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December 2016 Vol. XCV, No.4
NORTHEASTERN SECTION • AMERICAN CHEMIC
ALSO
CIET
Y
FOUNDED 1898
NESACS
Monthly MeetingA Medicinal Chemistry Symposium at SanofiGenzyme, Waltham
Report fromBinghamtonBy Morton Z. Hoffman
Summer Scholar ReportBy Amanda Carey and Michelle Foster
NSYCC CollaborativeSymposiaBy Catherine Rawlins
2 The Nucleus December 2016
At the November meeting Roy Hagenwas presented with the 2016 Arno HeynMemorial Book Prize. The prize honorslong-time Nucleus Editor and NESACSBoard member, Arno H. A. Heyn, whoedited the Nucleus for 16 years andpassed away in December 2004.
Roy joins previous recipients SamKounaves and Mark Spitler (2005), Vin-cent Gale (2006), Vivian Walworth(2007), Myron Simon (2008), ArthurObermayer (2009), Donald Rickter(2010), Harvey Steiner (2011), KarenPiper (2012), Mindy Levine (2013),
Morton Hoffman (2014) and Mary Ma-haney (2015). Recipients are recognizedfor their contributions to NESACS pub-lications, including the Nucleus and thewebsite. Recognition has also been ex-tended to members of the Board of Pub-lications for meritorious service.
Roy Hagen graduated in 1968 witha Bachelors Degree in Music Educationand Masters Degree in Music Theory andComposition in 1981. He taught in theSalem, Massachusetts, Public Schoolsfor 34 years until he retired in 2003.
During his first seven years inSalem, he taught music. In 1984 hebegan teaching TV Studio Production atthe high school. Many of his TV Studiostudents went on to pursue careers in tel-evision at CNN, Fox, ESPN, and severalmovie studios, some as producers andothers as editors.
Through his work with his TV Stu-dio Production he began incorporatingcomputers into the classroom for graph-ics and animation. As an early adopter
of computers in the classroom, he foundhis peers looking to him for support intheir efforts. For his last seven years inSalem he served as the District Technol-ogy Director, bringing computers andnetworking into all schools and provid-ing staff development. He learned webdesign as part of his duties, creating andmaintaining the school district’s website.
Upon retirement from education in2003, he continued designing websites.His clients include a South Shorelawyer, a building and remodeling com-pany, a plumbing and heating contractor,a Boston Symphony Orchestra memberwho sells and repairs basses, and severalmusicians and musical groups.
He began in July 2007, at the re-quest of Vivian Walworth and under thedirection of David Cunningham, work-ing on the NESACS website. The firstorder of business was to redesign thewebsite. The National ACS Meetingwas in Boston that summer in Augustand the goal was to have the new web-site live in time for the meeting. UnderDavid’s supervision and with input fromVivian and the Board of Publications,the website was changed from a news-paper-like format to a more graphicaldesign, and was up and running in timefor the National Meeting.
David provided guidance the firstyear. Everything to be posted would gothrough David, and he or Marilou Cash-man would forward it to Roy for post-ing. In the spring of 2009, a survey wasposted on the website at the request ofVince Gale, and some changes weremade to the Home Page as a result of thefeedback.
In the spring of 2010, David movedto Hawaii, and Roy began to work di-rectly with the new Administrative Co-ordinator, Anna Singer, and the peoplewho sent him items for posting. He nowreported to the BOP, informing them ofall the postings, and requesting informa-tion from them.
In early 2009, Larry Hardy ofSunovian Pharmaceuticals asked Roy to
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Roy Hagen – 2016 Arno Heyn MemorialBook Prize Recipient
The Nucleus December 2016 3
The Nucleus is published monthly, except June and August, by the Northeastern Section of the AmericanChemical Society, Inc. Forms close for advertising on the 1st of the month of the preceding issue. Textmust be received by the editor six weeks before the date of issue.Editor: Michael P. Filosa, Ph.D., 18 Tamarack Road, Medfield, MA 02052 Email:
[email protected]; Tel: 508-843-9070Associate Editors: Myron S. Simon, 60 Seminary Ave. apt 272, Auburndale, MA 02466
Morton HoffmanBoard of Publications: James Phillips (Chair), Mary Mahaney, Ajay Purohit, Ken DrewBusiness Manager: Joshua Fine, Email: [email protected] Manager: Vacant: contact Michael Filosa at [email protected] Coordinator: Xavier Herault, Email: [email protected]: Morton Hoffman and James PhillipsProofreaders: Donald O. Rickter, Morton Z. Hoffman, Carol Mulrooney Webmaster: Roy Hagen, Email: [email protected] 2016, Northeastern Section of the American Chemical Society, Inc.
The Northeastern Section of the American-Chemical Society, Inc.Office: Anna Singer, 12 Corcoran Road,Burlington, MA 01803(Voice or FAX) 781-272-1966.e-mail: [email protected] Homepage:http://www.NESACS.orgOfficers 2016ChairJerry P. JasinskiKeene State CollegeKeene, NH [email protected] L. Johnson, Jr.Conditas Biotechnology GroupP.O. Box 540Brookline, MA [email protected] Past ChairKatherine L. LeePfizer610 Main StreetCambridge, MA [email protected] SingerMilliporeSigma3 Strathmore Rd, Natick, MA 01760774-290-1391, [email protected] Piper19 Mill Rd, Harvard, MA 01451978-456-3155, [email protected] GordonArchivistKen MattesTrusteesDorothy Phillips, Ruth Tanner, Peter C. MeltzerDirectors-at-LargeDavid Harris, John Neumeyer, Ralph Scannell, John Burke, Ioannis PapayannopoulosCouncilors /Alternate CouncilorsTerm Ends 12/31/2016Michael Singer Raymond BorgMary Shultz Mukund ChorghadeRobert Lichter Mary MahaneySophia R. Su Raj RajurMarietta Schwartz Sonja Strah-PleynetTerm Ends 12/31/2017Michael P. Filosa John PodobinskiDoris I. Lewis Sonja Strah-Pleynet Patricia A. Mabrouk Anna Waclawa SromeksMark Tebbe Mary BurgessMorton Z. Hoffman Ralph ScannellTerm Ends 12/31/2018Katherine Lee Jackie O'NeilCatherine E. Costello Andrew ScholteRuth Tanner R. Christian (Chris) MoretonMichaeline Chen Ajay PurohitKenneth Mattes Robert Lichter
ContentsRoy Hagen-2016 Arno Heyn Prize Recipient__________________2Report from Binghamton_________________________________4A report on NERM by Morton Z. Hoffman
Monthly Meeting _______________________________________5A Medicinal Chemistry Symposium on “Drug Discovery: From Compound toClinic” at Sanofi Genzyme, Waltham, MA
Summer Scholar Report _________________________________6“Replicating Prebiotic Astrochemistry Through the Use of a Silicate Grain Sur-face Analog” by Amanda Carey and Michelle Foster, Department of Chemistry,University of Massachusetts, Boston.
