UNIVERSITY OF PENNSYLVANIA - SCHOOL OF MEDICINE Curriculum ...training.cvrc.virginia.edu/events/501resume.pdf · UNIVERSITY OF PENNSYLVANIA - SCHOOL OF MEDICINE Curriculum Vitae June

UNIVERSITY OF PENNSYLVANIA - SCHOOL OF MEDICINE Curriculum Vitae

June 2014

Michael Scott Parmacek, M.D. Home Address: 633 Black Rock Road Bryn Mawr, PA 19010-1801 Office Address: Hospital of the University of Pennsylvania Office of the Chairman 100 Centrex 3400 Spruce Street Philadelphia, PA 19104 Email: [email protected] Education: 1973-77 B.S. Tufts University (Biology/Psychology) 1977-81 M.D. Northwestern University Medical School Postgraduate Training and Fellowship Appointments: 1981-1982 Intern in Medicine, University of Michigan Medical School, Ann Arbor, MI 1982-1984 Resident in Medicine, University of Michigan Medical School, Ann Arbor, MI 1984-1987 Clinical/Research Fellowship, Cardiovascular Disease, Northwestern University

Medical School, Chicago, IL 1987-1989 Postdoctoral Research Fellowship (Molecular Cardiology), Howard Hughes

Medical Institute, University of Michigan, Ann Arbor, MI Faculty Appointments: 1987-1990 Instructor, Department of Internal Medicine, Section of Cardiology, University of

Michigan Medical School 1990-1992 Assistant Professor, Department of Internal Medicine, Section of Cardiology,

University of Michigan 1992-1997 Assistant Professor, Department of Medicine, Section of Cardiology and

Committees on Cancer Biology and Cell Physiology, University of Chicago 1992-1998 Co-Director, Cardiology Fellowship Training Program, University of Chicago,

Department of Medicine 1997-1998 Associate Professor, Department of Medicine, Section of Cardiology and

Committees on Cancer Biology and Cell Physiology, University of Chicago 1998-2002 Herbert C. Rorer Associate Professor of Medical Sciences, Perelman School of

Medicine University of Pennsylvania 2002-2014 Herbert C. Rorer Professor of Medical Sciences, Perelman School of Medicine

University of Pennsylvania 2014- Francis C. Wood Professor of Medicine, Perelman School of Medicine,

University of Pennsylvania

Michael S. Parmacek, M.D. Page 2

Hospital and Administrative Appointments: 1992-1998 Co-Director, University of Chicago Cardiology Fellowship Training Program, University of Chicago, Department of Medicine 1993-1998 Director, Molecular Cardiology Core Laboratory, Section of Cardiology,

University of Chicago 1998-2014 Chief, Cardiovascular Medicine Division, University of Pennsylvania Health

System 1998-2002 Founder and Director, Molecular Cardiology Program, Perelman School of

Medicine University of Pennsylvania 1999- Member, Cardiac Service Line Executive Committee, University of Pennsylvania

Health System 1999- Member, Graduate Group in Cell Biology and Molecular Biology, Pennsylvania

Muscle Institute, Perelman School of Medicine University of Pennsylvania 2000- Member, University of Pennsylvania Strategic Planning Committee for Cardiac

Clinical Services 2002-2003 Member, Scientific Advisory Board, Siemens AG, Forchheim, Germany 2002- Member, Strategic Planning CV Biology Working Group I Committee, Perelman

School of Medicine University of Pennsylvania 2003- Member, Planning Team, Center for Advanced Medicine, University of

Pennsylvania Health System 2003 - Member, Institute for Medicine and Engineering, Perelman School of Medicine

University of Pennsylvania and School of Engineering and Applied Science 2003-2006 Member, Scientific Advisory Board, Osiris/Boston Scientific Corporation, Natick

MA and Baltimore, MD 2003- Member, Academic Review Committee, Perelman School of Medicine University

of Pennsylvania 2004- Member, Task Force on Incentivizing Entrepreneurialism, Department of

Medicine, Perelman School of Medicine University of Pennsylvania 2004-2009 Member, Johnson and Johnson Public Policy Advisory Board, New York, NY 2005- Founding Director, University of Pennsylvania Cardiovascular Institute,

University of Pennsylvania 2005-2007 Member, Search Committee for Director of Division of Cardiology, Children’s

Hospital of Philadelphia (CHOP) 2007 Chairman, Search Committee/Chief, Division of Hematology/Oncology,

Perelman School of Medicine University of Pennsylvania 2009 Member, Search Committee, T. Grier Miller Professorship in Medicine, Division

of Gastroenterology, Perelman School of Medicine University of Pennsylvania 2009 Member, Search Committee, Francis C. Wood Professorship in Medicine,

Division of Medicine, Perelman School of Medicine University of Pennsylvania 2010 Member, Search Committee, NIH NHLBI Director Search Committee 2011 Member, Resourcing the Penn System, Penn Medicine Strategic Plan, Perelman

School of Medicine University of Pennsylvania 2011 Member, Search Committee, Chairman of Department of Radiology, Perelman

School of Medicine University of Pennsylvania 2011 Member, Committee of Center and Institute Directors, Perelman School of

Medicine University of Pennsylvania


Hospital and Administrative Appointments: continued 2012-2013 Member, Institute for Regenerative Medicine Review Committee, Perelman

School of Medicine University of Pennsylvania 2013-2014 Interim Chair, Department of Medicine, Perelman School of Medicine University

of Pennsylvania and University of Pennsylvania Health System 2013- Member, Finance Committee, Clinical Practices of the University of Pennsylvania 2013- Member, Board of Directors, Clinical Practices of the University of Pennsylvania 2013- Member, Basic Science Chairs, Perelman School of Medicine, University of

Pennsylvania 2013- Member, Robert Wood Johnson Clinical Scholars Programs, Perelman School of

Medicine University of Pennsylvania 2014- Chair, Department of Medicine, Perelman School of Medicine and University of

Pennsylvania Health System Specialty Certification: 1982 National Board of Medical Examiners 1984 American Board of Internal Medicine 1987 American Board of Internal Medicine/Cardiovascular Diseases Licensure: Illinois: 036-06905 Michigan: 045826 Pennsylvania: MD064840L Awards, Honors and Membership in Honorary Societies: 1977 Magna Cum Laude, Tufts University 1984 Most Outstanding House Officer in Internal Medicine, University of Michigan 1986 Chief Fellow, Section of Cardiology, Department of Internal Medicine,

Northwestern University School of Medicine 1987 Bristol/American College of Cardiology Affiliate Travel Award 1987 American Heart Association Bugher Fellowship (declined) 1995 Most Outstanding Basic Research Program, University of Chicago, Department of

Medicine, Section of Cardiology 1996-2001 American Heart Association Established Investigator Award 1996- Elected Member, American Society of Clinical Investigation (ASCI) 1997 Japanese Circulation Society Travel Award 1999 Elected Member, Association of University Cardiologists (AUC) 2001 Fellow, American Heart Association 2003- Elected Member, Interurban Clinical Society 2003 Richard A. Crampton Lectureship, University of Virginia 2004 Elected Member, Association of American Physicians (AAP) 2004 Elected Member, American Clinical and Climatological Association (ACCA)


