VERSION #2 - d1gm0mynlzh1bh.cloudfront.net of injection, and in less than 1% of cases, drooping eyelids or eyebrows that return ... afunctional ingredient helps promote skin whitening

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PRODUCTPRODUCTPRODUCTPRODUCT BRIEF/OVERVIEWBRIEF/OVERVIEWBRIEF/OVERVIEWBRIEF/OVERVIEW _________SECRET _________SECRET _________SECRET _________SECRET SERUMSSERUMSSERUMSSERUMS

VERSIONVERSIONVERSIONVERSION #2#2#2#2

PRODUCTPRODUCTPRODUCTPRODUCT NAME:NAME:NAME:NAME: BYEBYEBYEBYE BYEBYEBYEBYE WRINKLESWRINKLESWRINKLESWRINKLES

PRODUCTPRODUCTPRODUCTPRODUCT IDIDIDID #:#:#:#: NAD-15-004-BNAD-15-004-BNAD-15-004-BNAD-15-004-B

PRODUCTPRODUCTPRODUCTPRODUCT CATEGORY:CATEGORY:CATEGORY:CATEGORY: SKINSKINSKINSKIN CARECARECARECARE

DATEDATEDATEDATE: January 13, 2016

BACKGROUND:BACKGROUND:BACKGROUND:BACKGROUND:

Ever since the FDA approved Botox for cosmetic use seven years ago, women (and men)

have been singing Botoxʼs praises. The masses arenʼt deterred by its short shelf life --

effects last only three to six months -- or the need for ongoing shots costing $300 to

$1,000 per injection site or area. Nearly 3 million Botox treatments are administered in

the United States every year.

HereHereHereHereʼ̓̓̓ssss whywhywhywhy: This purified form of botulinum a toxin -- blocks the nerves that contract

muscles so that wrinkles canʼt form, and it softens existing wrinkles and prevents them

from deepening. As a result, Botox can keep you looking far younger than your years,

which has its advantages. Botox is most effective on wrinkles that havenʼt quite set --

“dynamic” wrinkles that appear while youʼre moving your face, such as when you frown.

BotoxBotoxBotoxBotox sidesidesideside effects:effects:effects:effects:

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Botox is safe but there are side effects including: headaches, bruising, and pain at the

site of injection, and in less than 1% of cases, drooping eyelids or eyebrows that return

to their natural position within a few months.

Now, there is an alternative to Botox ‒ Advanced BTX or Liquid Surgery without the

scars. You can now get the Botox effect without surgery or injection. There is no risk of

side effects and you still get immediate anti-aging benefits. AndAndAndAnd mostmostmostmost importantly,importantly,importantly,importantly, thethethethe

benefitsbenefitsbenefitsbenefits ofofofof BotoxBotoxBotoxBotox atatatat aaaa fractionfractionfractionfraction ofofofof thethethethe costcostcostcost ofofofof oneoneoneone BotoxBotoxBotoxBotox injectioninjectioninjectioninjection site.site.site.site.

Legacy Technologies Inc. introduces the SECRETSECRETSECRETSECRET SERUMSSERUMSSERUMSSERUMS containing three products

that yield immediate results ‒ BYEBYEBYEBYE BYEBYEBYEBYE WRINKLES,WRINKLES,WRINKLES,WRINKLES, MYMYMYMY SECRETSECRETSECRETSECRET ANTIANTIANTIANTI AGINGAGINGAGINGAGING TREATMENTTREATMENTTREATMENTTREATMENT

andandandand thethethethe EXFOLIATINGEXFOLIATINGEXFOLIATINGEXFOLIATING CLEANSER.CLEANSER.CLEANSER.CLEANSER. These three incredible, state-of-the-art products

provide immediate, visible results to the user with clinical studies on the ingredients to

support the claims.





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DESCRIPTION:DESCRIPTION:DESCRIPTION:DESCRIPTION:

A very unique treatment product correcting fine lines and wrinkles, smoothing out the skin,

and evening out the skin tone. Now you can get the Botox effect without using Botox. The

benefits include wrinkle reduction and smoother, younger-looking skin. No surgery, no risk of

side effects and immediate anti-age results. This powerful instant line filler makes fine lines and

wrinkles virtually invisible in seconds. Youʼll love the youthful way you look.

TECHNOLOGYTECHNOLOGYTECHNOLOGYTECHNOLOGY &&&& KEYKEYKEYKEY INGREDIENTS:INGREDIENTS:INGREDIENTS:INGREDIENTS:

ADVANCEDADVANCEDADVANCEDADVANCED BTX:BTX:BTX:BTX:

Advanced BTX provides the Botox effect without the injection. We now have a successful

fight against time that reduces the signs of aging without surgery. Advanced BTX penetrates

the dermis quickly and volumizes the dermis. It purges the carbon dioxide from the skin cell

allowing the skin cells to breathe and be refreshed, leaving the skin more youthful, even toned

and healthy.

Advanced BTX is omniphobic (not oil or water soluble). It positions itself between intercellular

lipids and moisture in the skin.

The AdvancedWrinkle Corrector is to be used over the entire fact and neck area.

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CLINICALCLINICALCLINICALCLINICAL STUDIES:STUDIES:STUDIES:STUDIES:

1.1.1.1. AdvancedAdvancedAdvancedAdvanced BTXBTXBTXBTX ‒‒‒‒ 10%.10%.10%.10%.

In Vivo Protocol. 30 Volunteers women ages 35 to 40 with visible wrinkles around the eye area.

10%was applied around the eyes twice a day for 7 days.

Result ‒ the moisture content of the skin increased gradually during the period reaching 52%

increase.

The number, depth and length of wrinkles decreased by 10 to 50%.







CLAIMS:CLAIMS:CLAIMS:CLAIMS:

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1. Helps decrease fine lines and wrinkles.

2. Helps increased the moisture content of the skin.

3. Helps the number and depth of wrinkles decreased

dramatically after 28 days of treatment.