NSYCC Collaborative Symposia ____________________________8By Catherine Rawlins, NSYCC Chair
16th Annual Sukant Tripathy Symposium ____________________9December 2, 2016, 8 am - 4 pm, University of Massachusetts, Lowell.
National Chemistry Week 2016 Photos ____________________10Photos from the Boston Museum of Science by Morton Z. Hoffman
October 2016 NESACS Monthly Meeting Photos_____________12Photos by Morton Z. Hoffman
Business Directory _________________________________14,15Calendar ____________________________________________16Cover: Professor Bassam Shakhashiri (University of Wisconsin) with DorisLewis (Suffolk University and NESACS) and David Sittenfeld (Boston Museum of Science) at the annual Phyllis A. Brauner Memorial Lecture presented by Professor Shakhashiri. (Photo by Morton Z. Hoffman).
Editorial Deadlines: February 2017 Issue: December 15, 2016 March 2017 Issue: January 15, 2017
All Chairs of standingCommittees, the editor of THE NUCLEUS, and the Trustees of SectionFunds are members of theBoard of Directors. AnyCoun cilor of the American Chemical Societyresiding within the section area is an ex officiomember of the Board of Directors.
4 The Nucleus December 2016
NERM 2016With almost 950 registrants, includinghigh school teachers and students, andmore than 640 abstracts, the 41st ACSNortheast Regional Meeting (NERM2016; Chemistry at the Crossroads ofEnergy and Life), which was hosted bythe Binghamton Local Section in cele-bration of its 75th anniversary, took placeon October 5-8 at the DoubleTree Hotelin downtown Binghamton, NY. The fullprogram of the meeting is available on-line at <http://nerm2016.sites.acs.org/.
Among the registrants were approx-imately 400 undergraduates, graduatestudents, and postdoctoral research as-sociates. The General Chair for NERM2016 was Wayne Jones (SUNY Bing-hamton); Christof Grewer and Nik Dim-itrov, also of Binghamton University,were the co-Program Chairs.
In attendance at NERM were mem-bers of the ACS Board of Directors(Laura Pence: District I; Ingrid Montes,Dorothy Phillips, and Kathleen Schulz:At-Large) and Allison Campbell, ACSPresident-Elect.
The meeting started on Wednesdayafternoon with a keynote lecture bySusan Band Horwitz of the Albert Ein-stein College of Medicine, Yeshiva Uni-versity, on “Taxol, Tubulin and Tumors:A Study in Drug Development,” whichwas followed by the opening night socialmixer, graduate school fair, expositionwith 20 exhibitors, and poster sessions,including those for undergraduate re-search. The next three days were filledwith many symposia, technical sessions,and workshops.
Catherine Rawlins (NortheasternUniversity), Chair of the NortheasternSection Younger Chemists Committee(NSYCC), organized a symposium on“Navigating ACS and Your Career: AGuide for Young Chemists” that fea-tured talks by Jens Breffke (NIST), GlenLabenski (Ortho Clinical Diagnostics),Dan Sykes (Pennsylvania State Univer-sity), Jennifer Maclachlan (PID Analyz-ers), and Thomas Gilbert (NortheasternUniversity).
In addition, Jennifer Maclachlan or-ganized a two-session program of oralpresentations on “Small Chemical Busi-nesses,” and gave two talks. This reporterspoke in a chemical education sessionabout collaborations in the Middle Eastfacilitated by the Malta Conferences.
Mindy Levine (University of RhodeIsland, NESACS Chair-Elect Designate)was the featured speaker at the WomenChemists Committee Luncheon onThursday; the title of her talk was, “Bal-ancing the Equation of Professorship,Parenting, and Personal Satisfaction asa Female Chemistry Professor.”
At the Awards Banquet on Fridaynight, Allison Campbell spoke about herpersonal history that led to her presentposition as Associate Laboratory Direc-tor for Earth and Biological Sciences atthe Pacific Northwest National Labora-tory. NESACS was then recognized withthree honors. The E. Ann Nalley North-east Region Award for Volunteer Serviceto the ACS was presented to JackDriscoll (PID Analyzers); the Stanley C.Israel Regional Award for AdvancingDiversity in the Chemical Sciences wentto Mindy Levine. The Green ChemistryCommitment: Beyond Benign, Inc., ofWilmington, MA, and the local collegesand universities that collaborate in theprogram won the Marinda Wu Partnersfor Progress and Prosperity-NortheastP3 Award. In addition, Tracy Suggs(Vestal, NY, Senior High School) re-ceived the ACS Division of ChemicalEducation Northeast Region Award forExcellence in High School Teaching;the award consisted of a plaque and acheck from CHED of $1,000.
NERM 2016 took place in conjunc-tion with the 28th Electronics PackagingSymposium and Workshop.NERACS Board Meeting
The Board of Directors of theNortheast Region of the ACS, Inc.(NERACS) met on Saturday morningduring NERM. Serving on the NER-ACS Board are representatives of theconstituent local sections in the North-east Region (Binghamton, Central Mas-
sachusetts, Central New York, Connecti-cut Valley, Cornell, Corning, EasternNew York, Green Mountain, Maine,Mid-Hudson, New Haven, Northeast-ern, Northern New York, Penn-York,Rhode Island, Rochester, Western Con-necticut, Western New York) and its of-ficers (Chair: Anthony Noce, EasternNew York; Vice Chair: Willem Leenstra,Green Mountain; Secretary: Alyssa
Report from BinghamtonMorton Z. Hoffman, Chair, NERM Committee, and NESACS Representativeto NERACS [[email protected]]
2015 NESACS SponsorsInstititution Contribution LevelAmgen PlatinumBiogen, Idec PlatinumDavos Pharma PlatinumJohnson-Matthey PlatinumSK Life Sciences PlatinumNavin Fluorine International GoldVertex GoldEsselen Fund of the Boston Silver
FoundationMerck and Co. SilverNational Institute of Standards Silver
(NIST)Pharmacore SilverPLR Brand Services (Polaroid) SilverSanofi SilverMilliporeSigma BronzeEuropean Chemical Sciences Bronze
(EuCheMS)The Royal Society of Chemistry BronzeGerman Chemical Society Bronze
(GDCh)Novartis BronzeStrem Chemicals BronzeContribution Levels DonationPlatinum $5,000+Gold $3,500-$4999Silver $2,000-$3,499Bronze $500-$1,999Meeting SponsorsAmgenCape Cod Community CollegeGenzyme-Sanofi Nova BiomedicalTakedaVertex
continued on page 14
The Nucleus December 2016 5
Monthly MeetingThe 965th Meeting of the Northeastern Section of the AmericanChemical SocietyA Medicinal Chemistry Symposium organized by the MedicinalChemistry Section of NESACSDrug Discovery: From Compound to ClinicThursday, December 8, 2016Sanofi Genzyme153 Second Avenue, Waltham, MA 02451Northeastern Conference Room3:00 pm Refreshments3:15 pm Welcome, Raj Rajur, Med Chem Program Chair, Creagen, Woburn,
MA3:20 pm Introductiory Remarks, Daniel Elbaum, Retrophin Inc., Cam-
bridge, MA3:30 pm Erik Hett, Biogen, Cambridge, MA
Title: What is your MOA? Target Deconvolution of a PhenotypicScreen
4:15 pm Andrew Fensome, Pfizer, Cambridge, MATitle: Inhibition of Autoimmune Pathways with Dual Inhibition ofJAK1 and TYK2: Discovery of PF-06700841
5:00 pm Maria Beconi, Retrophin, Inc., Cambridge, MATitle: “Beyond Discovery—Identifying and Managing Liabilities”
6:00 pm Social Hour6:45 pm Dinner7:45 pm Keynote Presentation: Mark Munson, Sanofi, Waltham, MA
Title: Visualizing Aggregate Data to Support Decisions in MedicinalChemistry
YOU MUST REGISTER IN ADVANCE TO ATTEND THE SYMPO-SIUM; THERE IS NO REGISTRATION FEE. DINNER RESERVA-TIONS ARE REQUIRED.
