Veterinary Diagnostic Laboratory

Impacting Iowa’s Animal Agriculture Industry

1st to identify and culture the new and highly virulent viruses Porcine Epidemic Diarrhea virus (PEDv) and Swine Delta Coronavirus in the U.S. in 2013 and 2014• 1st to sequence and fully characterize PEDv in the U.S.

• 1st to identify “where in the world” these new viruses came from

Played a major role in diagnosis and response to Highly Pathogenic Avian Influenza virus (HPAI) in Iowa in 2015• Partnered with IDALS, USDA and poultry

producers to conduct tests for continuity of business during the outbreak

• Conducted testing to allow re-population of sites

1st to identify an emerging vesicular disease (Senecavirus A, SVA) affecting U.S. swine.• Provided diagnostics for an unprecedented number of vesicular

disease-associated foreign animal disease investigations to rule out foot-and-mouth disease in 2015 and 2016

• Urgent testing required to resume movement of pigs and sale of pork out of Iowa’s slaughter facilities

vetmed.iastate.edu/vdl

In 2013-2016, VDL faculty obtained nearly $4.2 million through 58 grants to advance knowledge on diagnosis and control of PEDV, HPAI, and SVA.

QUESTIONS FROM CASES BECOME FUNDED RESEARCH PROJECTS

Access to innovative diagnostic technologies are essential for supporting and growing Iowa’s export-centric animal agricultural industries.

Investments in advanced diagnostic technologies have positioned the ISU VDL to effectively respond to introduction of new diseases in the last three years:

Intestine from a PEDv-infected pig

Comparing Genetic Similarities of SVA

U.S. PEDvPrototype-like Strains

U.S. PEDv S-INDEL-variant-like Strains

0.005

Comparing Genetic Similarities of PEDv

PED virus

ISU22376_Sioux_Chicken(H5N2)

ISU23684_Wright_Chicken(H5N2)

ISU21981_Kossuth_Chicken(H5N2)

ISU21506_OBrien_Chicken(H5N2)

ISU21233_Osceola_Chicken(H5N2)

ISU21699_BuenaVista_Turkey(H5N2)

ISU22716_Madison_Chicken(H5N2)

KR233982_MN_Turkey_2015(H5N2)

KR233998_OR_Chicken_2015(H5N2)

KR233990_WA_Chicken_2015(H5N2)

KR234030_KS_Chicken_2015(H5N2)

KP307976_WA_NOPI_2014(H5N2)

KP307984_WA_gyrfalcon_2014(H5N8)

KJ509036_Korea_Baikal_teal_2014(H5N8)

AB932556_Japan_Chicken_2014(H5N8)

KJ509116_Korea_Chicken_2014(H5N8)

KR232364_Netherlands_EAW_2015(H5N8)

KR233690_Netherlands_Chicken_2014(H5N8)

JQ973694_China_Duck_2010(H5N8)

KJ476657_China_Mallard_2013(H5N8)

KJ413834_Korea_Duck_2014(H5N8)

KJ508961_Korea_Baikal_teal_2014(H5N8)

NVSL1403_IN_Turkey_2016(H7N8)

Indiana H7 2016 HPAI cases

Iowa H5 2015 HPAI cases

Comparing Genetic Similarities of HPAI

AI virus

SVA virus

020406080100120

2010 2011 2012 2013 2014 2015 2016

NumberofVesicularDiseaseForeignAnimalDiseaseInvestigations

Vesicles on the nose and feet of pigs with SVA.

Senecavirus AU.S. contemporary

strains

Senecavirus ABrazilian contemporary

strains

Senecavirus AU.S. historical

strains

Veterinary Diagnostic Laboratory

• Partners to serve and grow Iowa’s $14.6 billion livestock and poultry industries and $17.9 billion animal protein processing sectors

• Provides timely, comprehensive, high-quality diagnoses for diseases and toxicoses

> 75,000+ cases/year > 1.2 million tests/year > Many with same-day results

• Protecting the safety and security of our food supply

• Fully accredited by the American Association of Veterinary Laboratory Diagnosticians

• One of 11 Tier 1 labs in the U.S. National Animal Health Laboratory Network

Iowa’s Only Full-Service Veterinary Diagnostic LaboratoryIMPACT: A 1% increase (or decrease) in Iowa’s Animal Agriculture Economy = $325 million impact on Iowa

• Continue to provide unbiased, critical diagnostic services to meet the needs of Iowa animal owners and consumers

• Position Iowa to continue to participate in national animal health networks and surveillance programs for domestic diseases

• Be prepared to detect and capably respond to the introduction of transboundary (Porcine Epidemic Diarrhea Virus 2013-14), foreign animal diseases (Highly Pathogenic Avian Influenza Virus 2015), and emerging diseases (Senecavirus A 2015-16)

• Provide the research infrastructure to be the nation’s leader in food-animal diagnostic medicine

• Preserve and continue to grow Iowa’s access to export markets: ~22% of U.S. pork, ~11% of U.S. beef, ~19% of U.S. chicken is exported

The $4-million direct appropriation through Agriculture and Natural Resources allows us to:

vetmed.iastate.edu/vdl

Iowa State University is requesting an inflationary increase of $80,000 (2%) for the ISU Veterinary Diagnostic Laboratory.

The caseload at the diagnostic laboratory has doubled over the past 5 years

Preserving Animal Health and Access to Export Markets

0%

5%

10%

15%

20%

25%

Beef

Pork

Chicken

Turkey

Agricultural Economies are Increasingly Dependent on Exports

% of Domestic Production Being Exported(Carcass Weight Basis)