PRODUCTPRODUCTPRODUCTPRODUCT BRIEF/OVERVIEWBRIEF/OVERVIEWBRIEF/OVERVIEWBRIEF/OVERVIEW ___ ___ ___ ___SECRETSECRETSECRETSECRET SERUMSSERUMSSERUMSSERUMS VERSIONVERSIONVERSIONVERSION #2#2#2#2

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PRODUCTPRODUCTPRODUCTPRODUCT NAME:NAME:NAME:NAME: MYMYMYMY SECRETSECRETSECRETSECRET ANTI-AGINGANTI-AGINGANTI-AGINGANTI-AGING TREATMENTTREATMENTTREATMENTTREATMENT



PRODUCTPRODUCTPRODUCTPRODUCT IDIDIDID #:#:#:#: NAD-15-006-ANAD-15-006-ANAD-15-006-ANAD-15-006-A



THETHETHETHE PATENTEDPATENTEDPATENTEDPATENTED DELIVERYDELIVERYDELIVERYDELIVERY SYSTEM:SYSTEM:SYSTEM:SYSTEM:

My Secret Anti-Aging Treatment contains a patented delivery and deposition technology

called Polyolprepolymer-2 (PP2). PP2 is composed of oligomers (molecules) of varying weights

and sizes. Because of the different sizes and chemical structures, they form a gradient within

the stratum corneum creating a long lasting liquid reservoir for release to the deeper layers of

the skin. Polyolprepolymers form a long-lasting liquid reservoir. They deposit and hold

cosmetic ingredients on and in the stratum corneum and epidermis. They are polyalkylene

glycol-based Polyurethane polymers.

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THETHETHETHE PATENTEDPATENTEDPATENTEDPATENTED DELIVERYDELIVERYDELIVERYDELIVERY SYSTEM:SYSTEM:SYSTEM:SYSTEM:

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Polyolprepolymers form a noninvasive liquid reservoir, which remains on and in the upper

layers of the skin. They can modify deposition and absorption characteristics of ingredients

into the skin.

PP2 has a strong affinity for the skin where it readily deposits on and within the stratum

corneum forming a reservoir rather than migrating further into the skin. PP2 remains on the

upper layers of the skin where is can act as a regulator for the deposition and release of various

ingredients.

The following are the key attributes to PP2:

• Creates a long-lasting reservoir for release to the deeper layers of the skin.

• Reduces skin irritation.

• Prolongs activity.

• Enhances wear ability.

• Reduces drying side effects.

• Leaves the skin soft and silky-looking.

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BV-OSC:BV-OSC:BV-OSC:BV-OSC:

Vitamin C has many functions as a cosmetic ingredient including skin lightening, promoting

collagen synthesis and inhibiting lipid peroxidation (cellular injury in plants and animals, is

used as an indicator of oxidative stress in cells and tissues. Lipid peroxides are unstable and

decompose to form a complex series of compounds including reactive carbonyl compounds.

The benefits of Vitamin C include:

� Anti-oxidant activity, inhibiting lipid peroxidation

� UV-A and UV-B protection

� Clarifying and brightening activity, inhibiting melanogenesis

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� Stimulation of collagen production

� Inhibition of MMPʼs

BV-OSC is a form of vitamin C that plays an important role in face whitening cream. It has

special properties that help inhibit melanin production while helping the skin produce

collagen. Studies behind the ingredient show that it may help provide protection for skin cells

than other certain vitamin compounds. The ingredient has been compared to ingredients

such as ascorbic acid and magnesium ascorbyl phosphate (other ingredients used in face

whitening products). BV-OSC (also known as tetrahexyldecy ascorbate) has been proven to be

a functional ingredient helps promote skin whitening.

The Patented Delivery System and BV-OSC work hand-in-hand. Millions of dollars of research

has gone into the PP2








BV-OSCBV-OSCBV-OSCBV-OSC

BV-OSCBV-OSCBV-OSCBV-OSC SUMMARY:SUMMARY:SUMMARY:SUMMARY:

•••• At 0.1% reduced melanin synthesis by 80%

•••• At 10% eliminates age spots in 16 weeks

•••• At 3% in vivo reduces Delta-L value by 15% versus placebo (22 people) a way to measure

whitening effect.

•••• At 0.1% in vitro increases collagen by 50%

• Increases collagen synthesis at least twice as much as ascorbic acid

• Delivers pure Vitamin C 50 times better than ascorbic acid

• Protects the cells

• Protects against UVA and UVB.

BV-OSCBV-OSCBV-OSCBV-OSC CLINICALCLINICALCLINICALCLINICAL STUDIESSTUDIESSTUDIESSTUDIES #1#1#1#1

InInInIn vivovivovivovivo

ReductionReductionReductionReduction ofofofof UV-inducedUV-inducedUV-inducedUV-induced pigmentationpigmentationpigmentationpigmentation

Test Period ‒ 56 day

Concentration: 2%

Study showed significant reduction in coloring. Before and after photos in literature.

ClinicalClinicalClinicalClinical StudyStudyStudyStudy #2#2#2#2


BV-OSCBV-OSCBV-OSCBV-OSC ProtectsProtectsProtectsProtects SkinSkinSkinSkin fromfromfromfrom UVBUVBUVBUVB

Reduction of cell damage caused by UV irradiation. The cells were then irradiated with UVB.

After a 24-hour cultivation, cell survival rate was measured by WST-1 assay. Protective effect of

the BV-OSC was higher than that of L-Ascorbic acid due to the fact that the conversion rate of

BVOSC into the cells is higher than that of pure ascorbic acid.







