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CURRICULUM VITAE

Panayiotis Mavroidis, Ph.D.

Karolinska Institutet and Stockholm University, Associate Professor

December 2009

CV – Panayiotis Mavroidis, Ph.D.

Summary Table of Publications

Total Number of Publications: 212

(40 articles, 156 abstracts, 16 chapters, books, monographies etc)

Articles in International Journals (peer reviewed) 34Articles in National Journals (peer reviewed) 6

Abstracts in International Conferences and Int. Journals 142(the abstracts are based on the results of 80 studies) 1.8 abstracts/study

Abstracts in National Conferences 14(the abstracts are based on the results of 14 studies) 1 abstracts/study Chapters in Books 7 Books and Monographies 3 Degree, M.Sc., Ph.Lic. Theses 3 International and National News Journals 2 Implementation of International Reports 1

Referree in International Journals 9International Distinctions 8Oral and Invited Presentations 18

Author Internat. Articles National Articles Abstracts1rst 17/34 4/6 37/1562nd or Senior 8/34 — 58/156

International Journal Number of Articles Impact Factor 2008 Acta Oncologica 6 2.739

Phys Med Biol 13 2.784Cancer 1 5.238Int J Radiat Oncol 1 4.639Strahlenther Onkol 1 3.005Clin Oncol - UK 1 2.184J Neurosurg 1 2.124Med Phys 1 3.871Technol Canc Res & Treat 2 1.951J Appl Clin Med Phys 1 1.225Head & Neck 1 2.603J BUON 2 —J Radiother Pract 1 —J Thoracic Dis 1 —

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Total Impact Factor 81.42 (39.94)*Average Impact Factor 2.81 (2.66)*

Number of International Articles (last 5 years) 25 (10)*Annual number of International Articles 2.8 (1.4)*Annual number of International Articles (last 5 years) 4.8 (2.0)*

Number of International Article pages 440 (249)*Number of pages per International Article 13.3 (14.7)*

Number of Citations (without self-references) 265 (152)*Annual Number of Citations (without self-references) 62.6 (32)*h-index (from SCOPUS) 10 (6)*

Number of Submitted Articles (under evaluation) 13 (4)*Number of Articles in manuscript form 25 (4)*

* The number in the parenthesis refers to the publications in which I have first authorship.

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CONTENTS

1. Personal Data 5

2. Present Position 5

3. Graduate Studies 5

4. Postgraduate Studies 5

5. Professional Licences 6

6. Languages 6

7. Member of Scientific Societies 6

8. Referree in International Journals 6

9. Awards - Recognitions 7

10. Computer Qualifications 7

11. Educational Activities 8

11.1. Graduate Lecturing 8

11.2. Postgraduate Lecturing 8

11.3. Lectures for Professionals 9

11.4. Supervision of Master Theses 9

11.5. Supervision of Doctorate (Ph.D.) Theses 11

12. Teaching Material for Undergraduate and Postgraduate Students 11

13. Research Activities – Radiobiology and Biostatistics 12

14. Hospital Education and Clinical-Professional Experience 14

15. Development of Computational Systems (Software) for Clinical Use 15

16. Administrative Experience 16

17. Organization of Seminars – Summer Schools 16

18. Participation in International and National Research Projects-Grants-Fellowships 16

18.1. International Research Projects 16

18.2. National Research Projects 17

18.3. Grants - Fellowships 18

19. Research Collaboration with other Institutes and Research Centers 19

20. Participation in International Conferences, Seminars and Courses of Doctorate Level 20

21. Participation in National Conferences and Seminars of Further Education 21

22. Recommendation Letters 21

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23. Ph.D. Thesis 22

24. Other University Theses 22

25. Articles in International Journals (Peer-Reviewed) 23

26. Articles in Regional and National Journals (Peer-Reviewed) 26

27. Chapters in Books 26

28. Books and Monographies 27

29. Publications in International and National News Journals 27

30. Implementation of International Reports 27

31. Submitted Articles in peer-reviewed International Journals 28

32. Articles to be submitted in peer-reviewed International Journals 29

33. Oral and Invited Presentations 31

34. Abstracts in International Journals and Presentations in International Conferences 33

35. Presentations in National Conferences – Abstracts 50

36. Citations from other authors – Without self-references 52

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1. Personal Data

Surname: MavroidisName: PanayiotisDate of Birth: 6 June 1971Place of Origin: Kalamata, GreeceFamily Status: Married (Children: 3)Addresses: Department of Medical Physics, University Hospital of Larissa,

Box 1425, 41 110 Larissa, Greece Department of Medical Radiation Physics, Karolinska

Institutet and Stockholm University, Box 260 S-171 76 Stockholm, SwedenTelephone: +30 2413-502865, +30 2410-555410, 08-5177 4718Fax: +30 2410-670117, 08-34 35 25e-mail: [email protected]

[email protected]

2. Present Position

2.1. Associate Professor, Department of Medical Radiation Physics, Karolinska Institutet and Stockholm University, Stockholm, Sweden

2.2. Medical Physicist, Department of Medical Physics, University Hospital of Larissa, Larissa, Greece (2003 up to date)

2.3. Visiting Professor, University of Texas Health Sciences Center, San Antonio, Texas, USA (March 2008)

3. Graduate Studies

3.1. University Degree in Physics Department of Physics, University of Patras, Patras, Greece October 1994, "Very Good".

4. Postgraduate Studies

4.1. Master of Science (M.Sc.) in Medical PhysicsPostgraduate Interdepartmental Program of Studies in Medical Physics, Laboratory of Medical Physics (Director: B. Proimos), Department of Medicine, University of Patras, Patras, GreeceOctober 1996, "Very Good".

4.2. Philosophy Licentiate (Ph.Lic.) in Medical PhysicsDepartment of Medical Radiation Physics, Stockholm University, Stockholm, Sweden,Title: Use of radiobiological models for treatment evaluation and clinical outcome optimization (Supervisors: Assoc. Prof. B.K. Lind, Assoc. Prof. C. Kappas and Prof. A. Brahme)December 2000, "Excellent".

4.3. Philosophy Doctor (Ph.D.) in Medical PhysicsSection of Medical Radiation Physics, Department of Oncology-Pathology, Karolinska Institutet,

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Stockholm, Sweden Title: Determination and use of radiobiological response parameters in radiation therapy optimization(Supervisors: Assoc. Prof. Β.Κ. Lind, Assoc. Prof. C. Kappas and Prof. A. Brahme), December 2001, "Excellent".

5. Professional Licences

5.1. Licence for Professional Action as a Hospital Physicist in the field of Medical Physics excluding the field of Ionizing Radiations(Issued by the Ministry of Health in Greece, Number of Decision: A5 2153/99 in 02/04/1999).

5.2. Licence for Professional Action as a Hospital Physicist in the field of Medical Radiation Physics(Issued by the Ministry of Health in Sweden and approved by the Council of Recognition of Professional Equivalency of Higher Educational Degrees of the Ministry of National Education and Religion of Greece, Number of Action: 36/2002 in 11/02/2002).

6. Languages

6.1. Excellent Command of the Greek Language (Mother Tongue).

6.2. Excellent Command of the English Language (Proficiency in English, Cambridge University).

6.3. Very Good Command of the Swedish Language (Nationella Provet, Skolverket).

7. Member of Scientific Societies

Active member of the following scientific societies:

7.1. European Society for Therapeutic Radiology and Oncology (ESTRO)

7.2. European Federation of Organizations for Medical Physics (EFOMP)

7.3. American Association for the Advancement of Science (AAAS)

7.4. Greek Society for Medical Physics (E.F.I.E.)

7.5. Svensk Förening för Radiofysik (Swedish Society for Radiation Physics)

8. Referree in International Journals

I am a regular referee in the following international journals:

8.1. Physics in Medicine and Biology (15 articles)

8.2. Radiotherapy and Oncology (6 articles)

8.3. Medical & Biological Engineering & Computing (3 articles)

8.4. Medical Physics

8.5. Journal of Applied Clinical Medical Physics

8.6. Investigative Opthalmology and Visual Science

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8.7. Physica Medica

8.8. Radiation Oncology

8.9. Journal of Cancer Research and Therapeutics

9. Awards - Recognitions

9.1. Jack Fowler – Young Investigator Award from the University of Wisconsin at the 8th ESTRO Biennial Meeting, Lisboa, 26-29 September, 2005

9.2. Invited speaker in the following conferences: ‘World Conference on Dosing of Anti-infectives’ and ‘Ehrlich Symposia’

9.3. Invitation from the Scientific Committee of the World Congress in Medical Physics and Biomedical Engineering that was held in Sidney, Australia, 2003 to include my work entitled ‘Statistical methods for clinical verification of dose-response parameters related to esophageal stricture and AVM obliteration from radiotherapy’, which was presented in this congress, in a special issue of the international journal ‘Physics in Medicine and Biology’ Vol 49, 16: 3797-3816

9.4. Invitation from the Scientific Committee of the Balkan Congress of Oncology that was held in Athens, July 3-7, 1996 to include my work entitled ‘An index for evaluating and increasing the probability of complication free tumor control in radiation therapy’, which was presented in this congress, in a special issue of the journal ‘Journal of BUON’ 3: 257-264

9.5. Invitation from the European Society for Therapeutic Radiology and Oncology (ESTRO) to evaluate and write a report about the Course of Basic Clinical Radiobiology, which was held in Santorini, October 12-16, 2003

9.6. Invitation from the Scientific Committee of the 2nd World Congress for Cancer, which was held in Beijing, China, 2009 to hold a talk as an invited speaker.

9.7. Invitation from the Scientific Committee of the World Congress in Medical Physics and Biomedical Engineering, which was held in Munich, Germany, 2009 to hold a talk as an special keynote invited speaker (Invited Special Plenary Speaker) presentation time 30 min.

9.8. Chairman in 2 sessions of the World Congress in Medical Physics and Biomedical Engineering, which was held in Munich, Germany, 2009.

10. Computer Qualifications

Programming Languages Operating Systems Software Packages

FORTRAN 77 PC - (DOS, WINDOWS) Microsoft OfficeC, C++ Macintosh Word,Excel,PowerPoint,AccessJava HP / Unix Photoshop, Canvas

SUN / Solaris AcrobatLinux Matlab, Mathematica

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I have used the above Software Packages and Programming Languages during my undergraduate and postgraduate studies as well as my professional activities. More specifically, I used:

● Hewlet Packard (HP) and SUN Ultra Spark computer workstations with Unix and Unix / Solaris operating systems at the Karolinska Institutet, Stockholm, Sweden. I used these systems during my Ph.D. research in this institution. The software applications that were developed concerned radiotherapy optimization using physical and radiobiological parameters and the programming languages were C and C++.

● Personal Computers (PC) with DOS operating system using different versions of WINDOWS. In the last years of my Ph.D. research and during my postdoc research, I used mainly these systems. Furthermore, the development of the computational systems, XP+ and JP+, which evaluate the effectiveness of radiation therapy, was performed on PCs using WINDOWS NT, WINDOWS 2000 Professional and Linux. The programming languages that have mainly been used are C++ and Java.

● Towards the end of my Ph.D. studies, I developed software programs for optimization of radiation therapy, which were written in FORTRAN 77. Furthermore, the use of various software packages (mainly for graphics and mathematics) was necessary for the production of the scientific articles, which were the final outcome of my research.

11. Educational Activities (More than 271 Lecturing Hours)

My educational capability was evaluated by a special evaluator of the University of Stockholm (Dr. Henrik Cederquist, Faculty Board), in the framework of my academic evaluation for the position of Associate Professor (Docent). This procedure was performed public in the presence of faculty members of Karolinska Institutet and University of Stockholm as well as postgraduate and Ph.D. students, who also expressed their own evaluations.

11.1. Graduate Lecturing

1. 1st year of studies, Department of Medicine. Subject: Medical PhysicsUniversity of Patras, Patras, Greece, 1995-1996Laboratorial exercises in Medical Physics (10 teaching hours)

2. 1st year of studies, Department of Medicine. Subject: Medical PhysicsUniversity of Thessaly, Larissa, Greece, 2003-2005Theoretical lectures and laboratorial exercises in Medical Physics (12 lecturing hours / academic year, 2 years)

3. 1st year of studies, Department of Health Sciences. Subject: Medical PhysicsTechnological Educational Institute (T.E.I.) of Larissa, Larissa, Greece, 2003-2004Theoretical lectures and practical applications in Medical Physics (157 lecturing hours)

11.2. Postgraduate Lecturing

1. Postgraduate (Master) Course in Medical Radiation Physics, 1997 - 2003Karolinska Institutet and Stockholm University, Stockholm - Subject: ‘Radiation Dosimetry’- Subject: ‘Photon and Electron Algorithms for Treatment Planning in Radiotherapy’- Organization and supervision of 2 laboratorial exercises- Supervision of postgraduate students

2. Postgraduate Interdepartmental Course in Medical Physics, 2003 up to dateUniversity of Patras, Patras, Greece

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- Subject: ‘Basic Aspects of Clinical Radiobiology’ (12 lecturing hours / academic year, 3 years)

- Subject: ‘Radiobiology’ (12 lecturing hours / academic year, 3 year)

3. Postgraduate International Course in Radiobiology, 2007Karolinska Institutet, Stockholm, Sweden Subject: ‘Dose-response relationships from clinical data’

4. Postgraduate Course in Medical Physics, 2008University of Texas Health Science Center of San Antonio, San Antonio, Texas, USA Subject: ‘Clinical Radiobiology’

11.3. Lectures for Professionals

1. Further education and training of specializers in Medical Radiation Physics 2003 up to dateUniversity Hospital of Larissa, Larissa, Greece Lectures and daily training (2 specializers per 12 month period according to the legislation for the acquisition of the Licence for Professional Action as a Hospital Physicist in the field of Medical Radiation Physics, from the Ministry of Health) Subject: Medical Radiation Physics and Radioprotection

2. Further education and training of new-employed Radiotherapy Technologists, 2003 up to dateUniversity Hospital of Larissa, Larissa, Greece Lectures and daily training (6 employees) Subject: Physics of Radiation Therapy and Radioprotection

3. Lecturing in Centers of Further Education for Professionals (Κ.Ε.Κ.), 2004 - 2005Institution: General Hospital of Larissa Subject: Basic Principles and Methodology in Biostatistics, code Ε-233 (20 lecturing hours)

4. Lecturing in Centers of Further Education for Professionals (Κ.Ε.Κ.), 2004 - 2005Institution: General Hospital of Larissa Subject: Basic training in the use of Personal Computers, code Ε-111 (12 lecturing hours)

5. Lecturing in Centers of Further Education for Professionals (Κ.Ε.Κ.), 2004 - 2005Institution: General Hospital of Larissa Subject: Basic training in the use of Personal Computers, code Ε-712 (12 lecturing hours)

11.4. Supervision of Master Theses

1. Title: The influence of positioning uncertainties on the dose distribution and lung complications after radiotherapy of the breastSofie AxelssonDepartment of Medical Radiation Physics, University of Stockholm, Stockholm, 2001

2. Title: Μodelling normal tissue complications – study of the radiobiological models suitable for radiobiologically optimized radiotherapyMagdalena Adamus-GórkaDepartment of Medical Physics, University of Mining and Metallurgy, Faculty of Physics and Nuclear Techniques, Krakow, Poland, 2002

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Department of Medical Radiation Physics, Stockholm University, Stockholm, Sweden

3. Title: Dose-response relations for anal sphincter regarding feacal leakage and blood or phlegm in stools after radiotherapy for prostate cancerMaria Gaitanou Laboratory of Medical Physics, Department of Medicine, University of Patras, Patras, Greece, 2004

4. Title: Clinically derived dose-response relations for esophageal strictures from head & neck radiotherapyEleftheria AlevrontaDepartment of Medical Radiation Physics, University of Stockholm, Stockholm, 2008Laboratory of Medical Physics, Medical School, University of Patras, Patras, 2008

5. Title: Clinically derived symptom documentation in lung cancer as a basis for therapy modificationsIoanna Chalimou Department of Medical Radiation Physics, University of Stockholm, Stockholm, 2009Laboratory of Medical Physics, Medical School, University of Patras, Patras, 2009

6. Title: Clinically derived dose-response relations for rectum and penile bulb from proton radiotherapyChristianna ValiantiDepartment of Medical Radiation Physics, University of Stockholm, Stockholm, 2009Laboratory of Medical Physics, Medical School, University of Patras, Patras, 2009

7. Title: Clinically derived dose-response relations for tumors and bladder from proton radiotherapyIoanna BoumpoutsiDepartment of Medical Radiation Physics, University of Stockholm, Stockholm, 2009Laboratory of Medical Physics, Medical School, University of Patras, Patras, 2009

8. Title: Clinically derived dose-response relations for tumors and normal tissues from brachytherapyChristianna-Zaira KatsilieriLaboratory of Medical Physics, Medical School, University of Patras, Patras, 2009

9. Title: Clinically derived dose-response relations for tumors and normal tissues from brachytherapyVasiliki KefalaLaboratory of Medical Physics, Medical School, University of Patras, Patras, 2009

10. Title: Senescence in a small cell lung cancer cell lineNikolaos MakrisDepartment of Medical Radiation Physics, University of Stockholm, Stockholm, Laboratory of Medical Physics, Medical School, University of Patras, Patras, 2009 in progress

11. Title: Tractography and fMRI post-processingValentina-Dafne PetrouliaDepartment of Medical Radiation Physics, University of Stockholm, Stockholm, Laboratory of Medical Physics, Medical School, University of Patras, Patras, 2009 in progress

12. Title: Brain aging processes and cognitive agingJoao CoreiaDepartment of Medical Radiation Physics, University of Stockholm, Stockholm, Laboratory of Medical Physics, Medical School, University of Patras, Patras, 2009 in progress

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11.5. Supervision of Doctoral (Ph.D.) Theses

1. Title: Study and development of radiobiological models for predicting normal tissue complications after radiotherapyPh.D. Student: Magdalena Adamus-GórkaDepartment of Medical Radiation Physics, Karolinska Institutet & Stockholm University, 2008

2. Τ itle: Evaluation of lung complications from external radiation therapy using radiobiological modelsPh.D. Student: Ioannis Tsougos Lab. of Medical Physics, Department of Medicine, University of Thessaly, Greece, 2005

3. Τ itle: Adaptive radiation therapy based on biologically effective uniform dosePh.D. Student: Su Fan-Chi Department of Medical Physics, University of Texas Health Science Center of San Antonio, San Antonio, Texas, USA, 2009

4. Τ itle: A pre-clinical verification methodology for real-time 4D tracking radiotherapy of tumors affected by organ motionPh.D. Student: Teboh Roland Department of Radiological Sciences, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA, 2009

5. Title: Determination and use of dose-response data for treatment optimization in stereotactic radiotherapyPh.D. Student: Bahram AndishehDept. of Medical Radiation Physics, Karolinska Institutet & Stockholm University, 2002 –

6. Τ itle: Determination of dose-response relations of tumors from radiotherapy of pelvic cancers Ph.D. Student: Georgios Komisopoulos Lab. of Medical Physics, Medical School, University of Patras, Greece, 2008 (in progress)

7. Τ itle: Use of biomedical informatics in the development of software for collection of clinical data and determination and clinical verification of dose-response relations of tumours and normal tissues from radiotherapy Ph.D. Student: Athanasios Tzikas Dept. of Medical Radiation Physics, Karolinska Institutet & Stockholm University, 2007 –

8. Τίτλος : Monte Carlo based dose calculation platform for external beam radiation therapy and brachytherapy with applications in DVS in-vivo dosimetry and XOFT electron brachytherapyPh.D. Student: Drosoula Giantsoudi Department of Radiological Sciences, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA, 2009 (in progress)

12. Teaching Material for Undergraduate and Postgraduate Students

12.1. Subject: Medical PhysicsPanayiotis Mavroidis1st year of studies, Department of Medicine, University of Thessaly, Larissa, Greece

12.2. Subject: Medical PhysicsPanayiotis Mavroidis1st year of studies, Department of Health Sciences, Technological Educational Institute (T.E.I.) of

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Larissa, Larissa, Greece

12.3. Subject: Basic Aspects of Clinical RadiobiologyPanayiotis MavroidisPostgraduate Studies in Medical Physics, University of Patras, Patras, Greece

12.4. Subject: A dosimetric report for the determination of absorbed dose from high-energy photon and electron beams (Task Group 21, AAPM)Panayiotis Mavroidis, Constantin Kappas 1st Summer School of Balkan Union of Oncology, 1997, Patras, Greece

12.5. Subject: Dose-response relationships from clinical dataPanayiotis MavroidisPostgraduate International Course in Radiobiology, Karolinska Institutet, Stockholm, Sweden

12.6. Subject: Clinical RadiobiologyPanayiotis MavroidisPostgraduate Course in Medical Physics, University of Texas Health Science Center of San Antonio, San Antonio, Texas, USA

13. Research Activities – Radiobiology and Biostatistics

13.1. Development and study of radiobiological models for cancer cell lines

This is basic research with the aim of improving the possibility to predict the results of cell line irradiations, which may lead to innovative solutions in radiotherapy. These solutions include the development of new models for treatment optimization based on physical and radiobiological criteria, new planning techniques and new improved equipment (at software and hardware levels), which may allow for an accurate conformation of the dose distribution.

