Volume 8, Number 3, May 2021Neurology.org/NN

A peer-reviewed clinical and translational neurology open access journal

ARTICLE

Rituximab-Induced Hypogammaglobulinemia and Infections in AQP4 and MOG Antibody-Associated Diseases e977

ARTICLE

Potential Role of CHI3L1+ Astrocytes in Progression in MS e972

ARTICLE

Anti-CD20 Disrupts Meningeal B-Cell Aggregates in a Model of Secondary Progressive Multiple Sclerosis e975

ARTICLE

Longitudinally Extensive Myelitis Associated With Immune Checkpoint Inhibitors e967

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A peer-reviewed clinical and translational neurology open access journal Neurology.org/NN

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TABLE OF CONTENTS Volume 8, Number 3, May 2021 Neurology.org/NN

Editorial

e988 The Calm Between Storms: Serum Biomarkers inAssessing Interattack Astrocytopathy inNeuromyelitis Optica Spectrum DisorderC. Goldschmidt and R.A. Bermel

Open Access Article

Articles

e964 Epigallocatechin Gallate in Progressive MS: ARandomized, Placebo-Controlled TrialR. Rust, C. Chien, M. Scheel, A.U. Brandt, J. Dorr, J. Wuerfel,K. Klumbies, H. Zimmermann, M. Lorenz, K.-D. Wernecke,J. Bellmann-Strobl, and F. Paul

Open Access Article Class of Evidence

e965 Investigating the Presence of Interattack AstrocyteDamage in Neuromyelitis Optica SpectrumDisorder: Longitudinal Analysis of Serum GlialFibrillary Acidic ProteinJ.-W. Hyun, Y. Kim, S.Y. Kim, M.Y. Lee, S.-H. Kim, and H.J. Kim

Open Access Article Editorial, p. e988

e967 Longitudinally Extensive Myelitis Associated WithImmune Checkpoint InhibitorsA. Picca, G. Berzero, K. Bihan, V. Jachiet, E. Januel, M. Coustans,C. Cauquil, J. Perrin, P. Berlanga, N. Kramkimel, B. Garel, P. Devic,F. Ducray, M. Benazra, F. Bompaire, D. Leclercq, J.-M. Michot,S. Ammari, and D. Psimaras

Open Access Article

e970 Hemophagocytic Lymphohistiocytosis Gene Mutationsin Adult Patients Presenting With CLIPPERS-LikeSyndromeG. Taieb, E. Kaphan, C. Duflos, C. Lebrun-Frenay, V. Rigau,E. Thouvenot, E. Duhin-Gand, R. Lefaucheur, K. Hoang-Xuan,S. Coulette, J.C. Ouallet, N. Menjot de Champfleur, C. Tranchant,C. Picard,M. Fusaro, F.E. Sepulveda, P. Labauge, andG.deSaint Basile

Open Access Article

e972 Potential Role of CHI3L1+ Astrocytes in Progressionin MSL. Cubas-Nuñez, S. Gil-Perotın, J. Castillo-Villalba, V. Lopez,L. Solıs Tarazona, R. Gasque-Rubio, S. Carratala-Bosca,C. Alcala-Vicente, F. Perez-Miralles, H. Lassmann, and B. Casanova

Open Access Article Class of Evidence

e975 Anti-CD20 Disrupts Meningeal B-Cell Aggregates ina Model of Secondary Progressive Multiple SclerosisJ. Roodselaar, Y. Zhou,D. Leppert, A.E. Hauser, E. Urich, andD.C. Anthony

Open Access Article

e974 Clinical and Prognostic Value of ImmunogeneticCharacteristics in Anti-LGI1 EncephalitisS. Muñiz-Castrillo, J. Haesebaert, L. Thomas, A. Vogrig, A.-L. Pinto,G. Picard, C. Blanc, L.-D. Do, B. Joubert, G. Berzero, D. Psimaras,A. Alentorn, V. Rogemond, V. Dubois, A. Ambati, R. Tamouza,E. Mignot, and J. Honnorat

