Virginia Modeling, Analysis and Simulation Center

Virginia Modeling, Analysis and Simulation Center

Modeling & Simulation Applications in Bio-MedicineDr. R. Michael Robinson

1030 University BoulevardSuffolk, VA 23435

June 15, 2010

Virginia Modeling, Analysis and Simulation CenterOld Dominion University Virginia Modeling, Analysis and Simulation Center

APPLIED RESEARCH AREAS• General BOK/Applied Principles of M&S (fundamental concepts: theory of

simulation, distributed simulation, interoperability, V&V, etc.)

• General / Social Science (non-medical life sciences: ecology, climate modeling, oceanography, biochemistry, etc.)

• Defense/HLS (interfacing M&S capabilities with C2, M&S OR support, analysis and visualization of military or HLS system problems)

• Medical & Healthcare (augmented VR, VOR, VR Rehabilitation, and physical systems modeling, etc.)

• Business & Supply Chain Modeling / M&S in Eng (changes in traditional eng disciplines: enterprise decision support, product design, optimization and more)

• Transportation (M&S to solve multimodal {road, rail and air} transportation problems – micro/macroscopic travel)

• Virtual Environments (domain specific virtual intelligent agents, construction of VE, flexible crowd models, task level planning of agents and immersive simulations)

• Education & Game-Based Learning – serious games to train soldiers, workforce and help achieve national STEM objectives.

Old Dominion University Virginia Modeling, Analysis and Simulation Center

APPLIED RESEARCH AREAS• General BOK/Applied Principles of M&S (fundamental concepts: theory of

simulation, distributed simulation, interoperability, V&V, etc.)

• General / Social Science (non-medical life sciences: ecology, climate modeling, oceanography, biochemistry, etc.)

• Defense/HLS (interfacing M&S capabilities with C2, M&S OR support, analysis and visualization of military or HLS system problems)

• Medical & Healthcare (augmented VR, VOR, VR Rehabilitation, and physical systems modeling, etc.)

• Business & Supply Chain Modeling / M&S in Eng (changes in traditional eng disciplines: enterprise decision support, product design, optimization and more)

• Transportation (M&S to solve multimodal {road, rail and air} transportation problems – micro/macroscopic travel)

• Virtual Environments (domain specific virtual intelligent agents, construction of VE, flexible crowd models, task level planning of agents and immersive simulations)

• Education & Game-Based Learning – serious games to train soldiers, workforce and help achieve national STEM objectives.


Medical M&S Application Areas

• Training and Diagnostic Tools• Patient Care and Treatment• Infectious Disease Spread• Hospital Operations


Training and Diagnostic Tools

• Used in tandem with a standardized patient (SP)• “Tracked VPS” or wireless control• Substitutes abnormal sounds for healthy sounds, supporting

diagnostic training• Licensed by Cardionics Inc.• Partners include ODU, EVMS/


Anterior Heart & Lung Sound Locations ( 12)

Posterior Heart & Lung Sound Locations (14)

Virtual Pathology Stethoscope



•Computer generated dynamic organ models

•Sonograph of fetus is shown•Virtual fetus is placed in

real environment on SP that is not pregnant.

•Practice proper placement and hand-eye coordination

•Selection of injury/disease effects

•ODU, EVMS

Virtual Pathology Sonography



• Virtual hospital for nurse education• Interact patient avatars• Variety of illnesses and injuries• Nurses trained on admittance interviews

• Patient priority• Immediate diagnostic requirements• Increased efficiency and accuracy

• Virtual Patient Library• VMASC/ODU, EVMS

Monarch General



Mechanical engineering strength and fatigue analyses

Strength models of bone and soft tissue (cadavers)

Simulated injuries

Diagnosis/treatment recommendations

Future work will develop models to treat trauma and diseases on a patient specific basis

Ankle Joint Injuries

Using Xbox 360 for Rehabilitation of Brain Injured Patients

• Improve patents’ cognitive and motor skills• Sponsored by Office of the Secretary of Defense, DoD.• SBIR Phase I with MYMIC LLC.