Awards, Honors and Membership in Honorary Societies: continued 2005 Laurence H. Green Memorial Lectureship, Brigham and Women’s Hospital 2007 “Top Docs”, Philadelphia Magazine and Castle Connolly Medical Ltd. 2007 5th Annual Shapur Naimi, M.D. Lecture, Tufts-New England Medical Center 2008 American College of Cardiology Foundation/Pfizer Visiting Professorship Awards, Honors and Membership in Honorary Societies: 2009-2013 NIH/ NHLBI Advisory Council 2009 University of Texas Southwestern Cardiovascular Biology Distinguished Lectureship 2012 Duke University Cardiovascular Research Center Retreat/Plenary Speaker 2013 “Philadelphia Super Doctors”, New York Times Magazine 2013 University of California, Los Angeles, Anna and Harry Borun Visiting Professor 2013 Arthur K. Asbury Outstanding Faculty Mentor Award, Perelman School of

Medicine, University of Pennsylvania Memberships in Professional and Scientific Societies:

National Societies: 1989- American Heart Association Basic Research Council, Member 1989- International Society for Heart Research 1990- American Federation of Clinical Research 1996- North American Vascular Biology Organization 1996- American Society for Microbiology 1998- Cardiac Muscle Society 1998- Association of Professors of Cardiology 2000- Fellow, American College of Cardiology 2001- Association of University Cardiologists 2001- Fellow, Council on Basic Cardiovascular Sciences, AHA 2002-2005 Council on Basic Cardiovascular Sciences, AHA, Leadership Committee 2002-2003 Councilor, Association of Professors of Cardiology (APC) 2003- Interurban Clinical Society 2003- Association of Subspecialty Professors 2004-2005 Secretary/Treasurer, Association of Professors of Cardiology 2004- Association of American Physicians 2004-2009 American Clinical and Climatological Association 1998- Association of Professors of Cardiology 2005-2006 President, Association of Professors of Cardiology 2009- Fellow, American College of Physicians Local Societies: 1998-present Pennsylvania Muscle Institute, University of Pennsylvania 1999-present John Morgan Society, University of Pennsylvania


National Scientific Committees: 1990-1991 Veterans Administration Merit Review External Reviewer 1991-1993 National Science Foundation External Reviewer 1994-2010 Director, Ara Parseghian Medical Research Foundation Board 1994-2010 Director, Scientific Advisory Board, Ara Parseghian Medical Research

Foundation 1994 NIH NHLBI Special Ad Hoc Review Committee 1995 NIH NHLBI, Special Program Project Review Committee 1996-1999 American Heart Association Vascular Wall Biology II Study Section 1997 NIH NHLBI, Special RFA Study Section Member 1998- Member, Nominating Committee of the Basic Research Council,

American Heart Association 2000-2002 NIH, NHLBI, Ad Hoc Reviewer, Pathology A Study Section 2001- Member, Distinguished Clinical Scientist Review Panel, Doris Duke

Charitable Foundation 2003- Member, Scientific Review Group, SCCOR in Pediatric Heart

Development and Disease, NHLBI, NIH 2003- Commonwealth of Pennsylvania, Health Research Advisory Committee

(Speaker of the House Nominee) 2004- NIH NHLBI Ad Hoc Reviewer, CDD Study Section 2004-2006 NIH NHLBI Ad Hoc Reviewer, Atherosclerosis and Inflammation of the

Cardiovascular System Study Section 2007-2008 NIH NHLBI Ad Hoc Reviewer, Cardiovascular Development (CDD)

Study Section 2009-2013 NIH /NHLBI Advisory Council

Memberships in Professional and Scientific Societies:

Local Scientific Committees: 1988-1989 Member, Postdoctoral Fellowship Selection Committee, Michigan Heart

Association 1992-1996 American Heart Association of Metro Chicago Research Council 1992-1996 Member, Research Council, AHA of Metropolitan Chicago 1994-1995 Chairman, AHA of Metro Chicago Fellowship/Grant Selection Committee 2001- Health Research Advisory Committee, Commonwealth of Pennsylvania 2011 Internal Advisory Board, Penn Diabetes Research Center

Editorial Positions: 2000-2005 Editorial Board, Current Controlled Trials in Cardiovascular Medicine 2000- Associate Editor, Gene Therapy 2007- Editorial Board, Journal of Clinical Investigation


Ad Hoc Reviewer: 1992-present Circulation 1992-present Circulation Research 1994-March 2012 Journal of Clinical Investigation 1997-present Molecular and Cellular Biology 1997-present Developmental Biology 1998-present Molecular Medicine 1999-present Genes and Development 2000-present Nature 2001-present Journal of Biological Chemistry 2002-present Arteriosclerosis Thrombosis and Vascular Biology 2003-present Development 2004-present New England Journal of Medicine 2005-present Molecular Biology Cell 2005-present Nature Medicine 2005-present Cell 2006-present Stem Cells 2006-present Chemistry and Biology 2010-present Nature Reviews Molecular Cell Biology Academic Committees: 1997 Member, Chairman Selection Committee, Department of Medicine,

University of Chicago 1998- Member, Cardiovascular Division/Cardiothoracic Surgery Division

Oversight Committee, University of Pennsylvania Health System. 1998 Member, Ad Hoc Committee on Appointments and Promotions, School of

Medicine, University of Pennsylvania Health System 1998 Member, Department of Medicine, Intern Selection Committee, University

of Pennsylvania Health System 1998- Member, Clinical Investigator Pathway Council, University of Pennsylvania 1999 Member, Philadelphia VAMC, Chairman of Medicine Search Committee,

University of Pennsylvania Health System 1999- Member, Internal Steering Committee, Clinical Pharmacology Training

Grant, University of Pennsylvania Health System 1999- Faculty, Cell and Molecular Biology Training Grant, Perelman School of

Medicine University of Pennsylvania 2000- Member, Internal Steering Committee, SCOR Grant, Hemostasis and

Thrombosis, Perelman School of Medicine University of Pennsylvania 2000- Member, Review Committee, Masters Program in Patient Oriented

Research, Center for Experimental Therapeutics, Perelman School of Medicine University of Pennsylvania

2000- Member, Clinical Trials Policies and Practices Committee, Perelman School of Medicine University of Pennsylvania


Academic Committees: (continued) 2000- Member, Internal Steering Committee, SCOR Grant, Airway Smooth

Muscle, Inflammation and Asthma, University of Pennsylvania 2000- Faculty, Training Grant for Underrepresented Minorities, Perelman School

of Medicine University of Pennsylvania 2000-2001 Chairman, Dean’s Committee to Review the Department of Biostatistics and

Epidemiology/Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine University of Pennsylvania

2001- Internal Advisory Board, FTICR/MS, SCOR, Pharmacology, Perelman School of Medicine University of Pennsylvania. Garret FitzGerald, PhD, Principal Investigator

2001- Internal Advisory Board, Program Project Grant, “Convergence of Biomechanics and the Genomics of Vascular Dynamics,” Peter F. Davies, PhD, Principal Investigator

2001 Nomination Committee for Stanley H. Baum Professorship in Radiology, Perelman School of Medicine University of Pennsylvania

2002- Dean’s Committee, Glaxo SmithKline Foundation Institution Support Application, Perelman School of Medicine University of Pennsylvania

2002- Dean’s Committee, Reynolds Foundation Application, Perelman School of Medicine University of Pennsylvania

2003- Cardiovascular Biology Theme Committee, Perelman School of Medicine University of Pennsylvania

2003 Advisory Committee, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine University of Pennsylvania

2004- Committee, Master of Science in Translational Research, Perelman School of Medicine University of Pennsylvania

2004- Scientific Review Group, Fellowship Awards, NHLBI, NIH 2004- External Reviewer, Cardiovascular Training Grant, Cardiovascular Division,

University of Virginia School of Medicine 2009- DeHaan-AHA Myogenesis Center, Internal Advisory Committee 2010 External Reviewer, Cardiology and Cardiothoracic Surgery Programs,

University of Chicago Medical Center 2012 External Reviewer, Cardiovascular Medicine Program, Yale School of

Medicine, Yale University 2014 Distinguished Graduate Award Selection Committee, Perelman School of

Medicine University of Pennsylvania Major Teaching and Clinical Responsibilities: 1. Co-Director, University of Chicago Cardiology Fellowship Program, (1994-1998). 2. Director, Cardiovascular Sciences Research Seminar Series University of Chicago (1993-

95). 3. Director, Cardiology Core Curriculum Conference, University of Chicago (1993-98). 4. Co-Director, Cardiology Clinical Conference, University of Chicago (1993-98). 5. Clinical Teaching Activities, University of Chicago.


