarcoma with SYT-SSX1 fusion gene expression: molecular and 50cytogenetic analysis

Carmen de Torres, Teresa M. Cardesa, Sandra Rodríguez-Perales, Juan C. Cigudosa, Jaume Mora

Quantitative molecular monitoring of BCR-ABL and MDR1 transcripts in patients 57with chronic myeloid leukemia during Imatinib treatment

Sara Galimberti, Giulia Cervetti, Francesca Guerrini, Rossana Testi, Simone Pacini, Rita Fazzi, Paolo Simi, Mario Petrini

GADD45A and EPB41 as tumor suppressor genes in meningioma pathogenesis 63S. Piaskowski, P. Rieske, M. Szybka, K. Wozniak, A. Bednarek, E. Pluciennik, D. Jaskolski, B. Sikorska, Pawel Piotr Liberski

Who takes the lead in the development of ulcerative colitis–associated 68colorectal cancers: mutator, suppressor, or methylator pathway?

Lara Maia, Joana Dinis, Marília Cravo, Isabel Claro, Célia Baltazar, Isabel Fonseca, Tavarela Veloso, Ana F. Capelinha, Fátima Carneiro, Carlos Nobre-Leitão

Cytogenetic findings in clear cell chondrosarcoma 74Jun Nishio, John D. Reith, Akira Ogose, Gary Maale, James R. Neff, Julia A. Bridge

Random aneuploidy in neoplastic and pre-neoplastic diseases, multiple myeloma, 78and monoclonal gammopathy

A. Amiel, N. Gronich, M. Yukla, S. Suliman, G. Josef, E. Gaber, G. Drori, M.D. Fejgin, M. Lishner

Short communicationsHOXA gene cluster rearrangement in a t(7;9)(p15;q34) in a child with MDS 82

Bruce Poppe, Nurten Yigit, Barbara De Moerloose, Anne De Paepe, Yves Benoit, Frank Speleman

Deletion 6q is not a characteristic marker of nodal lymphoplasmacytic lymphoma 85James R. Cook, Nadine Ives Aguilera, Shalini Reshmi, Xin Huang, Zhisheng Yu, Susanne M. Gollin, Susan L. Abbondanzo, Steven H. Swerdlow

Letters to the editorIsochromosome of a deleted 20q may be a relatively common abnormality in 89myeloid malignancies

Azra H. Ligon, Daniel J. DeAngelo, Leonard Atkins, Paola Dal Cin

A novel interstitial deletion on the long arm of chromosome 16 in a patient 92with chronic myelomonocytic leukemia

Lukasz K. Kozon, Deborah L. Wesley, John Van Brunt III, Marilyn M. Li

Contents continued


Volume 162, Number 2, October 15, 2005

Contents

Original articlesThe human Penumbra gene is mapped to a region on chromosome 7 frequently 95deleted in myeloid malignancies

Zhong Chen, Marcelo Pasquini, Bo Hong, Sarah DeHart, Marc Heikens, Schickwann Tsai

Characterization of genomic instability in ulcerative colitis neoplasia leads to 99discovery of putative tumor suppressor regions

Ru Chen, Mary P. Bronner, David A. Crispin, Peter S. Rabinovitch, Teresa A. Brentnall

Chromosomal aberrations in follicular non-Hodgkin lymphomas of Japanese patients, 107detected with comparative genomic hybridization and polymerase chain reaction analysis

Jan G. D'Haese, Kunihiro Tsukasaki, Friedrich W. Cremer, Christine Fischer, Claus R. Bartram, Anna Jauch

Alterations of 9p in squamous cell carcinoma and adenocarcinoma of 115the lung: association with smoking, TP53, and survival

Carmen J. Marsit, John K. Wiencke, Heather H. Nelson, Duk-Hwan Kim, Philip W. Hinds, Kenneth Aldape, Karl T. Kelsey

3� CBF� deletion associated with inv(16) in acute myeloid leukemia 122Johanna Kelly, Nicola J. Foot, Eibhlin Conneally, Helen Enright, Mervyn Humphreys, Karen Saunders, Michael J. Neat

Mutations of the FLT3 gene in adult acute myeloid leukemia: determination of 127incidence and identification of a novel mutation in a Thai population

Chirayu U. Auewarakul, Narongrit Sritana, Chanin Limwongse, Wanna Thongnoppakhun, Pa-thai Yenchitsomanus