THE PUBLIC IS INVITEDNESACS BOARD MEETING: The Board Meeting will be held from 4:30-
5:30 PM. at Celtics Conference Room.• For those who would like to join us for dinner, register by noon, Thursday, De-
cember 1, using PayPal: http://acssymposium.com/paypal.html. Select the paywith credit or debit card option and follow the additional instructions on thepage. Cost: Members, $30; Non-members, $35; Retirees, $20; Students, $10.Dinner reservations not cancelled at least 24 hours in advance must be paid.
• If you wish to join us for this meeting and not eat dinner, please register bynoon, Thursday, December 1, using PayPal: http://acssymposium.com/paypal.html. Select “Seminar only”. The fee is $1.
• New members or those seeking additional information, contact the NESACSadministrative coordinator, Anna Singer, at [email protected] or at (781)272-1966 during regular business hours only.
SpeakerBiographiesandAbstracts:Erik Hett, Ph.DAbstract: Cellular phenotypic screensare a powerful way to uncover novel bi-ology and discover druggable targets andchemical matter. One of the main bot-tlenecks for this approach, as opposed totarget-based screening, is determiningthe mechanism of action of lead hits.Our group is developing approaches todetermine the MOA of lead hits. Theseapproaches include using proteomics,RNAi, RNAseq, chemical probes, andin silico studies. We have utilized chem-ical proteomics and RNAi to unveil themechanism of a lead series for the proj-ect to be inhibition of a kinase that wasnot previously known to be involved inthe pathway. This finding reveals unex-pected biology in regards to regulationof this pathway.Biography: Dr. Erik Hett received hisPh.D. from Harvard University in thelab of Dr. Eric Rubin, studying protein-protein interactions important for my-cobacteria. His postdoctoral researchwas conducted in the lab of Dr. DeborahHung at Harvard, Broad Institute andMassachusetts General Hospital, wherehe conducted phenotypic HTS and uti-lized chemoproteomics for target ID. Hepreviously was a chemical biologist inthe MedChem Department at Pfizer andis currently leading a chemical biologyteam in the mechanisms and pathwaysgroup at Biogen.
Andrew Fensome, Ph.DAbstract: The Janus (JAK) kinases area family of four non-receptor tyrosinekinases that modulate cytokine signalingthrough the Signal and Transduction ofTranscription (STAT) pathways. The JAKkinases (JAK1, JAK2, JAK3 and TYK2)are important in both the innate andadaptive immune system, in a variety ofcell types, for example lymphocytes,
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6 The Nucleus December 2016
Through the use of a silicate grain surface analogue, it is pos-sible to replicate the prebiotic astrochemical processes thatoccur in dark interstellar clouds for terrestrial examination.Silicon dioxide was chosen as a substrate not only due to itsabundance in these clouds but also because it is generallyinert. SiO2 nano- and microparticles were subjected to waterunder controlled conditions, and monitored using diffuse re-flectance Fourier transform spectroscopy, allowing for a com-parative study of how reactions occur at their surfaces. It wasdetermined that undiluted nanoparticles are a favorable sur-face analog.I. IntroductionAstrochemistry is the study of the formation, interaction, anddestruction of elements and molecules in space. One mainarea of astrochemistry is the study of reactions that occur inthe interstellar medium where gas clouds are cold, diffuse, andrich in simple gas phase species. When dust grains (mineralin nature such as silicon, carbon, etc.) travel through theseclouds, gas molecules attach to the surface of the dust grainsand through either radical or thermal activation, react on thesurface of the dust grains which are acting as catalytic sur-faces. These reactions are theorized to eventually produce thesimple sugars or even amino acids that could then attach topassing meteors or asteroids and react further to produce sim-ple but biologically relevant molecules.
Herbst discusses the molecular nature of the interstellarmedium and its contribution to observable astrochemicalprocesses as well as the surface assisted formation of molec-ular hydrogen.1 Spectroscopic data suggests molecular hydro-gen exists in the interstellar medium in concentrations 104
times greater than that of atomic hydrogen. There must besome other plausible pathway of formation for H2 other thanthree-body collision given that the densities and temperaturesin the interstellar medium are so low. The formation of mo-lecular hydrogen and other small molecules is thought to fol-low the Langmuir-Hinshelwood surface mechanism wherephysisorbed hydrogen atoms move from lattice site to latticesite on the grain surface until they collide with another hydro-gen atom, reacting to create molecular hydrogen. As chemists,we can mimic and observe these surface processes in an at-tempt to better understand the chemical transformations thatoccur in the interstellar medium.
Silicon dioxide has been chosen as a substrate due to notonly its inertness but also its abundance in the interstellarmedium. Other possible substrates include solid NH3, solidH2O, and amorphous carbonaceous compounds.2 ExposingSiO2 micro- and nanoparticles to simple but abundant mole-cules such as water under controlled conditions allows for theobservation of the reactions as they would occur in interstellarspace. Particle size (5 nm-250 nm) and shape (amorphous)
has been chosen based on interstellar spectroscopic data out-lined by Draine.3 Similar studies using SiO2 nanoparticles andFourier transform infrared (FTIR) spectroscopy were per-formed by Dawley et al. to mimic processes that occur in theatmosphere of Saturn’s largest moon, Titan.4, 5
Because it is surfaces that are being studied, it is neces-sary to choose a surface-sensitive technique for analysis. FTIRspectroscopy, or more specifically, diffuse reflectance infraredFourier transform spectroscopy (DRIFTS), is often used insurface studies because each infrared absorption band is char-acterized by three independent parameters: frequency, inten-sity, and width.6 Most other commonly used techniquesmeasure average properties but infrared techniques can beused to measure specific functionalities directly. Qualitativechanges in intensity correspond to the behavior of physisorbedmolecules, which may change the frequency at which a fea-ture appears in the spectrum. The width of a peak correspondsto the homogeneity of surface groups; a narrow band indicatesa more homogenous environment and a broad band indicatesa wide array of geometric arrangement.