Patient Care and Treatment

Modeling Communication Helping Children with Severe Autism Communicate



Funded by Microsoft ResearchPartner: Clermont University, CA

Virtual RealityHelping Children with Cerebral Palsy Walk



•Opposed helicopter extraction model

•Improved modeling can be used to improve tactical planning



Development and Assessment of Physical Training Regimes

•Assess importance of individual physical fitness on survivability

•Data collection funded by ONR. Measure 12 meter “rush speeds

0.00%

50.00%

100.00%

0 15 30 45 60 75 90 105 120 135 150

Survivability vs Rushing Distance (m)

Survival Slow (2.34m/sec)

Survival Fast (3.78 m/sec)

Infectious Disease Spread

•Funded by NIH•Partners: ODU, Johns Hopkins, U. Maryland, U. Michigan


Tick-Borne Diseases: Rift Valley Fever •Collecting ticks from coastal Virginia sites from May through October•Develop and use model to predict optimal control strategy

Infectious Disease Spread

• Assess compliance to infection control protocols• Analyze potential spread of a pathogen• Increase awareness through visualization• Funded by NSF• Partners: ODU, Murray State U., Marymount U. , U. of TN


Cholera Model structure

Optimal Strategies for Controlling Cholera Outbreaks

Disaster Medical Assistance Team – DMAT Gaming Solution for Training and Assessment


Hospital Operations

Funded by Mymic LLC through SBIR Phase I and II (2007-2010) Partners: Mymic LLC, Forterra System Inc

Goal: Improve medical response team efficacy using research oriented short experiments and game based training


Hospital Operations

Populationwith

Non-EmergentNeed

fracton of popreceiving treatment 1B

PopulationDirected byEducation1

total market

enrollment1insurancecoverage1

insurance coverageintervention effects on PCP

utilization

utilization1B

repopulation life

education1

contact1

education interventioneffects on PCP utilization

PopulationDirected byInsurance

Coverage1utilization1A PopulationReceiving

PCPTreatment

aggregate1A

aggregate1B

fraction of popreceiving treatment 1A

TreatedPopulations

flow1

repopulation

aggregate life1B

aggregate life 1A

flow1 life

fraction of popreceiving treatment at

PCP

PopulationDirected byInsurance

Coverage2

PopulationDirected byEducation2

PopulationReceivng ED

Treatment

utilization2A

utilization2B

aggregate2A

aggregate2B

flow2

enrollment2

insurancecoverage2

effectiveness of insuranceintervention 2A

effectiveness ofeducation inervention 2B

education interventioneffects on ED utilization

contact2

education2

insurance coverageintervention effects on ED

utilization aggregate life 2A

aggregate life 2B

flow2 life

fraction of pop receivingtreatment in ED

fraction of popreceiving treatment 2A

fraction of popreceiving treatment 2B

Modeling the Sensitivity of Inappropriate Emergency Department Utilization

Patient Arrival

Triage Process and Registration

Test? Doctor/Nursetreatments

Admitted or/Depart from ER

Pod A

Pod B

Pod C

T

F

CAT 4

Wait for Bed and

assessment

Bed and Baseline Assessment



Test Evaluation

TestingCAT1

Bed available


T

F

Test Evaluation

TestingCAT 2/3


TF

Test Evaluation

TestingCAT 4

Hospital Operations


Optimizing Emergency Department Resources

Backup Slides


• Developing an internet based rehabilitation program for war-fighters with functional hearing loss secondary to blast and/or mTBI (OSD, SBIR-phase I and II)• Dr. Stacie Ringleb• ODU

• Developing VR assessment modules to determine return to duty and affective (OSD)• Dr. Stacie Ringleb• ODU

• Improving VR based rehabilitation systems to treat stroke patients and collecting fMRI data on these patients (ODU’s Office of Research)


• GaMeTT: Create a computer game-based software tool to track, assess, and train medical support teams to operate under stressful conditions. (Mymic LLC)• Dr. Gianluca De Leo• VMASC/ODU, Mymic LLC, Forterra Inc

• Iphone Application for Emergency Preparedness (Hampton Roads Planning District Commission )• Dr. Gianluca De Leo• VMASC/ODU


Documents

Virginia Modeling, Analysis and Simulation Center