Major Teaching and Clinical Responsibilities: - continued

6. Attending Physician in Medicine and Cardiology. 7. Medicine 303-Clinical Cardiology (1992-97). 8. Medicine 500, Cardiology Consultation, University of Chicago (1993-97). 9. Biological Science, 278, Molecular Physiology, University of Chicago (1992-93). 10. Pathology 401-01 Research in Pathology, University of Chicago (1994-97). 11. Clinical Transition Series-Cardiology I and II, University of Chicago (1994-97). 12. Pathology Molecular Mechanisms of Cardiovascular Disease, University of Chicago

(1996-97). 13. Attending Physician in Coronary Care Unit (CCU), Perelman School of Medicine

University of Pennsylvania. 14. 314A, Clinical Cardiology, University of Pennsylvania Medical Center (1998- ) 15. Curriculum 2000, CV Block, Department of Medicine, Perelman School of Medicine

University of Pennsylvania (1998- ). 16. Medicine 314E, Cardiac Intensive Care, Hospital of the University of Pennsylvania

(1999- ). 17. Pharmacology 570, Principles of Cardiovascular Biology, Perelman School of Medicine

University of Pennsylvania (1999- ). 18. Cell and Molecular Biology Graduate Studies Program, Perelman School of Medicine

University of Pennsylvania (2000- ). 19. Medicine Core Clerkship Mentor, Department of Medicine, Perelman School of

Medicine University of Pennsylvania (2003- ). 20. Molecular Basis of Congenital Heart Disease, 1st Annual University of Pennsylvania

Cardiovascular Institute Research Retreat, Plenary Speaker, Perelman School of Medicine University of Pennsylvania (2008).

Lectures by Invitation (past three years): April 2010 Yale University, Cardiology Grand Rounds "The Molecular and Genetic Basis of Congenital Heart Disease"

Yale University, Vascular Biology Therapeutics Seminar "Myocardin a Coactivator Poised at the Precipice of Death or Differentiation" New Haven, CT

March 2011 Monaco USA Arrhythmia Course “Developmental Insights into Atrial Arrhythmias” Princess Grace Hospital, Monaco April 2011 Northwestern University, Cardiology Grand Rounds

“The Molecular and Genetic Basis of Congenital Heart Disease” Chicago, IL

April 2012 Monaco USA Arrhythmia Course

“Developmental insights into the Cardiac Conduction System” Princess Grace Hospital, Monaco


Lectures by Invitation (past 3 years): (continued) April 2012 Beth Israel Deaconess, Cardiology Grand Rounds “The Molecular and Genetic Basis of Congenital Heart Disease” Boston, MA May 2012 University of Minnesota, Lillehei Heart Institute Lecture

“The Molecular and Genetic Basis of Congenital Heart Disease” Minneapolis, MN

January 2013 Duke University, Cardiovascular Research Center Retreat

“Transcriptional Programs Resulting Cardiovascular Development and Disease”

Durham, NC March 2013 Monaco USA Arrhythmia Course

“Developmental of the Cardiac Conduction System: 2013” Princess Grace Hospital, Monaco April 2013 University of California, Los Angeles, Anna and Harry Borun

Visiting Professor "Transcriptional Programs Regulating Cardiovascular Development and Disease"

Los Angeles, CA July 2013 International MADS Box Conference

“Myocardin Related Transcription Factor Signaling and the Pathogenesis of Heritable Forms of Vascular Disease”

Canandaigua, NY May 2014 University of Washington, Murray Visiting Lectureship “The Changing Face of Heart Disease” “Developmental Insights into Congenital Heart Disease” Seattle, WA Organizing Roles in Scientific Meetings: 1997 Chair, Gene Therapy Session, American Heart Association. 1997 Transcriptional Regulation Section, ISHR International Meeting, Vancouver. 1998 Chair, Workshop, Keystone Joint Symposium Molecular Biology of CV System,

Angiogenesis and Vascular Remodeling. 1999 Chair, Molecular Biology of Cardiovascular Session, American Heart Association 1999 Co-Chair, Session I, US-Russia Joint Symposium in Basic Research in

Cardiovascular and Pulmonary Diseases, National Institutes of Health, New Orleans, LA.

1999 Chair, Session on Gene Expression, The Second Seidel Symposium. Smooth


Organizing Roles in Scientific Meetings: (continued)

Muscle Cells, Structure, Motility and Signaling. Woods Hole, MA. 2000 Program Committee, University of Pennsylvania Cardiovascular Biology Retreat Perelman School of Medicine University of Pennsylvania, Bryn Mawr, PA. 2002 Program Committee, Symposium on Phenotyping Mouse CV Function, National

Institutes of Health, Bethesda, MD. 2003 Program Committee, Association of Professors of Cardiology, American College

of Cardiology, Chicago, IL. 2003 Program Committee, International Niemann-Pick Type C Scientific Conference,

Tucson, AZ. 2004 Program Committee, GlaxoSmithKline – PENN Medicine Alternative Drug

Discovery Initiative Symposium In Cardiology, Perelman School of Medicine University of Pennsylvania, Philadelphia, PA.

2004 Program Committee Chair, International Niemann-Pick Type C Scientific Conference/Ara Parseghian Medical Research Foundation, Tucson, AZ.

2005 Chair, Translational Research: Migrating therapeutic discoveries from the Bench to Bedside, Transcatheter Cardiovascular Therapeutics, Washington, DC

2005 Program Committee, Ara Parseghian Medical Research Foundation Niemann-Pick Type C Scientific Conference, Tucson, AZ.

2005 Chair, Cardiac Development – “MicroRNA, Neural Crest, and Stem Cells” Chair, Gene Expression / Molecular Biology 1, American Heart Association

Scientific Sessions, Dallas TX. 2006 Program Committee, Ara Parseghian Medical Research Foundation Niemann-

Pick Type C Scientific Conference, Tucson, AZ. 2006 Chair, MRTF-A and MRTF-B Mediate Redundant Functions Required for

Cardiac Development, AHA Scientific Sessions, Chicago, IL 2007 Program Committee, Ara Parseghian Medical Research Foundation Niemann-

Pick Type C Scientific Conference, Tucson, AZ. 2007 Chair: Controversies in Myocardial Regeneration, American Heart Association

Scientific Sessions, Orlando, FL. 2008 Moderator: Building the Vertebrate Heart, American Heart Association Scientific

Sessions, New Orleans, LA. 2008 Program Committee, Ara Parseghian Medical Research Foundation Niemann-

Pick Type C Scientific Conference, Tucson, AZ. 2009 Program Committee, Ara Parseghian Medical Research Foundation Niemann-

Pick Type C Scientific Conference, Tucson, AZ. Bibliography: Research Publications, peer reviewed: 1. Fox JH, Parmacek MS, Patel-Mandlik, K. (1975) The effect of aging on brain

respiration and carbohydrate metabolism of Syrian hamsters. Gerontologia 21:224-230. 2. Parmacek MS, Fox JH, Harrison WH, Garron DC, Swenie D. (1979) Effect of aging on

brain respiration and carbohydrate metabolism of CBF1 mice. Gerontology 25:185-191.