Water was chosen as the main adsorbate in this studygiven that the hydrogen bonds are largely electrostatic and aretherefore driven by Coulombic attractions.7 Water is alsoknown to exist in all of its phases in space but largely as anice mantle, either on its own or at the surface of a grain likethe ones mentioned here. This study aims to characterize anacceptable grain analog for DRIFTS studies that replicate pre-biotic astrochemical processes that occur in cold interstellarclouds as a result of small gas phase molecules and amorphousdust grains as outlined by Herbst.1
II. MethodsTwo SiO2 samples were analyzed: microparticles (Acros Or-ganics, 150-420 mm, 50 m2/g) and nanoparticles (SigmaAldrich, 7 nm-14 nm, 175-420 m2/g). The microparticles werediluted to 0.025% in spectral grade KBr (Sigma Aldrich) andthe nanoparticles were diluted to 1% in spectral grade KBr.The nanoparticles were also analyzed undiluted. The mixtureswere heated in a tube furnace to 450oC in a dry environmentbefore being cooled and ground with a pre-dried mortar andpestle. The samples were put into a Nicolet iS50 FTIR(Thermo Scientific) equipped with a Praying Mantis DRIFTSaccessory and coupled with an in situ high temperature reac-tion chamber (Harrick). The reaction chamber was connectedto a gas-handling manifold and recirculating water bath capa-ble of not only introducing known pressures of gases but alsoevacuating the chamber to 10-5 torr and heating and coolingthe sample in situ before and after exposure. The particleswere exposed to deionized H2O that had undergone five freeze-pump-thaw cycles at room temperature, and spectra were col-lected as a function of exposure. The pressures were monitored
Summer Scholar ReportReplicating Prebiotic Astrochemistry Through the Use of a Silicate Grain Surface AnalogAmanda Carey*and Michelle Foster, Department of Chemistry, College of Science and Mathematics, University of Massachusetts Boston, 100 Morrissey Boulevard, Boston, MA 02125
using baratron pressure gauges coupled to a PR 4000 display(MKS). The spectrometer has a liquid N2 cooled mercury cad-mium telluride (MCT) detector and the system is purged withgaseous N2 to ensure an inert environment. All spectra reportedwere collected and analyzed using OMNIC version 7 softwarewith 4 cm-1 resolution and 128 scans per spectrum. III. Results and DiscussionFigure 1 shows the DRIFTS spectra, using a gold foil back-ground, for the OH bending region of SiO2 for both the nano-and microparticles after the samples had been evacuatedovernight. The broad peak centered at 3150 cm-1 present inboth samples indicates that native water is molecularly ad-sorbed, likely to the KBr that was used to dilute the silica. Thenanoparticles show an additional sharp feature at 3745 cm-1,which is indicative of free hydroxyls, or Si-OH bonds. Thismeans that the nanoparticles provide a more advantageous cat-alytic surface than the microparticles would be able to provideand thereby a more favorable surface for this study.
Figure 2 shows the spectra for both 1% nanoparticles inspectral grade KBr and undiluted nanoparticles. The spectrumof pure SiO2 nanoparticles shows they are strong absorbers ofinfrared light below 2250 cm-1 and therefore must be dilutedwith an ionic salt to examine lower energy transitions such asthe bending mode of adsorbed water at ~1630 cm-1. Thedownside to using an ionic salt diluent is its hygroscopic na-ture, as shown by the OH stretching feature in the red spec-trum, and in all the diluted samples, at 3150 cm-1, indicativeof water adsorbed to KBr. This water is on the substrate evenafter the substrate has been heated to 750oC. The silanol fea-ture in the diluted sample is also much less intense with re-spect to the low energy Si-O band.
To further prove the adverse effect of the ionic salt dilu-ent, Figure 3 shows the DRIFTS of OH stretching region fordiluted SiO2 nanoparticles when exposed to increasingamounts of water vapor and the associated adsorptionisotherm. The sample was exposed to water in 1 torr incre-ments with spectra taken immediately after exposure at a pres-sure slightly lower than the stated pressure due to theequilibration of the gas line with the reaction chamber. Likelydue to the presense of molecular water on the surface of the
sample, features grow in at 3444 cm-1, 3230 cm-1, and 3113cm-1. The isolated silanol at 3744 cm-1 appears to decreasewith increased exposure.
In order to quantify these observations, adsorptionisotherms were constructed using the normalized peakheights, which were plotted as a function of water pressurefor each of the four features as shown in Figure 4. Theisotherms confirm that the Si-OH peak does decrease, whichcould be due to the physisorbed water masking the silanolgroups at the surface. The feature at 3444 cm-1 is due to wateradsorbing to the SiO2 and the peak at 3113 cm-1 is due to wateradsorbing to KBr. The feature at 3230 cm-1 follows a similartrend to the 3444 cm-1 (H2O/SiO2) feature, indicating it isprobably due to water on silica and not KBr.
The Nucleus December 2016 7
Summer Scholar ReportContinued from page 6
Figure 1: DRIFTS of the OH stretching region of SiO2 for both the nano-and microparticles. The spectra show similar broad OH stretching fea-tures but the nanoparticles exhibit a sharp Si-OH feature 3745 cm-1.
Figure 2: DRIFTS of SiO2 nanoparticles in both pure, undiluted form(black) and diluted in KBr (red). The sample was diluted to examine thewater bending features around 1630 cm-1, but the silanol became less in-tense and adsorbed water is present even after heat treatment, as shownby the bump around 3150 cm-1.
Figure 3: DRIFTS of OH stretching region for diluted nanoparticles as afunction of exposure to water. Features grow in at 3444 cm-1, 3230 cm-1,and 3113 cm-1 while the silanol at 3744 cm-1 appears to shrink.
Figure 4: Adsorption isotherms for 1% nanoparticles in KBr as a functionof exposure to gas phase water. The isotherms confirm that the peaks at3444 cm-1, 3230 cm-1, and 3113 cm-1 increase while the isolated silanol at3744 cm-1 decreases. continued on page 11
8 The Nucleus December 2016
The year 2016 has been busy for theNSYCC; we hosted more events thisyear than we ever have previously! Wehad two successful symposia this Fallwhere we got the chance to collaboratewith other committees in NESACS.