WHITENINGWHITENINGWHITENINGWHITENING INGREDIENTSINGREDIENTSINGREDIENTSINGREDIENTS



BV-OSCBV-OSCBV-OSCBV-OSC ProtectsProtectsProtectsProtects SkinSkinSkinSkin fromfromfromfrom UVAUVAUVAUVA

InhibitionInhibitionInhibitionInhibition ofofofof keratinocyteskeratinocyteskeratinocyteskeratinocytes DNADNADNADNA damagedamagedamagedamage inducedinducedinducedinduced bybybyby UVAUVAUVAUVA


The light parts on the pictures (taken 1 hour after UVA irradiation) indicate 8-hydroxyguanosine,

an index of DNA damage. The application of BV-OSC, inhibits the release of 8-

hydroxyguanosine, thereby protecting the cell against UVA damage.

ProtectionProtectionProtectionProtection ofofofof cellcellcellcell damagedamagedamagedamage inducedinducedinducedinduced bybybyby UVAUVAUVAUVA

Microscopic pictures of keratinocytes 24 hour after irradiation. BV-OSC treatment reduces cell

death by 31.5%

InhibitionInhibitionInhibitionInhibition ofofofof DNADNADNADNA FragmentationFragmentationFragmentationFragmentation inducedinducedinducedinduced bybybyby UVAUVAUVAUVA

HaCaT cells were treated with 80yM BV-OSC. After UVA irradiation, DNA fragmentation was

detected by nick end labeling method (TUNEL). BV-OSC significantly suppressed DNA

fragmentation (shown with fluorescent staining).


CellCellCellCell RevitalizingRevitalizingRevitalizingRevitalizing ActivityActivityActivityActivity /Cell/Cell/Cell/Cell ProliferationProliferationProliferationProliferation

BV-OSC was added at various concentrations to human fibroblasts (NB1RGB). After 3 days of

cultivation, the cell growth rate was measured by MTT reduction assay. As shown below, BV-

OSC proliferated human fibroblasts. And the result was dose-dependent.









CellCellCellCell RevitalizationRevitalizationRevitalizationRevitalization Activity/CellActivity/CellActivity/CellActivity/Cell ProliferationProliferationProliferationProliferation

BV-OSC was added at various concentrations to human fibroblasts (NB1RGB). After 3 days of

cultivation, the cell growth rate was measured by MTT reduction assay. As shown below, BV-

OSC proliferated human fibroblasts. And the result was dose dependent.

WHITENINGWHITENINGWHITENINGWHITENING INGREDIENTSINGREDIENTSINGREDIENTSINGREDIENTS



PromotionPromotionPromotionPromotion ofofofof CollagenCollagenCollagenCollagen SynthesisSynthesisSynthesisSynthesis

Proline involved in collagen synthesis was labeled by 3H and added to human fibroblasts

(NHDF) with various concentrations of BV-OSC/L-Ascorbic Acid and cultivated for 24 hours.

Then collagen fractions were obtained. The amount of 3H taken into the collagen fraction was


measured by using a liquid scintillation counter and slot blotter. As shown below, BV-OSC

significantly promoted collagen synthesis.


PercutaneousPercutaneousPercutaneousPercutaneous AbsorptionAbsorptionAbsorptionAbsorption ofofofof BV-OSCBV-OSCBV-OSCBV-OSC

Percutaneous Absorption of BV-OSC was measured with a tissue section isolated from human

skin. BV-OSC showed superior penetration into the epidermis. BV-OSC is an oil-soluble liquid

and has a high affinity for the skin. This seems to explain the excellent percutaneous

absorption. Overall BV-OSC smoothes skin and improves elasticity by increasing cell turnover.







AQUAXYLAQUAXYLAQUAXYLAQUAXYL


Thanks to HYDRACONCEPT technology, AQUAXYL helps control the skin hydrous flow.

Scientists have unveiled its mechanism of action at the heart of the cell, AQUAXYL optimizes

the water circulation and increases the water reserves. Its “anti-dehydration shield” increases

the production of essential lipids and improves the skin barrier organization and protein

synthesis. Finally, a visible efficacy with measurable results at 8 and 24 hours after one single

application. Skin is smoothed, soft with a desquamation under control! AQUAXYL is the

inevitable active for moisture, moisture, moisture.

PROPERTIESPROPERTIESPROPERTIESPROPERTIES OFOFOFOF AQUAXYL:AQUAXYL:AQUAXYL:AQUAXYL:

• Visible improvement after 1 month: skin is softer and desquamation is controlled.

• Water losses are decreased thanks to the specific “anti-dehydration shield” action.

• Hyaluronic acid is boosted inside the dermis and epidermis.

• Hair fiber hydration is improved and trapped inside the cuticle.

• Foaming formulationsʼ sensorial profil and tolerance is enhanced.


1.1.1.1. OptimizationOptimizationOptimizationOptimization ofofofof waterwaterwaterwater reserves.reserves.reserves.reserves.

InInInIn vitro.vitro.vitro.vitro.

6666 daysdaysdaysdays incubation.incubation.incubation.incubation.

IncreasedIncreasedIncreasedIncreased waterwaterwaterwater reservesreservesreservesreserves bybybyby 183%183%183%183% comparedcomparedcomparedcompared totototo thethethethe control.control.control.control.

2.2.2.2. InInInIn vivovivovivovivo ‒‒‒‒ testtesttesttest hydrationhydrationhydrationhydration statestatestatestate ofofofof epidermisepidermisepidermisepidermis upperupperupperupper layerslayerslayerslayers withwithwithwith corneometry.corneometry.corneometry.corneometry.

AquaxylAquaxylAquaxylAquaxyl atatatat 3%3%3%3% versusversusversusversus placebo.placebo.placebo.placebo.


25252525 volunteers25volunteers25volunteers25volunteers25 VOLUNTEERSVOLUNTEERSVOLUNTEERSVOLUNTEERS

OneOneOneOne monthmonthmonthmonth

ApplicationApplicationApplicationApplication twicetwicetwicetwice aaaa day.day.day.day.