For the above reasons, the knowledge of cell survival at a microscopic level plays a major role. The fundamental characteristics of most cell survival models is that clonogenic cell death is mainly an exponential procedure, which means that the number of cells being killed is analogous to the dose and the initial cell number before irradiation. This leads to a linear cell survival curve when plotted on a log-linear scale. During the last decades, a number of cell survival models have been presented. The linear-quadratic (LQ) model was initially proposed without having any link to some theory. Later on, a dual theory of energy and radiation was associated with this model as well as a ‘molecular theory’, which set DNA coil as the critical target. The popularity of this model, probably stems from the fact that it describes the experimental data fairly well in the clinical dose range and it is an easy model to handle. The LQ model, in its present form, cannot account for the low dose hypersensitivity and it leads to a decaying curve at high doses, which means that radiation becomes more effective per unit dose in the high dose region.

The recently proposed cell survival model (RCR) is based on the Poisson statistics. The model distinguishes between two different types of damages namely those that are potentially repairable but may also be lethal, i.e. non-repaired or misrepaired and those which are conditionally repairable that might lead to an apoptotic response of not repaired. When potentially repairable damage is being repaired, conditionally repairable damage may simultaneously be corrected by homologous repair. The RCR is the only model that allows for an accurate description of the cell survival curve over the whole dose range.

Based on the above, the main directions of my research activity in this field can be analyzed as follows: 1. Experimental derivation of cell survival curves for certain cell lines. 2. Mathematical modeling of the derived cell survival curves using existing or modifying

radiobiological models, which were mentioned above. 3. Correlation of radiobiological parameters derived from in vitro measurements with corresponding

tumors in patients treated with external radiotherapy. 4. Use of verified radiobiological parameters in models of radiotherapy optimization for prediction of

treatment outcome.

13.2. Determination of dose-response parameters for different healthy tissues and tumor types

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This is basic research for the determination of the radiobiological characteristics of different tumors and normal tissues for predicting their response to a given treatment plan. Any misalignment between the irradiating beam and the target reduces the probability of local control. The same is valid if for clinical or technical reasons, the prescribed tumor dose implies exceeding the tolerance dose to the involved healthy tissues. Consequently, to optimize the effectiveness of the treatment it is necessary to introduce further data in the clinical practice.

Information about dose-response relations of tumors and healthy tissues have been reported by many scientists. Newer and more accurate clinical data that are being published at an increasing rate make the radiobiological treatment plan evaluation more reliable. However, in order to introduce in the clinical routine information related to normal tissue radiation reactions, it is necessary to verify them through clinical trials. The radiobiological response of the healthy tissues, which relates the absorbed dose with their radiosensitivity, is quantitatively described by the dose-response models. These models describe the dose-response relations of the different tumors and normal tissues using the 3-dimensional dose distributions of the applied treatment plans and the radiobiological parameters, which describe the radiobiological characteristics of these organs. In this sense, radiobiological models can be significant tools for the computation of the normal tissue complication probabilities (NTCP) and consequently for the evaluation and comparison of treatment plans. The clinical implementation of NTCP modeling can be gradually achieved since the derived dose-response curves have reached the level of describing with accuracy the manifestation of certain complications from radiotherapy.

To perform optimization of radiotherapy treatment using radiobiological data, relevant dose-response parameters have to be determined from clinical materials. In the research that I have performed in this field, radiobiological dose-response parameters have been derived for stricture in the proximal esophagus from radiotherapy for head and neck cancer. Similarly, parameters were derived for obliteration of arteriovenous malformations (AVM) after single dose radiotherapy. Furthermore, the radiation complications of blood or phlegm in stools and faecal leakage, which are related to anal sphincter, could be quantified. Finally, the parameters describing the dose-response relation of radiation pneumonitis after radiotherapy for breast cancer could be determined. Presently, the quantification of similar dose-response relations is investigated for different tumors of prostate, cervix, rectum and larynx cancers.

13.3. Development of software for the determination of dose-response curves of tumors and healthy tissues

This research is about the development of algorithms for the calculation of tumor control or normal tissue complication probabilities after radiotherapy. In this case, 3-dimensional dose distributions are used from conventional and conformal radiotherapy as well as from stereotactic radiotherapy. This research began in 1996 with the development of a number of algorithms, most of which were incorporated in the ADAC Pinnacle, (ELECTA AB) treatment planning system.

The demands of the radiotherapy section of Karolinska Hospital as well as the research direction of the group, led to the development of XP+, a new computational system which was subsequently evolved to the JP+

system. This system has to ability of receiving 3-dimensional dose distributions from a treatment planning system, in order to calculate the expected response of every irradiated tissue and finally evaluate the proposed therapy based on physical (Dose-Volume Histograms – DVH) and biological (Uncomplicated Tumor Control Probability – P+) parameters and indices. This system has been completed and it is in the phase of validation before its clinical use.

13.4. Radiobiological optimization and conformal radiotherapy

This research is about the development of methods for optimization of treatment planning based on radiobiological parameters. These methods are based on studies of tissue response to radiation, which describe the radiosensitivity of different tumors and normal tissues. As a result, the treatment plan of a patient can be evaluated based both on the physical 3-dimensional dose-distribution and the biological effect of radiation to the different tissues involved (factor P+). Furthermore, a method is investigated for automatic selection of optimized beams regarding their incidence angles as well as their energy distributions. This project was developed in the framework of my doctoral (Ph.D.) research at Karolinska Institutet, Stockholm, Sweden, and continues in collaboration with further research centers and hospitals. The final outcome of this research will be incorporated in treatment planning systems and it will be used for patient radiotherapy. As a first step, a computational program (software) was developed for providing the optimized dose-distribution in brain radiotherapy using radiobiological criteria.

13.5. Development of software for the determination of dose from high energy photon

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and electron beams

This research is about a computational program (software), which was developed with the goal of covering the necessity for an accurate knowledge of the dose that is absorbed by the different tissues in radiation therapy or in experiments where cell lines are irradiated. The introduction of the dose-response probabilities, the optimized fractionation schedules and the use of the radiobiological characteristics of different tissues set as a prerequisite that the systematic errors in dosimetry should be significantly lower than the measurement uncertainties of tumor and normal tissue responses. The theoretical part of this system is based on the “Protocol for the determination of absorbed dose from high-energy photon and electron beams”, which was written by the Task Group 21 of the American Society for Medical Physics (AAPM). The development of the above algorithms was performed on personal computers (PC) using the Windows XP operating system as well as on HP Workstations with the UNIX operating system. The previously mentioned modules comprise the parts of the computational system TG21-CALC, which is planned to become a commercial computational package.

13.6. Biostatistics: Development of analytical methods and computational systems

This is research on the development and application of statistical methods in the clinical practice aiming at offering the possibility of manipulation of clinical data leading to the derivation of significant conclusions regarding the therapy that must be selected or the course of the therapy that has to be delivered. The predictive strength of the different radiobiological models depends on their ability to accurately describe the therapeutic and biological mechanisms as well as on the accuracy that characterize the biological parameters of the model. The most appropriate way to estimate the values of these parameters is by using clinical data with complete registration of the treatment regiment and follow-up procedure. This is a quite complicated task because it depends on many factors, which do not have standardized among the different radiotherapy centers. The biological modeling is a complicated procedure even if the available clinical data are accurate. This is because the available data cover only a limited range of the dose-response curve since the clinical data are derived from therapeutic regimes, which try to achieve maximum tumor control with minimal complications to the healthy tissues. The parameters that are used by the different biological models are generally derived from patient databases to have some clinical validity. The best estimates of the biological parameters are determined with the procedure of maximum likelihood fitting. Among the statistical methods that are applied to verify the validity of the parameters, the mean value of the log-likelihood function is used together with its variance assuming that the log-likelihood function is characterized by a normal distribution. Another approach to control the fitting is to use analysis based on receiver operating characteristic (ROC) curves, which are diagrams of the true positive rates against the false positive rates for different cutoffs of a diagnostic or a predictive test. Subsequently, the confidence limits of the parameters around their best estimates are calculated. The Pearson’s χ2 test is a statistical method, which characterizes the deviation of the observed frequencies from the expected ones. Finally, the method of the Odd Ratio and the statistical simulation with Monte Carlo are 2 very useful methods.

The above mentioned knowledge and methods of Biostatistics have been applied in many clinical cases (stricture of the proximal esophagus, AVM obliteration, blood or phlegm in stools, radiation pneumonitis etc). For this goal, computational algorithms that perform this data manipulation were developed for each of the above methods. The development of the above algorithms was performed on personal computers using the Windows XP and Linux operating systems as well as on HP Workstations with UNIX operating system. The previously mentioned modules comprise the parts of the computational system PARA-SOL, which is planned to become a commercial computational package for Biostatistics.

14. Hospital Education and Clinical-Professional Experience (12 years, 6 months)

There is a number of long and short training and professional activities in Cancer Institutes and Hospitals in different countries of Europe. The most significant activities are the following:

14.1. Department of Medical Physics, University Hospital of Patras, Patras, Greece (1997)

In this department, I worked as a trainee medical physicist in the section of Radiation Therapy.

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14.2. Karolinska Hospital, Department of Hospital Physics, Radiumhemmet, Sweden (1998 until 2001)

At Karolinska Hospital, I worked as a trainee medical physicist in the sections of Nuclear Medicine and Diagnostic Radiology. After the end of my clinical training, I continued to work in the section of Radiation Therapy introducing new therapeutic methods in the clinical practice. More specifically, I worked in issues concerning treatment verification and radiation therapy optimization.

14.3. Department of Medical Physics, University Hospital of Larissa, Larissa, Greece (2003 up to date)

In this department, I work as a medical physicist covering all the activities of the Radiation Therapy, Nuclear Medicine and Radiology sections, including their Radiation Protection, since March 2003. Especially, for the section of Radiation Therapy, which had just started when I was employed, many procedures at functional and technological level had to start from zero point. In all these procedures I participated actively during the period of setup as well as during the period of their clinical work.

Short description of the work1. Acceptance Test of 2 linear accelerators (ELECTA SL18 and SL75-5) and beginning of their

clinical use. This means complete acceptance tests for 3 photon energies and 7 electron energies.

2. Performance of daily and weekly quality assurance tests of the 2 linear accelerators as well as of the patient treatment plans and cards.

3. Development of software for fast and safe calculation of the monitor units delivered to the patients for photon and electron irradiation.

4. Performance of all the necessary activities related to the personnel dose monitoring of the University Hospital of Larissa (around 120 employees).

5. Calculation and control of the delivered dose for 3500 patients, who were treated with external radiotherapy during 2003-2008 as well as production of the treatment plans of a large proportion of these patients. For many of these patients I had to form lead blocks for protection of the involved healthy organs.

15. Development of Computational Systems (Software) for Clinical Use

15.1. XP+ - JP+P. Mavroidis, B.K. LindRadiobiological Treatment Plan Evaluation for Radiotherapy OptimizationKarolinska Institutet & Stockholm University, Stockholm, Sweden

15.2. TG21-CALCP. Mavroidis, C. KappasDetermination of absorbed dose from high-energy photon and electron beamsKarolinska Institutet & Stockholm University, Stockholm, Sweden and University of Patras

15.3. PARA-SOLP. Mavroidis, B.K. LindDetermination of dose-response parameter-sets for different TCP and NTCP models for use in radiation therapy optimizationKarolinska Institutet & Stockholm University, Stockholm, Sweden

15.4. Software for calculating the Monitor Units (MU) of electron beams in radiotherapy P . Mavroidis University Hospital of Larissa This software is in clinical use since 2004.

15.5. EUDcalcF-C. Su, P . Mavroidis , N. PapanikolaouUniversity of Texas Health Sciences Center, San Antonio, Texas, USA

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16. Administrative Experience

16.1. DYNARAD Project, BIOMED-I, European Unionparticipation: 32 European Hospitals and InstitutionsSteering Committee, Principal Assistant 1994 - 1997

16.2. Evaluator of candidates for the position of Associate Professor (Docent) of University of Stockholm, Stockholm Sweden.

16.3. Member of the Scientific Board of the University Hospital of Larissa since 01/01/2008.

16.4. Member of committees for the determination of quality criteria, evaluation and acceptance of medical devices and other supplies for the University Hospital of Larissa.

16.5. Responsible for the application of the ISO 9002 regarding the services of the Medical Physics Laboratory in Radiotherapy.

17. Organization of Seminars – Summer Schools

17.1. Summer School on Radiation Therapy PhysicsOrganizer: C. KappasPanayiotis Mavroidis, Member of the Organizing Committee Participation: 50 medical physicists, physicians and technicians from 8 Balkan countries Duration: 7 daysBalkan School of Oncology, Medical School, University of Patras, Hellas, June 30 – July 6, 1997

18. Participation in International and National Research Projects - Grants - Fellowships

18.1. International Research Projects

1.1. Development and Standardization of New Dynamic Radiothereapy Technics DYNARADProject, BIOMED-I, European Unionparticipation: 32 European Hospitals and Institutions, 1994 - 1997Αctive participation to the following research task-group: Conformal Radiotherapy

1.2. Program 00 ESQUIRE2Project code: 2002/203525, European UnionResearchers: Mavroidis P, Lind BK

1.3. Bilateral Agreement between University of Thessalia and Karolinska InstitutetProgram SOCRATES: Higher Education (ERASMUS) , EUParticipants: Mavroidis P, Theodorou K, Lind BK, Nilsson B.Duration: 2004 - 2007Subject: Medical Physics

1.4. Bilateral Agreement between University of Patras and Karolinska InstitutetProgram SOCRATES: Higher Education (ERASMUS) , EUDuration: 2006 - 2009Subject: Medical Physics

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1.5. Bilateral Agreement between University of Patras and University of StockholmProgram SOCRATES: Higher Education (ERASMUS) , EUDuration: 2007 - 2010Subject: Medical Physics

1.6. Intradose Νavigated Ιntraoperative Ρadiotherapy for improved dosimetric planningCALL FP7-ICT-2009-4, ICT-FP-INFSO, ICT Challenge 5, OBJECTIVE ICT-2009.5.2Duration: 2009-2012 (under evaluation)

18.2. National Researcher Projects

2.1. Αdaptive radiation therapy based on biologically effective uniform dose.Grant to the Department of Health and Human Services Public Health Services, University of Texas Health Sciences Center at San Antonio, Texas, USA in collaboration with the Department of Medical Radiation Physics, Karolinska Institutet and Stockholm University, Stockholm, SwedenDuration: 2007 - 2010Researcher: Su F.C., Mavroidis P., Shi C., Swanson G., Papanikolaou N.