On September 28th at Boston Uni-versity’s Metcalf Science Center, wehosted a symposium entitled, “ScienceDiplomacy, Policy, and Advocacy: TheImpact of Scientists Beyond the Bench.”The idea for this symposium began witha conversation with Mort Hoffman afterI saw his presentation about his workwith the Malta Conferences Foundationearlier this year.
We decided to make this sympo-sium a Senior Chemists and YoungerChemists Committee collaboration. Thegoal was to spread the knowledge ofwhat science diplomacy and policy isand, hopefully, invigorate younger“chemists” interest in this subject.
Emily Lewis, NSYCC Chair 2013-14, shared her experience in WashingtonD.C. with two consecutive fellowshipsas an ACS Congressional Fellow and anAAAS Science and Technology PolicyFellow. With her Ph.D. focusing on en-ergy science she was able to help forma bill that would help cut methane emis-sions from oil and gas drilling.
Doris Lewis of the NESACS Gov-ernment Affairs Committee shared herinsights from years of advocating at theState House in Boston and Capitol Hill.She showed how the Act4Chemistryprogram through ACS is one of the sim-plest ways to advocate for science fund-ing and policy that affects all of us.
In addition to moderating the sym-posium, I gave a short presentationabout the German Exchange Programand the history of its ties to NESACS. Iwas able to show the audience by exam-ple the lasting impact of this programand encourage them to apply for the up-coming exchange in March.
Last but not least, Mort Hoffmanpresented on the Malta ConferencesFoundation, a non-profit organizationthat hosts a biennial conference with sci-ence being the bridge to peace in the
Middle East. It was inspiring to hearhow, despite wars and political turmoil,scientists from Middle Eastern countriescould come together to have a produc-tive and fruitful discussion. A quote I’dlike to highlight, is “Molecules know noborders,” which illustrates well how sci-ence can serve as a common languageamong all of us.
We almost hit capacity in the roomwith 35 attendees comprised of studentsand scientists at different levels. Therewere excellent questions from the audi-ence, which encouraged us that weachieved our goal. Many scientists arenot aware of how they can make a dif-ference in policy and government affairs,and we hope this symposium inspiredthe attendees to get involved!
In addition, the NSYCC organizedits first symposium at the Northeast Re-gional Meeting (NERM) in Bingham-ton, NY, on October 8th. Thissymposium, entitled “Navigating ACSand Your Career: A Guide for YoungChemists,” was meant to show youngchemists in attendance the value of vol-unteering through ACS and how it canbenefit their career. However, many donot know how the ACS structure worksand what opportunities are available,which is what we hoped to introduce.
The speakers were organized by theYounger Chemists Committee, LocalSection ACS involvement, and NationalACS activities to highlight the differentways you can contribute to ACS as amember. Jens Breffke, a PostdoctoralResearcher at NIST, spoke about his ex-perience with the German Chemical So-ciety’s young chemists group (JCF),which is how he became connected toACS through the German ExchangeProgram. He served on the NationalYCC and now the International AffairsCommittee. It was inspiring to hear howvolunteerism and ACS involvement, haveinfluenced his life along the way.
For Local Section involvement weinvited Glen Labenski, Chair of theRochester Section, and Dan Sykes, Chairof the Central Pennsylvania Section, toshare their perspectives. Glen talked
about the ways ACS has impacted hiscareer and how the Rochester Sectionpromotes chemistry education and ca-reer opportunities to its members.
Dan gave some excellent advice onhow to better market your resume forjobs in industry and the need for moresupport to ACS members who seek ca-reers outside of academia. Represent-ing NESACS and national ACSinvolvement were Jennifer Maclachlanand Thomas Gilbert; they have bothbeen on many National committees andhave a lot of experience. From Jen-nifer’s talk, we learned how she uses so-
NSYCC Collaborative SymposiaBy Catherine Rawlins, NSYCC Chair
Back Row (L-R) Thomas Gilbert, Dan Sykes,Glen Labenski. Front Row (L-R) CatherineRawlins, Jennifer Maclachlan, Jack Driscoll,Jens Breffke.
(L-R) Emily Lewis, Doris Lewis, CatherineRawlins, Morton Z. Hoffman.
continued on page 14
hematopoetic cells and structural cells(keratinocytes and fibroblasts). The cur-rent work describes the discovery of a se-ries of selective JAK1/ TYK2 inhibitorsfor a range of inflammatory disorderssuch as inflammatory bowel disease,systemic lupus erythematosus and pso-riasis. Balancing the in-family kinase se-lectivity is important to optimize theinhibition of pathogenic cytokines whilelimiting immune suppression, as well asto limit effects driven by JAK2 signal-ing through EPO and other moleculesimportant in hematopoetic cell differen-tiation.
An important part of our programhas been our understanding of PK:PDdeveloped from our extensive experi-ence with tofacitinib (Xeljanz™) in theclinic and in preclinical animal models.This has been important in setting labobjectives for projecting efficacious tar-get cover and dose; in particular to un-derstand selectivity ratio targets tominimize effects on JAK2 signaling andthe hematopoetic system, whilst maxi-mizing efficacy.
We identified a series of ATP com-petitive pyrimidines from an early li-brary lead, and through a structurallyenabled program drove the biologicalprofile and property space to a pointwhere we could advance the lead com-pound (PF-06700841) into the clinic.
The role of primary cell assays hasbeen key to understanding the propertiesof the lead molecules, corroborated byPK:PD evaluation in-vivo. The lead is awell-behaved molecule with excellentin-vitro potency and a superior off-targetpoly-pharmacology profile. PF-06700841is currently in Phase 1 clinical study.Fensome Biography: Dr. Andrew Fen-some obtained his BSc and PhD fromthe University of Manchester Institute ofScience and Technology. He joinedWyeth Research in the UK in 1992 andmoved to the Philadelphia PA area in1995, and transitioned to the Pfizer me-dicinal chemistry organization in 2009.He has worked across multiple targetclasses: ion channels, nuclear hormone
The Nucleus December 2016 9
16th Annual SukantTripathy SymposiumThe University of Massachusetts Lowell will hold its 16th Anniversary Sympo-sium on December 2, 2016, to honor the memory of the late Prof. Sukant Tripa-thy, renowned researcher and former Director of the Center for AdvancedMaterials, University Provost and Vice Chancellor. This year’s program is alsodedicated to the memory of the late Prof. Daniel J. Sandman, former Co-Directorof the Center for Advanced Materials, and includes invited talks by former col-leagues and students of Dan’s, as well as student poster presentations.
December 2, 20168:00 a.m. - 4:00 p.m.
