Type IV collagen is an activating ligand for the adhesion G protein–coupled receptor GPR126

by Kevin J. Paavola, Harwin Sidik, J. Bradley Zuchero, Michael Eckart, and William S. Talbot

Sci. Signal.Volume 7(338):ra76-ra76

August 12, 2014

©2014 by American Association for the Advancement of Science

Type IV collagen binds specifically to the N-terminal region of Gpr126.

Kevin J. Paavola et al., Sci. Signal. 2014;7:ra76

©2014 by American Association for the Advancement of Science

Type IV collagen stimulates cAMP signaling in cells expressing Gpr126.

Kevin J. Paavola et al., Sci. Signal. 2014;7:ra76

©2014 by American Association for the Advancement of Science

A region of Gpr126 containing CUB and PTX domains mediates the high-affinity interaction with type IV collagen.

Kevin J. Paavola et al., Sci. Signal. 2014;7:ra76

©2014 by American Association for the Advancement of Science

The N-terminal region of Gpr126 inhibits receptor signaling activity.

Kevin J. Paavola et al., Sci. Signal. 2014;7:ra76

©2014 by American Association for the Advancement of Science

The gpr126st86 mutation truncates Gpr126 after the PTX domain and disrupts myelination and ear development.

Kevin J. Paavola et al., Sci. Signal. 2014;7:ra76

©2014 by American Association for the Advancement of Science