3. Parmacek MS, Magid NM, Lesch M, Decker RS, Samarel AM. (1986) Cardiac protein synthesis and degradation during thyroxine-induced left ventricular hypertrophy. Am J Physiol 251(5 Pt 1):C727-C736.

4. Parmacek, MS, Decker ML, Lesch M, Samarel AM, Decker RS. (1986) Lysosomal changes during thyroxine-induced left ventricular hypertrophy in rabbits. Am J Physiol 251 (5 Pt 1):C737-747.

5. Samarel AM, Parmacek MS, Magid NM, Decker RS, Lesch M. (1987) Protein synthesis and degradation during starvation-induced cardiac atrophy in rabbits. Circ Res 60:933-941.

6. Parmacek MS, Karpinski BA, Gottesdiener KM, Thompson CB, Leiden JM. (1989) Structure, expression and regulation of the murine 4F2 heavy chain. Nucleic Acids Res 17:1915-1931.

7. Parmacek MS, Leiden JM. (1989) Structure and expression of the murine slow/cardiac troponin C gene. J Biol Chem 264:13217-13225.

8. Coleman PS, Parmacek MS, Lesch M, Samarel AM. (1989) Protein synthesis and degradation during regression of thyroxine-induced cardiac hypertrophy. J Mol Cell Card 21:911-925.

9. Parmacek MS, Bengur AR, Vora AJ, Leiden JM. (1990) The structure and regulation of expression of the murine fast skeletal troponin C gene: Identification of a developmentally-regulated, muscle-specific transcriptional enhancer. J Biol Chem 265:15970-15976.

10. Lin H, Parmacek MS, Morle G, Bolling S, Leiden JM. (1990) Expression of recombinant genes in myocardium in vivo following direct injection of DNA. Circulation 82:2217-2221.

11. Parmacek MS, Leiden JM. (1991) Structure, function and regulation of troponin C. Circulation 84:991-1003.

12. Parmacek MS, Vora A, Shen T, Barr E, Jung F, Leiden JM. (1992) Identification and characterization of a cardiac-specific transcriptional regulatory element in the slow/cardiac troponin C gene. Mol Cell Biol 12:1967-1976.

13. Metzger JM, Parmacek MS, Barr E, Pasyk K, Lin W-I, Cochrane KL, Field LJ, Leiden JM. (1993) Skeletal troponin C reduces contractile sensitivity to acidosis in cardiac myocytes from transgenic mice. Proc Natl Acad Sci USA 90:9036-9040.

14. Barr E, Lin H, Parmacek MS, Leiden JM. (1992) Direct gene transfer into cardiac myocytes in vivo. Methods 4:169-176.

15. Parmacek MS, Ip HS, Jung F, Shen T, Martin JF, Vora AJ, Olson EN, Leiden JM. (1994) A novel myogenic regulatory circuit controls slow/cardiac troponin C gene transcription in skeletal muscle. Mol Cell Biol 14:1870-1885.

16. Ip HS, Wilson DB, Heikinheimo M, Tang Z, Ting C-N, Simon MC, Leiden JM, Parmacek MS. (1994) The GATA-4 transcription factor transactivates the cardiac-specific troponin C promoter-enhancer in non-muscle cells. Mol Cell Biol 14:7517-7526.

17. Chang MW, Barr E, Seltzer J, Jiang YO, Nabel GJ, Nabel EG, Parmacek MS, Leiden JM. (1995) Cytostatic gene therapy for vascular proliferative disorders with a constitutively active form of the retinoblastoma gene product. Science 267:518-522.

18. McDonald KS, Field LJ, Parmacek MS, Soonpaa M, Leiden JM, Moss RL. (1995) Length dependence of Ca2+ sensitivity of tension in mouse cardiac myocytes expressing skeletal troponin C. J Physiology 483:131-139.


Research Publications, peer reviewed: (continued)

19. Solway J, Seltzer J, Samaha FF, Kim S, Alger LE, Niu Q, Morrisey EE, Ip HS, Parmacek MS. (1995) Structure and expression of a smooth muscle cell-specific gene, SM22. J Biol Chem 270:13460-13469.

20. Samaha FF, Ip HS, Morrisey EE, Seltzer J, Tang Z, Solway J, Parmacek MS. (1996) Developmental pattern of expression and genomic organization of calponin h1 gene; a contractile smooth muscle cell marker. J Biol Chem 271:395-403.

21. Heydemann A, Juang G, Hennessy K, Parmacek MS, Simon MC. (1996) The myeloid-cell-specific c-fes promoter is regulated by Sp1, PU.1 and a novel transcription factor. Mol Cell Biol 16:1676-1686.

22. Morrisey EE, Ip HS, Lu MM, Parmacek MS. (1996) GATA-6: a zinc finger transcription factor that is expressed in multiple cell lineages derived from lateral mesoderm. Dev Biol 177:309-322.

23. Morrisey EE, Ip HS, Tang Z, Lu MM, Parmacek MS. (1997) GATA-5: A transcriptional activator expressed in a novel temporally and spatially-restricted pattern during embryonic development. Dev Biol 183:21-36.

24. Morrisey EE, Ip HS, Tang Z, Parmacek M S. (1997) GATA-4 activates transcription via two novel domains that are conserved within the GATA-4/5/6 subfamily. J Biol Chem 272:8515-8524.

25. Kim S, Ip HS, Lu MM, Clendenin C, Parmacek MS. (1997) A serum response factor-dependent transcriptional regulatory program identifies distinct smooth muscle cell sublineages. Mol Cell Biol 17:2266-2278.

26. Kuo CT, Morrisey EE, Anandappa R, Sigrist K, Lu MM, Parmacek MS, Soudais C, Leiden JM. (1997) The GATA-4 transcription factor is required for ventral morphogenesis and heart tube formation. Genes and Dev 11:1048-1060.

27. Kim S, Lin H, Barr E, Chu L, Leiden JM, Parmacek MS. (1997) Transcriptional targeting of replication-defective adenovirus transgene expression to smooth muscle cells in vivo. J Clin Invest 100:1006-1014.

28. Morrisey EE, Tang Z, Sigrist K, Lu MM, Jiang F, Ip HS, Parmacek MS. (1998) GATA-6 regulates HNF-4 and is required for differentiation of visceral endoderm in the mouse embryo. Genes and Dev 12:3579-3590.

29. Morrisey EE, Musco S, Chen MY, Lu MM, Leiden JM, Parmacek MS. (2000) The gene encoding the mitogen-responsive phosphoprotein Dab2 is differentially regulated by GATA-6 and GATA-4 in the visceral endoderm. J Biol Chem 275:19949-19954.

30. Camoretti-Mercado B, Liu HW, Halayko AJ, Forsythe SM, Kyle JW, Li B, Fu Y, McConville J, Kogut P, Vieira JE, Patel NM, Hershenson MB, Fuchs E, Sinha S, Miano JM, Parmacek MS, Burkhardt JK, Solway J. (2000) Physiological control of smooth muscle-specific gene expression through regulated nuclear translocation of serum response factor. J Biol Chem 275:30387-30393.

31. Aoki K, Akyürek LM, San H, Leung K, Parmacek MS, Nabel EG, Nabel GJ. (2000) Restricted expression of an adenoviral vector encoding Fas ligand (CD95L) enhances safety for cancer gene therapy. Mol Ther 1:555-565.

