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MinervaAnestesiol.1990Nov;56(11):1413-7.

[Useofatracuriumforthepreventionoffasciculationsandsuccinylcholinemyalgiainathletesundergoingorthopedicsurgery].

[ArticleinItalian]

PaganiI,RamaioliF,AlbertarioF,MoraR,DionigiRV.

Source

ServiziodiAnestesiaeRianimazioneII,I.R.C.C.S.PoliclinicoS.Matteo,Pavia.

Abstract

TheAuthorsreporttheirclinicalexperienceabouttheuseofatracuriumbesylateinpreventingsuccinylcholine-inducedfasciculationsandpostoperativemyalgiasinfiftyathletes(ASAclass1),submittedtoarthroscopicmeniscectomy.Thepatientswerepretreatedwithatracurium5mgi.v.orsalinesolutioninadouble-blindfashion.After2.5minutes,succinylcholine1.3mg/kgwasadministered,andfasciculationswererecordedonascalerangingfrom0to3.Twenty-fourhoursaftersurgeryallsubjectswerequestionedaboutmyalgiasoccurrence,scoredbya0-3scale.Fasciculationsoccurredinallpatientswho

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receivedsalineandin44%ofthosetreatedwithatracurium.Myalgiasonthepostoperativedaywereobservedin80%ofpatientstreatedwithsalinesolution,butonlyin36%ofpatientswhoreceivedatracurium.Thedifferencebetweenatracuriumandsalinesolutionwasstatisticallysignificant(plessthan0.001)eitherforfasciculationsormyalgiasincidence.Thesefindingsshowthatatracurium5mgi.v.iseffectiveinpreventingsuccinylcholine-inducedfasciculationsandpostoperativemyalgias,andsuggestatracuriumasthedrugofchoiceforthispurpose,particularlyinmuscularsubjects.

PMID:2084590[PubMed-indexedforMEDLINE]

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