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Validation of RANO Criteria: Contribution of T2/FLAIR Assessment in Patients with Recurrent Glioblastoma Treated with Bevacizumab Presented By Raymond Huang at 2014 ASCO Annual Meeting

Validation of RANO Criteria: Contribution of T2/FLAIR Assessment in Patients with Recurrent Glioblastoma Treated with Bevacizumab Presented By Raymond

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Page 1: Validation of RANO Criteria: Contribution of T2/FLAIR Assessment in Patients with Recurrent Glioblastoma Treated with Bevacizumab Presented By Raymond

Validation of RANO Criteria: Contribution of T2/FLAIR Assessment in Patients with Recurrent Glioblastoma Treated with Bevacizumab

Presented By Raymond Huang at 2014 ASCO Annual Meeting

Page 2: Validation of RANO Criteria: Contribution of T2/FLAIR Assessment in Patients with Recurrent Glioblastoma Treated with Bevacizumab Presented By Raymond

Background

Presented By Raymond Huang at 2014 ASCO Annual Meeting

Page 3: Validation of RANO Criteria: Contribution of T2/FLAIR Assessment in Patients with Recurrent Glioblastoma Treated with Bevacizumab Presented By Raymond

Slide 3

Presented By Raymond Huang at 2014 ASCO Annual Meeting

Page 4: Validation of RANO Criteria: Contribution of T2/FLAIR Assessment in Patients with Recurrent Glioblastoma Treated with Bevacizumab Presented By Raymond

RANO Criteria

Presented By Raymond Huang at 2014 ASCO Annual Meeting

Page 5: Validation of RANO Criteria: Contribution of T2/FLAIR Assessment in Patients with Recurrent Glioblastoma Treated with Bevacizumab Presented By Raymond

BRAIN trial (AVF3708g)

Presented By Raymond Huang at 2014 ASCO Annual Meeting

Page 6: Validation of RANO Criteria: Contribution of T2/FLAIR Assessment in Patients with Recurrent Glioblastoma Treated with Bevacizumab Presented By Raymond

Study design

Presented By Raymond Huang at 2014 ASCO Annual Meeting

Page 7: Validation of RANO Criteria: Contribution of T2/FLAIR Assessment in Patients with Recurrent Glioblastoma Treated with Bevacizumab Presented By Raymond

Response

Presented By Raymond Huang at 2014 ASCO Annual Meeting

Page 8: Validation of RANO Criteria: Contribution of T2/FLAIR Assessment in Patients with Recurrent Glioblastoma Treated with Bevacizumab Presented By Raymond

Inter-reader agreement

Presented By Raymond Huang at 2014 ASCO Annual Meeting

Page 9: Validation of RANO Criteria: Contribution of T2/FLAIR Assessment in Patients with Recurrent Glioblastoma Treated with Bevacizumab Presented By Raymond

Objective Response Rate

Presented By Raymond Huang at 2014 ASCO Annual Meeting

Page 10: Validation of RANO Criteria: Contribution of T2/FLAIR Assessment in Patients with Recurrent Glioblastoma Treated with Bevacizumab Presented By Raymond

Landmark analysis: Objective response versus Survival

Presented By Raymond Huang at 2014 ASCO Annual Meeting

Page 11: Validation of RANO Criteria: Contribution of T2/FLAIR Assessment in Patients with Recurrent Glioblastoma Treated with Bevacizumab Presented By Raymond

Progression

Presented By Raymond Huang at 2014 ASCO Annual Meeting

Page 12: Validation of RANO Criteria: Contribution of T2/FLAIR Assessment in Patients with Recurrent Glioblastoma Treated with Bevacizumab Presented By Raymond

Progression

Presented By Raymond Huang at 2014 ASCO Annual Meeting

Page 13: Validation of RANO Criteria: Contribution of T2/FLAIR Assessment in Patients with Recurrent Glioblastoma Treated with Bevacizumab Presented By Raymond

PFS: Macdonald vs RANO

Presented By Raymond Huang at 2014 ASCO Annual Meeting

Page 14: Validation of RANO Criteria: Contribution of T2/FLAIR Assessment in Patients with Recurrent Glioblastoma Treated with Bevacizumab Presented By Raymond

Landmark analysis: Progression vs Overall Survival

Presented By Raymond Huang at 2014 ASCO Annual Meeting

Page 15: Validation of RANO Criteria: Contribution of T2/FLAIR Assessment in Patients with Recurrent Glioblastoma Treated with Bevacizumab Presented By Raymond

Conclusions

Presented By Raymond Huang at 2014 ASCO Annual Meeting

Page 16: Validation of RANO Criteria: Contribution of T2/FLAIR Assessment in Patients with Recurrent Glioblastoma Treated with Bevacizumab Presented By Raymond

Future directions

Presented By Raymond Huang at 2014 ASCO Annual Meeting

Page 17: Validation of RANO Criteria: Contribution of T2/FLAIR Assessment in Patients with Recurrent Glioblastoma Treated with Bevacizumab Presented By Raymond

Acknowledgement

Presented By Raymond Huang at 2014 ASCO Annual Meeting