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Tryptophan Biosynthesis Protects Mycobacteria from CD4 T-Cell-Mediated Killing Yanjia J. Zhang, Manchi C. Reddy, Thomas R. Ioerger, Alissa C. Rothchild, Veronique Dartois, Brian M. Schuster, Andrej Trauner, Deeann Wallis, Stacy Galaviz, Curtis Huttenhower, James C. Sacchettini, Samuel M. Behar, Eric J. Rubin Cell Volume 155, Issue 6, Pages 1296-1308 (December 2013) DOI: 10.1016/j.cell.2013.10.045 Copyright © 2013 Elsevier Inc. Terms and Conditions

Tryptophan Biosynthesis Protects Mycobacteria from CD4 T-Cell-Mediated Killing Yanjia J. Zhang, Manchi C. Reddy, Thomas R. Ioerger, Alissa C. Rothchild,

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Page 1: Tryptophan Biosynthesis Protects Mycobacteria from CD4 T-Cell-Mediated Killing Yanjia J. Zhang, Manchi C. Reddy, Thomas R. Ioerger, Alissa C. Rothchild,

Tryptophan Biosynthesis Protects Mycobacteria from CD4 T-Cell-Mediated Killing 

Yanjia J. Zhang, Manchi C. Reddy, Thomas R. Ioerger, Alissa C. Rothchild, Veronique Dartois, Brian M. Schuster, Andrej Trauner, Deeann Wallis, Stacy Galaviz, Curtis Huttenhower, James C. Sacchettini, Samuel M. Behar, Eric J. Rubin 

Cell Volume 155, Issue 6, Pages 1296-1308 (December 2013)

DOI: 10.1016/j.cell.2013.10.045

Copyright © 2013 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 2: Tryptophan Biosynthesis Protects Mycobacteria from CD4 T-Cell-Mediated Killing Yanjia J. Zhang, Manchi C. Reddy, Thomas R. Ioerger, Alissa C. Rothchild,

Figure 1

Cell 2013 155, 1296-1308DOI: (10.1016/j.cell.2013.10.045) Copyright © 2013 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 3: Tryptophan Biosynthesis Protects Mycobacteria from CD4 T-Cell-Mediated Killing Yanjia J. Zhang, Manchi C. Reddy, Thomas R. Ioerger, Alissa C. Rothchild,

Figure 2

Cell 2013 155, 1296-1308DOI: (10.1016/j.cell.2013.10.045) Copyright © 2013 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 4: Tryptophan Biosynthesis Protects Mycobacteria from CD4 T-Cell-Mediated Killing Yanjia J. Zhang, Manchi C. Reddy, Thomas R. Ioerger, Alissa C. Rothchild,

Figure 3

Cell 2013 155, 1296-1308DOI: (10.1016/j.cell.2013.10.045) Copyright © 2013 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 5: Tryptophan Biosynthesis Protects Mycobacteria from CD4 T-Cell-Mediated Killing Yanjia J. Zhang, Manchi C. Reddy, Thomas R. Ioerger, Alissa C. Rothchild,

Figure 4

Cell 2013 155, 1296-1308DOI: (10.1016/j.cell.2013.10.045) Copyright © 2013 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 6: Tryptophan Biosynthesis Protects Mycobacteria from CD4 T-Cell-Mediated Killing Yanjia J. Zhang, Manchi C. Reddy, Thomas R. Ioerger, Alissa C. Rothchild,

Figure 5

Cell 2013 155, 1296-1308DOI: (10.1016/j.cell.2013.10.045) Copyright © 2013 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 7: Tryptophan Biosynthesis Protects Mycobacteria from CD4 T-Cell-Mediated Killing Yanjia J. Zhang, Manchi C. Reddy, Thomas R. Ioerger, Alissa C. Rothchild,

Figure 6

Cell 2013 155, 1296-1308DOI: (10.1016/j.cell.2013.10.045) Copyright © 2013 Elsevier Inc. Terms and Conditions

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Page 8: Tryptophan Biosynthesis Protects Mycobacteria from CD4 T-Cell-Mediated Killing Yanjia J. Zhang, Manchi C. Reddy, Thomas R. Ioerger, Alissa C. Rothchild,

Figure 7

Cell 2013 155, 1296-1308DOI: (10.1016/j.cell.2013.10.045) Copyright © 2013 Elsevier Inc. Terms and Conditions

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Page 9: Tryptophan Biosynthesis Protects Mycobacteria from CD4 T-Cell-Mediated Killing Yanjia J. Zhang, Manchi C. Reddy, Thomas R. Ioerger, Alissa C. Rothchild,

Figure S1

Cell 2013 155, 1296-1308DOI: (10.1016/j.cell.2013.10.045) Copyright © 2013 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 10: Tryptophan Biosynthesis Protects Mycobacteria from CD4 T-Cell-Mediated Killing Yanjia J. Zhang, Manchi C. Reddy, Thomas R. Ioerger, Alissa C. Rothchild,

Figure S2

Cell 2013 155, 1296-1308DOI: (10.1016/j.cell.2013.10.045) Copyright © 2013 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 11: Tryptophan Biosynthesis Protects Mycobacteria from CD4 T-Cell-Mediated Killing Yanjia J. Zhang, Manchi C. Reddy, Thomas R. Ioerger, Alissa C. Rothchild,

Figure S3

Cell 2013 155, 1296-1308DOI: (10.1016/j.cell.2013.10.045) Copyright © 2013 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 12: Tryptophan Biosynthesis Protects Mycobacteria from CD4 T-Cell-Mediated Killing Yanjia J. Zhang, Manchi C. Reddy, Thomas R. Ioerger, Alissa C. Rothchild,

Figure S4

Cell 2013 155, 1296-1308DOI: (10.1016/j.cell.2013.10.045) Copyright © 2013 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 13: Tryptophan Biosynthesis Protects Mycobacteria from CD4 T-Cell-Mediated Killing Yanjia J. Zhang, Manchi C. Reddy, Thomas R. Ioerger, Alissa C. Rothchild,

Figure S5

Cell 2013 155, 1296-1308DOI: (10.1016/j.cell.2013.10.045) Copyright © 2013 Elsevier Inc. Terms and Conditions

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Page 14: Tryptophan Biosynthesis Protects Mycobacteria from CD4 T-Cell-Mediated Killing Yanjia J. Zhang, Manchi C. Reddy, Thomas R. Ioerger, Alissa C. Rothchild,

Figure S6

Cell 2013 155, 1296-1308DOI: (10.1016/j.cell.2013.10.045) Copyright © 2013 Elsevier Inc. Terms and Conditions

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Page 15: Tryptophan Biosynthesis Protects Mycobacteria from CD4 T-Cell-Mediated Killing Yanjia J. Zhang, Manchi C. Reddy, Thomas R. Ioerger, Alissa C. Rothchild,

Cell 2013 155, 1296-1308DOI: (10.1016/j.cell.2013.10.045) Copyright © 2013 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions

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