Inactivation patterns of NF2 and DAL-1/4.1B (EPB41L3) in sporadic meningioma 135Fabio Nunes, Yiping Shen, Yo Niida, Roberta Beauchamp, Anat O. Stemmer-Rachamimov, Vijaya Ramesh, James Gusella, Mia MacCollin

Detection of ETV6 and RUNX1 gene rearrangements using fluorescence in situ 140hybridization in Mexican patients with acute lymphoblastic leukemia: experience at a single institution

Patricia Pérez-Vera, Oreth Montero-Ruiz, Sara Frías, Verónica Ulloa-Avilés, Rocío Cárdenas-Cardós, Rogelio Paredes-Aguilera, Roberto Rivera-Luna, Alessandra Carnevale

ABL1 amplification in T-cell acute lymphoblastic leukemia 146Paolo Bernasconi, Silvia Calatroni, Ilaria Giardini, Alessandro Inzoli, Carlo Castagnola, Paola Maria Cavigliano, Barbara Rocca, Marina Boni, Jessica Quarna, Rita Zappatore, Marilena Caresana, Clara Bianchessi, Enrico Bobbio Pallavicini, Mario Lazzarino

Finer delineation and transcript map of the 7q31 locus deleted in myeloid neoplasms 151Hong Liang, Patricia D. Castro, Jin Ma, Lalitha Nagarajan

Short communicationsA der(13)t(7;13)(p13;q14) with monoallelic loss of RB1 and D13S319 in 160myelodysplastic syndrome

Katsuya Yamamoto, Mitsuhiro Ito, Kentaro Minagawa, Norinaga Urahama, Akiko Sada, Atsuo Okamura, Toshimitsu Matsui

Constitutional partial 1q trisomy mosaicism and Wilms tumor 166Hon Fong L. Mark, Herman Wyandt, Agen Pan, Jeff M. Milunsky

Constitutional trisomy 8 mosaicism with myelodysplastic syndrome complicated by 172intestinal Behcet disease and antithrombin III deficiency

Sachiko Ando, Masayo Maemori, Hajime Sakai, Seisho Ando, Hideaki Shiraishi, Keisuke Sakai, Gregory W. Ruhnke

Contents continued


The presence of TEL/AML1 rearrangement and cryptic deletion of the TEL gene in adult 176acute lymphoblastic leukemia (ALL)

Dong Soon Lee, Young Ree Kim, Hyung Kyun Cho, Chung Kee Lee, Jee Hyung Lee, Han Ik Cho

Cryptic MLL-AF10 fusion caused by insertion of duplicated 5� part of MLL into 17910p12 in acute leukemia: a case report

Marie Jarosova, Sylvia Takacova, Milena Holzerova, Monika Priwitzerova, Martina Divoka, Ilona Lakoma, Vladimir Mihal, Karel Indrak, Vladimir Divoky

Letter to the editorIgM myeloma with t(4;14)(p16;q32) 183

Sam Ackroyd, Sheila J. O'Connor, Andy C. Rawstron, Roger G. Owen

Volume 163, Number 1, November 2005

Contents

Original articlesLarge cell transformation of mycosis fungoides: tetraploidization within skin tumor 1large cells

Martina Prochazkova, Edith Chevret, Marie Beylot-Barry, Béatrice Vergier, Jiri Sobotka, Jean-Philippe Merlio

Smoking may cause genetic alterations at 5q22.2~q23.1 in clear-cell renal cell carcinoma 7Yoshihito Korenaga, Hideyasu Matsuyama, Hiroshi Hirata, Kazuhiro Nagao, Chietaka Ohmi, Shigeru Sakano, Satoru Yoshihiro, Katsusuke Naito

Random aneuploidy and telomere capture in chronic lymphocytic leukemia and 12chronic myeloid leukemia patients

A. Amiel, G. Goldzak, E. Gaber, G. Yosef, M.D. Fejgin, M. Yukla, M. Lishner

Characterization of the TSU-PR1 cell line by chromosome painting and flow cytometry 17MS. Kim, SH. Kim, HJ. Kim, IN. Hoang, WM. Oh, JT. Koh, HO. Park, JY. Jeong, WJ. Kim, EJ. Lee, JY. Koh, BY. Kim, R.H. Jensen

Molecular characterization of the t(3;9) associated with immortalization in the 23MCF10A cell line

John K. Cowell, Jeffrey LaDuca, Michael R. Rossi, Tania Burkhardt, Norma J. Nowak, Sei-ichi Matsui

Immortalization of human extravillous cytotrophoblasts by human papilloma virus 30gene E6E7: sequential cytogenetic and molecular genetic characterization