AreaAreaAreaArea ‒‒‒‒ onononon legslegslegslegs






MATRIXYLMATRIXYLMATRIXYLMATRIXYL SYNTHE-6SYNTHE-6SYNTHE-6SYNTHE-6

Matrixyl Syntheʼ6 is palmitoyl tripeptide-38, a peptide produced from derivatives of the amino

acids lysine and methione sulfone (the latter is synthetic). Palmitoyl tripeptide-38 is a

matrikine-mimetic compound that regulates cell activity, wound repair and collagen tissue

remodeling.

As the name implies, Matrixyl Syntheʼ6 stimulates six major constituents of the skin matrix and

the dermal-epidermal junction. And these are:

1. CollagenCollagenCollagenCollagen IIII - It is the major component of the dermis.


2. CollagenCollagenCollagenCollagen IIIIIIIIIIII - This type of collagen is produced in the earliest phases of wound healing,

before type I collagen synthesis initiation. It is mostly found in elastic tissues, including

the skin, muscles and blood vessels, and it diminishes with age in favor of collagen I.

3. CollagenCollagenCollagenCollagen IVIVIVIV - This has important wound healing stimulation properties, as it interacts

with keratinocytes, which induce epidermal cell proliferation immediately after a skin

injury.

4. FibronectinFibronectinFibronectinFibronectin - A glycoprotein that appears to have a role in the stimulation and

acceleration of in vivo tissue repair.

5. HyaluronicHyaluronicHyaluronicHyaluronic AcidAcidAcidAcid - Known for facilitating wound repair, hyaluronic acid is thought to

improve skin moisture and elasticity. Hyaluronic acid has a demonstrated ability to

promote the delivery of active ingredients to the inner layers of the skin. Its free radical

scavenging properties indicate that it may also have a role in UV protection.

6. Laminin-5Laminin-5Laminin-5Laminin-5 - Alongside collagens and proteoglycans, laminins are important

components of the basement membrane. Laminin-5 anchors the epidermis to the

dermis. It also regulates keratinocyte migration, facilitating the healing of injured

epidermis.

https://www.truthinaging.com/ingredients/hyaluronic-acid








MOISTURIZATION:MOISTURIZATION:MOISTURIZATION:MOISTURIZATION:

Matrixyl Syntheʼ6 is known for its collagen boosting properties and also for itʼs moisturization

properties. It is known as palmitoyl tripeptide-38, a peptide produced from derivatives of the

amino acids lysine andmethione sulfone (the latter is synthetic). Palmitoyl tripeptide-38 is a

matrikine-mimetic compound that regulates cell activity, wound repair and collagen tissue

remodeling.

Matrixyl® syntheʼ6® fills in wrinkles from the inside both on the forehead and the crowʼs feet for

a visibly smoother and plumper skin. Thanks to its matrikine‒like effect, Matrixyl syntheʼ6

stimulates 6 major constituents of the skin matrix and the dermal‒epidermal junction (DEJ) and

ensures an optimal architecture of the tissue. I n vivo studies demonstrated that, after 2

months, the forehead and crowʼs feet wrinkles are visibly smoothed from the inside of the skin.


Many parameters demonstrated this smoothing effect (wrinkle volume, depth, surface...) and

more particularly the lifting effect and the wrinkle spread.

There are also the results of a placebo-controlled clinical study of 25 women aged 42 to 70

years. In this study, 2% palmitoyl tripeptide-38 was applied twice daily for two months on two

facial skin areas especially prone to wrinkling: the forehead and the crowʼs feet by the eyes.

Forehead wrinkle volume and depth decreased by 31 and 16.3%, respectively, and lifting

improved by 28%. On the crowʼs feet, wrinkle surface, volume, and maximum depth

diminished by 28.5, 21.1, and 15%, respectively.









On the forehead, measurements demonstrated a visible, mean reduction in wrinkle volume of

31%. This was complemented by a 28% reduction in the skinʼs texture, which can be associated

with a lifting effect. The maximum depth of the wrinkle decreased by a mean 16.3%. For the

crowʼs feet, the anti-0wrinkle effect was measured through a decrease in the surface occupied

by deep wrinkles by -28.5%, a decrease in the volume of a major wrinkle of -21% and a

reduction in the mean depth by -15%. There was also a lifting effect since there was an

approximate -13% reduction in skinʼs texture.

THETHETHETHE SCIENCE:SCIENCE:SCIENCE:SCIENCE:

These results are directly related to the in vitro results obtained, which demonstrated an

increase in the quantity of 6 major components of cutaneous tissue.

1.1.1.1. CollagenCollagenCollagenCollagen IIII improvedimprovedimprovedimproved bybybyby 111%111%111%111%

Constitutes the most abundant collagen in our dermis

2.2.2.2. CollagenCollagenCollagenCollagen IIIIIIIIIIII improvedimprovedimprovedimproved bybybyby 104%104%104%104%

Referred to as the youth collagen because it is produced by our young fibroblast

3.3.3.3. CollagenCollagenCollagenCollagen IVIVIVIV improvedimprovedimprovedimproved 42%42%42%42%

Anchors the proteins in the basement layers of the skin


4.4.4.4. HeatHeatHeatHeat ShockShockShockShock ProteinsProteinsProteinsProteins improvedimprovedimprovedimproved bybybyby 123%123%123%123%

Proteins whose expression is increased when cells are exposed to elevated temperatures or

other stress

5.5.5.5. LamininsLamininsLamininsLaminins improvedimprovedimprovedimproved 75%75%75%75%

Is involved in the healing of damaged skin

6.6.6.6. HyaluronicHyaluronicHyaluronicHyaluronic productionproductionproductionproduction improvedimprovedimprovedimproved 174%174%174%174%

An important component responsible for water retention






INGREDIENT:INGREDIENT:INGREDIENT:INGREDIENT: PHYTOCELLTECPHYTOCELLTECPHYTOCELLTECPHYTOCELLTEC™™™™ MALUSMALUSMALUSMALUS DOMESTICADOMESTICADOMESTICADOMESTICA


Secret Serum Stem Cell Serum works by harnessing the power of stem cell technology, a

process which is essential in skin rejuvenation. As we age, the reduced turnover of our cells


means we can lose control over how our skin ages. Epidermal stem cells needed to create

healthy new skin are significantly reduced and function less efficiently.