University of Massachusetts Lowell Inn & Conference Center, 50 Warren St., Lowell, MA 01852
Directions at http://www.acc-umlinnandconferencecenter.com/ Speakers• Bruce Foxman, Brandeis University, Thermal Reactions and Transforma-
tions in Crystals• Michael Rubner, Massachusetts Institute of Technology, Stimuli-Respon-
sive Polymer Assemblies for Biomedical Applications• D. Venkataraman, University of Massachusetts, Amherst Azobenzene-
based Polymers for Energy Storage• Dong-Chan Lee, University of Nevada, Las Vegas, π-Organogelators
Based on Phenazine Derivatives• Virinder S. Parmar, University of Delhi, Delhi, India, Development of
Novel Polymeric Nanomaterials, Nanocomposites and Dendrons via Bio-catalytic Routes
• Dionysios Christodouleas, University of Massachusetts Lowell, Paper-based Devices and Paper-like Materials - Fabrication and Applications
• Kimberly Hamad-Schifferli, University of Massachusetts Boston / MIT,Engineering the Nanoparticle-Biology Interface for Biomedical Applica-tions
Registration: Pre-registration is required by November 25, 2016 . Online reg-istration at: https://www.uml.edu/Research/CAM/Registration-Form.aspxParking: Garage gate right of ICC surface lot (student parking) will be open.If no spots are available, proceed to 2nd level entrance of the Lower Locks Mu-nicipal Garage. Parking rate is $8/day max. (Shuttle buses from UML campusesare recommended).Details and Changes: Agenda and all updates about this symposium will beposted on the website http://www.uml.edu/Research/CAM/Tripathy-Memorial/symposium.aspx or you may contact [email protected] or978-934-3695.
This year’s event sponsored by: Rogers Corporation (http://www.roger-scorp.com/index.aspx) and the University of Massachusetts Lowell, KennedyCollege of Sciences and Francis College of Engineering. u
Monthly Meeting Bios and Abstracts Continued from page 5
continued on page 13
10 The Nucleus December 2016
Solving mysteries through chemistry at the Museum of Science.
Professor Shakashiri with Sydney and Zachary.
Phyllis A. Brauner Memorial Lecture by Bassam Shakhashiri
Zachary and Sydney and their paper chromatography results.
Phyllis A. Brauner Memorial Lecture by Bassam Shakhashiri
Remembering Christine Jaworek-Lopes (Emmanuel College).
National Chemistry Week 2016 Photos Photographs by Morton Z. Hoffman
The Nucleus December 2016 11
The same experiment was repeated for the undilutednanoparticles and Figure 5 shows the DRIFTS of the OHstretching region as a function of exposure to water. Thestretching features for water grow in at 3683 cm-1, 3604 cm-1, and 3497 cm-1. The isolated silanol at 3744 cm-1 appears todecrease with the increase in water pressure, as it had with thediluted particles, but it is much larger with respect to the waterstretching features than seen on the dilute sample. An intrigu-ing result is that the features of interest for the undilutednanoparticles appear at a higher energy in the spectra than thefeatures of the diluted nanoparticles.
In order to quantify the behavior of water on the undilutednanoparticles, the normalized peak height was again plottedas a function of exposure to water, as shown in Figure 6. Thefeatures at 3604 cm-1 and 3497 cm-1 follow near identicaltrends, indicating that they are due to the same water-SiO2 in-teractions. The feature at 3683 cm-1 follows a different trend.This coupled with its high energy suggests it is a different typeof Si-OH interaction than the silanol, perhaps reaction be-tween water and a defective SiO2 surface. It may also be dueto the shift in the silanol peak due to H-bonding with adsorbedwater molecules.6
The shifts of the main features to higher energies in thespectra suggests that interactions are more energetic than theywould be in the presence of KBr diluent, which shows that
the undiluted nanoparticles are a better model for interstellarreactions using this type of methodology. One possible reasonfor this shift could be that there are more ways for the silanolgroups to stretch or bend at the surface of the sample. As sug-gested above, it could also be due to hydrogen bonding withmolecular water at the surface. Given the spacing of isolatedsilanols (>30 pm),8 it is not likely that the groups are hydrogenbonding with each other, but are capable of hydrogen bondingwith water to form some sort of water network on the surfaceof the nanoparticles, which agrees with previous data that sug-gests that the reactions do not occur on the surface of the par-ticle itself but rather in the icy mantle that likely forms therein the presence of gas phase water at low temperatures.1
IV. ConclusionIn conclusion, nanoparticles are favorable silicate grain sur-face analogs to study reactions in the interstellar medium.Using an ionic salt diluent, like KBr, to investigate the surfacereactions on SiO2 can be quite useful when studying the re-gions of strong absorption below 2750 cm-1. However, KBrcan also serve as a substrate for physisorption of polar mole-cules, and thus must be used with care in those types of in-vestigations. The slight shift and reduction of intensity of theSi-OH stretching features at ~3750 cm-1 indicate that they mayinteract with the water thin film forming on the substrate asthe water vapor pressure increases, probably via hydrogen-bonding. Undiluted nanoparticles are most desirable due tothe ability of water and presumably other molecules to phy -sisorb to the surface at even room temperature, thus it is ableto serve as a model for space reactions, especially under con-ditions comparable to those of deep space.V. AcknowledgementsFunding for this research was provided in part by the OracleEducation Foundation grant to the College of Science andMathematics. Undergraduate funding for this project was pro-vided by the Norris-Richards Undergraduate Research Schol-arship awarded by the Northeastern Section of the AmericanChemical Society. A special thanks to Professor Michelle Fos-ter and the Foster Lab at UMass Boston for making this proj-ect possible.VI. References1. Herbst, E. Chemistry of Star-Forming Regions. J Phys.
Chem. A 2005, 109, 4017-4029.2. Allamandola, L. J.; Greenberg, J. M.; van de Butt, C. E. P.
M. Ices in Space. J. Phys. Chem. 1983, 87, 4243-4260.3. Draine, B. T. “Interstellar Dust Grains.” Annual Review of
Astronomy and Astrophysics Annu. Rev. Astro. Astro-phys. 41.1 (2003): 241-89. Web.
4. Dawley, M. M.; Pirim, C.; Orlando, T. M. Thermal Process-ing of Formamide Ices on Silicate Grain Analog. J. Phys.Chem. A 2014, 118, 1220-1227.
5. Dawley, M. M.; Pirim, C.; Orlando, T. M. Radiation Pro-cessing of Formamide: Water ices on Silicate Grain Analog.J. Phys. Chem. A 2014, 118, 1228-1236.
6. McDonald, R. S. Surface Functionality of Amorphous Sil-ica by Infrared Spectroscopy. J. Phys. Chem. 1958, 62,1168–1178. continued on page 14
Summer Scholar ReportContinued from page 7
Figure 5: DRIFTS of OH stretching region for undiluted nanoparticles asa function of exposure to water. As had been seen with the diluted parti-cles, the isolated silanol decreases with exposure while the other peaks at3683 cm-1, 3604 cm-1, and 3497 cm-1 all increase.
