USES guia del USES 4.0. EUSES (European Union System for the Evaluation of Substances) Multimedia

USESUSESguia del USES 4.0.

http://www.rivm.nl/bibliotheek/rapporten/601450012.html

EUSESEUSES

(European Union System for the Evaluation of Substances)

Multimedia Transport and Transformation Model

According to the supporting Technical Guidance Documents

(TGD) for European risk assessment

Euses:

http://ecb.jrc.it/Euses/

EUSESEUSES

Aim:

To harmonise risk assessment in a systematic and transparent

approach

Include :

Emission, exposure, bio-effects and risk estimation for the

environment and humans

Compartments in Euses

–EUSES

–Stand-alone application

– Multimedia models for:- emissions- transport & transformation- exposure of man and environment

– Effects assessment for man and environment

– Risk characterisation for man and environment

– Conservative results as ‘reasonable worst-cases’

– 3 spatial scales (personal, local, regional)

– 2 time scales:- long-term, sub-/chronic

- short-term, acute

– Uses equations of the Technical Guidance Documents (TGD) of the EU

RELEASE ESTIMATION

•Production

•Formulation

•Processing

•Private Use

•Recovery

The local scale of EUSES generic world. The local point source emitting directly ore indirectly into the different compartments [EUSES 1.00]

Structure of the regional distribution model Simple Box of EUSES

Visualisation of the complexity

of EUSES

– 466 parameters

– 967 connections (dependencies)

[Berding, Schwartz, Matthies (1999)]

Complexity of EUSES [Berding et al. (1999)]

PhysicochemicalProperties

Molecular weightBoiling PointMelting Point

Water SolubilityVapour PressureOctanol Water

partition Coeffizient

MammalianAcute Toxicity

Oral LD50Oral discriminatory dose

Dermal LD50Inhalation LD50

Mammalian(Sub-)chronic Toxicity

Oral NOAL/LOAELInhalatory NOAEL/LOAEL

Dermal NOAEL/LOAELNOAEL/LOAEL via food

Inhalatory (fibre) NOAEL/LOAEL

Birds effect inputLC50 in avian dietary study

NOAELNOAEL via food

Mammalian effects input

Characterization of Biodegradabilitydegradation rates inAir, Soil and Water

Human effects input(sub-)chronic


Dermal NOAEL/LOAELDermal NOAE/LOAEL in mediumInhalatory (fibre) NOAEL/LOAEL

Current classificationof the substance

corrosive ?irritating to skin or eyes ?

causing sensation to skin or eyes?causes cancer?

Release estimation

Continental

Regional

Local

AirWastewater

Surface waterIndustrial soil

Agricultural soil

Production volumesCharacterization and tonnage

HPV chemical?Volume of chemical imported

exported to EU

ProductionFormulationProcessingPrivate useRecovery

Emission to-Air

-Wastewater

Ecosystem

Micro-organism effect input data

EC50 MO in STPEC10 for MO in a STPNOEC for MO in a STP

Aquatic effect input LC50/NOEC for fish

LC50/NOEC for daphniaEC50/NOEC for algae

LC50/NOEC for other aquaticspecies

Terrestrial effect inputLC50/NOEC for earthworms

LC50/NOEC for plantsEC50/NOEC micro-organisms

LC50/NOEC other terrestrian species

Humans Fate

Input data for EUSES used in the Naphtha assessment













NOAELNOAEL via food









Release estimation

Continental

Regional

Local

AirWastewater


Agricultural soil



exported to EU


Emission to-Air

-Wastewater

Ecosystem









Humans Fate














NOAELNOAEL via food









Release estimation

Continental

Regional

Local

AirWastewater


Agricultural soil



exported to EU


Emission to-Air

-Wastewater

Ecosystem









Humans Fate


Overview over the EUSES software structure

PEC: The Predicted Environmental Concentration

Is the concentration in the environment or food which is predicted by a model.

PNEC: The Predicted No Effect Concentration

Is a concentration level in the environment or food below which adverse effects are most likely not to occur.