Scientists have found that an extract derived from the stem cells of a rare apple tree cultivated

for its extraordinary longevity shows tremendous ability to rejuvenate aging skin. By

stimulating aging skin stem cells, this plant extract has been shown to lessen the appearance of

unsightly wrinkles. Clinical trials show that this unique formulation increases the longevity of

skin cells, resulting in skin that has a more youthful and radiant appearance.

STEMSTEMSTEMSTEM CELLSCELLSCELLSCELLS

Cells in our bodies are programmed for specific functions. A skin cell, a brain cell, and a liver cell

all contain the same DNA, or set of genes. However, each cellʼs fate is determined by a set of

epigenetic (able to change gene expression patterns) signals that come from inside it and from

the surrounding cells as well. These signals are like command tags attached to the DNA that

switch certain genes on or off. This selective coding creates all of the different kinds of cells in

our bodies, which are collectively known as differentiated (specialized) cells.

Although differentiated cells vary widely in purpose and appearance, they all have one thing in

common: they all come with a built-in operational limit. After so many divisions, they lose their

ability to divide andmust be replaced. This is where stem cells come in.

Your body also produces other cells that contain no specific programming. These stem cells are

“blank,” so your body can essentially “format” them any way it pleases. Two universal aspects

shared by this type of cell are: (1) the ability to replenish itself through a process of self-renewal

and (2) the capacity to produce a differentiated cell.


In animals and humans, two basic kinds of stem cells exist: embryonic and adult stem cells.

EmbryonicEmbryonicEmbryonicEmbryonic stemstemstemstem cellscellscellscells have the power to change into any differentiated cell type found

anywhere in your body. AdultAdultAdultAdult stemstemstemstem cells,cells,cells,cells, on the other hand, are generally more limited. They

can only evolve into the specific type of cell found in the tissue where they are located. The

primary function of these adult stem cells is maintenance and repair.







THETHETHETHE ROLEROLEROLEROLE OFOFOFOF STEMSTEMSTEMSTEM CELLSCELLSCELLSCELLS ININININ SKINSKINSKINSKIN CARE:CARE:CARE:CARE:

The basal (innermost) layer of the skinʼs epidermis comprises two basic types of cells: (1) the

slowly dividing epidermal stem cells (that represent about 2-7% of the basal cell population)

and (2) their rapidly dividing offspring that supply new cells to replace those that are lost or

dying.

The slow self-renewal process of epidermal stem cells, however, creates a problem. Because

each epidermal stem cell only lasts for a certain number of divisions, and because each division

runs the risk of lethal DNAmutation, the epidermal stem cell population can become depleted.


When this happens, lost or dying skin cells begin to outnumber their replacements and the

skinʼs health and appearance start to decline.

PlantsPlantsPlantsPlants alsoalsoalsoalso havehavehavehave stemstemstemstem cells.cells.cells.cells. LikeLikeLikeLike humans,humans,humans,humans, plantplantplantplant stemstemstemstem cellscellscellscells dependdependdependdepend onononon epigeneticepigeneticepigeneticepigenetic controlcontrolcontrolcontrol andandandand

signalssignalssignalssignals fromfromfromfrom surroundingsurroundingsurroundingsurrounding cellscellscellscells forforforfor theirtheirtheirtheir development.development.development.development. UnlikeUnlikeUnlikeUnlike humans,humans,humans,humans, however,however,however,however, eacheacheacheach plant-plant-plant-plant-

derivedderivedderivedderived adultadultadultadult stemstemstemstem cellcellcellcell possessespossessespossessespossesses thethethethe abilityabilityabilityability totototo generategenerategenerategenerate aaaa wholewholewholewhole newnewnewnew plant.plant.plant.plant. ScientistsScientistsScientistsScientists havehavehavehave

foundfoundfoundfound aaaa waywaywayway totototo harnessharnessharnessharness thethethethe powerpowerpowerpower ofofofof plantplantplantplant stemstemstemstem cellscellscellscells bybybyby growinggrowinggrowinggrowing plantplantplantplant tissuestissuestissuestissues inininin culture.culture.culture.culture.

Today, apples are cultivated primarily to enhance their appearance and flavor. But before the

rise of refrigeration, an appleʼs ability to stay fresh for a long time was its most sought-after

characteristic.

For this reason, a special variety of apple was cultivated in the middle of the 18th century that

could be stored for a greatly extended period of time. In essence, it was the genetically

modified, longer-living stem cells of this tannin-rich variety of apple, called the Uttwiler

Spätlauber apple, which were responsible for its unique storage longevity. The Spätlauber

variety derives from a seedling that was planted in the middle of the 18th century. There are

still some Uttwiler Spätlauber tree left in certain areas in Switzerland. The apples of one of these

trees were used to obtain tissue explants in order to initiate a plant cell culture. A success full

liquid culture in bioreactors of Uttwiler Spätlauber stem cells could be established. An extract

of these cells was tested in a series of studies for anti-aging efficacy in skin and hair

In a certain isolated area of rural Switzerland, a few of these hardy apple trees still survive today.

Scientists obtained an explant from the leaf of one of these trees to produce a special anti-

aging stem cell extract.