Yuesheng Jin, Hui-chen Feng, Wen Deng, Hao Zhang, Mei Lv, Charlotte Jin, Sai Wah Tsao, Yok-Lam Kwong

The association of the DNA repair gene XRCC3 Thr241Met polymorphism with 38susceptibility to colorectal cancer in a Chinese population

Ming-Juan Jin, Kun Chen, Liang Song, Chun-Hong Fan, Qing Chen, Yi-Min Zhu, Xin-Yuan Ma, Kai-Yan Yao

Chromosomal alterations cause the high rates and wide ranges of drug resistance 44in cancer cells

Ruhong Li, Ruediger Hehlman, Rainer Sachs, Peter Duesberg

Search for large genomic alterations of the BRCA1 gene in a Finnish population 57Eeva Laurila, Kirsi Syrjäkoski, Kaija Holli, Anne Kallioniemi, Ritva Karhu

Short communicationsCD79a expression in acute myeloid leukemia t(8;21) and the importance of cytogenetics in 62the diagnosis of leukemias with immunophenotypic ambiguity

Igor Kozlov, Kevin Beason, Cheng Yu, Michael Hughson

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Expression patterns of the LPP–HMGA2 fusion transcript in pulmonary chondroid 68hamartomas with t(3;12)(q27~28;q14~15)

Inga von Ahsen, Piere Rogalla, Jörn Bullerdiek

Translocation (6;17)(q23;q11.2): a novel cytogenetic abnormality in congenital acute myeloid 71leukemia?

Elspeth C. Ferguson, Polly Talley, Ajay Vora

Poor clinical course in a child with myelodysplastic syndrome and del(13)(q14q22) 74Hale Ören, Erdinç Yüksel, Sebnem Yilmaz, Meral Türker, Fatih Demircioglu, Gülersu Irken

Rarity of IgH translocations in Waldenström macroglobulinemia 77Sam Ackroyd, Sheila J.M. O'Connor, Roger G. Owen

Renal oncocytoma with loss of chromosomes Y and 1 evolving to papillary carcinoma in 81connection with gain of chromosome 7. Coincidence or progression?

Tahseen Al-Saleem, Binaifer R. Balsara, Zemin Liu, Madelyn Feder, Joseph R. Testa, Hong Wu, Richard E. Greenberg

Letters to the editorA cryptic three-way translocation involving chromosomes 8, 14, and 21 in a case of 86acute myeloid leukemia subtype M1

Lai-Ching Lau, Liang-Piu Koh, Tse-Hui Lim, Li-Eng Loo, Sim-Leng Tien

Absence of mutations in DICE1/DDX26 gene in human cancer cell lines with 91frequent 13q14 deletions

M. Hernández, N. Papadopoulos, T.A. Almeida

Identification of a complex (11;17;15) translocation in acute promyelocytic leukemia 93Nathalie Douet-Guilbert, Frédéric Morel, Marie-Josée Le Bris, Marc De Braekeleer

Reconsidering cell line cross-contamination in NCOL-1 95Uwe Wenzel, Hannelore Daniel

Reply to the letter from Wenzel and Daniel 97Ralph Melcher

Obituary 98

Erratum 99

Volume 163, Number 2, December 2005

Contents

Original articlesDeletion mapping of 18q in conventional renal cell carcinoma 101

Hiroshi Hirata, Hideyasu Matsuyama, Hiroaki Matsumoto, Yoshihito Korenaga, Chietaka Ohmi, Shigeru Sakano, Satoru Yoshihiro, Katsusuke Naito

Chromosomal radiosensitivity of breast cancer with a CHEK2 mutation 106Ans Baeyens, Kathleen Claes, Petra Willems, Kim De Ruyck, Hubert Thierens, Anne Vral

Cytogenetic study of 75 erythroleukemias 113M. Lessard, S. Struski, V. Leymarie, G. Flandrin, M. Lafage-Pochitaloff, M.-J. Mozziconacci, P. Talmant, C. Bastard, C. Charrin, L. Baranger, C. Hélias, P. Cornillet-Lefebvre, F. Mugneret, C. Cabrol, M.-P. Pagès, D. Fert-Ferret, F. Nguyen-Khac, B. Quilichini, C. Barin, R. Berger, on behalf of the Groupe Francophone de Cytogénétique, Hématologique (GFCH) and the Groupe Français d’Hématologie Cellulaire (GFHC)