Open Access Article

e973 CNS Autoimmune Responses in BCMA-DeficientMiceProvide Insight for the Failure of Atacicept in MSG. Kumar, Z. Maria, U. Kohli, A. Agasing, J.L. Quinn, R.M. Ko,S.S. Zamvil, and R.C. Axtell

Open Access Article

e971 Interferon-β Is Less Effective Than Other Drugs inControlling theRateofRetinalGanglionCellLoss inMSY. You, M.H. Barnett, C. Yiannikas, J.D.E. Parratt, J.G. Matthews,S.L. Graham, and A. Klistorner

Open Access Article Class of Evidence

e977 Rituximab-Induced Hypogammaglobulinemiaand Infections in AQP4 and MOGAntibody–Associated DiseasesA. Avouac, A. Maarouf, J.-P. Stellmann, A. Rico, C. Boutiere,S. Demortiere, R. Marignier, J. Pelletier, and B. Audoin

Open Access Article

e978 Disability Outcomes in the N-MOmentum Trial ofInebilizumab in Neuromyelitis Optica SpectrumDisorderR. Marignier, J.L. Bennett, H.J. Kim, B.G. Weinshenker, S.J. Pittock,D. Wingerchuk, K. Fujihara, F. Paul, G.R. Cutter, A.J. Green, O. Aktas,H.-P. Hartung, F.D. Lublin, I.M. Williams, J. Drappa, D. She,D. Cimbora, W. Rees, M. Smith, J.N. Ratchford, E. Katz, andB.A.C. Cree, on behalf of the N-MOmentum Study Investigators

Open Access Article Class of Evidence

Cover ImageProliferating B cells in delayed-type hypersensitivity-tertiary lymphoid-like structure (DTH-TLS) lesions. FocalMS-like DTH-TLS lesions wereestablished in mice. Brains were stained for B cells (B220 in red),proliferation (Ki67 in green), and DAPI (blue) usingimmunofluorescence. TheDTH-TLSmodel features proliferating B cellsin both the meninges (first row) and in vessel cuffs (second row).CD138+ plasma cells were also present in the lesions, outside of the areaoccupied by B cells (not shown here). Stylized by Haley McNiff, DigitalMultimedia/Podcast Coordinator.See page e975

Continued

e979 Evolution of Brain Volume Loss Rates in Early Stagesof Multiple SclerosisT. Uher, J. Krasensky, C. Malpas, N. Bergsland, M.G. Dwyer,E. Kubala Havrdova, M. Vaneckova, D. Horakova, R. Zivadinov, andT. Kalincik

Open Access Article

e980 B-Cell Activity Predicts Response to GlatiramerAcetate and Interferon in Relapsing-RemittingMultiple SclerosisS. Tacke, S. Braune, D.M. Rovituso, T. Ziemssen, P.V. Lehmann,H. Dikow, A. Bergmann, and S. Kuerten

Open Access Article Class of Evidence

e981 Epigallocatechin Gallate in Relapsing-RemittingMultiple Sclerosis: A Randomized, Placebo-Controlled TrialJ. Bellmann-Strobl, F. Paul, J. Wuerfel, J. Dorr, C. Infante-Duarte,E. Heidrich, B. Kortgen, A. Brandt, C. Pfuller, H. Radbruch, R. Rust,V. Siffrin, O. Aktas, C. Heesen, J. Faiss, F. Hoffmann, M. Lorenz,B. Zimmermann, S. Groppa, K.-D. Wernecke, and F. Zipp

Open Access Article Class of Evidence

e982 Exercise Diminishes Plasma Neurofilament LightChain and Reroutes the Kynurenine Pathway inMultiple SclerosisN. Joisten, A. Rademacher, C. Warnke, S. Proschinger, A. Schenk,D.Walzik, A. Knoop, M. Thevis, F. Steffen, S. Bittner, R. Gonzenbach,J. Kool, W. Bloch, J. Bansi, and P. Zimmer