TheTheTheThe AmazingAmazingAmazingAmazing ResultsResultsResultsResults

In order to test the theory that this unique plant extract would produce anti-aging effects,

scientists at Mibelle Biochemistry first obtained human stem cells from the blood of an

umbilical cord. TheirTheirTheirTheir firstfirstfirstfirst in-housein-housein-housein-house studystudystudystudy onononon cellcellcellcell viabilityviabilityviabilityviability showedshowedshowedshowed that,that,that,that, atatatat aaaa concentrationconcentrationconcentrationconcentration ofofofof

onlyonlyonlyonly 0.1%,0.1%,0.1%,0.1%, anananan extractextractextractextract ofofofof UttwilerUttwilerUttwilerUttwiler SpSpSpSpäääätlaubertlaubertlaubertlauber stemstemstemstem cellscellscellscells stimulatedstimulatedstimulatedstimulated thethethethe proliferationproliferationproliferationproliferation ofofofof humanhumanhumanhuman

stemstemstemstem cellscellscellscells bybybyby anananan astoundingastoundingastoundingastounding 80%!80%!80%!80%!

In a second experiment, these scientists irradiated the umbilical cord blood stem cells with UV

light. Nearly 50% of the stem cells cultured in growth medium alone died, but the cells grown

in the culture containing the special apple extract showed only a small decrease in the number

of living cells.

Another in vitro experiment conducted by the scientists involved fibroblast cells. These are the

most common of all cells in the connective tissue of the skin. They manufacture the collagen,

glycosamino glycans, reticular and elastic fibers, and glycoproteins that make up the

extracellular matrix (connective tissues providing support to cells). Fibroblasts not only help

provide a structural framework for the skin, they also play a critical role in wound healing.


In their experiment, the scientists treated fibroblast cells with hydrogen peroxide for two hours

until the cells began to show classic signs of aging. In scientific terms, this means that several

genes essential for cell proliferation and growth were significantly down-regulated. However,

after incubating these cells for 144 hours in a 2% Uttwiler Spätlauber extract, this down-

regulation of genes was effectively neutralized, and in some cases, it was actually reversed! In

addition, the scientists noted that the expression of an important antioxidant enzyme

called heme oxigenase 1was also stimulated.







CLINICALCLINICALCLINICALCLINICAL STUDIESSTUDIESSTUDIESSTUDIES


1.1.1.1. Anti-WrinkleAnti-WrinkleAnti-WrinkleAnti-Wrinkle EffectEffectEffectEffect onononon thethethethe CrowCrowCrowCrowʼ̓̓̓ssss FeetFeetFeetFeet AreaAreaAreaArea TheTheTheThe anti-wrinkleanti-wrinkleanti-wrinkleanti-wrinkle efficacyefficacyefficacyefficacy ofofofof PhytoCellTecPhytoCellTecPhytoCellTecPhytoCellTec

MalusMalusMalusMalus DomesticaDomesticaDomesticaDomesticawas demonstrated in a clinical trial over 4 weeks with 20 subjects. A

cream with 2% PhytoCellTec™ Malus Domestica was applied twice daily to the crowʼs

feet area. Wrinkle depth was analyzed with the PRIMOS system after 2 and 4 weeks.

Digital photos of the crowʼs feet area were taken at the beginning and the end of the

study. The PhytoCellTec™ Malus Domestica cream was found to significantly reduce

wrinkle depth after two and after four weeks, by 8% and 15% respectively. The effect

can be nicely demonstrated by generation of 3D pictures. Such an example is shown in

Fig. 7.

The anti-wrinkle efficacy could also been shown on digital photos (Fig. 8)








DESCRIPTIONDESCRIPTIONDESCRIPTIONDESCRIPTION CONTINUED:CONTINUED:CONTINUED:CONTINUED:








INGREDIENT:INGREDIENT:INGREDIENT:INGREDIENT: GROWTHGROWTHGROWTHGROWTH FACTORSFACTORSFACTORSFACTORS ANDANDANDAND PEPTIDESPEPTIDESPEPTIDESPEPTIDES

CG-EGF Encapsulated (.1%)

CG-bFGF Encapsulated (.1%)

CG-TGF-β3 Encapsulated (.1%)












rh-Oligopeptide-1 is a single chain recombinant human peptide, obtained by genetic

engineering technology (microbial recombinant). The starting gene is directly isolated from a

human cell which codes for Epidermal Growth Factor (EGF). Totally identical to natural EGF,

known as a “BEAUTY FACTOR”, boosts and regulates stem cell proliferation.

EGF is found within the fibroblast cells of the dermal layer and aids in stimulating cells to

produce collagen. This is small (Contains only 53 amino-acids) but a very key peptide that adds

the youthful appearance of the skin.

In 1986, Stanley Cohen received the Nobel Prize for his work elucidating the role of the

Epidermal Growth Factor (EGF) in the regulation of cell growth and development. EGF protein

was found to enhance epidermal growth and keratinization.

EGF in summary is widely used in skin care products with the following outcomes:

• RejuvenatesRejuvenatesRejuvenatesRejuvenates skinskinskinskin - EGF can help skin stem cells to absorb nutrients, speed cell

metabolism, accelerate skin cell division and growth, and stimulate the synthesis of

hyaluronic acid and glycoproteins.

http://rg-cell.com/egf-beauty-factor/


•••• 2222

• AcceleratesAcceleratesAcceleratesAccelerates cellcellcellcell regenerationregenerationregenerationregeneration andandandand tissuetissuetissuetissue repairrepairrepairrepair - EGF can promote the healing of wound

surface of skin and mucosa, reduce scar contracture and skin cellʼs abnormal

proliferation.

• WhitenWhitenWhitenWhiten skinskinskinskin - EGF can promote the growth of new cells which replace cells injured by

ultraviolet radiation. It does this by reducing the number of melanocytes in the skin.











Rh-polypeptide 1 also known as Human Fibroblast Growth Factor-basic or shorter bFGF, FGF-β

or FGF2 is a heparin-binding member of the FGF superfamily of molecules. FGF2 is a bioactive

protein intended for use in cell culture applications. It plays important role in cell proliferation

and differentiation associated with embryogenesis, tissue regeneration and wound healing.