32. Akyürek LM, Yang ZY, Aoki K, San H, Nabel GJ, Parmacek MS, Nabel EG. (2000) SM22 promoter targets gene expression to vascular smooth muscle cells in vitro and in vivo. Mol Med 6:983-991.



33. Zhang JC, Kim S, Helmke BP, Yu WW, Du KL, Lu MM, Strobeck M, Yu Q, Parmacek MS. (2001) Analysis of SM22-deficient mice reveals unanticipated insights into smooth muscle cell differentiation and function. Mol Cell Biol 21:1336-1344.

34. Strobeck M, Kim S, Zhang JC, Clendenin C, Du KL, Parmacek MS. (2001) Binding of SRF to CArG box sequences is necessary but not sufficient to restrict gene expression to arterial smooth muscle cells. J Biol Chem 276:16418-16424.

35. Li WE, Waldo K, Linask KL, Wessels A, Parmacek MS, Kirby ML, Lo CW. (2002) An essential role for connexin43 gap junctions in mouse coronary artery development. Development 129:2031-2042.

36. Zhang JC, Helmke BP, Shum A, Du K, Yu WW, Lu MM, Davies PF, Parmacek MS. (2002) SM22 encodes a lineage-restricted cytoskeletal protein with a unique developmentally-regulated pattern of expression. Mech Dev 115:161-166.

37. Mohler ER, Sehgal CM, Ferrari VA, Parmacek MS, Shih A, Wilensky RL. (2002) A novel ultrasound method for evaluation of angiogenesis. Vasc Med 7:169-175.

38. Naimark WA, Lepore JJ, Klugherz BD, Wang Z, Guy TS, Osman H, Moainie SL, Gorman RC, Reed G, Gorman JH, Palasis M, Parmacek MS, Wilensky RL. (2003) Adenovirus-catheter compatibility increases gene expression after delivery to porcine myocardium. Hum Gene Ther 14:161-166.

39. Du K, Ip HS, Li J, Chen M, Dandre F, Yu W, Lu MM, Owens GK, Parmacek MS. (2003) Myocardin is a critical serum response factor cofactor in the transcriptional program regulating smooth muscle cell differentiation. Mol Cell Biol 23:2425-2437.

40. Du K, Chen M, Li J, Lepore JJ, Mericko P, Parmacek MS. (2004) Megakaryoblastic leukemia factor–1 transduces cytoskeletal signals and induces smooth muscle cell differentiation from undifferentiated embryonic stem cells. J Biol Chem 279:17578-17586.

41. Zeidan A, Swärd K, Nordström I, Ekblad E, Zhang JCL, Parmacek MS, Hellstrand P. (2004) Ablation of SM22 decreases contractility and actin contents of mouse vascular smooth muscle. FEBS Lett 562:141-146.

42. Horwitz PA, Tsai E, Epstein JA, Putt ME, Gilmore J, Lepore JJ, Parmacek MS, Kao AC, Desai S, Goldberg LR, Brozena S, Jessup ML, Cappola TP. (2004) Detection of Cardiac Allograft rejection and response to immunosuppressive therapy with peripheral blood gene expression. Circulation 110:3815-3821.

43. Ding R, Darland DC, Parmacek MS, D’Amore PA. (2004) Endothelial-mesenchymal interactions in vitro reveal molecular mechanisms of smooth muscle/pericyte differentiation. Stem Cells Dev 13:509-520.

44. Barron MR, Belaguli NS, Zhang SX, Trinh M, Iyer D, Merlo X, Lough JW, Parmacek MS, Bruneau BG, Schwartz RJ. (2005) Serum response factor, an enriched cardiac mesoderm obligatory factor, is a downstream target for Tbx genes. J Biol Chem 280:11816-11828.

45. Lepore JJ, Cappola TP, Mericko PA, Morrisey EE, Parmacek MS. (2005) GATA-6 regulates genes promoting synthetic functions in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 25:309-314.

46. Proweller A, Pear WS, Parmacek MS. (2005) Notch signaling represses myocardin-induced smooth muscle cell differentiation. J Biol Chem 280:8994-9004.



47. Zhang SX, Garcia-Gras E, Wycuff DR, Marriott SJ, Kadeer N, Yu W, Olson EN, Garry DJ, Parmacek MS, Schwartz RJ. (2005) Identification of direct serum-response factor gene targets during Me2S0-induced P19 cardiac cell differentiation. J Biol Chem 280:19115-19126.

48. Lepore JJ, Chang L, Lu MM, Mericko PA, Morrisey EE, Parmacek MS. (2005) High-efficiency somatic mutagenesis in smooth muscle cells and cardiac myocytes in SM22-CRE transgenic mice. Genesis 41:179-84.

49. Abdullah I, Lepore JJ, Epstein JA, Parmacek MS, Gruber PJ. (2005) MRL mice fail to heal the heart in response to ischemia-reperfusion injury. Wound Repair Regen 13:205-208.

50. Li J, Zhu X, Chen M, Cheng L, Zhou D, Lu MM, Du K, Epstein JA, Parmacek MS. (2005) Myocardin-related transcription factor B is required in cardiac neural crest for smooth muscle differentiation and cardiovascular development. Proc Natl Acad Sci USA 102:8916-8921.

51. Capo-Chichi CD, Rula ME, Smedberg JL, Vanderveer L, Parmacek MS, Morrisey EE, Godwin AK, Xu XX. (2005) Perception of differentiation cues by GATA factors in primitive endoderm lineage determination of mouse embryonic stem cells. Dev Biol 286:574-586.

52. Niu Z, Yu W, Zhang S, Barron M, Belaguli N, Schneider M, Parmacek MS, Nordheim A, Schwartz RJ. (2005) Conditional mutagenesis of the murine serum response factor gene blocks cardiogenesis and the transcription of downstream gene targets. J Biol Chem 280:32531-32538.

53. Iyer D, Chang D, Marx J, Wei L, Olson EN, Parmacek MS, Balasubramanyam A, Schwartz RJ. (2006) Serum response factor MADS box serine-162 phosphorylation switches proliferation and myogenic gene programs. Proc Natl Acad Sci USA 103:4516-4521. PMCID:PMC1450203

54. Lepore JJ, Mericko PA, Cheng L, Lu MM, Morrisey EE, Parmacek MS. (2006) GATA-6 regulates Semaphorin 3C and is required for cardiac outflow tract patterning. J Clin Invest 116:929-939. PMCID:PMC1409743

55. Camoretti-Mercado B, Fernandes DJ, Dewundara S, Churchill J, Ma L, Kogut PC, McConville JF, Parmacek MS, Solway J. (2006) Inhibition of TGF β1-enhanced SRF-dependent transcriptional activity by Smad7. J Biol Chem 281:20383-20392.

56. Proweller A, Tu L, Lepore J, Cheng L, Lu MM, Seykora J, Millar S, Pear W, Parmacek MS. (2006) Impaired notch signaling promotes de novo squamous cell carcinoma formation. Cancer Res 66:7438-7444.

57. Hannenhalli S, Putt M, Gilmore J, Wang J, Parmacek MS, Epstein J, Morrisey E, Margulies K, Cappola T. (2006) Transcriptional genomics associates FOX transcription factors with human heart failure. Circulation 114:1269-1276.

58. High FA, Zhang M, Proweller A, Tu L, Parmacek MS, Pear WS, Epstein JA. (2007) An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation. J Clin Invest 117:353-363. PMCID:PMC1783803

59. Mohler ER, Fang Y, Shaffer RG, Moore J, Wilensky RL, Parmacek MS, Levitan I. (2007) Hypercholesterolemia suppresses Kir channels in porcine bone marrow progenitor cells in-vivo. Biochem Biophys Res Commun 358:317-324.