2.2. Radiobiological ToolsKarolinska Institutet & Stockholm University, Stockholm, SwedenResearcher: P. Mavroidis Duration: 1999 – 2003Funding Foundation: Research Center for Radiation Therapy, The Swedish Board for Industrial and Technical Development

2.3. Treatment optimization for the Gamma KnifeKarolinska Institutet & Stockholm University, Stockholm, SwedenResearcher: P. Mavroidis Duration: 1999 – 2002Funding Foundation: Research Center for Radiation Therapy, The Swedish Board for Industrial and Technical Development

2.4. Setup and quality assurance of a clinically derived database of dose response relationsKarolinska Institutet & Stockholm University, Stockholm, SwedenΔιάρκεια : 2007-2008Funding Foundation: Cancerföreningen

2.5. Development of a follow-up and radiobiological research programI3N Physics Department, University of AveiroDepartment of Medical Physics, Institute Portuguese of Oncology of CoimbraFunding Foundation: Foundantion for Science and Technology, PortugalDuration: 2009 – 2012 (under evaluation)

2.6. Modeling of tumor and healthy tissue responses to radiation of various ionization densitiesKarolinska Institutet & Stockholm University, Stockholm, SwedenDuration: 2010-2012Funding Foundation: Cancerfonden

2.7. A pre-clinical verification methodology for real-time 4D tracking radiotherapy of tumors affected by organ motionGrant to the Department of Health and Human Services Public Health Services, University of Texas Health Sciences Center at San Antonio, Texas, USA in collaboration with the

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Department of Medical Radiation Physics, Karolinska Institutet and Stockholm University, Stockholm, SwedenResearchers: Roland T, Papanikolaou N, Liu Y, Stathakis S, Shi C, Crownover R, Mavroidis PDuration: 2007 - 2009

2.8. Monte Carlo based dose calculation platform for external beam radiation therapy and brachytherapy with applications in DVS in-vivo dosimetry and XOFT electron brachytherapyGrant to the Department of Health and Human Services Public Health Services, University of Texas Health Sciences Center at San Antonio, Texas, USA in collaboration with the Department of Medical Radiation Physics, Karolinska Institutet and Stockholm University, Stockholm, SwedenResearchers: Giantsoudi D., Papanikolaou N., Shi C., Esquivel C., Crownover R., Mavroidis P.Duration: 2009 - 2011

2.9. Prediction of radiation pneumonitis after radiotherapy of breast and lung cancer patients based on physical and biological factors Duration: 2002-2005Financing Organization: Program ‘ΗERAKLITUS’, Ε.P.Ε.Α.Ε.Κ. ΙΙ

2.10. Radiobiological evaluation of treatment plans in radiotherapy using clinically determined dose-response relationsResearchers: G. Komisopoulos, G. Sakellaropoulos, G. Nikiforidis and P. MavroidisDuration: 2009-2012 (under evaluation)Funding Foundation: Program ‘ΗERAKLITUS’, Ε.P.Ε.Α.Ε.Κ. ΙΙ

18.3. Grants - Fellowships

3.1. 5 grants from CancerFöreningen i Stockholm / Konung Gustaf V:s Jubileumsfond for the academic years 1997-1998, 1999-2000, 2001-2002, 2006-2007 and 2007-2008

3.2. 2 fellowshipts from CancerFöreningen i Stockholm / Konung Gustaf V:s Jubileumsfond for the academic years 1995-1996 and 1998-1999

3.3. 2 fellowships from Karolinska Institutet, Stockholm, Sweden for the academic years 1996-1997 and 1997-1998

3.4. 7 grants from the Research Center for Radiation Therapy και The Swedish National Board for Industrial and Technical Development during the period 2000-2003

3.5. 1 award from the University of Wisconsin, 2005

3.6. 1 fellowshipt from the European Program BIOMED 1 for Development and Standardization of New Dynamic Radiotherapy Techniques “DYNARAD”, Contract No: BMH1-CT94-1783 (1994-1997)

19. Research Collaboration with International Centers

19.1. Karolinska Institutet and Stockholm University, Departments of Medical Radiation Physics (Dr. B.K. Lind and Dr. A. Brahme), Stockholm, Sweden

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19.2. Karolinska Hospital, Departments of Hospital Physics-Radiumhemmet (T. Kraepelien and Dr. I. Lax), Epidemiology (Dr. M. Al-abany), Oncology (Dr. J.O. Fernberg), Neurosurgery (Dr. B. Karlsson), Otolaryngology (Α. Ahlberg), Stockholm, Sweden

19.3. University of Umeå, Department of Otolaryngology (Dr. G. Laurell), Umeå, Sweden

19.4. University of Göteborg, Department of Epidemiology (Dr. H. Lind and Dr. G. Steineck), Göteborg, Sweden

19.5. Institute CURIE, Department of Medical Physics, (Dr. J.C. Rosenwald) Paris, France

19.6. Faculté de Médecine - Hôpital Tenon - Departement de Radiothérapie, Paris, France (Prof. M. Schlienger and Dr. D. Lefkopoulos)

19.7. Ste Anne Hôpital, Departement de Neurochirurgie (Dr. F. Nataf), Paris, France

19.8. Tampere University Hospital, Department of Radiation Therapy (Dr. S. Hyödynmaa, Dr. M.A. Pitkänen and J. Rajala, M.Sc.), Tampere, Finland

19.9. University of Amsterdam, Academic Medical Center, Department of Radiotherapy (Dr. J. van Dijk and Dr. K. Koedooder), Amsterdam, The Netherlands

19.10. Gent University Hospital, Departments of Radiation Oncology (Dr. W. de Neve), Hospital Physics (Dr. C. de Wagter), Gent, Belgium

19.11. London University College, Department of Medical Physics and Bioengineering, Middlesex Hospital, Department of Radiotherapy (Dr. B. Planskoy), United Kingdom

19.12. Regina Elena National Cancer Institute of Rome, Laboratory of Medical Physics (Dr. M. Benassi), Rome, Italy

19.13. Borgo Trento Hospital of Verona, Department of Medical Physics (Dr. G. Chierego), Verona, Italy

19.14. University Hospital of Lund, Departments of Oncology (Dr. E. Kjéllen) and Medical Physics (Dr. P. Nilsson), Lund, Sweden

19.15. University Hospital of Little Rock, Department of Oncology (Dr. J. Penagaricano), University of Arkansas, Arkansas, USA

19.16. University of Texas Health Sciences Center, Department of Radiological Sciences (Dr. N. Papanikolaou, Dr. S. Stathakis, Dr. C. Shi, Dr. F-C. Su), San Antonio, Texas, USA

19.17. University of Aveiro, Department of I3N Physics (Dr. B. Costa Ferreira), Aveiro, Portugal

19.18. University Hospital of Larissa, Department of Radiotherapy (Dr. G. Kyrgias, K. Sotiriadou) and Medical Physics (Dr. C. Kappas, Dr. K. Theodorou), Larissa, Greece

19.19. ‘Papageorgiou’ General Hospital, Department of Radiotherapy (Dr. D. Misailidou and

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C. Hatziioannou), Thessaloniki, Greece

19.20. Klinisch fysicus, Afdeling Radiotherapie, Erasmus MC - Daniel den Hoed (Dr. E. Asteinidou), Rotterdam, The Netherlads

19.21. ‘Hygeia’ General Hospital, Department of Radiotherapy (Dr. P. Sandilos, Dr. P. Karaiskos, E. Koutsouveli, M.Sc.), Athens, Greece

19.22. University of Patras, Medical School, Laboratory of Medical Physics (Dr. G. Sakellaropoulos, Dr. G. Nikiforidis), Patras, Greece

19.23. Department of Medical Physics & Engineering, Strahlenklinik, Klinikum Offenbach GmbH (Dr. D. Baltas), Offenbach, Germany

19.24. Department of Oncology, Aberdeen Royal Infirmary (Dr. G.A. Plataniotis), Aberdeen, UK

19.25. Department of Neurosurgery, Tehran University of Medical Sciences and Iran Gamma Knife Center (Dr. A. Bitaraf, B. Andisheh, M.Sc.), Tehran, Iran

19.26. Divisions of Oncology and Medical Physics, Department of Oncology, Radiology and Clinical Immunology, University of Uppsala (Dr. I. Turesson, Dr. A. Montelius), Uppsala, Sweden

20. Participation in International Conferences, Seminars of Further Education and Courses of Doctoral Level

1. IBRO Workshop on Mechanisms of Neuronal Plasticity, Patras, Greece, October 8-11, 1992

2. International Workshop on Developments on Radiation Therapy Planning and Dose Delivery, Stockholm, Sweden, March 11-13, 1996

3. 1st Balkan Congress of Oncology, Athens, July 3-7, 19964. Course on Molecular Radiobiology, Stockholm, Sweden, March 17-21, 19975. World Congress on Medical Physics and Biomedical Engineering, Nice, France,

September 14-19, 19976. Summer School in Radiation Therapy Physics, Balkan Union of Oncology, Patras,

Hellas, June 30 – July 6, 1997.7. Course in Radiation Dosimetry, Linköping and Stockholm, Sweden, Autumn, 19978. Course in Transport Theory and Treatment Optimization Methods in External

Radiation Therapy Dose Planning, Hemavan, Sweden, April 23-28, 19989. VI International Conferance on Medical Physics, European Federation of Medical

Physics, Patras, Hellas, September 1-4, 199910. Course in Interaction of Ionizing Radiation with Matter, Linköping and Stockholm,

Sweden, 200011. Course on Basic Object Oriented Programming in C++, Stockholm, Sweden, 200012. World Congress on Medical Physics and Biomedical Engineering, Chicago, USA,

July 23-28, 200013. Course on Biostatistics for Physicists, Stockholm, Sweden, Spring, 200114. 21st ESTRO Annual Meeting, Prague, Czech Republic, September 17-23, 2002

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15. World Congress on Medical Physics and Biomedical Engineering, Sydney, Australia, August 24-29, 2003

16. ESTRO Course on Clinical Radiobiology, Santorini, Greece, October 12-16, 200317. 23rd ESTRO Annual Meeting, Αmsterdam, The Netherlands October 24-28, 200318. 8th ESTRO Biennial Meeting, Lisbon, Portugal, September 26-29, 200519. Course on Research Supervision and Guidance, Stockholm, Sweden, May 3-5, 200620. 25th ESTRO Annual Meeting, Leipzig, Germany, October 9-12, 200621. 9th ESTRO Biennial Meeting, Barcelona, Spain, September 9-13, 200722. 27th ESTRO Annual Meeting, Göteborg, Sweden, September 14-18, 200823. Symposium on Curing with radiotherapy while maintaining quality of life: How to

combine qualitative patient-specific data with given absorbed dose. Göteborgs Universitet, Göteborg, Sweden, January 27-28, 2009

21. Participation in National Conferences and Seminars of Further Education

1. Postgraduate Seminar of Radiation Protection, Department of Medicine, University of Thessaly, Larissa, Greece, April 18, 2003

2. 11th Scientific Conference of Medical Students of Greece, Alexandroupolis, May 13-15, 2005

3. 2nd Seminar of Basic Education in Magnetic Resonance, Larissa, Greece, 29 June-1 July, 2007

4. 1ο Seminar of Radiology, Spine and Joints, Larissa, Greece, October 6, 20075. 9th Hellenic Conference of Radiotherapeutic Oncolog, Alexandroupolis, Greece, June 19-

22, 2008

22. Recommendation Letters

22.1. Professor Anders Brahme Department of Medical Radiation Physics, Karolinska Institutet and Stockholm University, Sweden

22.2. Professor Bengt KarlssonDepartment of Neurosurgery, Karolinska Hospital, Stockholm, Sweden and West Virginia University, Morgantown WV, USA

22.3. Professor Dimitrios LefkopoulosDepartment of Medical Physics, Gustav Roussi Hospital, Paris, France

22.4. Professor Jean-Claude RosenwaldDepartment of Medical Physics, Institute Curie, Paris, France

22.5. Associate Professor Constantin Kappas Laboratory of Medical Physics, Medical School, University of Thessaly, Larissa, Greece

22.6. Associate Professor Bengt K. LindDepartment of Medical Radiation Physics, Karolinska Institutet and Stockholm University, Sweden

22.7. Associate Professor Bo NilssonDepartment of Medical Radiation Physics, Karolinska Institutet and Stockholm University, Sweden

22.8. Associate Professor Jan-Olof FernbergDepartment of Oncology, Radiumhemmet, Karolinska Hospital, Stockholm, Sweden

22.9. Associate Professor Göran Laurell

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Department of Otolaryngology, Head and Neck Surgery, Karolinska Hospital, Stockholm, Sweden

22.10. Associate Professor Simo HyödynmaaDepartment of Hospital Physics, Tampere University Hospital, Tampere, Finland

22.11. Associate Professor Nikos Papanikolaou Department of Radiation Oncology, University of Little Rock, Arkansas, USA

22.12. Assistant Professor Georgios A. PlataniotisDepartment of Radiotherapy, Medical School, University of Thessaly, Larissa, Greece

23. Ph.D. Thesis

Title: Determination and Use of Radiobiological Response Parameters in Radiation Therapy OptimizationInvestigation of treatment plan optimization using radiobiological parameters for predicting the clinical outcome from radiotherapy. Determination of dose-response relations was performed for lung, esophagus and AVM.Section of Medical Radiation Physics, Department of Oncology-Pathology, Karolinska Institutet, December 2001

24. Other University Theses

24.1. Study of Meniere disease with the method of Acoustic Evoked Potentials (AEP) Supervisor: Assis. Prof. Anastasios Bezerianos University Thesis, Department of Physics (Grade ‘Excellent’). The thesis was conducted at the Laboratory of Medical Physics, University of Patras, Patras, Greece, 1993-94.

24.2. Development of radiobiologically-based procedure for evaluating and increasing the probability of complication free tumor control in radiation therapy Supervisors: Assoc. Prof. Constantin Kappas, Αssoc. Prof. Bengt K. Lind Master Thesis for the Postgraduate Inter-departmental Program of Studies in Medical Physics (Grade ‘Excellent’). The thesis was conducted at the Department of Medical Radiation Physics, Karolinska Institutet and Stockholm University, Stockholm, Sweden and the Laboratory of Medical Physics and Department of Radiation Therapy of the University Hospital of Patras, Patras, Greece, 1995-96.

24.3. Use of radiobiological models for treatment evaluation and clinical outcome optimization Supervisors: Assoc. Prof. B.K. Lind, Prof. A. Brahme and Assoc. Prof. C. Kappas Philosophy Licentiate Thesis, Department of Medical Radiation Physics, Stockholm University, Stockholm, Sweden, December 2000.

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25. Articles in International Journals (Peer-Reviewed)

25.1. P. Mavroidis, C. Kappas and B.K. Lind 1997 A computer program for evaluating the probability of complication-free tumor control incorporated in a commercial treatment planning system. J. BUON 3, 257-64

25.2. B.K. Lind, P. Mavroidis, S. Hyödynmaa and C. Kappas 1999 Optimization of the dose level for a given treatment plan to maximize the complication free tumor cure. Acta Oncol. 38, 787-98

25.3. P. Mavroidis, B.K. Lind, J. Van Dijk, K. Koedooder, W. De Neve, C. De Wagter, B. Planskoy, J.C. Rosenwald, B. Proimos, C. Kappas, C. Danciu, M. Benassi, G. Chierego and A. Brahme 2000 Comparison of conformal radiation therapy techniques within the dynamic radiotherapy project ‘DYNARAD’. Phys. Med. Biol. 45, 2459-81

25.4. P. Mavroidis, B.K. Lind and A. Brahme 2001 Biologically effective uniform dose ( ) for specification, report and comparison of dose response relations and treatment plans. Phys. Med. Biol. 46, 2607-30

25.5. P. Mavroidis, B.K. Lind and A. Brahme 2002 , an effective uniform dose linked to the probability of response. Phys. Med. Biol. 47, L3-9

25.6. P. Mavroidis, K. Theodorou, D. Lefkopoulos, F. Nataf, M. Schlienger, B. Karlsson, I. Lax, C. Kappas, B.K. Lind and A. Brahme 2002 Prediction of AVM obliteration after stereotactic radiotherapy using radiobiological modelling. Phys. Med. Biol. 47, 2471-94

25.7. P. Mavroidis, S. Axelsson, S. Hyödynmaa, J. Rajala, M.A. Pitkänen, B.K. Lind and A. Brahme 2002 Effects of positioning uncertainty and breathing on dose delivery and radiation pneumonitis prediction in breast cancer. Acta Oncol. 41, 471-85

25.8. G. Laurell, T. Kraepelien, P. Mavroidis, B.K. Lind, J.O. Fernberg, M. Beckman and M.G. Lind 2003 Stricture of the proximal esophagus in head and neck carcinoma patients after radiotherapy. Cancer 97, 1693-700

25.9. P. Mavroidis, G. Laurell, T. Kraepelien, J.O. Fernberg, B.K. Lind and A. Brahme 2003 Determination and clinical verification of dose-response parameters for esophageal stricture from head and neck radiotherapy. Acta Oncol. 42, 865-81

25.10. M. Al-Abany, A.R. Helgason, A.K. Ågren Cronqvist, B.K. Lind, P. Mavroidis, P. Wersäll, E. Qvanta and G. Steineck 2004 Dose to the anal sphincter region and risk of faecal leakage. Acta Oncol. 43, 117-8

25.11. P. Mavroidis, B.K. Lind, K. Theodorou, G. Laurell, J.O. Fernberg, D. Lefkopoulos, C. Kappas, B.K. Lind and A. Brahme 2004 Statistical methods for clinical verification of dose-response parameters related to esophageal

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stricture and AVM obliteration from radiotherapy. Phys. Med. Biol. 49, 3797-816

25.12. M. Al-Abany, A.R. Helgason, A.K. Ågren Cronqvist, B.K. Lind, P. Mavroidis, P. Wersäll, H. Lind, E. Qvanta and G. Steineck 2005 Toward a definition of a threshold for harmless doses to the anal-sphincter region and the rectum. Int. J. Radiat. Oncol. Biol. Phys. 61, 1035-44

25.13. P. Mavroidis, M. Al-Abany, A.R. Helgason, A.K. Ågren Cronqvist, P. Wersäll, K. Theodorou, C. Kappas, H. Lind, B.K. Lind, G. Steineck and A. Brahme 2005 Dose-response relations for anal sphincter regarding faecal leakage and blood or phlegm in stools after radiotherapy for prostate cancer. Strahlenterapie und Onkologie 181, 293-306

25.14. Ι. Tsougos, P. Mavroidis, J. Rajala, K. Theodorou, R. Järvenpää, M.A. Pitkänen, K. Holli, A.T. Ojala, B.K. Lind, S. Hyödynmaa and C. Kappas 2005 Evaluation of dose-response models and parameters predicting radiation induced pneumonitis using clinical data from breast cancer radiotherapy. Phys. Med. Biol. 50, 3535-54

25.15. Ι. Tsougos, P. Mavroidis, K. Theodorou, J. Rajala, M.A. Pitkänen, K. Holli, A.T. Ojala, S. Hyödynmaa, R. Järvenpää, B.K. Lind and C. Kappas 2006 Clinical validation of the LKB model and parameter sets for predicting radiation-induced pneumonitis from breast cancer radiotherapy. Phys. Med. Biol. 51, L1-9

25.16. P. Mavroidis, B. Costa Ferreira, Ν. Papanikolaou, R. Svensson, C. Kappas, B.K. Lind and A. Brahme 2006 Assessing the difference between planned and delivered intensity-modulated radiotherapy dose distributions based on radiobiological measures. Clin. Oncol. 18, 529-38

25.17. P. Mavroidis, G.A. Plataniotis, M. Adamus-Górka and B.K. Lind 2006 Comments on ‘Reconsidering the definition of a dose–volume histogram’—dose–mass histogram (DMH) versus dose–volume histogram (DVH) for predicting radiation-induced pneumonitis. Phys. Med. Biol. 51, L43-50

25.18. Ι. Tsougos, P. Nilsson, K. Theodorou, Ε. Κjéllen, Sven-Börje Ewers, Olof Jarlman, B.K. Lind, C. Kappas and P. Mavroidis 2007 NTCP modelling and pulmonary function tests evaluation for the prediction of radiation induced pneumonitis in non-small-cell lung cancer radiotherapy. Phys. Med. Biol 52, 1055-73

