UniversityCollegeDublinNanomaterialRiskAssessmentTemplate

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This risk assessment template should be used when risk assessing the use of nanomaterials /nanoparticlesinUCDlaboratories.Itcanalsobeusedtoassesstherisksfromnon-nanochemicalsinuseduringanyprocessinvolvingnanomaterials.PersonscompletingthisassessmentshouldrefertotheUCDChemicalSafetyManualandmustreviewtherelevantSDSforallchemicalsconcerned

1.GeneralInformationNameofPerson(s)involvedintheProcessandtheirPosition

PrincipalInvestigator/Supervisor(Personresponsibleforensuringsafety)

DateofAssessment LocationofWorks FrequencyofProcess Nanomaterialinuse Otherchemicalagentsinuse

2.TitleandDetailsoftheProcessInvolvingtheuseofHazardousAgents–givedetailsoftheprocess(es)inquestion-ifnecessaryattachawrittenprocedure.

TitleofProcess:Details:(clearlystatehowthenanomaterialsandotherchemicalswillbeusedandconsiderthewholelifecycleofthematerialfromdelivery/developmenttodisposal)

3.PotentialExperimental/ReactionOutcomes(givedetailswhereapplicable)Exothermic: Explosive: Releaseofgas/vapours: Pressurisation: Generationofunstablecompounds: Effectsonnormalatmosphericconditions:Other:_________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________

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4.ControlBandingOfNanoparticle(s)inUseCompleteAppendix1toidentityaControlBandforthenanomaterialsinuseandtickrelevantband.Nobandingapplied Usestandardlabprecautionsandgoodlaboratorypractice

Band/ControlTypeA

Usecapturinghood/localexhaustventilationdischargedtoasafeplaceoutside.HEPAfiltrationtobeusedifairistoberecirculatedbackintotheworkplace.

Band/ControlTypeB

Partialenclosuredischargedtoasafeplaceoutside.HEPAfiltrationtobeusedifairistoberecirculatedbackintotheworkplace.E.g.standardfumehoodorClass1biosafetycabinet.

Band/ControlTypeC

PartialenclosuredischargedtoasafeplaceoutsideviaHEPAfiltere.g.ductedClass2biosafetycabinet.

Band/ControlTypeD

FullenclosurewithHEPAfiltrationanddischargedtosafeplaceoutside.

Note that the use of nanomaterials with poorly understood or a high level of toxicity (e.g.carcinogens)inawaythatgivesrisetoairborneparticlesmustnotbeundertakenuntilspecialistadvicehasbeenobtained.5.HazardousAgent(s)tobeusedGHS01

GHS02

GHS03

GHS04

GHS05

GHS06

GHS07

GHS08

Chemicalname(orformulawherenoname)

HazardStatementsHazardClass

SignalWord PrecautionaryStatements

Amount Form (Addadditionaltablesasrequired)Hasasaferalternativebeenconsideredforallhazardouschemicalsincludingnanoparticles(Givedetails)?____________________________________________________________________________________________________________________________________________________________________ProvidescientificjustificationforthecontinueduseofchemicalsclassedasCarcinogen,MutagenorReproductiveToxinsandhighrisknanoparticles(HARNs;carbonnanotubes;materialsofunknowntoxicity)____________________________________________________________________________________________________________________________________________________________________

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Areanyofthechemicalsinuseincompatible(givedetails):__________________________________________________________________________________CheckpotentialreactionswiththeChemicalReactivityWorksheetLocationofSDSforeachChemical:_____________________________________________________6.NanomaterialHazardsIdentifyeachhazardassociatedwiththenanomaterialanddetailthecontrolmeasuresapplicabletoreducetherisksfromsame

a) Whatistheformofthenanomaterial?E.g.powder,solution,pelletized,agglomerated,etc.

b) Inwhatproportionsisthenanomaterialpresent?

c) Aretheparticleslongandthin/fibrousinnature?

d) Whatistheparticlesizedistribution? e) Howdustyisthematerial? f) Isitwatersoluble? g) Isthenanomaterialtoxic,acarcinogen,a

mutagen,ateratogen,asensitizer,abiopersistentHARNorflammable?Ifyeshavesaferalternativesbeenconsidered?Isexpertadvicerequired?

h) Isthestabilityandreactivity,especiallytheflammabilityandexplosionrisks,fromdrynanomaterialsarisk?Ifsohowhasthisbeenaddressed?

i) Areanynanoparticleslikelytobemadeairborne?Ifyeshowisthisaddressed?

7.PotentialExposure/HighRiskActivities

j) Who(andhowmany)couldpotentiallybeexposedtothesechemicalsandinparticularanynanoparticles

k) Isthereapartoftheprocesswhichcouldleadtoareleaseofthenanomaterialoranyotherchemicalsintotheairorontoasurface(Givedetails).Whatcontrolsareinplacetopreventthis?

l) Whatarethepotentialroutesofexposureforeachchemical?(Inhalation,ingestion,dermal,transplacental,sharps)

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m) Whatisthechanceoftheexposureoccurringforeachchemical?(Unlikely,Likely,VeryLikely)

n) Concentration/intensity,durationandfrequencyofexposureforeachchemical

o) Aremaintenanceactivitiesofconcernre.potentialforexposure?

8.ControlsinPlace

a) PPEinuse

LabCoat: SafetyGlasses:SafetyGoggles:FaceShield: Gloves:(indicatetype)____________ Other:(givedetails)_____________

b) Engineeringcontrols–refertoSection4Fumehood:LEV/DeskExhaustBiosafetycabinet:Other:

c) Othercontrols

d) Storagearrangements–howwillthenanoparticlesandotherchemicalsbestoredsafely?

e) Wastedisposalprocedure.Inparticularhowwillnanoparticlesandmaterialscontaminatedwithsamebedisposedof?