60. Shaffer RG, Greene S, Arshi A, Supple G, Bantly A, Moore JS, Parmacek MS, Mohler ER. (2006) Effect of acute exercise on endothelial progenitor cells in patients with peripheral arterial disease. Vasc Med 11:219-226.

61. Proweller A, Wright AC, Horng D, Cheng L, Lu MM, Lepore JJ, Pear WS, Parmacek MS. (2007) Notch signaling in vascular smooth muscle cells is required to pattern the cerebral vasculature. Proc Natl Acad Sci USA 104:16275-16280. PMCID:PMC2042197

62. Huang J, Cheng L, Li J, Chen M, Zhou D, Lu MM, Proweller A, Epstein JA, Parmacek MS. (2008) Myocardin regulates smooth muscle cell contractile genes required for closure of the ductus arteriosus. J Clin Invest 118:515-525. PMCID:PMC2176191

63. Zhang Z, Goss AM, Cohen ED, Kadzik R, Lepore JJ, Muthukumaraswamy K, Yang J, DeMayo F, Whitsett JA, Parmacek MS, Morrisey EE. (2008) A Gata6-Wnt pathway required for epithelial stem cell development and airway regeneration. Nat Genet 40:862-870. PMCID: PMC2562713

64. Mohler ER, Shi Y, Moore J, Bantly A, Hamamdzic D, Yoder M, Rader DJ, Putt M, Zhang L, Parmacek MS, Wilensky RL. (2009) Diabetes reduces bone marrow and circulating porcine endothelial progenitor cells, an effect ameliorated by atorvastatin and independent of cholesterol. Cytometry 75:75-82.

65. Beppu H, Malhotra R, Beppu Y, Lepore JJ, Parmacek MS, Bloch KD. (2009) BMP type II receptor regulates positioning of outflow tract and remodeling of atrioventricular cushion during cardiogenesis. Dev Biol 331:167-175. PMCID: PMC2745439

66. Huang J, Lu MM, Cheng L, Yuan LJ, Zhu X, Stout AL, Chen M, Li J, Parmacek MS. (2009) Myocardin is required for cardiomyocyte survival and maintenance of heart function. Proc Natl Acad Sci USA 106:18734-18739. PMCID: PMC2773995

67. Liu C, Morishima M, Yu T, Matsui SI, Zhang L, Fu D, Pao A, Costa AC, Gardiner KJ, Cowell JK, Nowak NJ, Parmacek MS, Liang P, Baldini A, Yu YE. (2011) Genetic analysis of Down syndrome-associated heart defects in mice. Hum Genet. 130:623-32 PMCID: PMC3257027

68. Shen D, Li J, Lepore JJ, Anderson TJT, Sinha S, Yin AY, Cheng L, Dedhar S, Parmacek MS*, Gerszten RE*. (2011) Aortic Aneurysm Generation in Mice with Targeted Deletion of Integrin Linked Kinase (ILK) in Vascular Smooth Muscle Cells. Circ Res Sep 2;109:616-28 (*denotes equal contributions as Co-Senior Authors). PMCID: PMC3351207

69. Huang J, Elicker J, Bowens N, Liu X, Chen L, Cappola TP, Zhu X, Parmacek MS. (2012) Myocardin regulates BMP10 expression and is required for heart development. J Clin Invest. Oct 1;122(10):3678-91. PMCID:PMC3461917

70. Li J, Bowens N, Cheng L, Zhu X, Chen M, Hannenhalli S, Cappola TP, Parmacek MS. (2012) Myocardin-like Protein (MKL)-2 Regulates TGF- β Signaling in Embryonic Stem Cells and the Developing Vasculature. Development Oct;139(19):3531-42. PMCID: PMC3436110

71. Rong L, Liu J, Qi Y, Graham AM, Parmacek MS, Li S. (2012) GATA6 promotes cell survival by up-regulating BMP-2 expression during embryonic stem cell differentiation. Mol Biol Cell Sep;23(18):3754-63. PMCID:PMC3442421



72. Ramos E, Bien-Willner G, Li J, Hughes A, Giacalone J, Chasnoff S, Kulkarni S, Parmacek M, Cole F, Druley T. (2013) Genetic variation in MKL2 and decreased downstream PCTAIRE1 expression in extreme, fatal primary human microcephaly. Clin Genet May 21. [epub ahead of print](HMG-2013-W-0028)

73. Branchetti E, Poggio P, Sainer R, Shang E, Grau JB, Jackson BM, Lai E, Parmacek MS, Gorman RC, Gorman JH, Bavaria JE, Ferrari G. (2013) Oxidative stress modulates vascular smooth muscle cell phenotype via CTGF in thoracic aortic aneurysm. Cardiovasc Res Nov 1;100(2):316-24.

74. Liu C, Morishima M, Jiang X, Yu T, Meng K, Ray D, Pao A, Ye P, Parmacek MS, Yu EY. (2013) Engineered chromosome-based genetic mapping establishes a 3.7-Mb critical genomic region for Down syndrome-associated heart defects in mice. Hum Genet Dec 22. [Epub ahead of print]

Abstracts (selected): 1. Parmacek MS, Vora AJ, Leiden JM. (1990) Distinct cis-acting sequences regulate

cardiac troponin C gene expression in heart and skeletal muscle. Circulation Suppl 82:III-105.

2. Leiden JM, Parmacek MS, Bolling S, Lin H. (1990) Expression of heterologous genes following direct injection into myocardium suggests a novel approach to gene therapy in the heart. Circulation Suppl 82:III-107.

3. Parmacek MS, Barr E, Vora AJ, Jung F, Leiden JM. (1991) Identification of a cardiac-specific transcriptional enhancer that regulates the expression of the slow/cardiac troponin C gene in vitro and in vivo. Circulation Suppl 84:II-86.

4. Parmacek MS, Vora A, Shen T, Barr E, Jung F, Leiden JM. (1991) Analysis of slow/cardiac troponin C gene expression demonstrates distinct transcriptional regulatory circuits in cardiac and skeletal muscle. Circulation Suppl 84:I-493.

5. Parmacek MS, Vora A, Jung F, Leiden JM. (1992) A novel myod-dependent regulatory circuit controls the expression of the slow/cardiac troponin C gene in skeletal muscle. Circulation Suppl 86:I-348.

6. Ip H, Jung F, Westfall P, Leiden JM, Parmacek MS. (1993) Molecular characterizations of novel trans-acting factors that bind to the cardiac-specific slow/cardiac troponin C promoter/enhancer. Circulation Suppl 88:I-236.

7. Soudais C, Wilson DB, Simon MC, Ip HS, Parmacek MS, Leiden JM. (1994) Targeting disruption of the GATA-4 gene in embryonic stem cells abolishes cardiac myocyte development in differentiating embryoid bodies. Circulation Suppl 90:I-78.

8. Seltzer J, Chang M, Barr E, Parmacek MS, Leiden JM. (1994) Inhibition of vascular smooth muscle cell proliferation in vitro and in vivo by a replication-defective adenovirus encoding a non-phosphorylatable retinoblastoma gene product. Circulation Suppl 90:I-90.

9. Solway J, Seltzer J, Samaha FF, Kim S, Morrisey EE, Ip H, Parmacek MS. (1995) Structure and expression of a smooth muscle cell-specific gene, SM22. Circulation Suppl 92:I-633.