25.19. P. Mavroidis, B. Costa Ferreira, C. Shi, B.K. Lind and N. Papanikolaou 2007 Treatment plan comparison between Helical Tomotherapy and MLC-based IMRT using radiobiological measures. Phys. Med. Biol. 52, 3817-36

25.20. P. Mavroidis, B. Costa Ferreira, C. Shi, B.K. Lind and N. Papanikolaou 2008 Comparison of the 3D-Conformal, Helical Tomotherapy and MLC-based IMRT radiation modalities using radiobiological measures. J. BUON 13, 75-86

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25.21. M. Adamus-Górka, A. Brahme, P. Mavroidis and B.K. Lind 2008 Variation in radiation sensitivity and repair kinetics in different parts of the spinal cord. Acta Oncol. 47, 928-36

25.22. B. Costa Ferreira, P. Mavroidis, M. Adamus-Gorka, R. Svensson and B.K. Lind 2008 Impact of different dose-response parameters on biologically optimized IMRT in breast cancer. Phys. Med. Biol. 53, 2733-52

25.23. P. Mavroidis, G. Komisopoulos, B.K. Lind and N. Papanikolaou 2008 Interpretation of the dosimetric results of three uniformity regularization methods in terms of expected treatment outcome. Med. Phys. 35, 5009-19

25.24. M. Adamus-Górka, P. Mavroidis, A. Brahme and B.K. Lind 2008 The dose response relation for rat spinal cord paralysis analyzed in terms of the effective size of the functional subunit. Phys. Med. Biol. 53, 6533-47

25.25. P. Mavroidis, B. Costa Ferreira, C. Shi, M.G. Delichas, B.K. Lind and N. Papanikolaou 2009 Comparison of the Helical Tomotherapy and MLC-based IMRT radiation modalities in treating brain and cranio-spinal tumors. Technology in Cancer Research and Treatment 8, 3-14

25.26. P. Mavroidis and B.K. Lind 2009 In response to ‘Behind EUD’. Acta Oncol. 48, 610-4

25.27. B. Andisheh, H. Saberi, B.K. Lind, P. Mavroidis, M.A. Bitaraf and A. Brahme 2009 Clinical and radiological evaluation of ion beam stereotactic radiosurgery for large intracranial arteriovenous malformations, a meta-analysis. J. Neurosurg. In press

25.28. P. Mavroidis, S. Stathakis, A. Gutierrez, C. Esquivel, C. Shi and N. Papanikolaou 2009 Expected clinical impact of the differences between planned and delivered dose distributions in Helical Tomotherapy for treating head and neck cancer using Helical Megavoltage CT Images. J. Appl. Clin. Med. Phys. 10, 2969-2989

25.29. F-C. Su, C. Shi, P. Mavroidis, V. Goytia, R. Crownover and N. Papanikolaou 2009 Assessing four-dimensional radiotherapy planning and respiratory motion-induced dose difference based on biologically effective uniform dose. Technol. Cancer Res. Treat. 8, 187-200

25.30. A. Ahlberg, M. al-Abany, E. Alevronta, S. Friesland, H. Hellborg, P. Mavroidis, B.K. Lind and G. Laurell 2009 Oesophageal stricture in head- and neck-cancer patients after radiotherapy - experience of a single institution during two treatment time periods. Head & Neck In press

25.31. T. Roland, P. Mavroidis, A. Gutierrez, V. Goytia and N. Papanikolaou 2009 A radiobiological analysis of the effect of 3D versus 4D image-based planning in lung cancer radiotherapy. Phys. Med. Biol. 54, 5509-23

25.32. F. Su, C. Shi, P. Mavroidis, V. Goytia, R. Crownover and N. Papanikolaou

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2009 Evaluation on lung cancer patients' adaptive planning of tomotherapy utilizing radiobiological measures and planned adaptive module. J. Radiother. Pract. Accepted

25.33. G.A. Plataniotis, M.A. Theofanopoulou, K. Sotiriadou, K. Theodorou, P. Mavroidis and G. Kyrgias 2009 Palliative hypofractionated radiotherapy for non-small-cell lung cancer (NSCLC) patients previously treated by induction chemotherapy. J. Thoracic Diseases Accepted

25.34. T. Roland, C. Shi, Y. Liu, R. Crownover, P. Mavroidis and N. Papanikolaou 2009 Tradeoffs for assuming rigid target motion in MLC-based real time target tracking radiotherapy: A dosimetric and radiobiological analysis. Technol. Cancer Res. Treat. Accepted

26. Articles in National Journals (Peer-Reviewed)

26.1. P. Mavroidis, G. Laurell, G. Komisopoulos, K. Theodorou, B.K. Lind, I. Fezoulidis, G.A. Plataniotis, C. Kappas 2005 Stricture in the proximal esophagus after radiotherapy of head and neck carcinoma: Dose-response relations. Forum of Clinical Oncology 4(1), 61-70

26.2. P. Mavroidis, M. al-Abany, T. Topaltzikis, A.R. Helgason, B.K. Lind, G.A. Plataniotis, G. Steineck 2007 Investigation for the determination of a threshold for doses of low risk in the region of anal sphincter and rectum. Forum of Clinical Oncology 6(1-2), 38-49

26.3. P. Mavroidis, A. Iconomi, S. Hyödynmaa, G.A. Plataniotis and Β.Κ. Lind 2007 Modelling in radiotherapy treatment planning using models of clinical radiobiology. Hellenic Radiology 38(3), 325-38

26.4. A. Polymenidou, G. Soulimioti, P. Mavroidis, K. Sotiriadou 2008 Ear cancer: Radiotherapy technique and case report. Aktinotechnologia 18, 25-28

26.5. P. Mavroidis, G. Laurell, G. Komisopoulos, K. Sotiriadou, Thomas Kraepelien, J.O. Fernberg, B.K. Lind and G. Plataniotis 2008 Dose-response parameters for esophageal stricture from head & neck cancer radiotherapy. Hellenic Radiology Accepted

26.6. E. Lavdas, P. Mavroidis, V. Roka, I.V. Fezoulidis and K. Vasiou 2009 Pitfalls in the production of enhancement kinetic curves in 3T dynamic magnetic resonance mammography and means of avoidance. Archives of Hellenic Medicine Accepted

27. Chapters in Books

27.1. P. Mavroidis, B.K. Lind, B. Proimos, C. Kappas and A. Brahme 1999 Dosimetric information from films irradiated in the conformal therapy test phantom of the Dynarad project. Proc. of the 6th Int. Conf. on Medical Physics editors: C. Kappas, A. Del Guerra, Z. Kolitsi, G. Damilakis and K. Theodorou (Bologna: Monduzzi) pp.127-34

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27.2. A. Brahme, P. Mavroidis and B.K. Lind 2009 Fundamentals of therapeutic radiation biology. Development of biologically optimized radiation therapy techniques. (Singapore: World Scientific Publishing Co. Pte. Ltd.) pp.1-67 In press

27.3. A. Brahme, P. Mavroidis and B.K. Lind 2009 The radiation biological bases of radiation therapy. Development of biologically optimized radiation therapy techniques. (Singapore: World Scientific Publishing Co. Pte. Ltd.) pp.68-127 In press

27.4. A. Brahme, J. Löf, P. Mavroidis and B.K. Lind 2009 Fundamentals of physically and biologically based radiation therapy optimization. Development of biologically optimized radiation therapy techniques. (Singapore: World Scientific Publishing Co. Pte. Ltd.) pp.170-213 In press

27.5. K. Moaierifar, P. Mavroidis, B.K. Lind and A. Brahme 2009 Properties and potentials of biologically based treatment planning optimization. Development of biologically optimized radiation therapy techniques. (Singapore: World Scientific Publishing Co. Pte. Ltd.) pp.170-210 In press

27.6. P. Mavroidis 2009 Dose-response relations, treatment plan optimization. Principles of Radiotherapeutic Oncology. (Athens: Hellenic Society of Radiotherapeutic Oncology) pp. 145-176

27.7. G. Komisopoulos, P. Mavroidis 2009 Modern radiotherapy techniques. Principles of Radiotherapeutic Oncology. (Athens: Hellenic Society of Radiotherapeutic Oncology) pp. 177-189

28. Books and Monographies

28.1. P. Mavroidis 2001 Determination and use of radiobiological response parameters in radiation therapy optimization (Stockholm: Karolinska University Press) ISBN 91-7349-092-X

28.2. C. Kappas, Κ. Theodorou, P. Mavroidis and G. Komisopoulos 2005 Pregnancy and Medical Radiation. ISBN 008-043-901-2

28.3. A. Brahme, B.K. Lind, R. Svensson, B. Nilsson, P. Mavroidis et al 2008 Development of biologically optimized radiation therapy techniques (Singapore: World Scientific Publishing Co. Pte. Ltd.) In press

29. Publications in International and National News Journals

29.1. P. Mavroidis 2003 ESTRO teaching course on “Basic Clinical Radiobiology” in Santorini, Greece, October 12-16, ESTRO news 56, pp. 17

29.2. P. Mavroidis and G. Laurell 2005 Dose-response relation for stricture in proximal esophagus after radiotherapy for head and neck cancer, Medical News of Thessaly, September, pp. 14-15

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30. Implementation of International Reports

30.1. P. Mavroidis, C. Kappas 1997 A dosimetric report for the determination of absorbed dose from high-energy photon and electron beams (Task Group 21, AAPM). Basic steps in the application of the protocol. Development of a software for easier and reliable clinical implementation of the protocol. 1st summer school of Balkan Union of Oncology (B.U.ON.) pp.1-35

31. Submitted Articles in peer-reviewed International and National Journals

31.1. P. Mavroidis, F. Su, D. Giantsoudi, S. Stathakis, G. Komisopoulos, C. Shi, G. Swanson and N. Papanikolaou 2009 Radiobiological and dosimetric effects of daily Megavoltage CT registration techniques on adaptive radiotherapy with Helical Tomotherapy. Phys. Med. Biol.

31.2. P. Mavroidis, C. Shi, G. A. Plataniotis, M. G. Delichas, B. C. Ferreira, B. K. Lind and N. Papanikolaou 2009 Comparison of the Helical Tomotherapy against the MLC-based IMRT and 3D-Conformal radiation modalities in lung cancer radiotherapy. Br. J. Radiol.

31.3. B. Andisheh, M.A. Bitaraf, P. Mavroidis, A. Brahme and B.K. Lind 2009 Vascular structure and binomial statistics for response modeling in radiation therapy of cerebral arteriovenous malformations. Phys. Med. Biol.

31.4. G. A. Plataniotis, M. Theofanopoulou, G. Kyrgias, K. Sotiriadou, K. Theodorou and P. Mavroidis 2009 Volumetric radiobiological modeling in a group of patients with non-small-cell lung cancer and brain metastases, treated by whole brain radiotherapy (WBRT). J. Palliative Care

31.5. E. Alevronta, A. Ahlberg, P. Mavroidis, M. al-Abany, S. Friesland, A. Tilikidis, G. Laurell and B.K. Lind 2009 Determination of Dose-Response Parameters for Stricture in the Proximal Oesophagus from Head & Neck Radiotherapy. Radiother. Oncol.

31.6. F. Su, P. Mavroidis and N. Papanikolaou 2009 A graphic user interface toolkit for specification, report and comparison of dose response relations and treatment plans using the biologically effective uniform dose. J. Appl. Clin. Med. Phys.

31.7. T. Roland, P. Mavroidis, C. Shi, S. Stathakis, R. Crownover and N. Papanikolaou 2009 A radiobiological assessment of the clinical improvement when tumor tracking is used in lung cancer radiotherapy. Phys. Med. Biol.

31.8. T. Roland, P. Mavroidis, C. Shi and N. Papanikolaou 2009 Incorporating system latency associated with real time target tracking radiotherapy in the dose prediction step. Phys. Med. Biol.

31.9. D. Baltas, G. Lymperopoulou, E. Löffler and P. Mavroidis 2009 A Theoretical Investigation on Dose and Dose Rate for Permanent Implant Brachytherapy of Breast using 125I or 103Pd Sources. Med. Phys.

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31.10. B. C. Ferreira, M. C. Lopes, J. Mateus, M. Capela and P. Mavroidis 2009 Radiobiological and dosimetric advantages of forward and inverse IMRT of head and neck tumours. Phys. Med. Biol.

31.11. P. Mavroidis, A. Tzikas, N. Papanikolaou and B.K. Lind 2009 Radiobiological tools for determination and clinical verification of dose-response relations. J. Appl. Clin. Med. Phys.

31.12. E. Lavdas, P. Mavroidis, V. Roka, K. Vasiou, M. Vlychoy and I.V. Fezoulidis 2009 Elimination of Chemical Shift artifacts of Thoracic Spine with contrast-enhanced FLAIR imaging with fat suppression at 3.0T. Magn. Reson. Imag.

31.13. P. Mavroidis, B. Costa Ferreira, G. Komisopoulos, K. Sotiriadou, G. Soulimioti, E. Lavdas, C. Shi, B.K. Lind and N. Papanikolaou 2009 Comparison of Helical Tomotherapy and Intensity Modulated Radiation Therapy treatment plans using radiobiological measures. Βήμα Κλινικής Ογκολογίας

32. Articles to be submitted in peer-reviewed International and National Journals (in manuscript form)

32.1. M. Adamus-Górka, P. Mavroidis, B.K. Lind and A. Brahme 2009 Comparison of dose response and volume dependences of rat spinal cord.

32.2. Β. Costa Ferreira, P. Mavroidis and M. do Carmo Lopes 2009 Iso-probability distributions and probability-volume histograms (PVH) in treatment plan evalution and optimization.

32.3. P. Mavroidis, S. Hyödynmaa, B. Costa Ferreira, S. Axelsson, N. Papanikolaou and B.K. Lind, Radiobiological optimization of breast cancer radiotherapy taking into account patient positioning, breathing and radiation pneumonitis scoring.

32.4. P. Mavroidis, J. Rajala, R. Järvenpää, M.A. Pitkänen, K. Holli, A.T. Ojala, S. Hyödynmaa and B.K. Lind 2009 Determination of dose-response parameters for predicting radiation induced pneumonitis from breast cancer radiotherapy.

32.5. P. Karaiskos, P. Mavroidis, B.C. Ferreira, N. Papanikolaou, S. Stathakis, P. Sandilos, E. Koutsouveli, C. Scarleas and K. Dardoufas 2009 Organ delineation using CT vs CT-MRI images during treatment planning in prostate cancer radiotherapy.

32.6. S. Rodriguez, F. Su, P. Mavroidis and N. Papanikolaou 2009 Development of software for performing radiobiological studies and treatment plan optimization.

32.7. E. Koutsouveli, P. Mavroidis, P. Karaiskos, P. Sandilos, N. Papanikolaou, C. Stergiou and M. Torrens 2009 Assessment of clinical response factors of acoustic neuromas after Gamma Knife treatment.

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32.8. C. Buckey, S. Stathakis, A. Gutiérrez, C. Esquivel, P. Mavroidis, D. Mihailidis and N. Papanikolaou 2009 The inter- and intra-fraction reproducibility of three common IMRT delivery techniques.

32.9. P. Mavroidis, N. Papanikolaou, O. Calvo, E. Dzintars, D. Mihailidis and S. Stathakis 2009 DVM vs. DMH in lung cancer radiotherapy.

32.10. S. Stathakis, C. Buckey, P. Mavroidis, G. Swanson, D. Mihailidis and N. Papanikolaou 2009 Is IMRT better than 3D conformal therapy for prostate cancer? A radiobiological comparison.

32.11. E. Dzintars, P. Mavroidis, S. Stathakis, C. Shi, A. Gutiérrez, C. Esquivel, F. Su and N. Papanikolaou 2009 Radiobiological evaluation of inhomogenity corrections in tissue for lung cancer patients.

32.12. S. Rodriguez, F. Su, C. Shi, S. Stathakis, A. Gutiérrez, C. Esquivel, P. Mavroidis and N Papanikolaou 2009 Comparison of Helical Tomotherapy, MLC-based IMRT, and 3D-Conformal radiation modalities in BEUD utilization and analysis.

32.13. J. Xu, C. Buckey, G. Swanson, S. Stathakis, C. Esquivel, A. Gutiérrez, C. Shi, P. Mavroidis and N. Papanikolaou 2009 Impact of proper bladder and rectum delineation in the evaluation of the effectiveness of IMRT in prostate cancer radiotherapy.

32.14. P. Tynan, M. Joyner, M. Smith, A. Gutiérrez, S. Stathakis, P. Mavroidis, N. Papanikolaou and G. Swanson 2009 Comparison of Pre- and Post-Implant Prostate Volume Segmentation Using Trans-Rectal Ultrasound and Computed Tomography.

32.15. G. Komisopoulos, G. Sakellaropoulos, G. Nikiforidis, N. Papanikolaou, B.K. Lind and P. Mavroidis 2009 Demonstration of dose-response relations for a series of tumors and normal tissues after external radiotherapy.

32.16. D. Baltas, Z. Katsilieri, V. Kefala, S. Papaioannou, A. Karabis, P. Mavroidis and N. Zamboglou 2009 Influence of Modulation Restriction in Inverse Optimization with HIPO of Prostate Implants on Plan Quality: Analysis using Dosimetric and Radiobiological Indices.

32.17. T. Roland, P. Mavroidis and N. Papanikolaou 2009 A radiobiological assessment of the clinical improvement when tumor tracking versus conventional techniques is used for lung cancer radiotherapy.

32.18. I. Chalimou, H. Lind, P. Mavroidis, G.C. Sakellaropoulos, G.C. Nikiforidis, N. Papanikolaou and B.K. Lind 2009 Treatment strategies in radiotherapy for advanced non-small cell lung cancer: Differences in attitude in Europe.

32.19. S. Rodriguez, P. Mavroidis and N. Papanikolaou 2009 BEUD analysis and secondary malignancy risk: Radiobiological comparison of HT, MLC-based IMRT,

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and CRT.

32.20. E. Alevronta, H. Lind, B.K. Lind, M. Al-Abany, A.C. Waldenstrom, C. Olsson, G. Dunberger, P. Mavroidis, T. Nyberg, A.K. Johansson, E. Åvall-Lundqvist and G. Steineck 2009 Dose-effect relationships for organs-at-risk related to long-lasting complete fecal evacuation without premonition.

32.21. B. Andisheh, P. Mavroidis and B.K. Lind 2009 Is there an appropriate model for stereotactic high dose body radiotherapy? Review of different models and evaluation of their accuracy.

32.22. B. Costa Ferreira, P. Mavroidis and M. do Carmo Lopes 2009 Analysis of fractionation correction methodologies for radiation therapy based on multiple treatment plans.

32.23. C. Shi, P. Mavroidis, Y. Zhai, J. Xu, B.K. Lind and N. Papanikolaou 2009 Evaluation of IMRT dose delivery using the concepts of Gamma Index and Biologically Effective Uniform Dose.