Figure 6: Adsorption isotherms for water on undiluted nanoparticles. Theisotherms confirm that the peaks at 3683 cm-1, 3604 cm-1, and 3497 cm-1
increase while the isolated silanol at 3744 cm-1 decreases.
12 The Nucleus December 2016
NESACS Chair Jerry Jasinski presents Joseph DonaldSmith with his certificate as a 50-year member of the ACS.
NESACS Chair Jerry Jasinski presents Jack Driscoll withhis certificate as a 50-year member of the ACS.
NESACS Secretary Michael Singer (R) presents retiringNESACS Treasurer James Piper with a certificate honoringhis many years of service to NESACS.
(L-R) Anthony Cromwell (Tony) Hill, son of Henry A. Hill, with Karen and Jim Piper, 2016 recipients of the Henry A. Hill Award for OutstandingContributions to NESACS.
Karen and Jim Piper (at center), recipients of the 2016 Henry A. HillAward for Outstanding Contributions to NESACS, with Jerry Jasinski (atleft), NESACS Chair, and Michael Singer, NESACS Secretary.
Malika Jeffries-El (Boston University), at center, speaker on “From Molecules to Materials: Designing Organic Semiconductors for AdvancedApplications” with Jerry Jasinski (at right), NESACS Chair, and LeeJohnson, NESACS Chair-Elect.
October 2016 Meeting Photos Photographs by Morton Z. Hoffman
receptors, kinases and solute trans-porters, for programs in women’shealthcare, neuroscience, inflammationand auto-immunity. He has served as theteam leader on programs from early ex-ploratory target identification, throughlead identification and optimization intoclinical candidates, and into phase 1clinical development. He currentlyholds the position of Associate ResearchFellow in the Medicine’s Design depart-ment, at the Pfizer Cambridge, MA site.Maria Beconi, Ph.DBiography: Maria Beconi is serving asthe CSO at Retrophin. Prior to joiningRetrophin, Dr. Beconi has served asFounder of KAB DMPK Strategies,LLC, acting as independent consultantfor nonclinical sciences to clients in-cluding Lundbeck (Ovation), TB Al-liance, Boehringer Ingelheim Vet Medand others. Before that, Dr. Beconi heldthe position of Director DMPK at CHDIFoundation, a virtual not-for-profit bio -technology company aimed at findingtherapies for the treatment of Hunting-ton’s disease. Dr. Beconi’s previous po-sitions included Director, DrugMetabolism at Abbott Laboratories;Manager and US-Site Head, riCEDD
DMPK at GlaxoSmithKline; ResearchFellow and Principal Investigator atMerck Research Labs; and GroupLeader at Upjohn/Pharmacia/Monsanto.Dr. Beconi received a Bachelor of Sci-ence degree in agricultural engineeringfrom the University of Buenos Aires, aMaster’s degree in Animal Science/Sta-tistics from the University of Kentuckyand a Ph.D. in Biochemistry/ Chemistryfrom Michigan State University.Mark Munson, Ph.DAbstract: Identifying strategies to in-crease the probability of success fromlead optimization to candidate selectionremain a significant challenge withinpharma. Surprisingly, in an increasinglycompetitive pharmaceutical field where“fail fast” is an accepted paradigm, thereare limited reports of methods quantita-tively assessing the progress of lead optimization campaigns. Until very re-cently, little emphasis has been put intoin silico analyses to assess and guide, inreal time, the trajectory (positive or neg-ative) of lead optimization. Providingboth qualitative and quantitative insightsthrough interactive dashboards couldimprove cycle times and outcome. Wepresent methodology to analyze and dis-play complex aggregate data through in-teractive dashboards, employingcustomizable software to report resultsto project teams and management. Biography: Mark Munson received hisPhD in 1993 from the University ofMinnesota under Professor GeorgeBarany. He began his industrial careerat Amgen working on peptidomimeticsand establishing the early lead genera-tion group. In 1998, he became a found-ing member of Array Biopharma wherehis medicinal chemistry work focusedon kinase targets in oncology, immunol-ogy and fibrosis. During his 14 year ca-reer at Array, he led several programsinto Phase I and II development. In2012, he joined the oncology unit atSanofi in Cambridge. He is presentlyDirector of Medicinal Chemistry, sup-porting several therapeutic areas includ-ing rare diseases, oncology andneuroscience. u
Monthly Meeting Bios and AbstractsContinued from page 9 redesign the website of the New Drug
Metabolism Discussion Group (NED-MDG) and provide regular maintenancefor it. He worked with Larry until early2010, when Vaughn Miller of AgilentTechnologies became the contact. Inearly 2010, Dr. Jerry Jasinski contactedRoy to update the website for the Amer-ican Institute of Chemists.
In the spring of 2011, Roy beganworking with Mindy Levine as the rep-resentative of the BOP to revise the NE-SACS website to simplify the homepage and modernize, streamline, and im-prove navigation through the site. It wasa pleasure working with her. She had aclear vision of the changes that she andthe BOP wanted him to make, and theprocess went very well.
Over the years Roy has had thepleasure of working with many of themembers of the Section who regularlysend items to post: Mike Filosa with theseminar calendar, Mort Hoffman withmany photos from meetings and activi-ties, Harvey Steiner with the PDF of theNucleus, Ruth Tanner with membershipforms, Bobbie Lamont with NEACTconferences, Marietta Schwartz with in-formation about many of the awards, RajRajur with Medicinal Chemistry activi-ties, Jack Driscoll with public relationsnews, and, of course, Anna Singer withinformation about many other activities.
Recently, Kathy Lee and membersof the Board of Publications have ex-pressed a desire for a new design thatwill bring the ACS branding to the NE-SACS website and at the same time fur-ther modernize, streamline, and improvenavigation. Roy has begun working withKathy and Ajay Purohit to come up witha plan and proposal for a new design.
Roy looks forward to making thewebsite continue to meet the needs of thesection while aligning even closer to theAmerican Chemical Society’s brand. u
The Nucleus December 2016 13
Roy HagenContinued from page 2
Directions:From North or South 95/Rt 128 South. Take Exit 27B/Winter Street. Followsigns for Second Avenue (stay in rightlane).Take a right after the Embassy SuitesHotel onto Second Avenue. Go pastCostco on the right.At Forum Pharmaceuticals take a rightbetween the Forum garage and Forumoffices.(There is a sign directing you to Gen-zyme) Proceed about 100 feet.Genzyme will be on the right. Pleaseenter through the main entrance (nearstairs) and present yourself. u
Monthly MeetingDirectionsContinued from page 5
Your source to career-related linksWWW.NESACS.ORG/CAREERS
For late breaking news, job postings and the latest meeting and event information please visit us at
WWW.NESACS.ORG
Thomas, Central New York; Treasurer:Wayne Jones, Binghamton).