Predicted environmental concentration and Predicted no effect concentration [Boeije (1999)]

RCR (EUSES): Risk Characterisation RCR (EUSES): Risk Characterisation RatioRatio

RCR is the ratio of the Predicted Environmental Concentration and the Predicted No-Effect Concentration (RCR = PEC/PNEC) and expresses the likelihood of adverse effects to occur. Margin of Safety (MOS) (EUSES):Margin of Safety (MOS) (EUSES):

Is the ratio ‘effect level’/’exposure level’=MOS and describes the degree of risk.

A significant influence on all PECs have:

the melting point,emissions to regional air,the wind speed,the atmospheric mixing height.

.

The soil-PECs are strongly affected by:

the degradation rate in soil,the vapour pressure,the aerosol collection efficiency,the specific mixing depth,the constant of Junge equation,the volume fraction of solids in soil,the density of solid phase,the surface area of aerosol particles,partially by the average daily precipitation the octanol-water partition coefficient

The water/sediment-PECs depend on:

the volume fraction of water in sediment,the fraction connected to STP,partially on the octanol-water partition coefficient,partially on the average daily precipitation,partially on the weight fraction of organic carbon in suspended matter,partially on the density of water phase.

Comparison - Outputs

– on site / off site concentrations in air, water, sediment, plants and soil

– concentrations in breast milk, fish, milk, meat, eggs, tap/swimming water

– daily human doses by inhalation, ingestion (breast milk, water, milk, meat, fish, soil) and dermal uptake

– individual human lifetime risk attributable to exposures over a certain period

– soil clean-up goals (depending on a target risk)

EUSESCalTOX

– estimates for releases to air, water and soil, life cycle step-wise and spatial scale

– predicted environmental concentrations (PEC) in surface water, air, soils and sediment

– concentrations in fish, plants, drinking water, milk, meat

– exposure of consumers via products

– workplace exposure of humans

– daily human doses by inhalation, ingestion (water, milk, meat, fish, crops), dermal contact

– Predicted No-Effect Concentrations (PNEC) in the environment

– Risk Characterisation Ratio for the environment (RCR=PEC/PNEC) =

likelihood of adverse effects occurring

– Margin Of Safety for humans (MOS= ‘effect’/’exposure’) = degree of risk

Comparison -Applicability

– non-ionic organic chemicals, radionuclides, fully dissociating in-/ organic chemicals, solid-phase metal species, partially dissociated in-/organic species

– site specific

– very low concentrations (not exceeding the solubility limit in any phase)

– long time scales (preferably one year to decades)

– areas greater than 1000 m2 with a water fraction of max. 10 % of the surface area

EUSESEUSESCalTOXCalTOX

– unacceptable errors may occur

assessing: poorly soluble, inorganic or

ionisable substances

– petroleum can only be assessed using

the Hydrocarbon Block Method (HBM)

– not site specific without proper data

adjustments

– several hazards are not considered:

global warming, ozone depletion,

acidification, eutrophication, etc.

– short and long time scales

– all spatial scales smaller than

continental areas

Comparison -

Benefits

– easy export/import of data/results for

visualisation

– possibility of Dynamic Data Exchange

(DDE) to other applications from

within Excel

– applicability of sensibility/uncertainty

analysis

– relatively well structured

input/output sections

– easy to understand and use

EUSESCalTOX– assessment for the environment and

humans

– implemented step by step input of the necessary data

– control of the range of the data introduced by the user

– possibility of introducing the data in different units

– great amount of different output data

– estimation routines for a lot of the necessary data (emissions, effects, etc.)

– great amount of European default data

– wide range of time and spatial scales

– implemented life cycle steps

Comparison Disadvantages

– only risk assessments for humans

– the implemented macros do not run

very well

– no control of the range of the values

introduced by the user

– fixed units

– default data are valid for California

(and therefore not applicable for

European risk assessment)

– limited applicability for short term

exposure and small areas/sites

– limited output of risk values

(only non/cancer risk for humans)

EUSESCalTOX

– very complex and difficult to understand

– data exchange/export is very difficult if

not impossible and does not work

automatically

– sensitivity/uncertainty analysis are not

applicable

– graphical visualisation of the results is

not implemented