Truncating mutations in the ACVR2 gene attenuates activin signaling in prostate cancer cells 123Michael R. Rossi, Yurij Ionov, Andrei V. Bakin, John K. Cowell

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Molecular genetic alterations and gene expression profile of a malignant rhabdoid 130tumor of the kidney

Toshihito Nagata, Yasuo Takahashi, Yukimoto Ishii, Satoshi Asai, Megumi Sugahara-Kobayashi, Yayoi Nishida, Akiko Murata, Shunji Yamamori, Yoshiyasu Ogawa, Takeshi Nakamura, Hitohiko Murakami, Masanori Nakamura, Hiroyuki Shichino, Motoaki Chin, Kiminobu Sugito, Taro Ikeda, Tsugumichi Koshinaga, Hideo Mugishima

Multimodal genetic diagnosis of solid variant alveolar rhabdomyosarcoma 138Nuno Cerveira, Lurdes Torres, Franclim R. Ribeiro, Rui Henrique, Armando Pinto, Susana Bizarro, Ana M. Ferreira, Carlos Lopes, Manuel R. Teixeira

Cytogenetic analysis of carboplatin resistance in early-stage epithelial ovarian carcinoma 144Lovisa Österberg, Kristina Levan, Karolina Partheen, Khalil Helou, György Horvath

Glucose transporter polymorphisms are associated with clear-cell renal carcinoma 151Tobias Page, Andrea D. Hodgkinson, Martin Ollerenshaw, John C. Hammonds, Andrew G. Demaine

Short communicationsMyeloid/natural killer cell precursor acute leukemia with tetraploidy 156

Günçag Dinçol, Sükrü Palandüz, Meliha Nalçacı, Ali Uçur, Banu Büyükaydın

Insertion (8;11) in a renal oncocytoma with multifocal transformation 160to chromophobe renal cell carcinoma

Marta Salido, Josep Lloreta, Carme Melero, Mar García, José Placer, Blanca Espinet, Olaya Villa, Oscar Bielsa, Antoni Gelabert-Mas, Sergi Serrano, Francesc Solé

BCR/ABL rearrangement in two cases of Philadelphia chromosome negative chronic 164myeloid leukemia: deletion on the derivative chromosome 9 may or not be present

Denise A.S. Batista, Anita Hawkins, Kathleen M. Murphy, Constance A. Griffin

Mutation analysis of the HIF-1α oxygen-dependent degradation domain in 168invasive breast cancer

Marije M. Vleugel, Astrid E. Greijer, Elsken van der Wall, Paul J. van Diest

Masked Philadelphia chromosome due to atypical BCR/ABL localization on the 9q34 band 173and duplication of the der(9) in a case of chronic myelogenous leukemia

Giuseppina Fugazza, Anna Garuti, Stefania Marchelli, Maurizio Miglino, Roberto Bruzzone, Anna Maria Gatti, Sandra Castello, Mario Sessarego

A comparison of two contrasting recurrent isochromosomes 20 found 176 in myelodysplastic syndromes suggests that retention of proximal 20q is a significant factor in myeloid malignancies

Ruth N. MacKinnon, Lynda J. Campbell

Multicolor fluorescence in situ hybridization characterization of cytogenetically 180polyclonal hematologic malignancies Josef Davidsson, Kajsa Paulsson, Bertil Johansson

Letters to the editorTrisomy 2 as the sole karyotypic abnormality in a lymphoproliferative disorder 184post-liver transplant

M.T. Ferro Delgado, M. Talavera, P. Garcia-Miguel, M.T. Sordo, C. Villalon, A. Leon, J.M. Garcia-Sagredo, C. San Roman

An aggressive Ewing sarcoma associated with a new variant translocation, 186t(4;11;22)(q25;q24;q12), hyperdiploid karyotype, and tetrasomy 8

Nouha Bouayed Abdelmoula, Christine Perot, Jean Louis Taillemite, Jacqueline Van Den Akker, Marie France Portnoi, Barbara Tourniaire, Judith Landman Pakker, Patrice Josset, Liliane Boccon-Gibod, Martine Peters, Olivier Delattre

Duplication of the Ph-chromosome as a possible mechanism of resistance to imatinib 189mesylate in patients with chronic myelogenous leukemia

A. Ossard-Receveur, A. Bernheim, B. Clausse, G. Danglot, D. Fauvet, B. Leon, F. Lozach, D. Bories, C. Brouzes, J.H. Bourhis, A.G. Turhan

Obituary 191

Author Index 192

Subject Index 199

Volume Contents 214

Contents continued

Documents

Volume Contents