32.24. T. Roland, P. Mavroidis, S. Stathakis, A. Gutierrez and N. Papanikolaou 2009 Analysis of 4D tumor tracking radiotherapy for mobile tumors using radiobiological measurements.

32.25. P. Mavroidis, G.A. Plataniotis, G. Komisopoulos, K. Sotiriadou, M. Adamus-Górka, S. Hyödynmaa, B.K. Lind 2009 Dose-Mass Histograms (DMH) and Dose-Volume Histograms (DVH) for predicting radiation pneumonitis after breast cancer radiotherapy.

33. Oral and Invited Presentations

33.1. P. Mavroidis*, B.K. Lind and C. Kappas, An index for evaluating and increasing the probability of complication free tumor control in radiation therapy.1st Balkan Congress of Oncology, Athens, Hellas, July 3-7, 1996

33.2. P. Mavroidis* and B.K. Lind, A dosimetric report for the determination of absorbed dose from high-energy photon and electron beams (Task Group 21, AAPM). Basic steps in the application of the protocol. Development of a software for easier and reliable clinical implementation of the protocol.1st Summer School in “Radiation Therapy Physics”, Balkan Union of Oncology, Patras, Hellas, June 30 – July 6, 1997

33.3. P. Mavroidis* and B.K. Lind, Software for assessing optimal complication free tumor control, dose level and fractionation schedule.World Congress on Medical Physics and Biomedical Engineering, Nice, France, September 14-19, 1997

33.4. I. Tsougos*, P. Mavroidis , J. Rajala, R Järvenpää, K. Theodorou, S. Hyödynmaa, M.A. Pitkänen, K. Holli, B.K. Lind and C. Kappas, Is NTCP modeling really useful for the prediction of radiation induced pneumonitis?

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Dose-response parameters from breast radiotherapy.23st Annual ESTRO Meeting, Amsterdam, The Netherlands, October 24-28, 2004

33.5. Jack Fowler University of Wisconsin Award, P. Mavroidis*, I. Tsougos, J. Rajala, K. Theodorou, R. Jarvenpaa, M.A. Pitkanen, K. Holli, A.T. Ojala, B.K. Lind, S. Hyodynmaa, C. Kappas, Clinical evaluation of dose-response models and parameter sets predicting radiation induced pneumonitis from breast cancer radiotherapy8th Biennial ESTRO Meeting on Physics and Radiation Technology for Clinical Radiotherapy, Sept. 2005

33.6. P. Mavroidis* , M. Al-Abany, A.R. Helgason, A.-K. Agren Cronqvist, P. Wersäll, H. Lind, E. Qvanta, C. Kappas, B.K. Lind, G. Steineck and A. Brahme, Dose-response relations for faecal leakage and blood or phlegm in stools related to anal sphincter irradiation from prostate cancer radiotherapy. 8th Biennial ESTRO Meeting, Lisboa, Portugal, September 24-29, 2005

33.7. P. Mavroidis , B. Costa Ferreira*, R. Svensson, K. Theodorou, B. Lind and A. Brahme, Quantification of differences between planned and delivered IMRT dose distributions in terms of complication-free cure. 8th Biennial ESTRO Meeting, Lisboa, Portugal, September 24-29, 2005

33.8. I. Tsougos*, P. Mavroidis , K. Theodorou, P. Nilsson, E. Kjéllen, J. Rajala, R. Järvenpää, S. Hyödynmaa, M.A. Pitkänen, K. Holli, A.T. Ojala, O. Jarlman, B.K. Lind and C. Kappas, A comparison of NTCP models and parameters predicting radiation induced pneumonitis in breast and lung cancer radiotherapy. 25th ESTRO Meeting, Leipzig, Germany, October 8-12, 2006

33.9. N. Papanikolaou*, P. Mavroidis, S. Axelsson, S. Hyödynmaa, J. Rajala, M.A. Pitkänen, B.K. Lind, A. Brahme, Expected risk for radiation pneumonitis from breast cancer radiotherapy taking into account breathing and setup uncertainties.Annual RSNA Meeting, Chicago, USA, November 25-30, 2007

33.10. P. Mavroidis, B.C. Ferreira, C. Shi, B.K. Lind, S. Stathakis and N. Papanikolaou*, Comparing the expected effectiveness of Helical Tomotherapy and MLC-based IMRT using biological measures. 49th AAPM Annual Meeting, Minneapolis, Minnesota, USA, July 22-26, 2007

33.11. Ανάλυση κλινικών δεδομένων σχετικά με την εμφάνιση στένωσης στον τραχηλικό οισοφάγο μετά από ακτινοθεραπεία νεοπλασμάτων κεφαλής και τραχήλου.Panayiotis Mavroidis * , Göran Laurell, Giorgos Komisopoulos, Kyriaki Theodorou, Constantin Kappas, Thomas Kraepelien, Jan-Olof Fernberg, Bengt K. Lind, Giorgos A. Plataniotis Proceedings of the 9th Hellenic Conference of Radiotherapeutic Oncology, Alexandroupolis, June 19-22, 2008

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33.12. N. Papanikolaou*, S. Stathakis and P. Mavroidis, Expected clinical impact of the differences between planned and delivered dose distributions in Helical Tomotherapy. 50th AAPM Annual Meeting, Houston, Texas, USA, July 27-31, 2008

33.13. B. Guo, Y. Liu, C. Shi, P. Mavroidis, C. Ha and N. Papanikolaou*, Dose calculation for proton radiotherapy based on Monte Carlo simulation using anatomical detailed human model. 27th ESTRO Annual Meeting, Göteborg, Sweden, September 14-18, 2008

33.14. F. Su*, C. Shi, P. Mavroidis and N. Papanikolaou, Utilizing Planned Adaptive Module and Radiobiological Measures to Evaluate Helical Tomotherapy for Lung Cancer Patients. SWAAPM Spring Meeting, San Antonio, Texas, USA, March 26 – 28, 2009

33.15. S. Rodriguez*, P. Mavroidis and N. Papanikolaou, Comparison of Helical Tomotherapy, MLC-based IMRT, and 3D-Conformal radiation modalities in BEUD utilization and analysis. SWAAPM Spring Meeting, San Antonio, Texas, USA, March 26 – 28, 2009

33.16. Ε. Alevronta*, Η. Lind, Β.Κ. Lind, Μ. Al-Abany, Α.C. Waldenstrom, C. Olsson, G. Dunberger, P. Mavroidis, T. Nyberg, K.A. Johansson, E. Åvall-Lundqvist, G. Steineck, Dose-effect relationships for organs-at-risk related to long-lasting complete fecal evacuation without premonition.10th Biennial ESTRO Meeting, Maastricht, The Netherlads, Aug. 30 – Sept. 3, 2009

33.17. D. Baltas*, Z. Katsilieri, V. Kefala, S. Papaioannou, A. Karabis, P. Mavroidis, N. Zamboglou, Influence of Modulation Restriction in Inverse Optimization with HIPO of Prostate Implants on Plan Quality: Analysis using Dosimetric and Radiobiological Indices. World Congress in Medical Physics and Biomedical Engineering, Munich, Germany, September 7 – 12, 2009

33.18. P. Mavroidis*, Biological Model-Based IMRT Plan Optimization. World Congress in Medical Physics and Biomedical Engineering, Munich, Germany, September 7 – 12, 2009

34. Abstracts in International Journals and International Conferences

34.1. P. Mavroidis, B.K. Lind and C. Kappas, An index for evaluating and increasing the probability of complication free tumor control in radiation therapy.1st Balkan Congress of Oncology, Athens, Hellas, July 3-7, 1996J. Balcan Union Oncol. 1, pp.39, 1996

34.2. P. Mavroidis and B.K. Lind, A dosimetric report for the determination of absorbed dose from high-energy photon and electron beams (Task Group 21, AAPM). Basic steps in the application of the protocol. Development of a software for easier and reliable clinical implementation of the protocol.

33


1st Summer School in “Radiation Therapy Physics”, Balkan Union of Oncology, Patras, Hellas, June 30 – July 6, 1997

34.3. P. Mavroidis and B.K. Lind, Software for assessing optimal complication free tumor control, dose level and fractionation schedule.World Congress on Medical Physics and Biomedical Engineering, Nice, France, September 14-19, 1997 Proceedings Vol. 35, Suppl. Part 2, pp. 929, 1997

34.4. P. Mavroidis, B.K. Lind, B. Proimos and A. Brahme, Comparison of conformal radiation therapy techniques within the dynamic radiotherapy project DYNARAD.6th International Conference on Medical Physics, Patras, Hellas, Sept. 1-4, 1999Phys Medica 15 (3), pp.188-9, 1999

34.5. P. Mavroidis, K. Theodorou, D. Lefkopoulos, M. Schlienger, B. Lind, C. Kappas, Extraction of biological parameters for AVM stereotactic radiotherapy treatment.Proceedings in World Congress on Medical Physics and Biomedical Engineering, Chicago, USA, July 23-28, 2000

34.6. P. Mavroidis 2002 Determination and use of radiobiological response parameters in radiation therapy optimization. Med. Phys. 29, 1639

34.7. P. Mavroidis 2002 Determination and use of radiobiological response parameters in radiation therapy optimization. Acta Oncol. 41, 318

34.8. P. Mavroidis, B.K. Lind and A. Brahme, Biologically effective uniform dose for appropriate dose prescription and treatment plan comparison.Proceedings in 21st Annual ESTRO Meeting, Prague, Czech Republic, September 17-21, 2002Radiother. Oncol. 64 (Suppl. 1) pp. 224, 2002

34.9. M. Adamus-Górka, P. Mavroidis, B.K. Lind and A. Brahme, Comparison of normal tissue damage models for radiobiologically optimized radiation therapy.Proceedings in 21st Annual ESTRO Meeting, Prague, Czech Republic, September 17-21, 2002Radiother. Oncol. 64 (Suppl. 1) pp. 200, 2002

34.10. M. Al-Abany, A. Helgason, A. Ågren, B.K. Lind, P. Mavroidis, P. Wersäll, E. Qvanta and G. Steineck, Anal sphincter dose and faecal leakage after radiotherapy for prostate cancer.Proceedings in 21st Annual ESTRO Meeting, Prague, Czech Republic, September 17-21, 2002Radiother. Oncol. 64 (Suppl. 1) pp. 282, 2002

34.11. P. Mavroidis, G. Laurell, T. Kraepelien, J.O. Fernberg, B.K. Lind and A. Brahme, Derivation of dose-response parameters for esophageal stricture from head & neck radiotherapy.

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Proceedings in World Congress on Medical Physics and Biomedical Engineering, Sydney, Australia, August 24-29, 2003

34.12. G. Steineck, M. Al-Abany, A. Helgason, A. Agren-Cronqvist, B. Lind, P. Mavroidis, P. Wersall, H. Lind and E. Qvanta, Towards a definition of a threshold for harmless doses to the anal sphincter region and the rectum.Proceedings in 5th Nordic Conference on Radiation Oncology, Bergen, Norway, June 10-12, 2004BJU Int. 94 (Suppl. 2) pp. 217, 2004

34.13. I. Tsougos, P. Mavroidis , J. Rajala, R Järvenpää, K. Theodorou, S. Hyödynmaa, M.A. Pitkänen, K. Holli, B.K. Lind and C. Kappas, Is NTCP modeling really useful for the prediction of radiation induced pneumonitis? Dose-response parameters from breast radiotherapy.Proceedings in 23st Annual ESTRO Meeting, Amsterdam, The Netherlands, October 24-28, 2004Radiother. Oncol. 73 (Suppl. 1) pp. 53, 2004

34.14. B. Costa Ferreira, P. Mavroidis , R. Svensson, B. Lind and A. Brahme, The influence of patient radiosensitivity on biological treatment plan optimization for early breast cancer with positive lymph nodes.Proceedings in 23st Annual ESTRO Meeting, Amsterdam, The Netherlands, October 24-28, 2004Radiother. Oncol. 73 (Suppl. 1) pp. 249, 2004

34.15. A. Tsezou, M. Satra, Y. Tsougos, K. Theodorou, V. Papanikolaou, P. Mavroidis, N. Vamvakopoulos and C. Kappas, Residual telomerase activity as a marker of cell survival after exposure to ionizing radiation in vitro.Proceedings in 23st Annual ESTRO Meeting, Amsterdam, The Netherlands, October 24-28, 2004Radiother. Oncol. 73 (Suppl. 1) pp. 365, 2004

34.16. P. Mavroidis , G. Laurell, K. Theodorou, J.O. Fernberg, D. Lefkopoulos, C. Kappas, B.K. Lind and A. Brahme, Clinical verification of derived dose-response parameters for AVM obliteration and esophageal stricture using statistical methods.Proceedings in 23st Annual ESTRO Meeting, Amsterdam, The Netherlands, October 24-28, 2004Radiother. Oncol. 73 (Suppl. 1) pp. 367, 2004

34.17. M. Al-Abany, A. Helgason, A. Agren-Cronqvist, B. Lind, P. Mavroidis , P. Wersäll, H. Lind, E. Qvanta and G. Steineck, Towards a definition of a threshold for harmless doses to the anal sphincter region and the rectum.Proceedings in 23st Annual ESTRO Meeting, Amsterdam, The Netherlands, October 24-28, 2004Radiother. Oncol. 73 (Suppl. 1) pp. 408, 2004

34.18. B. Andisheh, B. Lind, M. Bitaraf, P. Mavroidis and A. Brahme, Clinical and radiobiological advantages of stereotactic light ion beam radiation therapy for large intracranial arteriovenous malformations.

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Proceedings in 7th International Stereotactic Radiosurgery Society Congress, Brussels, Belgium, September 11-15, 2005

34.19. P. Mavroidis , M. Al-Abany, A.R. Helgason, A.-K. Agren Cronqvist, P. Wersäll, H. Lind, E. Qvanta, C. Kappas, B.K. Lind, G. Steineck and A. Brahme, Dose-response relations for faecal leakage and blood or phlegm in stools related to anal sphincter irradiation from prostate cancer radiotherapy. Proceedings in 8th Biennial ESTRO Meeting, Lisboa, Portugal, September 24-29, 2005Radiother. Oncol. 74 (Suppl. 1) pp. 22-3, 2005

34.20. Jack Fowler – Young Investigator Award: P. Mavroidis , I. Tsougos, J. Rajala, K. Theodorou, R. Järvenpää, M.A. Pitkänen, K. Holli, A.T. Ojala, B.K. Lind, S. Hyödynmaa and C. Kappas, Clinical evaluation of dose-response models and parameter sets predicting radiation induced pneumonitis from breast cancer radiotherapy. Proceedings in 8th Biennial ESTRO Meeting, Lisboa, Portugal, September 24-29, 2005Radiother. Oncol. 74 (Suppl. 1) pp. 70-1, 2005

34.21. P. Mavroidis , B. Costa Ferreira, R. Svensson, K. Theodorou, B. Lind and A. Brahme, Quantification of differences between planned and delivered IMRT dose distributions in terms of complication-free cure. Proceedings in 8th Biennial ESTRO Meeting, Lisboa, Portugal, September 24-29, 2005Radiother. Oncol. 74 (Suppl. 1) pp. 98, 2005

34.22. P. Mavroidis , I. Tsougos, S. Hyödynmaa, N. Papanikolaou, S. Axelsson, J. Rajala, M.A. Pitkänen, B.K. Lind, C. Kappas and A. Brahme, The effects of breathing and setup uncertainties on the prediction of radiation pneumonitis from breast cancer radiotherapy. Proceedings in 8th Biennial ESTRO Meeting, Lisboa, Portugal, September 24-29, 2005Radiother. Oncol. 74 (Suppl. 1) pp. 157, 2005

34.23. N. Papanikolaou, C. Shi, P. Mavroidis , C. Kappas and J. Penagaricano, Plan evaluation using the Biologically Uniform Dose (BUD) concept. Proceedings in 8th Biennial ESTRO Meeting, Lisboa, Portugal, September 24-29, 2005Radiother. Oncol. 74 (Suppl. 1) pp. 208-9, 2005

34.24. I. Tsougos, P. Mavroidis , P. Nilsson, E. Kjéllen, O. Jarlman, B.K. Lind, K. Theodorou and C. Kappas, NTCP modeling and pulmonary function tests evaluation for the prediction of radiation induced pneumonitis in lung cancer radiotherapy. Proceedings in World Congress on Medical Physics & Biomedical Engineering Seoul, Korea, 2006 – 27 August - 1 September, 2006

34.25. P. Mavroidis , B. Costa Ferreira, C. Shi, J. Penagaricano, B.K. Lind and N. Papanikolaou, The use of biologically effective uniform dose in comparing

36


dose distributions from tomotherapy and IMRT treatment plans. Proceedings in World Congress on Medical Physics & Biomedical Engineering Seoul, Korea, 2006 – 27 August - 1 September, 2006

34.26. I. Tsougos, P. Mavroidis , K. Theodorou, P. Nilsson, E. Kjéllen, J. Rajala, R. Järvenpää, S. Hyödynmaa, M.A. Pitkänen, K. Holli, A.T. Ojala, O. Jarlman, B.K. Lind and C. Kappas, A comparison of NTCP models and parameters predicting radiation induced pneumonitis in breast and lung cancer radiotherapy. Proceedings in 25th ESTRO Meeting, Leipzig, Germany, October 8-12, 2006Radiother. Oncol. 81 (Suppl. 1) pp. 135, 2006

34.27. P. Mavroidis , F. Costa Ferreira, S. Shi, J. Penagaricano, B.K. Lind and N. Papanikolaou, Comparison of dose distributions from Tomotherapy and IMRT treatment plans using the biologically effective uniform dose. Proceedings in 25th ESTRO Meeting, Leipzig, Germany, October 8-12, 2006Radiother. Oncol. 81 (Suppl. 1) pp. 245, 2006

34.28. G. Plataniotis, P. Mavroidis , M Adamus-Górka, S. Hyödynmaa and B.K. Lind, Comparison of the dose-mass-histogram (DMH) and dose-volume-histogram (DVH) concepts in predicting radiation induced pneumonitis from breast cancer radiotherapy. Proceedings in 25th ESTRO Meeting, Leipzig, Germany, October 8-12, 2006Radiother. Oncol. 81 (Suppl. 1) pp. 281, 2006

34.29. K. Hatziioannou, G. Komisopoulos, D. Misailidou, P. Plataniotis, B.K. Lind and P. Mavroidis , Statistical methods for determination and validation of dose-response relations from clinical patient datasets. Proceedings in 25th ESTRO Meeting, Leipzig, Germany, October 8-12, 2006Radiother. Oncol. 81 (Suppl. 1) pp. 415, 2006

