Type 1 Diabetes Increases the Expressionof Proinflammatory Cytokines and

AdhesionMolecules in the ArteryWallof Candidate Patients for Kidney

Transplantation

Featured Article:

Javier Triñanes, MSc, Eduardo Salido, M.D., Ph.D., Julián Fernández, M.D., Ph.D., Margartia Rufino, M.D., Ph.D., José Manuel González- Posada, M.D., Ph.D., Armando Torres, M.D., Ph.D., Domingo Hernández, M.D., Ph.D.

Diabetes Care Volume 35:427–433

February, 2012

Study Objective

• To assess the influence of type 1 diabetes on atheromatosis-related inflammation in patients with chronic kidney disease (CKD)

Triñanes J et al. Diabetes Care 2012;35:427-433

Study Design

• Analyzed expression of proinflammatory cytokines and adhesion molecules in inferior epigastric artery walls of type 1 diabetic patients with CKD (n = 22) compared with nondiabetic patients with CKD (n = 92) at time of kidney transplantation

• Evaluated expression of IL-6, MCP-1, VCAM-1, intercellular adhesion molecule-1, and activation of NFkB-p65

 • Common carotid IMT determined by conventional echography

Triñanes J et al. Diabetes Care 2012;35:427-433

Triñanes J et al. Diabetes Care 2012;35:427-433

Triñanes J et al. Diabetes Care 2012;35:427-433

Triñanes J et al. Diabetes Care 2012;35:427-433

Triñanes J et al. Diabetes Care 2012;35:427-433

Conclusion

• Type 1 diabetes produces a proinflammatory state in arteries of CKD patients, with increased levels of IL-6, MCP-1, and VCAM-1, and more NFkB- p65 activation

 • Associated with more severe vascular lesions and higher c-

IMT

• Findings support major role of inflammation in type 1 diabetic patients with CKD

Triñanes J et al. Diabetes Care 2012;35:427-433