Update on PED Research

Lisa Becton, DVM, MS, DACVPMDir. Swine Health Information & Research

National Pork Board

Current Status of PED • PED continues to be a major health challenge for U.S.

producers into 2014

• Since it was first diagnosed in May of 2013, there have been a total of 2962 cases reported: – CASE reports are different than SITE reports.– IA = 1095; OK = 290; NC = 367; MN = 396; KS = 171– Data can be found at www.aasv.org

PED case #’s/month (as of Jan 31st , 2013)

Apr-13 May-13 Jun-13 Jul-13 Aug-13 Sep-13 Oct-13 Nov-13 Dec-13 Jan-140

100

200

300

400

500

600

700

800

900

1000

PED Cases 2013-2014

# of

Pos

itive

Cas

es

Case #'s StatesApr-13 12 OH, IN, IA

May-13 103 CO, MN, PA, OK, MO, SD, IL, MIJun-13 197 KS, NY, NCJul-13 122 TN, TX

Aug-13 119 WISep-13 173Oct-13 252 KY, MDNov-13 394Dec-13 712 NE, CA, WYJan-14 887 SC

National Pork Board Focus• Research focus - New virus therefore needed

research on PEDv and impact for US producers

• Development and communication of producer information/resources

• Containment/management strategies– Work with USDA/stakeholders and develop next steps

for emerging disease response – Other needs?

PED Research Efforts

Development of Research Priorities• *Swine Health Committee – producers,

veterinarians, advisors (university, government, industry)

• PED Strategic Task Force

• Input from AASV and NPPC membership

• State Pork Association input

PEDv Research PrioritiesInitial Research Priorities: Basic understanding of the characteristics and pathogenesis of PEDv and

development of standard samples for use

Development and validation of diagnostic testing for antigen and antibody detection for PEDv and for oral fluids

Environmental stability of the virus on various surfaces and substrates and effectiveness of sanitation efforts

Epidemiology of the disease

7

Funded PEDv Research – June 2013• Hesse, KSU: 13-228 Tissue localization, shedding, virus carriage, antibody

response and aerosol transmission of Porcine Epidemic Diarrhea virus (PEDV) following inoculation of feeder pigs

• Wang, OSU: 13-222 Propagation of PEDV in tissue culture and development of standardized reference samples for use in diagnostic testing

• Collins, UMN: 13-238 Development and validation of isolation and diagnostic testing detection for PEDv

• Collins, UMN: 13-239 Development and validation of diagnostic testing for antigen and antibody detection for PEDV

• Yoon, ISU: 13-226 Oral fluid testing for cost-effective and efficient surveillance and control of porcine epidemic diarrhea virus in swine populations

Funded PEDv Research (continued)

• Morrison, UMN: 13-216 Epidemiologic investigation on propensity for lateral spread of PED virus

• Goyal, UMN: 13-215 Environmental Stability of PEDV (Porcine Epidemic Diarrhea virus)

• Holtkamp, ISU: 13-227 Evaluation of time and temperature sufficient to kill PEDV in swine feces on metal surfaces

• Holtkamp, ISU: 13-248 Evaluation of the efficacy of Stalosan®F for inactivating porcine epidemic diarrhea virus (PEDv) and PRRS in swine feces on the surface of trailers used to haul live pigs

PEDv Research for Fall 2013• RFP was posted at www.pork.org/Research

• Proposals submitted to NPB

• Sow immunity proposals selected by the Committee

• Remaining proposals that meet the call priorities will be reviewed Feb 19-20th, 2014

Funded Research for Sow Immunity - 2013• Giménez-Lirola, ISU: 13-264 Defining PEDV maternal humoral

immunity and correlates of neonatal protection

• Clement, SDSU: 13-263 Duration and level of PEDV neutralizing antibodies for clinical protection using feedback protocols

• Murtaugh, UMN: 13-262 PEDV feedback protocol optimization to improve immunity and productivity

Since June 2013, the Board has approved >$1,000,000 for PED

Additional PED project funded 2013-2014• Pillatzki, ISU: 13-266 Feed transmission of PEDV to neonatal

pigs

• Bowman, OSU: 14-150 Bioassay for Porcine Epidemic Diarrhea Virus contaminated feed

Since June 2013, the Board has approved >$1,000,000 for PEDFunding for 2014 - TBD

PEDv Research Focus for 2014• Committee discussion Feb 19-20th on continuing

needs for PED research, to include:– Further investigation of feed stuffs as vehicle for

infection– Development of a rapid/pen-side test for feed – Assess capabilities for whole genome sequencing

from current sample types – Cooperation, communication and collaboration are

key to address this ongoing issue!

PED Research• Information and

updates on funded projects available at www.pork.org/PED

This message funded by America’s Pork Checkoff Program.

Thank you!

lbecton@pork.org515-223-2791