34.30. G. Komisopoulos, M. Al-Abany, G. Plataniotis, A. Helgasson, A.K. Ågren Cronqvist, P. Wersäll, B.K. Lind, G. Steineck and P. Mavroidis , Comparison of dose-response relations of anal sphincter and anal canal regarding the radiation effects of faecal leakage and blood or phlegm in stools from prostate cancer radiotherapy. Proceedings in 25th ESTRO Meeting, Leipzig, Germany, October 8-12, 2006Radiother. Oncol. 81 (Suppl. 1) pp. 441, 2006

34.31. B. Andisheh, M.A. Bitaraf, B.K. Lind, P. Mavroidis and A. Brahme, Evaluation of effective number of crucial vessels in arteriovenous malformation nidus based on clinical data and binomial modeling. Proceedings in 8th Bi-Annual Congress of the Stereotactic Radiosurgery Society (ISRS), San Francisco, USA, June 23-27, 2007

34.32. M. Adamus-Górka, P. Mavroidis, A. Brahme and B.K. Lind, An “Effective functional subunit size” model for the dose response of rat spinal cord paralysis. Proceedings in 13th International Congress of Radiation Research in San Francisco, USA, 8-12 July 2007

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34.33. P. Mavroidis, B.C. Ferreira, C. Shi, B.K. Lind, S. Stathakis and N. Papanikolaou, Comparing the expected effectiveness of Helical Tomotherapy and MLC-based IMRT using biological measures. Proceedings in 49th AAPM Annual Meeting, Minneapolis, Minnesota, USA, July 22-26, 2007 Med. Phys. 34 (6) pp. 2550-2550, 2007

34.34. P. Mavroidis, B.C. Ferreira, N. Papanikolaou, R. Svensson, B.K. Lind and A. Brahme, Expected clinical impact of the differences between planned and delivered IMRT dose distributions. Proceedings in 49th AAPM Annual Meeting, Minneapolis, Minnesota, USA, July 22-26, 2007Med. Phys. 34 (6) pp. 2452-2452, 2007

34.35. S. Stathakis, V. Sarkar, P. Rassiah-Szegedi, P. Mavroidis and N. Papanikolaou, Monte Carlo based dose verification for Serial Tomotherapy.Proceedings in 49th AAPM Annual Meeting, Minneapolis, Minnesota, USA, July 22-26, 2007Med. Phys. 34 (6) pp. 2470-2470, 2007

34.36. N. Papanikolaou, C. Eller, C. Esquivel, C. Shi, P. Mavroidis and S. Stathakis, Investigation of the use of transmission type detectors for daily IMRT patient dose reconstruction. Proceedings in 49th AAPM Annual Meeting, Minneapolis, Minnesota, USA, July 22-26, 2007Med. Phys. 34 (6) pp. 2464-2465, 2007

34.37. P. Mavroidis, B.C. Ferreira, S. Hyödynmaa, M.A. Pitkänen, J. Rajala, N. Papanikolaou, B.K. Lind, The impact of patient positioning, breathing and radiation pneumonitis scoring in the optimization of breast cancer radiotherapy.Proceedings in 9th Biennial ESTRO Meeting, Barcelona, Spain, September 8-13, 2007Radiother. Oncol. 84 (Suppl. 1) pp. 282, 2007

34.38. N. Papanikolaou, B.C. Ferreira, C. Shi, B.K. Lind, P. Mavroidis, Expected effectiveness of Conformal, Helical Tomotherapy and MLC-based IMRT in lung cancer radiotherapy.Proceedings in 9th Biennial ESTRO Meeting, Barcelona, Spain, September 8-13, 2007Radiother. Oncol. 84 (Suppl. 1) pp. 277, 2007

34.39. S. Stathakis, P. Mavroidis, N. Papanikolaou, Evaluation of dose delivery variations in Helical Tomotherapy using Helical megavoltage CT images.Proceedings in 9th Biennial ESTRO Meeting, Barcelona, Spain, September 8-13, 2007Radiother. Oncol. 84 (Suppl. 1) pp. 187, 2007

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34.40. M. Adamus-Górka, A. Brahme, P. Mavroidis, B.K. Lind, Determination of the dose-response relations of thoracic and cervical myelopathy from external radiotherapy.Proceedings in 9th Biennial ESTRO Meeting, Barcelona, Spain, September 8-13, 2007Radiother. Oncol. 84 (Suppl. 1) pp. 156, 2007

34.41. B. Andisheh, P. Mavroidis, B.K. Lind, M.A. Bitaraf, A. Brahme, Estimation of the effective number of crucial vessels in arteriovenous malformation nidus based on clinical data and binomial modeling.Proceedings in 9th Biennial ESTRO Meeting, Barcelona, Spain, September 8-13, 2007Radiother. Oncol. 84 (Suppl. 1) pp. 264, 2007

34.42. C. Shi, S. Stathakis, C. Ramer, V. Sarkar, D. Giantsoudi, P. Mavroidis and N. Papanikolaou, Treatment setup uncertainties as quantified based on daily megavoltage (MV) CT imaging. Proceedings in 9th Biennial ESTRO Meeting, Barcelona, Spain, September 8-13, 2007Radiother. Oncol. 84 (Suppl. 1) pp. 180, 2007

34.43. G. Swanson, S. Stathakis, S. Su, C. Shi, P. Mavroidis and N. Papanikolaou, Treatment planning for prostate: a quantitative comparison between 3DRTP and three IMRT delivery techniques.Proceedings in 9th Biennial ESTRO Meeting, Barcelona, Spain, September 8-13, 2007Radiother. Oncol. 84 (Suppl. 1) pp. 199, 2007

34.44. P. Mavroidis, N. Papanikolaou, S. Axelsson, S. Hyödynmaa, J. Rajala, M.A. Pitkänen, B.K. Lind, A. Brahme, Expected risk for radiation pneumonitis from breast cancer radiotherapy taking into account breathing and setup uncertainties.Proceedings in Annual RSNA Meeting, Chicago, USA, November 25-30, 2007

34.45. B. Andisheh, M.A. Bitaraf, B.K. Lind, P. Mavroidis and A. Brahme, Evaluation of the effective number of critical vessels inside arterio-venous malformation based on clinical data and binomial modelling. Proceedings in 14th International Meeting Leksell Gamma Knife Society, Quebec, Canada, May 18-22, 2008

34.46. M. Adamus-Górka, A. Brahme, P. Mavroidis and B.K. Lind, Dose-response parameters for thoracic and cervical myelopathy after external radiotherapy.50th AAPM Annual Meeting, Houston, Texas, USA, July 27-31, 2008Med. Phys. 35 (6) pp. 2816-2816, 2008

34.47. F.C. Su, C. Shi, P. Mavroidis and N. Papanikolaou, Radiobiological evaluation on the four-dimensional stereotactic radiotherapy plan. 50th AAPM Annual Meeting, Houston, Texas, USA, July 27-31, 2008 Med. Phys. 35 (6) pp. 2824-2824, 2008

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34.48. F.C. Su, P. Mavroidis, G. Swanson, C. Buckey, S. Stathakis and N. Papanikolaou, Radiobiological-based comparisons among conventional radiotherapy and IMRT delivery techniques for prostate treatment planning.50th AAPM Annual Meeting, Houston, Texas, USA, July 27-31, 2008Med. Phys. 35 (6) pp. 2821-2821, 2008

34.49. S. Hyödynmaa, P. Mavroidis, B. Costa Ferreira, S. Axelsson, N. Papanikolaou and B.K. Lind, Radiobiological optimization of breast cancer radiotherapy taking into account patient positioning, breathing and radiation pneumonitis scoring. 50th AAPM Annual Meeting, Houston, Texas, USA, July 27-31, 2008Med. Phys. 35 (6) pp. 2821-2821, 2008

34.50. G. Swanson, C. Shi, P. Mavroidis, S. Stathakis, F.C. Su, C. Ramer, V. Sarkar, B. Costa Ferreira, G. Komisopoulos, D. Giantsoudi, and N. Papanikolaou, Radiobiologically Quantified Treatment Setup Uncertainties based on Megavoltage (MV) CT Imaging. 50th AAPM Annual Meeting, Houston, Texas, USA, July 27-31, 2008Med. Phys. 35 (6) pp. 2822-2822, 2008

34.51. P. Mavroidis, G.A. Plataniotis, M. Adamus Górka, S. Hyödynmaa, N. Papanikolaou and B.K. Lind, Dose-mass-histogram (DMH) vs. dose-volume histogram (DVH) in predicting lung complications. 50th AAPM Annual Meeting, Houston, Texas, USA, July 27-31, 2008Med. Phys. 35 (6) pp. 2823-2823, 2008

34.52. P. Mavroidis, F.C. Su, D. Giantsoudi, S. Stathakis, G. Komisopoulos, C. Shi, G. Swanson and N. Papanikolaou, Radiobiological investigation of the dosimetric effects of daily Megavoltage CT registration techniques on adaptive radiotherapy with Helical Tomotherapy. 50th AAPM Annual Meeting, Houston, Texas, USA, July 27-31, 2008Med. Phys. 35 (6) pp. 2823-2823, 2008

34.53. M.G. Delichas, B. Costa Ferreira, C. Shi, A. Gutierrez, B.K. Lind, N. Papanikolaou and P. Mavroidis, Radiobiological effectiveness of 3D-Conformal Radiotherapy, MLC-based IMRT and Helical Tomotherapy in lung cancer. 50th AAPM Annual Meeting, Houston, Texas, USA, July 27-31, 2008Med. Phys. 35 (6) pp. 2821-2821, 2008

34.54. G. Komisopoulos, P. Mavroidis, N. Papanikolaou and B.K. Lind, Interpretation of the dosimetric results in terms of expected treatment outcome when optimizing treatment plans using different methods of regularizing dose inhomogeneity50th AAPM Annual Meeting, Houston, Texas, USA, July 27-31, 2008Med. Phys. 35 (6) pp. 2820-2820, 2008

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34.55. C. Esquivel, P. Mavroidis, C. Shi, B. Costa Ferreira, B.K. Lind, A. Gutierrez, S. Stathakis and N. Papanikolaou, Radiobiological comparison of Helical Tomotherapy and MLC-based IMRT for brain and cranio-spinal tumors.50th AAPM Annual Meeting, Houston, Texas, USA, July 27-31, 2008Med. Phys. 35 (6) pp. 2822-2822, 2008

34.56. N. Papanikolaou, S. Stathakis and P. Mavroidis, Expected Clinical Impact of the Differences between planned and delivered dose distributions in Helical Tomotherapy.50th AAPM Annual Meeting, Houston, Texas, USA, July 27-31, 2008Med. Phys. 35 (6) pp. 2937-2937, 2008

34.57. D. Giantsoudi, Y. Liu, A. Diaz, P. Mavroidis and N. Papanikolaou, Neutron energy and dose considerations of Cf-252 brachytherapy sources for various geometries.50th AAPM Annual Meeting, Houston, Texas, USA, July 27-31, 2008Med. Phys. 35 (6) pp. 2728-2728, 2008

34.58. S. Stathakis, A. Gutiérrez, P. Rassiah-Szegedi, P. Mavroidis and N. Papanikolaou, Commissioning of flattening filter free Varian 600C linear accelerator.50th AAPM Annual Meeting, Houston, Texas, USA, July 27-31, 2008Med. Phys. 35 (6) pp. 2781-2781, 2008

34.59. P. Desai, S. Stathakis, A. Gutiérrez, P. Mavroidis and N. Papanikolaou, Investigation of the transmission detectors for daily dose verification and QA of IMRT treatments.50th AAPM Annual Meeting, Houston, Texas, USA, July 27-31, 2008Med. Phys. 35 (6) pp. 2765-2765, 2008

34.60. S. Stathakis, A. Gutiérrez, P. Mavroidis and N. Papanikolaou, Dosimetric verification of the CCCS algorithm for spatially fractionate radiation therapy.50th AAPM Annual Meeting, Houston, Texas, USA, July 27-31, 2008Med. Phys. 35 (6) pp. 2888-2888, 2008

34.61. M.G. Delichas, P. Mavroidis, B. Costa Ferreira, C. Shi, A. Gutierrez, B.K. Lind, N. Papanikolaou and C. Ha, Comparison of 3D-CRT, MLC-Based IMRT and Helical Tomotherapy for Lung Cancer Radiotherapy.50th ASTRO Annual Meeting, Boston, MA, USA, September 21-25, 2008

34.62. G. Komisopoulos, P. Mavroidis, N. Papanikolaou and B.K. Lind, Inhomogeneity regularization methods in treatment plan optimization.50th ASTRO Annual Meeting, Boston, MA, USA, September 21-25, 2008

34.63. A. Gutierrez, P. Mavroidis, F.C. Su, D. Giantsoudi, S. Stathakis, G. Komisopoulos, C. Shi, G. Swanson, C. Ha and N. Papanikolaou, Daily Megavoltage CT registration on adaptive radiotherapy with Helical Tomotherapy. 50th ASTRO Annual Meeting, Boston, MA, USA, September 21-25, 2008

34.64. N. Papanikolaou, S. Stathakis, P. Mavroidis and C. Ha, Patient setup correction in

41


treating head and neck cancer with Helical Tomotherapy.50th ASTRO Annual Meeting, Boston, MA, USA, September 21-25, 2008

34.65. C. Shi, P. Mavroidis, C. Esquivel, B. Costa Ferreira, A. Diaz, N. Papanikolaou, Brain and cranio-spinal cancer treatment using Helical Tomotherapy and MLC-based IMRT.50th ASTRO Annual Meeting, Boston, MA, USA, September 21-25, 2008

34.66. S. Stathakis, C. Shi, P. Mavroidis, G. Swanson, C. Ramer, V. Sarkar, B. Costa Ferreira, G. Komisopoulos, D. Giantsoudi and N. Papanikolaou, Use of Megavoltage CT imaging for quantifying treatment setup uncertainties 50th ASTRO Annual Meeting, Boston, MA, USA, September 21-25, 2008

34.67. F. Su, P. Mavroidis, C. Shi, S. Stathakis and N. Papanikolaou, Treatment planning for prostate cancer: biologically quantitative comparisons among conventional radiotherapy and three IMRT delivery techniques.50th ASTRO Annual Meeting, Boston, MA, USA, September 21-25, 2008

34.68. C. Buckey, S. Stathakis, G. Swanson, P. Mavroidis, F.C. Su and N. Papanikolaou, Are current IMRT plans superior to 3d conformal therapy for prostate cancer? A dosimetric comparison.50th ASTRO Annual Meeting, Boston, MA, USA, September 21-25, 2008

34.69. M. Adamus-Górka, P. Mavroidis, A. Brahme and B.K. Lind, Analysis of the dose-response relation of rat spinal cord paralysis using an “effective functional subunit size” model. 27th ESTRO Annual Meeting, Göteborg, Sweden, September 14-18, 2008

34.70. E. Alevronta, A. Ahlberg, P. Mavroidis, M. al-Abany, S. Friesland, A. Tilikidis, G.C. Sakellaropoulos, G.C. Nikiforidis, G. Laurell and B.K. Lind, Dose-response parameters of stricture in the proximal esophagus from head & neck radiotherapy.27th ESTRO Annual Meeting, Göteborg, Sweden, September 14-18, 2008

34.71. A. Ahlberg, M. al-Abany, E. Alevronta, P. Mavroidis, S. Friesland, A. Tilikidis, B.K. Lind and G. Laurell, Determination of a dose threshold regarding esophageal stricture from head & neck radiotherapy.27th ESTRO Annual Meeting, Göteborg, Sweden, September 14-18, 2008

34.72. B. Andisheh, P. Mavroidis, B.K. Lind, M.A. Bitaraf and A. Brahme, Evaluation of stereotactic light ion radiation therapy regarding the treatment of large intracranial arteriovenous malformations.27th ESTRO Annual Meeting, Göteborg, Sweden, September 14-18, 2008

34.73. B. Costa Ferreira, P. Mavroidis, M. Adamus-Górka, R. Svensson and B.K. Lind, Varying dose-response parameters in the biological optimization of breast cancer IMRT.27th ESTRO Annual Meeting, Göteborg, Sweden, September 14-18, 2008

34.74. C. Buckey, S. Stathakis, G. Swanson, P. Mavroidis, F.C. Su and N. Papanikolaou, Dosimetric comparison of prostate treatment modalities.