FGF2 in summary is widely used in skin care products with the following outcomes:

• Reduce and prevent fine lines and wrinkles by actively generating new skin cells

• Skin rejuvenator involves in normal growth, healing, & wound repair

• Strengthen skin elasticity by inducing the synthesis of collagen and elastin

• Help blood circulation in the scalp and revitalizing hair follicles

The nutrient-rich growth factors, peptides and proteins that are contained in the stem cells are

the work horses for skin repair. The growth factors are responsible for cellular growth,

proliferation and repair. They play an important role in maintaining healthy skin structure and

function. They help repair wounds; they help promote the formation of collagen; they help

regenerate new, healthy tissue. The result: reduced hyperpigmentation, enhanced elasticity,

and reduced fine lines and wrinkles. The genes that are most important to the health and

appearance of the skin are Elastin, Collagen, Epidermal Growth Factors, Keratinocyte Growth

Factors and Fibroblast Growth Factors.








CG-EGF Encapsulated (.1%) Targets the Epidermal

CG-bFGF Encapsulated (.1%) Targets the Fibroblast

CG-TGF-β3 Encapsulated (.1%) Targets cell transformation








INGREDIENTINGREDIENTINGREDIENTINGREDIENT:::: PHYTOPHYTOPHYTOPHYTO DEFENSEDEFENSEDEFENSEDEFENSE

ANTI-INFLAMMATORYANTI-INFLAMMATORYANTI-INFLAMMATORYANTI-INFLAMMATORY

PhytoDefense CLRTM is designed for the pre- and post-treatment of sensitive skin. It strongly

and positively influences the most important features of sensitive skin, neurogenic

inflammation andmechanical stress-induced erythema.

The most important factor of sensitive skin is a sensation of burning, stinging or prickling, the

so-called neurogenic inflammation, often accompanied by redness. Mechanical stress is yet

another very well-known cause of erythema in sensitive skin. For example friction from clothes,

shoes or diapers as well as working with the hands, waxing and, most well-known of all,

shaving.

To address this problematic skin, it is essential to combat neurogenic inflammation and

erythema. PhytoDefense CLRTM is a lipophilic active based on the bark of southern magnolia

(Magnolia grandiflora) which is native to the southeastern United States and known in

Traditional Chinese Medicine (TCM), Indian Ayurveda and Japanese Kampomedicine for its

calming and soothing properties.







INGREDIENTINGREDIENTINGREDIENTINGREDIENT:::: DAYMOISTDAYMOISTDAYMOISTDAYMOIST CLRCLRCLRCLR

DayMoist CLR™ is a complex of natural plant-derived active ingredients potently supporting

the Natural Moisturizing Factors (NMF) in arranging a high level of hydration in the stratum

corneum. DayMoist CLR™ has an immediate and long-lasting effect. Just one single application

of a cosmetic formulation containing 3.0−5.0% DayMoist CLR™ improves the hydration level of


the upper layers of the skin, a fast-acting effect which lasts for at least 24 hours. Just 1.0% of

DayMoist CLR™ leads to a significant moisturization for at least 8 hours.

The moisturizing properties of DayMoist CLR™ have been proven objectively and reliably by a

combination of two in vivo technologies: Confocal RamanMicrospectroscopy and

Corneometry. DayMoist CLR™ also moisturizes hair, improving hair condition and protecting

against heat stress and color fading. In addition to its beneficial effect on the properties of skin

and hair, DayMoist CLR™, when formulated in skin care formulations, gives great skin feel.

InInInIn vivovivovivovivo TestTestTestTest SummarySummarySummarySummary

Immediate and long-lasting effects after one single application:

• Increase in hydration level: 3-5%: 24 hours 1%: 8 hours

• Increase in the concentration of NMF in the upper Stratum Corneum for 24 hours







1. Contains a patented delivery system, PP2, specifically designed to deliver

drug ingredients to the skin.

2. PP2 forms a non-invasive reservoir for release to the deeper layers of the

skin.

3. PP2 can significantly modify the distribution and absorption

characteristics of ingredients on the skin.

4. PP2 helps reduces skin irritation.

5. PP2 resists wash-off. Ingredients remain on the skin longer.

6. It prolongs activity and enhances wear ability.

7. PP2 leaves the skin soft and silky-looking.

8. PP2 helps provide vitamins and nutrients to the skin.

9. Helps smooth and improve skin surface.

10. Helps reduce fine lines and wrinkles.

11. Helps provide moisture to the skin.

12. BV-OSC at 0.1% reduced melanin synthesis by 80%

13. BV-OSC At 3% in vivo helps to reduce Delta-L value by 15% versus placebo (22

people) a way to measure whitening effect.


14. BV-OSC helps increases collagen by 50%.

15. BV-OSC helps increases collagen synthesis at least twice as much as ascorbic

acid.

16. BV-OSC helps protects the cells against UVA and UVB damage.

17. Helps brighten the skin.

18. Helps whiten the skin.

19. Helps protect the longevity of skin stem cells.

20. Helps to combat chronological aging.

21. Contains a patent-pending stem cell ingredient.

22. Provides vitamins and nutrients to the skin.

23. Helps moisturize the skin.

24. Helps improve epidermis hydration from the first day of treatment.

25. Helps prevent water loss.

26. Helps to instantly smooth and improve skin surface.

27. Instantly helps reduce fine lines and wrinkles.


PRODUCTPRODUCTPRODUCTPRODUCT NAME:NAME:NAME:NAME: EXFOLIATINGEXFOLIATINGEXFOLIATINGEXFOLIATING CLEANSERCLEANSERCLEANSERCLEANSER





The Exfoliating Cleanser will thoroughly clean your skin to remove any impurities. This includes

make-up, oil, dirt, dead skin cells and it will also help to unclog pores. With the Exfoliating

Cleanser you are getting a 2-1 cleanse ‒ the first to remove any surface debris and the second

to clean and exfoliate the skin with the MICROSCRUB 50 PC powder. This is to be used morning

and evening to exfoliate the dead cell layer of the skin, leaving it soft, supple, clean and smooth.