Open Access Article Class of Evidence

e984 Microglia Activation in Basal Ganglia Is a Late Eventin Huntington Disease PathophysiologyN.P. Rocha, O. Charron, L.B. Latham, G.D. Colpo,P. Zanotti-Fregonara, M. Yu, L. Freeman, E. Furr Stimming, andA.L. Teixeira

Open Access Article

e985 Pain, Depression, andQuality of Life inNeuromyelitisOptica Spectrum Disorder: A Cross-SectionalStudy of 166 AQP4 Antibody–SeropositivePatientsIlya Ayzenberg, Daniel Richter, Eugenia Henke, Susanna Asseyer,Friedemann Paul, Corinna Trebst, Martin W. Hummert,Joachim Havla, Tania Kumpfel, Marius Ringelstein, Orhan Aktas,Brigitte Wildemann, Sven Jarius, Vivien Haußler,Jan-Patrick Stellmann, Makbule Senel, Luisa Klotz,Hannah L. Pellkofer, Martin S. Weber, Marc Pawlitzki,Paulus S. Rommer, Achim Berthele, Klaus-Dieter Wernecke,Kerstin Hellwig, Ralf Gold, and Ingo Kleiter,on behalf of the NEMOS (Neuromyelitis Optica Study Group)

Open Access Article

e987 Autoantibodies Against the Purkinje Cell ProteinRGS8 in Paraneoplastic Cerebellar SyndromeR. Miske, M. Scharf, P. Stark, H. Dietzel, C.I. Bien, C. Borchers,P. Kermer, A. Ott, Y. Denno, N. Rochow, K. Borowski, C. Finke,B. Teegen, C. Probst, and L. Komorowski

Open Access Article Class of Evidence

e986 Effect of Teriflunomide on Cells From Patients WithHuman T-cell Lymphotropic Virus Type1–Associated Neurologic DiseaseY. Enose-Akahata, N. Ngouth, J. Ohayon, M. Mandel, J. Chavin,T.J. Turner, and S. Jacobson

Open Access Article

e990 Skin Reactions in Patients With Multiple SclerosisReceiving Cladribine TreatmentL. Rolfes, S. Pfeuffer, J. Hackert, M. Pawlitzki, T. Ruck,W. Sondermann, M. Korsen, H. Wiendl, S.G. Meuth,C. Kleinschnitz, and R. Pul

Open Access Article

e991 VaccineHesitancy in PatientsWithMultiple Sclerosis:Preparing for the SARS-CoV-2 VaccinationChallengeL. Diem, C. Friedli, A. Chan, A. Salmen, and R. Hoepner

Open Access Article

e992 Demyelinating Events Following Initiationof Anti-TNFα Therapy in the British Society forRheumatology Biologics Registry in RheumatoidArthritisThomas R.P. Taylor, James Galloway, Rebecca Davies,Kimme Hyrich, and Ruth Dobson

Open Access Article

Clinical/Scientific Notes

e966 Disseminated Histoplasmosis in a Patient WithMultiple Sclerosis Treated With FingolimodA.A. Abrahamowicz, E.J. Chow, D.D. Child, A. Dao, E.D. Morrison,S.K. Gill, D.M. Rogers, and K. Garvin

Open Access Article

e989 CLIPPERSWith Exclusive Extra Pontine InvolvementH. Picarelli, V.N. Yamaki, Y.R. Casal, M.H. de Brito, L.G.C.A. de Lima,A.S. Ayres, and M.C.B. de Oliveira

Open Access Article

Views & Reviews

e976 Neuroprotective Properties of 4-AminopyridineM. Dietrich, H.-P. Hartung, and P. Albrecht

Open Access Article

Corrections

e983 CSF SERPINA3 Levels Are Elevated in Patients WithProgressive MS

e995 A Case of CIDP Concurrent With MGUS IgG KappaResponsive to Autologous Stem CellTransplantation

TABLE OF CONTENTS Volume 8, Number 3, May 2021 Neurology.org/NN

2021;8; Neurol Neuroimmunol Neuroinflamm 8 (3)

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