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27th ESTRO Annual Meeting, Göteborg, Sweden, September 14-18, 2008

34.75. M.G. Delichas, P. Mavroidis, B. Costa Ferreira, C. Shi, A. Gutierrez, B.K. Lind, N. Papanikolaou and C. Ha, Lung cancer radiotherapy using 3D-CRT, MLC-based IMRT and Helical Tomotherapy. 27th ESTRO Annual Meeting, Göteborg, Sweden, September 14-18, 2008

34.76. F. Su, C. Shi, P. Mavroidis, A. Gutierrez and N. Papanikolaou, Radiobiological evaluation on the four-dimensional stereotactic radiotherapy plan.27th ESTRO Annual Meeting, Göteborg, Sweden, September 14-18, 2008

34.77. B. Guo, Y. Liu, C. Shi, P. Mavroidis, C. Ha and N. Papanikolaou, Dose calculation for proton radiotherapy based on Monte Carlo simulation using anatomical detailed human model. 27th ESTRO Annual Meeting, Göteborg, Sweden, September 14-18, 2008

34.78. S. Hyödynmaa, P. Mavroidis, B. Costa Ferreira, S. Axelsson, N. Papanikolaou and B.K. Lind, Investigating the expected effects of patient positioning, breathing and radiation pneumonitis scoring in breast cancer radiotherapy.27th ESTRO Annual Meeting, Göteborg, Sweden, September 14-18, 2008

34.79. P. Karaiskos, P. Mavroidis, B. Costa Ferreira, N. Papanikolaou, P. Sandilos, E. Koutsouveli, C. Scarleas and K. Dardoufas, Investigating the impact of using CT vs CT-MRI images during organ delineation and treatment planning in prostate cancer radiotherapy.27th ESTRO Annual Meeting, Göteborg, Sweden, September 14-18, 2008

34.80. G. Komisopoulos, P. Mavroidis, N. Papanikolaou and B.K. Lind, Treatment plan optimization using different methods of dose inhomogeneity regularization.27th ESTRO Annual Meeting, Göteborg, Sweden, September 14-18, 2008

34.81. E. Koutsouveli, P. Mavroidis, P. Karaiskos, P. Sandilos, C. Stergiou and M. Torrens, Determination of the dose-response relations of acoustic neuromas after treatment with Gamma Knife.27th ESTRO Annual Meeting, Göteborg, Sweden, September 14-18, 2008

34.82. P. Mavroidis, F.C. Su, D. Giantsoudi, S. Stathakis, G. Komisopoulos, C. Shi, G. Swanson, C. Ha and N. Papanikolaou, Investigating the expected clinical impact of daily Megavoltage CT registration on adaptive radiotherapy with Helical Tomotherapy. 27th ESTRO Annual Meeting, Göteborg, Sweden, September 14-18, 2008

34.83. N. Papanikolaou, S. Stathakis, P. Mavroidis and C. Ha, Planned vs. Delivered Dose Distributions with and without Patient Setup Correction in Helical Tomotherapy.27th ESTRO Annual Meeting, Göteborg, Sweden, September 14-18, 2008

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34.84. G.A. Plataniotis, P. Mavroidis, M. Adamus Górka, S. Hyödynmaa, N. Papanikolaou and B.K. Lind, Association of dose-mass-histogram (DMH) with the expected lung complications from breast cancer radiotherapy. 27th ESTRO Annual Meeting, Göteborg, Sweden, September 14-18, 2008

34.85. T. Roland, P. Rassiah-Szegedi, M. Szegedi, P. Mavroidis and N. Papanikolaou, A phantom based investigation of the effects of MIP versus AIP derived internal target volumes on 4D treatment planning. 27th ESTRO Annual Meeting, Göteborg, Sweden, September 14-18, 2008

34.86. C. Shi, P. Mavroidis, C. Esquivel, B. Costa Ferreira, A. Diaz and N. Papanikolaou, Helical Tomotherapy and MLC-based IMRT in treating brain and cranio-spinal tumors.27th ESTRO Annual Meeting, Göteborg, Sweden, September 14-18, 2008

34.87. S. Stathakis, C. Shi, P. Mavroidis, G. Swanson, C. Ramer, V. Sarkar, B. Costa Ferreira, G. Komisopoulos, D. Giantsoudi and N. Papanikolaou, Treatment setup uncertainties quantified by megavoltage CT imaging. 27th ESTRO Annual Meeting, Göteborg, Sweden, September 14-18, 2008

34.88. A. Tzikas, P. Mavroidis, B.K. Lind and Anders Brahme, Software for clinical implementation of radiobiological treatment plan optimization.27th ESTRO Annual Meeting, Göteborg, Sweden, September 14-18, 2008

34.89. Y. Zhai, P. Mavroidis, C. Shi, J. Xu and N. Papanikolaou, Developing a new gamma evaluation index with biological information of organs.19th ACRO Annual Meeting, Las Vegas, Nevada, USA, February 26-28, 2009

34.90. F.C. Su, C. Shi, P. Mavroidis and N. Papanikolaou, Assessment of four-dimensional radiotherapy planning and respiratory motion induced dose difference based on radiological measures.19th ACRO Annual Meeting, Las Vegas, Nevada, USA, February 26-28, 2009

34.91. P. Mavroidis, A. Tzikas, N. Papanikolaou, S. Stathakis and B.K. Lind, Development of software for performing radiobiological studies and treatment plan optimization. 51rst AAPM Annual Meeting, Anaheim, California, USA, July 26-30, 2009

34.92. E. Koutsouveli, P. Mavroidis, P. Karaiskos, P. Sandilos, N. Papanikolaou, S. Stathakis, C. Stergiou and M. Torrens, Assessment of clinical response factors of acoustic neuromas after Gamma Knife treatment. 51rst AAPM Annual Meeting, Anaheim, California, USA, July 26-30, 2009

34.93. B. Andisheh, P. Mavroidis, A. Brahme, M.A. Bitaraf, N. Papanikolaou and B.K. Lind, Investigating the benefits of stereotactic light ion radiation therapy for treating large intracranial AVMs. 51rst AAPM Annual Meeting, Anaheim, California, USA, July 26-30, 2009

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34.94. C. Buckey, S. Stathakis, A. Gutiérrez, C. Esquivel, P. Mavroidis, D. Mihailidis and N. Papanikolaou, The inter- and intra-fraction reproducibility of three common IMRT delivery techniques. 51rst AAPM Annual Meeting, Anaheim, California, USA, July 26-30, 2009

34.95. Y. Liu, T. Roland, C. Shi, G. Swanson, P. Mavroidis and N Papanikolaou, Visibility study of fiducial marker for real-time MLC beam tracking delivery using MV fluence video. 51rst AAPM Annual Meeting, Anaheim, California, USA, July 26-30, 2009

34.96. F. Su, C. Shi, P. Mavroidis and N. Papanikolaou, Utilizing Radiobiological Measures and Planned Adaptive Software to Evaluate Adaptive Tomotherapy Plans for Lung Cancer Patients. 51rst AAPM Annual Meeting, Anaheim, California, USA, July 26-30, 2009

34.97. T. Roland, C. Shi, Y. Liu, P. Mavroidis and N. Papanikolaou, Evaluation of tracking versus conventional delivery for lung cancer radiotherapy via 4D treatment planning. 51rst AAPM Annual Meeting, Anaheim, California, USA, July 26-30, 2009

34.98. T. Roland, C. Shi, Y. Liu, S. Stathakis, P. Mavroidis and N. Papanikolaou, Tracking versus gating for lung cancer radiotherapy. A retrospective study involving 5 patient 4DCT data sets. 51rst AAPM Annual Meeting, Anaheim, California, USA, July 26-30, 2009

34.99. N. Papanikolaou, O. Calvo, P. Mavroidis, E. Dzintars, D. Mihailidis and S. Stathakis, DVM vs. DMH in lung cancer radiotherapy. 51rst AAPM Annual Meeting, Anaheim, California, USA, July 26-30, 2009

34.100. S. Stathakis*, C. Buckey, P. Mavroidis, G. Swanson, D. Mihailidis and N. Papanikolaou, Is IMRT better than 3D conformal therapy for prostate cancer? A radiobiological comparison. 51rst AAPM Annual Meeting, Anaheim, California, USA, July 26-30, 2009

34.101. S. Stathakis*, C. Buckey, A. Gutiérrez, P. Mavroidis, C. Esquivel, C. Shi, D. Mihailidis and N. Papanikolaou, Dosimetric Evalualtion of a Commercial Compensator for Spatially Fractionated Radiation Therapy. 51rst AAPM Annual Meeting, Anaheim, California, USA, July 26-30, 2009

34.102. E. Dzintars, P. Mavroidis, S. Stathakis, C. Shi, A. Gutiérrez, C. Esquivel, F. Su and N. Papanikolaou*, Radiobiological evaluation of inhomogenity corrections in tissue for lung cancer patients. 51rst AAPM Annual Meeting, Anaheim, California, USA, July 26-30, 2009

34.103. L. Vazquez*, A. Gutiérrez, S. Stathakis, T. Roland, C. Esquivel, C. Shi, P. Mavroidis and N. Papanikolaou, Dosimetric comparison among 3D conformal, IMRT, and phase-average compensators for SBRT treatment planning. 51rst AAPM Annual Meeting, Anaheim, California, USA, July 26-30, 2009

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34.104. O. Calvo*, A. Gutiérrez, S. Stathakis, P. Mavroidis, S. Moral, C. Esquivel, C. Shi and N. Papanikolaou, Validation of the Delta4 dosimetry phantom against ionometric measurements. 51rst AAPM Annual Meeting, Anaheim, California, USA, July 26-30, 2009

34.105. O. Calvo*, S. Stathakis, A. Gutiérrez, P. Mavroidis, S. Moral, C. Esquivel, C. Shi and N. Papanikolaou, Characterization of small volume ion chambers for absolute dosimetry. 51rst AAPM Annual Meeting, Anaheim, California, USA, July 26-30, 2009

34.106. S. Rodriguez*, F. Su, C. Shi, S. Stathakis, A. Gutiérrez, C. Esquivel, P. Mavroidis and N Papanikolaou, Comparison of Helical Tomotherapy, MLC-based IMRT, and 3D-Conformal radiation modalities in BEUD utilization and analysis. 51rst AAPM Annual Meeting, Anaheim, California, USA, July 26-30, 2009

34.107. J. Xu*, C. Buckey, G. Swanson, S. Stathakis, C. Esquivel, A. Gutiérrez, C. Shi, P. Mavroidis and N. Papanikolaou, Impact of proper bladder and rectum delineation in the evaluation of the effectiveness of IMRT in prostate cancer radiotherapy. 51rst AAPM Annual Meeting, Anaheim, California, USA, July 26-30, 2009

34.108. P. Tynan*, S. Stathakis, P. Mavroidis and N. Papanikolaou, Comparison of Commercial 2D and 3D Devices for Patient-Specific IMRT QA. 51rst AAPM Annual Meeting, Anaheim, California, USA, July 26-30, 2009

34.109. P. Tynan*, M. Joyner, M. Smith, A. Gutiérrez, S. Stathakis, P. Mavroidis, N. Papanikolaou and G. Swanson, Comparison of Pre- and Post-Implant Prostate Volume Segmentation Using Trans-Rectal Ultrasound and Computed Tomography. 51rst AAPM Annual Meeting, Anaheim, California, USA, July 26-30, 2009

34.110. N. Papanikolaou*, Y. Liu, T. Roland, P. Mavroidis and C. Shi, Measurements of Fiducial marker positions for real-time MLC beam tracking delivery using MV fluence video. 51rst AAPM Annual Meeting, Anaheim, California, USA, July 26-30, 2009

34.111. P. Mavroidis*, G. Soulimioti, K. Sotiriadou, N Papanikolaou and B.K. Lind, Clinical aspects of the BEUD, EUD, Deff and gEUD biological doses. ECCO 15 – ESMO 34th Multidisciplinary Congress, Berlin, Germany, September 20-24, 2009

34.112. G. Komisopoulos, K. Sotiriadou*, G. Soulimioti, N. Papanikolaou, B.K. Lind and P. Mavroidis, Demonstration of dose-response relations for a series of tumors and normal tissues after external radiotherapy. ECCO 15 – ESMO 34th Multidisciplinary Congress, Berlin, Germany, September 20-24, 2009

34.113. G. Soulimioti*, K. Sotiriadou, P. Mavroidis and G. Kyrgias, Radiotherapy of pituitary’s adenomas.

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34th Neuroradiology Annual Meeting, Athens, Greece, September 17-20, 2009

34.114. D. Baltas*, Z. Katsilieri, V. Kefala, S. Papaioannou, A. Karabis, P. Mavroidis and N. Zamboglou, Influence of Modulation Restriction in Inverse Optimization with HIPO of Prostate Implants on Plan Quality: Analysis using Dosimetric and Radiobiological Indices. World Congress in Medical Physics and Biomedical Engineering, Munich, Germany, September 7-12, 2009

34.115. P. Mavroidis*, B. Costa Ferreira, N. Papanikolaou, R. Svensson, B.K. Lind and A. Brahme, Radiobiological analysis of planned and delivered IMRT dose distributions. World Congress in Medical Physics and Biomedical Engineering, Munich, Germany, September 7-12, 2009

34.116. F. Su*, C. Shi, P. Mavroidis, V. Goytia, R. Crownover, P. Rassiah-Szegedi, D. Baltas and N. Papanikolaou, Evaluation on Lung Cancer Patients’ Four-dimensional Treatment Plans Utilizing Biologically Effective Uniform Dose. World Congress in Medical Physics and Biomedical Engineering, Munich, Germany, September 7-12, 2009

34.117. P. Mavroidis*, Biological Model-Based IMRT Plan Optimization. World Congress in Medical Physics and Biomedical Engineering, Munich, Germany, September 7 – 12, 2009

34.118. P. Mavroidis, N. Papanikolaou and B.K. Lind, The BEUD, EUD, Deff and gEUD biological doses in treatment planning. 51rst ASTRO Annual Meeting, Chicago, IL, USA, November 1-5, 2009

34.119. T. Roland, P. Mavroidis and N. Papanikolaou, A radiobiological assessment of the clinical improvement when tumor tracking versus conventional techniques is used for lung cancer radiotherapy. 51rst ASTRO Annual Meeting, Chicago, IL, USA, November 1-5, 2009

34.120. I. Chalimou, H. Lind, P. Mavroidis, G.C. Sakellaropoulos, G.C. Nikiforidis, N. Papanikolaou and B.K. Lind, Treatment strategies in radiotherapy for advanced non-small cell lung cancer: Differences in attitude in Europe. 51rst ASTRO Annual Meeting, Chicago, IL, USA, November 1-5, 2009

34.121. G. Komisopoulos, P. Mavroidis, B. Costa Ferreira, N. Papanikolaou, S. Stathakis, G.A. Plataniotis and B.K. Lind, Dose-response parameters for different tumors and normal tissues. 51rst ASTRO Annual Meeting, Chicago, IL, USA, November 1-5, 2009

34.122. N. Papanikolaou, B.K. Lind, S. Stathakis, P. Mavroidis, Determination and clinical verification of dose-response relations from patient databases. 51rst ASTRO Annual Meeting, Chicago, IL, USA, November 1-5, 2009

34.123. C.R. Buckey*, P. Mavroidis, G. Swanson, S. Stathakis, N. Papanikolaou, Impact of proper bladder and rectum delineation in the evaluation of the effectiveness of

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IMRT in prostate cancer radiotherapy. 51rst ASTRO Annual Meeting, Chicago, IL, USA, November 1-5, 2009

34.124. S. Rodriguez, F. Su, P. Mavroidis, A. Gutiérrez, S. Stathakis, C. Esquivel, C. Shi, N. Papanikolaou, BEUD analysis and secondary malignancy risk: Radiobiological comparison of HT, MLC-based IMRT, and CRT. Proceedings in Annual RSNA Meeting, Chicago, USA, Nov. 29 - Dec. 4, 2009

34.125. Fan-Chi Su, P. Mavroidis and N. Papanikolaou, The application of the radiobiological evaluation on adaptive tomotherapy for lung cancer patients. Proceedings in Annual RSNA Meeting, Chicago, USA, Nov. 29 - Dec. 4, 2009

34.126. M. Torrens, E. Koutsouveli, P. Karaiskos, P. Sandilos and P. Mavroidis, Significance of dose in relation to response rate and hearing preservation during vestibular schwannoma radiosurgery.XIV World Congress of Neurological Surgery, Boston, Massachusetts, USA, Aug. 30 – Sept. 4, 2009

34.127. P. Mavroidis, N. Papanikolaou and B.K. Lind, Comparison of the Biologically Effective Uniform Dose, Equivalent Uniform Dose, Effective Dose and Generalized Equivalent Uniform Dose concepts. 10th Biennial ESTRO Meeting, Maastrich, The Netherlands, Aug. 30 – Sept. 3, 2009

34.128. E. Alevronta, H. Lind, B.K. Lind, M. Al-Abany, A.C. Waldenstrom, C. Olsson, G. Dunberger, P. Mavroidis, T. Nyberg, A.K. Johansson, E. Åvall-Lundqvist and G. Steineck, Dose-effect relationships for organs-at-risk related to long-lasting complete fecal evacuation without premonition. 10th Biennial ESTRO Meeting, Maastrich, The Netherlands, Aug. 30 – Sept. 3, 2009

34.129. B. Andisheh, P. Mavroidis and B.K. Lind, Is there an appropriate model for stereotactic high dose body radiotherapy? Review of different models and evaluation of their accuracy. 10th Biennial ESTRO Meeting, Maastrich, The Netherlands, Aug. 30 – Sept. 3, 2009

34.130. B. Costa Ferreira, P. Mavroidis and M. do Carmo Lopes, Analysis of fractionation correction methodologies for radiation therapy based on multiple treatment plans. 10th Biennial ESTRO Meeting, Maastrich, The Netherlands, Aug. 30 – Sept. 3, 2009

34.131. F. Su, P. Mavroidis and N. Papanikolaou, A radiobiological-based toolkit for treatment plan evaluation and outcome prediction. 10th Biennial ESTRO Meeting, Maastrich, The Netherlands, Aug. 30 – Sept. 3, 2009

34.132. P. Karaiskos, P. Mavroidis, B. Costa Ferreira, N. Papanikolaou, P. Sandilos, E. Koutsouveli, C. Scarleas and K. Dardoufas, Investigating the impact of

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using CT vs. CT-MRI images during organ delineation and treatment planning in prostate cancer radiotherapy. 10th Biennial ESTRO Meeting, Maastrich, The Netherlands, Aug. 30 – Sept. 3, 2009

34.133. E. Koutsouveli, P. Mavroidis, P. Karaiskos, P. Sandilos, C. Stergiou, B. Andisheh, N. Papanikolaou, B.K. Lind and M. Torrens, Analysis of acoustic neuromas response and cochlear complications after treatment with Gamma Knife. 10th Biennial ESTRO Meeting, Maastrich, The Netherlands, Aug. 30 – Sept. 3, 2009

34.134. C. Shi, P. Mavroidis, Y. Zhai, J. Xu, B.K. Lind and N. Papanikolaou, Evaluation of IMRT dose delivery using the concepts of Gamma Index and Biologically Effective Uniform Dose. 10th Biennial ESTRO Meeting, Maastrich, The Netherlands, Aug. 30 – Sept. 3, 2009

34.135. T. Roland, P. Mavroidis, S. Stathakis, A. Gutierrez and N. Papanikolaou, Analysis of 4D tumor tracking radiotherapy for mobile tumors using radiobiological measurements. 10th Biennial ESTRO Meeting, Maastrich, The Netherlands, Aug. 30 – Sept. 3, 2009

34.136. A. Tzikas, P. Mavroidis, N. Papanikolaou, S. Stathakis and B.K. Lind, Clinical implementation of radiobiological treatment plan optimization using a database and calculation module integrated to a treatment planning system. 10th Biennial ESTRO Meeting, Maastrich, The Netherlands, Aug. 30 – Sept. 3, 2009

34.137. E. Asteinidou, P. Mavroidis, H. van der Est, P.C. Levendag , B.J. Heijmen, Choosing an Intensity-Modulated Radiation Therapy Technique in the Treatment of Head-and-Neck Cancer based on radiobiological criteria. 10th Biennial ESTRO Meeting, Maastrich, The Netherlands, Aug. 30 – Sept. 3, 2009

34.138. S. Rodriguez, F. Su, P. Mavroidis, A. Gutiérrez, S. Stathakis, C. Esquivel, C. Shi, N. Papanikolaou, BEUD/Secondary Malignancy Analysis: Comparison of HT, MLC-based IMRT, and CRT in Prostate Treatment Planning. 10th Biennial ESTRO Meeting, Maastrich, The Netherlands, Aug. 30 – Sept. 3, 2009

34.139. C.R. Buckey*, S. Stathakis, A.N. Gutiérrez, P. Mavroidis, C. Esquivel, C. Shi, D.N. Mihailidis, N. Papanikolaou, Dosimetric evaluation of a grid compensator for spatially fractionated radiation therapy. 10th Biennial ESTRO Meeting, Maastrich, The Netherlands, Aug. 30 – Sept. 3, 2009

