Contains not less than 4% of sum of Hyperoside andIsoquercitrin

RAFUMAScientific name : Apocynum venetum L.Family name : ApocynaceaeOrigin : Tarim Basin, Xinjiang Uighur Autonomous Region, China

Widely used as food

Specifiation of VENETRON® （Rafuma extract）

Abundance of clinical data on VENETRON® by

comparison of changes in Factor II （Initiation and maintenance of sleep）

Ingestion at 50 mg/day led to significant improvementbetween groups in Initiation and maintenance of sleep

comparison of changes in fluctuation rates of performance

comparison of changes in stressed states such asnervousness and irritation

Improvement of insomnia

Focusing ability / stress reduction

Relaxation effects（synergistic effects with gamma-aminobutyric acid ［GABA］）

Change of CgA concentration

(average)

Placebo

VENETRON® （25 mg）

VENETRON®Placebo

GABA （25 mg）

VENETRON® （25 mg）+ GABA （25 mg）

Yoto, et al., Journal of Physiological Anthropology 14(3), 151-155, 2009.

Nakata, et al., Japanese Pharmacology & Therapeutics 46(1), 117-125, 2018.

Nakata, et al., Japanese Pharmacology & Therapeutics 46(1), 117-125, 2018. Nakata, et al., Japanese Pharmacology & Therapeutics 46(1), 117-125, 2018.

Yamatsu et al., Journal of Nutritional Science and Vitaminology 61(2), 182-187, 2015.

Evaluation of synergistic effects regarding relaxationbased on the Uchida-Kraepelin test

Comparison of stress marker （CgA in saliva）

Ingestion of VENETRON® （25 mg） + GABA （25 mg） led to significantsuppression of increase in CgA concentration among groups.

Other data from humans● Improvement of depressive symptoms （at 50 mg/day）. 　（Increase of serotonin concentration in platelets and decrease of MHPG concentration, a marker for anxiety）● Improvement of premenstrual syndrome （at 25-50 mg/day）.

The leaves have been used for tea in China since ancient times. In Japan,beverage containing Rafuma leaves, said to promote improvement in highblood pressure, has been designated as food for specified health use.

Listed in the Pharmacopoeia of the People’s Republic of China

Rafuma (or luobuma in Chinese) is listed in the Chinese Pharmacopoeia as acrude drug used for insomnia, hypertension and enervation.

post-ingestion（30min）

comparison of the ratio of non-REM sleep duration

pre-ingestion（0min）

Self-evaluation of sleep based on OSA Sleepquestionnaire （Middle aged and Aged version）

Evaluation of focusing ability based onthe Uchida-Kraepelin test Evaluation of stress based on questionnaire

Objective evaluation of the quality of sleep basedon electroencephalography

Ingestion at 50 mg/day led to significantimprovement between groups in deep sleep.

Ingestion at 50 mg/day led to significant improvementbetween groups in psychological stress induced by deskwork.

Ingestion at 50 mg/day led to significant improvementbetween groups in focusing ability. ※fluctuation rates of performance: An index for evaluation ofunevenness of work performance

Worsening（decrease）

-5 0 5

0-0.3-0.6 0.3 0.6

10 15 20 （score） -5-10-15 0 5 10 15 20 （％）

Improvement（increase）

Worsening（decrease）

Improvement（increase）

VENETRON®Placebo

VENETRON®Placebo

Worsening（increase）

Improvement（decrease）

＊： < 0.05p

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