Also in attendance at the meetingwere Laura Pence (ACS District I Direc-tor) and Dorothy Phillips (ACS Direc-tor-at-Large).
The Board reelected Alyssa Thomasas Secretary and Wayne Jones as Treas-urer for two-year terms (2017-18).
Treasurer Jones reported that thetotal net assets of NERACS are nowslightly less than $68,000 as a result ofthe return of the seed loan for NERM2015 and a return of approximately$9,100 (40% of the surplus) from thatmeeting last year at Ithaca College.
Wayne Jones reported that NERM2016 was on track to bring in more than$100,000 in revenue; however, expenseswere proving to be higher than bud-geted. A surplus of approximately$15,000 is anticipated, from which 40%will return to NERACS.
A special task force presented revi-sions to the NERACS by-laws for ap-proval by the Board, which was sovoted. The new document will be postedon the NERACS website <http://neracs.sites.acs.org/>.
This reporter provided informationabout the Atlantic Basin Conference onChemistry (ABCChem, formerly At-lantiChem) from the International Activ-ities Committee meeting in Philadelphiain August. The conference, which willbe sponsored by ACS, EuCheMS, Cana-dian Society for Chemistry, MexicanChemical Society, and other partners,will take place on January 24-27, 2018,at the Iberostar Resort in Cancun, Mex-ico, with an overall theme of “Materialsand Nanochemistry.” Approximately500 scientists are expected to attend.
Plans for the Eastern New YorkLocal Section to host NERM 2017 havefallen through, so no meeting will beheld that year. Because of ABCChemand the ACS national meeting in Bostonin 2018, no NERM will be held that yeareither. The Rochester Local Section hasexpressed interest to host the meeting inFall 2019, and the Green MountainLocal Section is considering holding ameeting in Burlington, VT, in Spring-Summer 2020. Inasmuch as the ACS
Fall 2021 national meeting has beenmoved from Boston to Atlanta, the ques-tion was raised again as to whether NE-SACS would be interested in hostingNERM that year, possibly in NewHampshire jointly with the Maine LocalSection or on or near Cape Cod togetherwith the Rhode Island Local Section.
The next annual meeting of theNERACS Board will take place at noonon Tuesday, August 22, 2017, in Wash-ington, DC, on the occasion of the ACSnational meeting. u
14 The Nucleus December 2016
B U S I N E S S D I R E C T O R Y
SERVICESSERVICESBinghamton ReportContinued from page 4
cial media to promote her company, PIDAnalyzers, which she runs with her fa-ther Jack Driscoll, and advice on how tomanage social media to leverage one’scareer.
Thomas Gilbert concluded the ses-sion with his vision on new directionsfor ACS to serve better its members, es-pecially younger chemists, as part of hiscampaign for President-Elect. The dis-cussions that occurred and the connec-tions that were made were very valuable,and we hope to repeat these symposia atfuture ACS meetings!
These symposia were made possi-ble because of the excellent NESACSboard members and associates whowere supportive of our efforts. We lookforward to another great year and to fur-ther collaboration with other NESACScommittees! u
NSYCC SymposiaContinued from page 8
7. Israelachvili, J. N. Intermolecular andSurface Forces, 3rd ed.; AcademicPress: San Diego, CA, 2011; p 674.�
8. Papirer, Eugene. “Hydrogen Bond-ing.” Adsorption on Silica Surfaces.New York: Marcel Dekker, 2000. 49-52. Print. u
Summer ScholarContinued from page 11
The Nucleus December 2016 15
CAREER SERVICESSERVICES
B U S I N E S S D I R E C T O R Y
SERVICES
Index of AdvertisersEastern Scientific Co. ......16Micron, Inc. .....................14NuMega Resonance Labs15Organix, Inc. ....................15PCI Synthesis.....................2Rilas Technologies, Inc. ..15Robertson Microlit Labs..14Tyger Scientific, Inc. .......15
Check the NESACS home pagefor late Calendar additions:http://www.NESACS.orgNote also the Chemistry Department webpages for travel directions and updates.These include:http://www.bc.edu/schools/cas/chemistry/s
eminars.htmlhttp://www.bu.edu/chemistry/seminars/http://www.brandeis.edu/departments/chem
istry/events/index.htmlhttp://chemistry.harvard.edu/calendar/upco
minghttp://www.northeastern.edu/cos/chemistry/
events-2/http://chemistry.mit.edu/events/allhttp://chem.tufts.edu/seminars.htmlhttp://engineering.tufts.edu/chbe/newsEven
ts/seminarSeries/index.asphttp://www.chem.umb.eduhttp://www.umassd.edu/cas/chemistry/http://www.uml.edu/Sciences/chemistry/Se
minars-and-Colloquia.aspxhttp://www.unh.edu/chemistry/events
November 28Prof. Vincent Meunier (RPI)Boston University, Life Sciences and Engineer-ing Building, Rm B01 4:00 pm
December 1Prof. Jing Zhao (Univ. of Connecticut)Boston College, Merkert 130 4:00 pm
December 2Prof. Stephen L. Buchwald (MIT)Boston College, Merkert 127 4:00 pm
December 3Dr. John Macor (Bristol-Myers Squibb)Boston College, Merkert 127 4:00 pmProf. Stephen L. Buchwald (MIT)Boston College, Merkert 127 11:15 am
December 5Prof. Ohyun Kwon (UCLA)Phosphines and phosphinocatalysisBrandeis, Gerstenzang 1214:00 pmProf. Joshua Pierce (North Carolina State)Marine Natural Products Synthesis as a DrivingForce for Chemical and Biological DiscoveryBoston University, Life Sciences and Engineer-ing Building, Rm B014:00 pm
December 6Dr. Glenn Harris (908 Devices)Univ. of New Hampshire, Parsons N10411:10 amProf. Ross Berbeco (Brigham and Women’sHospital) Nanoparticles for Imaging and Dose Amplifica-tion in Radiation TherapyTufts, Pearson, Rm. P106 4:30 pm
December 7Prof. Kim Baines (University of Western On-tario)Harvard/MIT Inorganic Chem Seminar, MIT Room 4-3704:15 pmProf. Svetlana Lutsenko (Johns Hopkins Univer-sity)WPI, GP1002 12:00 NoonProf. Irina Bezsonova (University ofConnecticut)“USP7: Structure, function and inhibition.” Northeastern, 129 Hurtig Hall12:00 pm
December 12Prof. Timothy H. Warren(Georgetown University)Boston University, Life Sciences andEngineering Building, Rm B014:00 pm
December 14Prof. Jonathan Lindsey (North Carolina State)Harvard University, TBA4:15 pm
Notices for The NucleusCalendar of Seminars should besent to:Xavier Herault, email:xherault(at)outlook.com u
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