This cleanser contains the following active ingredients:

EXFOLIATINGEXFOLIATINGEXFOLIATINGEXFOLIATING INGREDIENTS:INGREDIENTS:INGREDIENTS:INGREDIENTS:

MultiMultiMultiMulti FruitFruitFruitFruit BSCBSCBSCBSC

MicroMicroMicroMicro ScrubScrubScrubScrub 50505050 PCPCPCPC

ANTI-IRRITANTANTI-IRRITANTANTI-IRRITANTANTI-IRRITANT INGREDIENTS:INGREDIENTS:INGREDIENTS:INGREDIENTS:

SymReliefSymReliefSymReliefSymRelief SSSS







INGREDIENT:INGREDIENT:INGREDIENT:INGREDIENT: MULTIFRUITMULTIFRUITMULTIFRUITMULTIFRUIT BSC:BSC:BSC:BSC:

Multifruit® BSC is a concentrated blend of five botanical extracts: bilberry, sugar cane, sugar

maple, orange, and lemon. These extracts contain several naturally occurring alpha hydroxy

acids. Alpha hydroxy acids have been shown to promote smoother, younger looking skin by

increasing the rate of cell renewal. Alpha hydroxy acids (AHAs) have been used in skin care for

many years.


At first, they were used mainly by dermatologists as skin peeling and moisturizing agents;

cosmetic companies have since “discovered” AHAs and their almost miraculous activity and

formulate with them regularly in their skin care lines.

Multifruit® BSC gently exfoliates skin with natural alpha-hydroxy acids derived from botanical

extracts. It is produced by taking several species of plants and running them through an

exhaustive extraction process, which reduces color and odor, and concentrates the active

principles. The extracts are blended at the following percentages: Bilberry 57.00%; Sugar Cane

24.00%; Sugar Maple 3.00%; Orange 8.00%; Lemon 8.00%. Once blended, the extracts are

concentrated by vacuum distillation until a specified concentration of actives is achieved. The

product is then filtered to eliminate any particulate matter. Since Multifruit® BSC is a natural

product it will contain a Tartaric Acid wide variety of residual natural substances, such as

cellulose, carbohydrates, proteins, water soluble vitamins and minerals.

Lactic Acid 28 ‒ 32% Glycolic Acid 12 - 17% Citric Acid 2-6% Malic Acid 1%Max

Tartaric Acid ‒ 1%

When the process is complete, the material contains the following concentrations of alpha

hydroxy acids: The primary action of AHAs lies in their keratolytic ability̶ they weaken bonds

that hold dead skin cells together. When these bonds are weakened, the dead cells can be shed

from the surface of the skin, resulting in skin that appears fresher, smoother and younger.

Although the keratolytic activity of AHAs is very important, it is also interesting to note that

many AHAs function as intermediates in several key metabolic pathways.







INGREDIENT:INGREDIENT:INGREDIENT:INGREDIENT: MULTIFRUITMULTIFRUITMULTIFRUITMULTIFRUIT BSC:BSC:BSC:BSC:








INGREDIENT:INGREDIENT:INGREDIENT:INGREDIENT: MICROMICROMICROMICRO SCRUBSCRUBSCRUBSCRUB 50505050 PCPCPCPC

MICROSCRUB 50 provides complete cleansing while also focusing on skin conditioning and

treating. It is a low density, high molecular weight Polyethylene powder with a maximum

particle size of 297 microns (50 mesh). MICROSCRUB 50 has excellent solvent resistance and

resists attack by fragrances. MICROSCRUB 50 is best suited for use as a scrub additive in

industrial hand cleaners and soaps. Close quality control of particle size prevents oversized

particles which can plug pump delivery systems. The warmth helps the scrub provide a deeper

cleansing, deep down-to-the-pores, minimizing the pore appearance and leaving the skin

feeling soft and smooth.







INGREDIENT:INGREDIENT:INGREDIENT:INGREDIENT: SYMRELIEFSYMRELIEFSYMRELIEFSYMRELIEF S:S:S:S:

SensitiveSensitiveSensitiveSensitive SkinSkinSkinSkin means:means:means:means: Constant dissatisfaction and disappointed hopes with existing market

products for sensitive skin. Problem having a negative impact which affects the person

physically as well as mentally: lowering self-esteem and added feeling of vulnerability.

Skin reacting stronger and faster than “normal” skin with handicapping visible manifestations:

redness, scaling, thinning… loss of integrity, of protection. Difficult experience from discomfort

to pain with: tightness, pressure, heat, dryness, cracking … tingling, burning.


An over-valorization of outer causes (climate, products, pollution). Fragile skin that requires

constant care.

CLINICALCLINICALCLINICALCLINICAL STUDYSTUDYSTUDYSTUDY #1:#1:#1:#1:







INGREDIENT:INGREDIENT:INGREDIENT:INGREDIENT: SYMRELIEF:SYMRELIEF:SYMRELIEF:SYMRELIEF:

CLINICALCLINICALCLINICALCLINICAL STUDYSTUDYSTUDYSTUDY #1#1#1#1 CONTINUED:CONTINUED:CONTINUED:CONTINUED:







INGREDIENT:INGREDIENT:INGREDIENT:INGREDIENT: SYMRELIEFSYMRELIEFSYMRELIEFSYMRELIEF SSSS

CLINICALCLINICALCLINICALCLINICAL STUDYSTUDYSTUDYSTUDY #1#1#1#1 CONTINUED:CONTINUED:CONTINUED:CONTINUED:








1. Helps remove the dead cell layer from the skin.

2. Helps relieve skin irritation. (SymRelief S)

3. Leaves the skin clean, fresh and hydrated.

4. Helps brighten the skin.

Documents

VERSION #2 - d1gm0mynlzh1bh.cloudfront.net of injection, and in less than 1% of cases, drooping eyelids or eyebrows that return ... afunctional ingredient helps promote skin whitening