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VITAMIN DM. AKBAR MAULANA

30101407231

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Defnition - Organic compound required in small

amounts.

Vitamin AVitamin B1, B2, B3, B5, B6, B, B!,B12

Vitamin DVitamin "Vitamin # 

A $e% %ords a&out eac'.

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Vitamin D re$ers to a group o$ similar lipid-solu&le molecules(ma)or $orms are D2 and D3, also D1, D*, D5+.

Vitamin D3 (c'olecalci$erol+ Vitamin D2 (ergocalci$erol+

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Vitamin D3 can &e o&tained in diet, or deried $rom c'olesterolin a reaction t'at requires V lig't.

V lig't

spontaneous

lieren/me

25-'/dro0/lase

Vitamin D3

calcitriol

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Vitamin D &inds to a itamin D &inding protein (VD+ $ortransport to target organs.

Vitamin D is not actie itsel$ (it4s a pro'ormone+ it is modifed to

/ield &iologicall/ actie $orms, suc' as calcitriol.

alcitriol (deried $rom itamin D+ is a transcription $actor,in7uencing e0pression o$ proteins inoled in calcium a&sorptionand transport.

Vitamin D is also important $or immune s/stem $unction.

Defcienc/ causes ric8ets, &one loss.

alcitriol,$rom itaminD.

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Vitamin D production requires V lig't (sunlig't+.

9ometime a$ter 'umans migrated nort' out o$ A$ricaa&out 5:,::: /ears ago, mutations appeared t'atreduced melanin (pigment+ production in t'e s8in,permitting itamin D production %it' less sunlig't.

Disadantages o$ less melanin production are s8in t'at iseasil/ damaged &/ t'e sun, s8in cancer ris8, and loss o$$olic acid due to V damage.

 ;'e melanin-reducing mutations 'elped earl/ 'umansma8e itamin D in nort'ern europe in %inter.

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 ;'ousands o$/ears ago.

<uman migration.

=ap $rom

 ;'ese groups 'aemutations resulting int'e most dramaticmelanin defcienc/.

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>n ;e0as, t'ere is too muc' sun and plent/ o$ itaminD, so > %ant m/ melanin &ac8 ?

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