VACCINOLOGYVACCINOLOGY

JEOPARDY!JEOPARDY!2010

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Concepts Facts ApplicationDefinitionsTie-

Breakers

Antibodies can be produced against almost any

substance…

TRUE OR FALSE?

1-1-Q

TRUE

1-1-A

The more similar a vaccine is to the natural pathogen,

the better the immune response to the vaccine…

TRUE OR FALSE?

1-2-Q

TRUE

1-2-A

All vaccines present modified/selected antigen(s)

that induce an immune response without causing

INFECTION…

TRUE OR FALSE?

1-3-Q

FALSE

1-3-A

Humoral and cell-mediated immune responses CANNOT

occur at the same time…

TRUE OR FALSE?

1-4-Q

FALSEFALSE

1-4-A

FALSE

Which of the following statements are true of acquired, but not innate immunity?

(a) Involves cytokines and complement

(b) Can be induced by vaccine(c) Key mechanism is to prevent

injury and death from infection(d) Gets stronger over time

1. a and c2. b and d3. a, b, and c

1-5-Q

2. b and d

1-5-A

Some antibodies coat

organisms, making them more readily ingested by

phagocytes…

TRUE OR FALSE?

2-1-Q

TRUE

2-1-A

T-cell independent responses usually

produce immunological

memory?

TRUE OR FALSE?

2-5-Q

FALSE

2-5-A

What type of response is depicted here?

(a) T-cell independent(b) T-cell dependent

2-4-Q

IgM

BB

B*B*

B*B*

(a) T-cell independent

2-4-A

Factors that affect the immune response include:

(a) Route of vaccine administration

(b) Presence of maternal antibody

(c) Characteristics of the antigen(d) Host’s nutritional status

1. b, c, and d2. b and c3. a, b, c, and d

2-3-Q

3. a, b, c & d

2-3-A

Functions of the complement system include:(a) cell lysis(b) attracting phagocytes to the site of inflammation(c) coating antigens to make them more susceptible to phagocytosis(d) promoting inflammation

1. a, b, c, & d2. a, b & c3. a & d

2-2-Q

Daily DoubleDaily Double

1. a, b, c & d

2-2-A

Interruption of a series of vaccinations does not require starting the series over again,

regardless of the interval elapsed.

TRUE OR FALSE?

3-3-Q

TRUE

3-3-A

If two live parenteral vaccines are given 14 days apart, the vaccine that was given first should be repeated 28 days

later.

TRUE OR FALSE?

3-1-Q

FALSE

3-1-A

A live oral vaccine and a live injectable vaccine must be

administered on the same day or one month apart.

TRUE OR FALSE?

3-4-Q

FALSE

3-4-A

What vaccines should NOT be given to a perinatally HIV-infected toddler with a normal CD4 count and no history of opportunistic infections?

(a) MMR(b) Varicella(c) Hepatitis B(d) Pneumococcal Conjugate

1. b2. a and b3. None of the above

5-4-Q

3. None of the above

5-4-A

If a person will be having a splenectomy in 2 week’s time, it is too late to immunize them

with the recommended vaccines.

TRUE OR FALSE?

5-1-Q

FALSE

5-1-A

The immunoglobulin that predominates in the secondary

immune response

(a) IgM(b) IgG(c) IgA(d) IgE

4-5-Q

(b) IgG

4-5-A

This type of vaccine stimulates

B cells without the help of T cells

(a) Conjugated polysaccharide vaccine (b) Pure polysaccharide

vaccine (c) Recombinant vaccine

4-4-Q

(b) Pure polysaccharide

vaccine

4-4-A

Lymphocytes that mediate cell-mediated immunity are

called ...

(a) T-lymphocytes

(b) B-lymphocytes

(c) T4 lymphocytes

4-1-Q

(a) T-lymphocytes

4-1-A

These are non-antibody proteins that function as

chemical messengers that regulate all immune

responses.

(a) Antigen-presenting cells (APCs)(b) Cytokines(c) Complement

4-2-Q

(b) Cytokines

4-2-A

A cascade of blood proteins that can destroy foreign or

infected cells.

(a) Interleukins(b) Complement(c) Natural killer cells

4-3-Q

Daily DoubleDaily Double

(b) Complement

4-3-A

Vaccine doses given at less than the recommended

interval may result in less than optimal antibody response and should not be counted as part

of a primary series.

TRUE OR FALSE?

3-2-Q

TRUE

3-2-A

Simultaneous administration of a passive immunizing

agent (E.g. immune globulin) and an inactivated vaccine is not recommended

for post exposure prophylaxis.

TRUE OR FALSE?

3-5-Q

FALSE

3-5-A

Inactivated vaccines are not likely to be affected by

circulating maternal antibodies.

TRUE OR FALSE?

5-3-Q

TRUE

5-3-A

How do premature infants differ from full term infants in terms

of when, after birth, they should be immunized with

DTaP-IPV-Hib?

(a) They don’t differ – they should be immunized at the same

chronological age as full-term infants (b) They should be immunized at

the age that adds on for their number of

weeks of prematurity (c) They should weigh at least

2000g.

5-5-Q

(a) They don’t differ – they should be

immunized at the same chronological

age as full-term infants

5-5-A

Cell-mediated immunity is mediated by B lymphocytes….

TRUE OR FALSE?

5-2-Q

FALSE

5-2-A

NOTE: Can wager up to full total of team’s

points!

Final Jeopardy

An accelerated, memory immune response to an

antigen is also referred to as the _________ response.

(a) Anergic response(b) Anamnestic response(c) Arthus response

Final Jeopardy

(b) Anamnestic response