9.FurtherRiskControlMeasuresTheseadditionalriskcontrolmeasuresshouldbedesignedtotacklethehazardsidentifiedinSections4,5,and6above.Allquestionsmustbeanswered.

a) Cananyofthehazardousagentsbereplacedwithlesshazardousmaterials?(givedetails)

b) Cantheamountofchemicalinusebereduced?

c) Cantheduration/intensityofexposure/numbersofpersonsexposedbereduced?

d) Arefurthersafety/hygienefacilitiesrequired?

e) Iswarningsignagerequired? f) Aretransportorstoragearrangements

contributingtorisk?

g) Isappropriatefirstaidequipment/antidotesavailable?

h) Isadditionalsafetyequipmentrequired?

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10.EmergencyResponses(ConsultrelevantSDSforfurtherinformation)

ResponseMeasures Locationofkits/specialistorresponseequipment

a) Fire

b) FirstAid

i) Inthecaseofhighriskmaterialsarestorageandlabellingprovisionsadequate?Highriskmaterialsincludenanomaterialsofunknowntoxicity,biopersistentHARNs,carbonnanotubes,fibrelikenanomaterials/,carcinogens,mutagens,teratogensandsensitizers.

j) Inthecaseofhighriskmaterialscanasealedworkingsystembeused?

k) Inthecaseofhighriskmaterialsdoestheworkingarearequiredemarcation?

l) Inthecaseofhighriskmaterialsdotheusersrequiremedicalsurveillance?

m) Cantheprocessbemodifiedtoreduceexposurerisks?

n) Isfurthertrainingforpersonnelrequired? o) Candifferentequipmentbeusedtocontrol

risk?

p) Isfurtherpperequired? q) Canfurtherengineeringcontrolsbeputinto

place?

r) Istheproductoftheprocesscreatingahighriskthatcanbereduced?

s) Doestheworkingarearequiredemarcation? t) Aresafehandlingproceduresinplace? u) Isoccupationalexposuremonitoring

required?

v) Doignitionsourcesrequireisolation? w) Cantheemergencyresponsesbeimproved? x) Ishealthsurveillancerequired?

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c) AccidentalRelease/

SpillResponse.Fornanomaterialsbespecificaboutthepotentialforspillages,locations,formofthenanomaterialandspillageresponse.IfRPEisneededtodealwithaspillagethenusersmustbefacefittedandtrained.

11.RiskRating

1. TrivialRisk:Nofurtheractionneeded2. AcceptableRisk:Noadditionalriskcontrolmeasuresrequired3. ModerateRisk:Implementfurtherriskcontrolmeasuresifpossible4. SubstantialRisk:Furthercontrolmeasuresmustbeimplemented.Ifthisisnotpossiblethen

workmustbestrictlymanagedtoensuresafety.Expertadvicemayberequired.5. Intolerable:Workmustbeprohibiteduntilfurthercontrolmeasuresareimplemented.Istheriskratingacceptable: Yes NoIfyessignanddatebelowandensureallriskcontrolmeasureshavebeenimplemented.

Low Medium HighLow Trivial Acceptable ModerateMedium Acceptable Moderate SubstantialHigh Moderate Substantial Intolerable

SeverityofOutcome LikelihoodofExposureLow SlightlyHarmful(low) UnlikelyMedium Harmful(medium) LikelyHigh VeryHarmful(high) VeryLikely

Severity Likelihood RiskRating

Severity

Likelihood

AssessmentofLikelihoodandSeverity

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Ifnoidentifyfurthercontrolmeasuresandreassessrisk.Iftheriskcannotbereducedtoanacceptablelevelthentheprocesscannotbecarriedout.Isthisworksuitableforloneworking:Yes NoSigned: Date: Position:________________ __________ ________________Signed: Date: Position:________________ ___________ ________________Thisdocumentmustbesignedbythepersoncarryingouttheassessmentandtheiracademicsupervisor/manager(personresponsibleforensuringsafety).

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Appendix 1. Nanoparticle Control Banding Assessment (tick boxes as applicable) Notethattheuseofnanomaterialswithpoorlyunderstoodtoxicityinawaythatgivesrisetoairborneparticlesmustnotbeundertakenuntilspecialistadvicehasbeenobtained. Will the nanoparticle be……….

Bound in a matrix

Will the matrix be cut or abraded?

No further action required

Use minimum of Type B or C Control

No

Yes

Abraded / cut using power tools

Abraded / cut by hand

UseminimumofTypeAControl

Followgoodpractice

ChartNo.1

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Suspended in a solution

Will the NPs be extracted and dried

Go to the beginning of Chart No. 3

Use minimum of Type B or C Control

No

Yes

Couldanaerosolbeproduced?

Intentional?

UseminimumofTypeCControl

Followgoodpractice

ChartNo.2

Followgoodpractice

No

Yes

No

Areanysubstancesusedtoxic,flammable,carcinogenic,mutagenic,reproductivetoxins,CNT,biopersistentHARNorasesntiser?

No

Yes

Yes

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TheabovechartsandbandingprotocolhavebeenadaptedfromWorkingSafelywithNanomaterialsInResearch&Development.UKNSG,2016.

Dry and free

Are NPs to be made airborne deliberately?

Use minimum of Type B or C Control

Yes

No

CouldNPsbecomeairborneinadvertently?

UseminimumofTypeDControl

Followgoodpractice

ChartNo.3

Yes

Areanysubstancesusedtoxic,flammable,carcinogenic,mutagenic,reproductivetoxins,CNT,biopersistentHARNorasesntiser?

No

Yes

UseminimumofTypeBorC

Control

No

Followgoodpractice