Abstracts (selected): continued

10. Solway J, Samaha FF, Seltzer J, Ip HS, Niu Q, Parmacek MS. (1995) Isolation and structural characterization of cDNA and genomic clones encoding the smooth muscle specific protein SM22. Am J Respir Crit Care Med 151(4, Pt 2): A158.

11. Morrisey EE, Ip HS, Tang Z, Leiden JM, Parmacek MS. (1995) A novel transcriptional activation domain regulates activity of the cardiac muscle lineage-restricted transcription factor, GATA-4. Circulation Suppl 92:I-759.

12. Morrisey EE, Ip HS, Kuo C, Soudais C, Tang Z, Leiden JM, Parmacek MS. (1996) The GATA-4/5/6 subfamily of transcription factors and cardiovascular development. Keystone Symposia, The Molecular Biology of the Cardiovascular System: A001.

13. Ip HS, Morrisey E, Tang Z, Parmacek MS. (1996) GATA-4 and GATA-6 have distinct patterns of expression during murine embryogenesis and postnatal development. Keystone Symposia, The Molecular Biology of the Cardiovascular System (B3):A214.

14. Morrisey EE, Ip HS, Tang Z, Leiden JM, Parmacek MS. (1996) Novel transcriptional activation domains regulate activity of the cardiac muscle lineage-restricted transcription factor, GATA-4. Keystone Symposia: A223.

15. Kim S, Parmacek MS. (1996) Functional characterization of the vascular smooth muscle cell-specific SM22 promoter in transgenic mice. Circulation Suppl 94:I-166.

16. Morrisey EE, Ip HS, Kuo C, Leiden JM, Parmacek MS. (1997) The GATA-4/5/6 subfamily of transcription factors and cardiovascular development. Keystone Symposia, Molecular Biology of Muscle Development (E2):A7.

17. Kuo CT, Soudais C, Parmacek MS, Clendenin C, Leiden JM. (1997) The GATA4 transcription factor is required for heart tube formation in mice. Keystone Symposia, Molecular Biology of Muscle Development (E2):A123.

18. Morrisey EE, Ip HS, Tang Z, Lu MM, Parmacek MS. (1997) GATA-5: a transcriptional activator expressed in a novel temporally and spatially-restricted pattern during embryonic development. Keystone Symposia, Molecular Biology of Muscle Development (E2):A350.

19. Ding R, Parmacek MS, D’Amore PA. (1998) Investigation of smooth muscle (SM) cell differentiation in vitro using SM22 promoter-reporter constructs. FASEB 13:A531.

20. Akyürek LM, Yang Z-Y, Aoki K, Hong S, Nabel GS, Parmacek MS, Nabel EG. (1999) SM22 promoter targets gene expression to vascular smooth muscle cells. Circulation Suppl 100:I-47.

21. Parmacek MS, Kim S, Zhang J, Powell-Braxton LM, Davidson NO. (2000) Transcriptional regulation of vascular smooth muscle cell development. Keystone Symposia, Molecular Biology of the Cardiovascular System (A3).

22. Strobeck M, Du K, Zhang JCL, Tang Z, Kim S, Parmacek MS. (2000) CArG box-specificity restricts gene expression to arterial smooth muscle cells in transgenic mice. Circulation Suppl 102:II-359.

23. Zhang JCL, Kim S, Shum A, Strobeck M, Du K, Musco S, Parmacek MS. (2000) Characteristics of mice harboring a targeted mutation in the gene encoding the smooth muscle cell-specific protein SM22. Circulation Suppl 102:II-325.

24. Mohler ER III, Sehgal CM, Ferrari VA, Parmacek MS, Wilensky RL. (2001) A novel ultrasound method for evaluation of angiogenesis. J Am Coll Cardiol 37(2):227A.


Abstracts (selected): continued

25. Du KL, Jian L, Chen M, Lu MM, Parmacek MS. (2002) Myocardin is a critical activator of the SRF-dependent transcriptional program regulating smooth muscle cell differentiation. Circulation Suppl 106(19):II-108.

26. Mohler ER, Shih A, Osman H, Ferrari VA, Parmacek MS, Sehgal C, Lech G, Im J, Kime R, Chance B, Wilensky RL. (2003) Vascular dysfunction occurs early after diabetic state in mini-pig model. 4th Annual Conference on Arteriosclerosis, Thrombosis and Vascular Biology.

27. Horwitz P, Epstein JA, Lepore JJ, Parmacek MS, Kao A, Desai S, Goldberg LH, Jessup ML, Cappola TP. (2003). Novel predictors of cardiac allograft rejection determined by peripheral blood gene expression. Circ Suppl 108(17):IV-1803.

28. Lepore JJ, Cappola TP, Mericko PA, Morrisey EE, Parmacek MS. (2004) GATA-6 regulates genes promoting synthetic vascular smooth muscle phenotype. Circ Suppl 110(17):III-146.

29. Lepore JL, Mericko, PA, Morrisey EE, Parmacek MS. (2005) Cardiac outflow tract and aortic arch patterning defects in mice lacking GATA-6 in neural crest derived smooth muscle cells. American Heart Association Scientific Sessions, Dallas TX.

30. Iyer D, Chang D, Olson E, Parmacek MS, Balasubramanyam A, Schwartz RJ. (2005) Serum response factor “MADS Box” phosphorylation is a switch that regulates proliferation and differentiation gene programs during myogenesis. American Heart Association Scientific Sessions, Dallas TX

31. Li J, Zhu Z, Cheng L, Minmin L, Chen M, Parmacek MS. (2006) MRTF-A and MRTF-B Mediate Redundant Functions Required for Cardiac Development. American Heart Association Scientific Sessions, Chicago, IL.

32. Beppu H, Beppu Y, Malhotra R, Yu PB, Lepore JL, Parmacek MS, Bloch K. (2007) Conditional Deletion of the BMP Type II Receptor Reveals Multiple Tissue-Specific Roles in Cardiovascular Development. American Heart Association Scientific Sessions, Orlando, FL.

Editorials, Reviews, Chapters, including participation in committee reports: (print or other media) 1. Ip HS, Wilson DB, Heikinheimo M, Tang Z, Ting C-N, Simon MC, Leiden JM, Parmacek

MS. (1995) The GATA-4 transcription factor transactivates the cardiac-specific troponin C promoter-enhancer in non-muscle cells. Adv Exp Med Biol 382:117-124.

2. Ip HS, Wilson DB, Heikinheimo M, Leiden JM, Parmacek MS. (1998) The GATA-4 transcription factor transactivates the cardiac specific troponin C promoter-enhancer in non-muscle cells. In: Molecular and Subcellular Cardiology: Effects on Structure and Function. Sideman S, Beyer R (Eds), Plenum Publishing, New York, NY.

3. Parmacek MS, Leiden JM. (1998) GATA transcription factors and cardiovascular development. (Chapter 17) In: Heart Development. Harvey RP, Rosenthal N (Eds), Academic Press, San Diego, CA, pp. 291-306.

4. Parmacek MS. (2001) Transcriptional programs regulating vascular smooth muscle cell development and differentiation. Curr Top Dev Biol 51:69-89.


Editorials, Reviews, Chapters, including participation in committee reports: (print or other media): continued

5. Epstein JA, Rader DJ, Parmacek MS. (2002) Cardiovascular disease in the post-genomic

era: Lessons learned and challenges ahead. Endocrinology 143:2045-2050. 6. Parmacek MS. (2004) Myocardin—not quite MyoD. Arterioscler Thromb Vasc Biol

24:1535-1537. 7. Parmacek MS, Solaro RJ. (2004) Biology of the troponin complex in cardiac myocytes.