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34.140. S. Stathakis*, P. Mavroidis, C. Buckey, G. Swanson, A. Gutierrez, C. Esquivel, N. Papanikolaou, IMRT vs. 3D conformal therapy for prostate cancer. A radiobiological comparison. 10th Biennial ESTRO Meeting, Maastrich, The Netherlands, Aug. 30 – Sept. 3, 2009

34.141. F. Su, C. Shi, P. Mavroidis and N. Papanikolaou, Utilizing Planned Adaptive Module and Radiobiological Measures to Evaluate Helical Tomotherapy for Lung Cancer Patients. SWAAPM Spring Meeting, San Antonio, Texas, USA, March 26 – 28, 2009

34.142. S. Rodriguez, P. Mavroidis and N. Papanikolaou, Comparison of Helical Tomotherapy, MLC-based IMRT, and 3D-Conformal radiation modalities in BEUD utilization and analysis. SWAAPM Spring Meeting, San Antonio, Texas, USA, March 26 – 28, 2009

35. Presentations in National Conferences – Abstracts

35.1. Applications of Laser in Medicine I.A. Vlachodimitris, S. Karveli, G. Papagiannis, I. Pezikoglou, P. Mavroidis Proceedings of the 11th Scientific Conference of Medical Students of Greece, Alexandroupolis, May 13-15, 2005, pp. 133

35.2. Operation Principles of PET SCANNER and Clinical Applications S. Paschou, A. Pavlidis, E. Soga, P. Georgoulias, P. Mavroidis Proceedings of the 11th Scientific Conference of Medical Students of Greece, Alexandroupolis, May 13-15, 2005, pp. 134

35.3. Radiobiological approach of radiation pneumonitis in breast cancer radiotherapy Ι. Tsougos, P. Mavroidis, Κ. Theodorou, Κ. Kappas Proceedings of the 1rst Hellenic Conference of Basic Medical Sciences, Athens, December 7-10, 2005, pp. ΡΟ33

35.4. Ιστογράμματα δόσης-μάζας (DMH) και ιστογράμματα δόσης-όγκου (DVH) για την πρόβλεψη ακτινικής πνευμονίτιδας από την ακτινοθεραπεία καρκίνου του μαστού.Παναγιώτης Μαυροειδής, Γεώργιος Α. Πλατανιώτης, Ελευθερία Αλέβροντα, Κωνσταντινιά Σωτηριάδου, Magdalena Adamus Górka, Simo Hyödynmaa, Bengt K. Lind Πρακτικά του 9ου Πανελλήνιου Συνεδρίου Ακτινοθεραπευτικής Ογκολογίας, Αλεξανδρούπολη, Ιούνιος 19-22, 2008

35.5. Χρήση ακτινοβιολογικών παραμέτρων για τη σύγκριση της δραστικότητας μεταξύ της ελικοειδούς τομοθεραπείας και της διαμορφούμενης έντασης ακτινοθεραπείας με χρήση πολύφυλλων κατευθυντήρων.Παναγιώτης Μαυροειδής, Brigida Costa Ferreira, Μιλτιάδης Δεληχάς, Γεωργία Σουλιμιώτη, Chengyu Shi, Bengt K. Lind, Νίκος Παπανικολάου Πρακτικά του 9ου Πανελλήνιου Συνεδρίου Ακτινοθεραπευτικής Ογκολογίας, Αλεξανδρούπολη, Ιούνιος 19-22, 2008

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35.6. Σύγκριση της σύμμορφης ακτινοθεραπείας, της ελικοειδούς τομοθεραπείας και της διαμορφούμενης έντασης ακτινοθεραπείας με χρήση πολύφυλλων κατευθυντήρων για τη θεραπεία καρκίνου του πνεύμονα.Παναγιώτης Μαυροειδής, Brigida Costa Ferreira, Μιλτιάδης Δεληχάς, Γεωργία Σουλιμιώτη, Chengyu Shi, Bengt K. Lind, Νίκος Παπανικολάου Πρακτικά του 9ου Πανελλήνιου Συνεδρίου Ακτινοθεραπευτικής Ογκολογίας, Αλεξανδρούπολη, Ιούνιος 19-22, 2008

35.7. Χρήση μοντέλων κλινικής ακτινοβιολογίας στη βελτιστοποίηση του σχεδιασμού πλάνου ακτινοθεραπείας.Παναγιώτης Μαυροειδής, Aικατερίνη Oικονόμη, Simo Hyödynmaa, Γεώργιος Α. Πλατανιώτης, Βengt Κ. Lind Πρακτικά του 9ου Πανελλήνιου Συνεδρίου Ακτινοθεραπευτικής Ογκολογίας, Αλεξανδρούπολη, Ιούνιος 19-22, 2008

35.8. Παράμετροι δόσης-απόκρισης για στένωση στον τραχηλικό οισοφάγο από ακτινοθεραπεία καρκινωμάτων κεφαλής και τραχήλου.Παναγιώτης Μαυροειδής, Göran Laurell, Γεώργιος Κομισόπουλος, Κωνσταντινιά Σωτηριάδου, Thomas Kraepelien, Jan-Olof Fernberg, Γεώργιος Α. Πλατανιώτης, Bengt K. Lind Πρακτικά του 9ου Πανελλήνιου Συνεδρίου Ακτινοθεραπευτικής Ογκολογίας, Αλεξανδρούπολη, Ιούνιος 19-22, 2008

35.9. Ανάλυση κλινικών δεδομένων σχετικά με την εμφάνιση στένωσης στον τραχηλικό οισοφάγο μετά από ακτινοθεραπεία νεοπλασμάτων κεφαλής και τραχήλου.Παναγιώτης Μαυροειδής, Göran Laurell, Γεώργιος Κομισόπουλος, Κυριακή Θεοδώρου, Κωνσταντίνος Κάππας, Thomas Kraepelien, Jan-Olof Fernberg, Bengt K. Lind, Γεώργιος Α. Πλατανιώτης Πρακτικά του 9ου Πανελλήνιου Συνεδρίου Ακτινοθεραπευτικής Ογκολογίας, Αλεξανδρούπολη, Ιούνιος 19-22, 2008

35.10. Διερεύνηση για τον προσδιορισμό ενός κατωφλίου δόσεων για χαμηλό κίνδυνο επιπλοκών στην περιοχή του σφιγκτήρα και του ορθού. Ακτινοθεραπεία αδενοκαρκινώματος του προστάτη.Παναγιώτης Μαυροειδής, Massoud al-Abany, Θεόφιλος Τοπαλτζίκης, Ásgeir R. Helgason, Anna-Karin Ågren Cronqvist, Peter Wersäll, Helena Lind, Eva Qvanta, Bengt K. Lind, Γεώργιος Α. Πλατανιώτης, Gunnar Steineck Πρακτικά του 9ου Πανελλήνιου Συνεδρίου Ακτινοθεραπευτικής Ογκολογίας, Αλεξανδρούπολη, Ιούνιος 19-22, 2008

35.11. Hög esofagusstriktur hos huvud- och halscancerpatienter efter strålbehandling.A. Ahlberg, M. al-Abany, E. Alevronta, P. Mavroidis, S. Friesland, A. Tilikidis, B.K. Lind and G. LaurellRiksstämman, Annual Meeting, Göteborg, Sweden, November 26-28, 2008

35.12. Όγκοι παρωτίδας και ακτινοθεραπεία.Γεωργία Σουλιμιώτη, Κωνσταντινιά Σωτηριάδου, Γεώργιος Κύργιας, Κωνσταντίνος Κάππας, Κυριακή Θεοδώρου, Παναγιώτης Μαυροειδής ,

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Γεώργιος Κομισόπουλος, Μαρία Μανώλη, Γεωργία Γκουγκουμάτη, Παναγιώτα Νάστου, Μαγδαλινή Κυπαρίσσου, Αγγέλα Κουκολέτσου, Βιολέτα Σαμαρά, Απόστολος Κωτσής Πρακτικά του 22ου Ιατρικού Ενόπλων Δυνάμεων, Θεσσαλονίκη, Νοέμβριος 6-9, 2008

35.13. Η χρήση της αξονικής τομογραφίας στο σχεδιασμό πλάνου ακτινοθεραπείας σε συμπαγείς όγκους.Γεωργία Σουλιμιώτη, Κωνσταντινιά Σωτηριάδου, Αλεξάνδρα Ρουπακιά, Παναγιώτης Μαυροειδής, Γεώργιος Κομισόπουλος, Γεώργιος Κύργιας, Ιωάννης Φεζουλίδης Πρακτικά του 18ου Διαπανεπιστημιακού Συνεδρίου Ακτινολογίας, Ιωάννινα, Νοέμβριος 14-16, 2008

35.14. Διερεύνηση των αναμενόμενων επιδράσεων των αβεβαιοτήτων από την τοποθέτηση του ασθενούς και την αναπνοή στην ακτινοθεραπεία καρκίνου του μαστού.Παναγιώτης Μαυροειδής, Αλεξάνδρα Ρουπακιά, Γεωργία Σουλιμιώτη Πρακτικά του 11ου Πανελλήνιου Συνεδρίου Μαστολογίας, Αθήνα, Απρίλιος 2-4, 2009

36. Citations from other authors – Without self-references

For the publication 25.1: Mavroidis P et al, J BUON 3, 257-64, 19971. Gaitanou M. MSc. Thesis. University of Patras, Patras, Greece, 20042. Alevronta E. MSc. Thesis. University of Patras, Patras, Greece, 2008

For the publication 25.2: Lind BK et al, Acta Oncol. 38, 787-98, 19991. Acta Oncol. 40 (6): 718-24, 20012. Radiother. Oncol. 72 (2): 129-38, 20043. Med. Dosim. 30 (1): 12-9, 20054. Physica Medica 23 (3-4): 115-25, 20075. Phys. Med. Biol. 53 (4): 1131-49, 20086. Progress in Biomedical Optics and Imaging - Proceedings of SPIE 6845, art. no.

68450O, 2008 7. Med. Phys. 35 (12): 5851-60, 2008 8. Progress in Biomedical Optics and Imaging - Proceedings of SPIE 6845, art. no.

68450O, 20089. Int. J. Radiat. Biol. 85 (3): 227-37, 200910. Acta Oncol. 48 (4): 614-17, 200911. Ten Haken RK. The optimization of IMRT. 7th Biennial ESTRO Meeting, Geneva,

Radiother. Oncol. 68: (Suppl 1), 200312. Alexander Bulinskia, Andrei Khrennikov. Generalization of the Critical Volume

NTCP model in the radiobiology. arXiv:math.PR/0504225 v1 11 Apr 200513. Eriksson K, Rehbinder H. Advanced tools for radiobiological evaluation and

optimization for treatment plans. RaySearch Laboratories. ICCR 200714. Tsougos I. Ph.D. Thesis, University of Thessaly, 200515. Axelsson S. MSc. Thesis. Stockhom University 200216. Gaitanou M. MSc. Thesis. University of Patras, Patras, Greece, 200417. Alevronta E. MSc. Thesis. University of Patras, Patras, Greece, 2008

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18. Su F. Ph.D. Thesis. University of Texas Health Sciences Center, 200919. Valianti C. MSc. Thesis. University of Patras, Patras, Greece, 200920. Boumpoutsi I. MSc. Thesis. University of Patras, Patras, Greece, 200921. Katsilieri Z. MSc. Thesis. University of Patras, Patras, Greece, 200922. Kefala V. MSc. Thesis. University of Patras, Patras, Greece, 200923. Chalimou I. MSc. Thesis. University of Patras, Patras, Greece, 2009

For the publication 25.3: Mavroidis P et al, Phys. Med. Biol. 45, 2459-81, 20001. Phys. Med. Biol. 47 (5): L3-L9, 20022. Acta Oncol. 42 (8): 852-64, 20033. Oncologia 26 (10): 17-27, 20034. Med. Phys. 31 (4): 734-43, 20045. Int. J. Radiat. Oncol. 64 (1): 189-96, 20066. Adamus-Górka M. MSc. Thesis. Stockholm University, 20017. Adamus-Górka M. Ph.D. Thesis. Stockholm University, 20088. Gaitanou M. MSc. Thesis. University of Patras, Patras, Greece, 20049. Alevronta E. MSc. Thesis. University of Patras, Patras, Greece, 200810. Webb S. Contemporary IMRT: Developing Physics and Clinical Implementation.

Institute of Physics Publishing (CRC press), 200411. AAPM Report No 85. Report of Task Group No. 65 of the radiation therapy

committee of the American Association of Physicists in Medicine, 200412. Expert Working Group on Radiation Oncology Services. The development of

radiation oncology services in Ireland. 200313. Su F. Ph.D. Thesis. University of Texas Health Sciences Center, 200914. Valianti C. MSc. Thesis. University of Patras, Patras, Greece, 200915. Boumpoutsi I. MSc. Thesis. University of Patras, Patras, Greece, 200916. Katsilieri Z. MSc. Thesis. University of Patras, Patras, Greece, 200917. Kefala V. MSc. Thesis. University of Patras, Patras, Greece, 200918. Chalimou I. MSc. Thesis. University of Patras, Patras, Greece, 2009

For the publication 25.4: Mavroidis P et al, Phys. Med. Biol. 46, 2607-30, 20011. Phys. Med. Biol. 47 (5): L3-L9, 20022. Med. Phys. 29 (7): 1447-55, 20023. Phys. Med. Biol. 47 (20): 3567-78, 20024. Phys. Med. Biol. 47 (20): 3579-89, 20025. Phys. Med. Biol. 48 (20): 3307-26, 20036. Phys. Med. Biol. 48 (21): 3521-42, 20037. Phys. Med. Biol. 49 (16): 3649-64, 20048. Med. Phys. 31 (9): 2711-20, 20049. Int. J. Radiat. Oncol. 60 (5): 1602-10, 200410. Phys. Med. Biol. 50 (12): 2765-77, 200511. Med. Dosim. 30 (1): 12-9, 200512. Phys. Med. Biol. 51 (13): R381-402, 200613. Phys. Med. Biol. 52 (1): 291-302, 200714. Phys. Med. Biol. 52 (7): 1831-43, 200715. Phys. Med. Biol. 52 (19): 5973-84, 200716. Acta Oncol. 47 (5): 917-27, 200817. Acta Oncol. 48 (4): 614-17, 200918. Journal of Global Optimization 42 (4) 587-607, 200819. Ferreira B. Ph.D. Thesis, Stockholm University, 2004

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20. Tsougos I. Ph.D. Thesis, University of Thessaly, 200521. Adamus-Górka M. MSc. Thesis. Stockholm University, 200122. Adamus-Górka M. Ph.D. Thesis. Stockholm University, 200823. Gaitanou M. MSc. Thesis. University of Patras, Patras, Greece, 200424. Koussi E. MSc. Thesis. University of Patras, Patras, Greece, 200725. Grout J. MSc. Thesis. University of Patras, Patras, Greece, 200726. Alevronta E. MSc. Thesis. University of Patras, Patras, Greece, 200827. Su F. Ph.D. Thesis. University of Texas Health Sciences Center, 200928. Valianti C. MSc. Thesis. University of Patras, Patras, Greece, 200929. Boumpoutsi I. MSc. Thesis. University of Patras, Patras, Greece, 200930. Katsilieri Z. MSc. Thesis. University of Patras, Patras, Greece, 200931. Kefala V. MSc. Thesis. University of Patras, Patras, Greece, 200932. Chalimou I. MSc. Thesis. University of Patras, Patras, Greece, 2009

For the publication 25.5: Mavroidis P et al, Phys. Med. Biol. 47, L3-9, 20021. Acta Oncol. 47 (5): 917-27, 20082. Alevronta E. MSc. Thesis. University of Patras, Patras, Greece, 20083. Valianti C. MSc. Thesis. University of Patras, Patras, Greece, 20094. Boumpoutsi I. MSc. Thesis. University of Patras, Patras, Greece, 20095. Katsilieri Z. MSc. Thesis. University of Patras, Patras, Greece, 20096. Kefala V. MSc. Thesis. University of Patras, Patras, Greece, 20097. Chalimou I. MSc. Thesis. University of Patras, Patras, Greece, 2009

For the publication 25.6: Mavroidis P et al, Phys. Med. Biol. 47, 2471-94, 20021. Med. Phys. 32 (3): 726-32, 20052. Can. J. Neurol. Sci. 33 (2): 189-94, 20063. Revue Neurologique 162 (12): 1189-203, 20064. Neurosurgery 60 (3): 443-51, 20075. Stereotact Funct Neurosurg 86: 191-9, 20086. Acta Oncol. 47 (5): 917-27, 20087. Revue Neurologique 164 (10): 787-92, 2008 8. European Journal of Medical Research 14 (3): 93-101, 20099. Canadian Journal of Neurological Sciences 36 (4): 500-503, 200910. Alevronta E. MSc. Thesis. University of Patras, Patras, Greece, 200811. N.R. Miller, F. Burton Walsh, W. Fletcher Hoyt, N.J. Newman. Walsh and Hoyt's

Clinical Neuro-ophthalmology. Lippincott Williams & Wilkins, 200512. IRSA® (International RadioSurgery Association) Radiosurgery Practice Guideline

Initiative. Practice Guideline Report #2-03. Stereotactic Radiosurgery for Patients with Intracranial Arteriovenous Malformations (AVM). IRSA 2003

For the publication 25.7: Mavroidis P et al, Acta Oncol. 41, 471-85, 20021. Technol. Cancer Res. T. 3 (6): 639-46, 20042. Med. Phys. 32 (1): 65-75, 20053. Cancer / Radiotherapie 9 (6-7): 414-21, 20054. Australasian Physical and Engineering Sciences in Medicine 31 (2): 110-21, 20085. 2007 IEEE/NIH Life Science Systems and Applications Workshop, LISA, art. no.

4400875, 23-6, 2008 6. Bulletin du Cancer 96 (1): 111-21, 2009 7. Ferreira B. Ph.D. Thesis, Stockholm University, 20048. Tsougos I. Ph.D. Thesis, University of Thessaly, 2005

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9. AAPM Report No 85. Report of Task Group No. 65 of the radiation therapy committee of the American Association of Physicists in Medicine, 2004

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353-5, 20057. Journal of Otolaryngology 35 (5): 327-31, 20068. Gastrointestinal Endoscopy 64 (5): 789-92, 20069. Gastrointestinal Endoscopy 64 (5): 822-8, 200610. Head and Neck 29 (1): 12-7, 200711. Nutrition in Clinical Practice 22 (1): 68-73, 200712. Head and Neck 29 (2): 137-42, 200713. Techniques in Gastrointestinal Endoscopy 9 (2): 74-83, 200714. Gastrointestinal Endoscopy 65 (4): 714-20, 200715. Giornale Italiano di Endoscopia Digestiva 30 (3): 265-7, 200716. American Journal of Otolaryngology - Head and Neck Medicine and Surgery 29 (1):

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