Prog Cardiovasc Dis 47:159-176. 8. Parmacek MS, Epstein JA. (2005) Pursuing cardiac progenitors: Regneration rudux. Cell

120:295-298. 9. Epstein JA, Parmacek MS. (2005) Recent advances in cardiac development with

therapeutic implications for adult cardiovascular disease. Circulation 112:592-597. 10. Parmacek MS. (2006) Cardiac stem cells and progenitors: Developmental biology and

therapeutic challenges. Trans Am Clin Climatol Assoc 117:239-255. PMCID:PMC1500935 11. Parmacek MS. (2007) Myocardin-related transcription factors: Critical coactivators

regulating cardiovascular development and adaptation. Circ Res 100:633-644. 12. Parmacek MS. (2008) Myocardin: Dominant driver of the smooth muscle cell contractile

phenotype. Aterioscler Thromb Vasc Biol 28:1416-1417. PMCID: PMC2633633 13. Parmacek MS, Epstein JA. (2009) Cardiomyocyte renewal. N Engl J Med 361:86-88. 14. Parmacek MS. (2009) MicroRNA-modulated targeting of vascular smooth muscle cells. J

Clin Invest 119:2526-2528. PMCID: PMC2735911 15. Parmacek MS. (2010) Myocardin-Related Transcription Factor-A: Mending a Broken

Heart. Circ Res 107;168-170. PMCID: PMC2917046 16. Bowens N and Parmacek MS. (2011) Development of the smooth muscle cell lineage. In:

Muscle: Fundamental Biology and Mechanisms of Disease. Hill JA and Olson EN (Eds), Elsevier, Amsterdam, Netherlands.

17. Rader DJ, Parmacek MS. (2012) Secreted miRNAs suppress atherogenesis. Nat Cell Biol Feb 29;14(3):233-5.

18. Huang J, Parmacek MS (2012) Modulation of smooth muscle cell phenotype: The Other Side of the Story. Circ Res Aug 31;111(6):659-61. PMCID:PMC3439141

19. Nguyen AT, Gomez D, Bell RD, Campbell JH, Clowes AW, Gabbiani G, Giachelli CM, Parmacek MS, Raines EW, Rusch NJ, Speer MY, Sturek M, Thyberg J, Towler DA, Weiser-Evans MC, Yan C, Miano JM, Owens GK. (2013) Smooth muscle cell plasticity: Fact or Fiction? Circ Res Jan 4;112(1):17-22.

20. Parmacek MS and Epstein JA. (2013) An epigenetic roadmap for cardiac myocyte differentiation. Circ Res Mar 15;112(6):881-3.

Books: None Alternative Media: (List any other non-peer reviewed contributions to alternative communication formats, such as instructional audio or video tapes, articles in the lay press, educational material via Internet, etc.)


Patents: “DNA Constructs and Viral Vectors Comprising a Smooth Muscle

Promoter” U.S. Patent Number: 6/090,618

Date of Patent: July 18, 2001- (Julian Solway, MD, co-inventor)

“Promoter for Smooth Muscle Cell Expression” U.S. Patent Application No: 08/726,807 Date Filed: August 29, 1997 Japanese Patent No: 3457332 Date of Patent: August 1, 2003 (Julian Solway, MD, co-inventor)

“Method for Preventing Smooth Muscle Cell Contraction” U.S. Patent Application Serial No: 08/727,817

Date Filed: October 7, 1996 (Julian Solway, MD, co-inventor)

Grant Support ACTIVE 1R01HL102968-02 (Parmacek, PI) 04/01/2010-03/31/2015 1.2 calendar months NIH/NHLBI $279,197 Myocardin Related Transcription Factor Function in the Vasculature The overall goal of this proposal is to elucidate the role of myocardin and two related transcriptional co-activators, MRTF-A and MRTF-B, in the embryonic and adult vasculature. The specific aims are: 1) Examine the cell autonomous function(s) of myocardin, MRTF-A and MRTF-B, respectively, which promote vascular SMC differentiation and maintenance of the contractile SMC phenotype, 2) Examine functions mediated by MRTF-B and MRTF-A during differentiation of neural crest-derived SMCs and patterning of the cardiac outflow tract and great arteries, and 3) Characterize genetically engineered mice containing null and conditional null mutations in the Myocd gene to elucidate the function of myocardin during embryonic angiogenesis and in maintenance and adaptation of the postnatal vasculature. T32 HL007843-16 (Parmacek, PI) 09/01/1996-06/30/2017 1.2 calendar months NIH/NHLBI $453,834 Training Program in Cardiovascular Biology and Medicine The primary purpose of this training grant is to provide rigorous research training for cardiology fellows and PhD scientists in cardiovascular biology and medicine with the ultimate goal of preparing trainees as independent clinician-scientists and investigators. Research programs consisting of didactic training coupled with laboratory investigation have been created for basic/molecular trainees as well as translational cardiovascular research. T32 HL007891-12 (Parmacek, Co-I) 07/01/2008-6/30/2013 0 calendar months Strom, Brian, PI NIH/NHLBI $643,378


Grant Support - continued ACTIVE Cardiology and Pulmonary Research Training Grant The Penn Center for Clinical Epidemiology and Biostatistics, the Cardiovascular Institute and the Pulmonary, Allergy and Critical Care Division of the Perelman School of Medicine University of Pennsylvania jointly submitted this interdisciplinary training program to strengthen the links among traditional epidemiology and clinical cardiovascular and pulmonary medicine. The objective of this program is to train physicians to be rigorous and independent academic investigators able to use a range of approaches available in epidemiology to address clinical research issues relevant to cardiovascular and pulmonary disease. R01 HL113178-01 (Parmacek, Co-I) 07/01/2012-06/30/2017 1.2 calendar months Goncharova, Elena, PI NIH/NHLBI mTOR coordinates cell metabolism, growth and survival in pulmonary hypertension The overall goal of this proposal is to examine the hypothesis that increased proliferation and survival of pulmonary arterial smooth muscle cells in pulmonary hypertension requires activation of both mTORC1 and mTORC2. The specific aims are: 1) To examine activation of mTORC1 and mTORC2 signaling pathways in lung tissue samples from PAH patients and healthy donors, 2) Determine whether mTORC1 and mTORC2 employ differential molecular mechanisms to modulate proliferation and survival of human PAH smooth muscle cells, and 3) To determine whether suppression of both mTORC1 and mTORC2 inhibits proliferation and induces apoptosis in human PAH smooth muscle cells and prevents or attenuates pulmonary vascular remodeling in a rat chronic hypoxia model of PAH. R01 (Parmacek, Co-I) 07/01/2012-06/30/2017 1.2 calendar months Reilly, Muredach, PI NIH/NHLBI Translational Studies of ADAMTS7, a Novel GWAS Locus for Coronary Atherosclerosis The overall goal of this translational research study is to examine the biochemical, molecular and genetic basis of ADAMTS7 function in the vasculature and to determine how the biology of ADAMTS7 relates to the associated clinical phenotype of premature coronary atherosclerosis. My role in this study is to characterize a genetically altered mouse model in which the ADAMTS7 gene is selectively ablated in smooth muscle cells. In addition, my laboratory will characterize the phenotype of vascular smooth muscle cells in which the ADAMTS7 gene has been ablated.

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UNIVERSITY OF PENNSYLVANIA - SCHOOL OF MEDICINE Curriculum ...training.cvrc.virginia.edu/events/501resume.pdf · UNIVERSITY OF PENNSYLVANIA - SCHOOL OF MEDICINE Curriculum Vitae June