TRC19 Abstract Book 19 Aug v10 - EMBL Heidelberg · Diverse mechanisms of translation inhibition by tRNA-derived regulatory RNAs 154 Jansova, Denisa Imaging of single RNA molecule

Posters A-Z

Abendroth, Ulrike Presenter: Gregorova, Pavlina The multispecies conservation of oxidative stress-induced changes in tRNA modifications

64

Akirtava, Christina Quantitative analysis of yeast Kozak variants for AUG and near-AUG start codons using a massively parallel reporter assay

65

Albanese, Tanino Recycling of stalled ribosome complexes in the absence of trans-translation

66

Alghoul, Fatima The mechanism of inhibition of cap-dependent translation by the Translational Inhibitory Elements (TIE) a3 and a11 in Hox mRNAs

67

Amirbeigiarab, Susan Age-dependent dynamics of ribosomal proteins in mouse brain 68

Andreev, Dmitry E A uORF in the Ago1 mRNA provides a rare example of >100 triplet long, AUG-initiated translated uORF which is evolutionary conserved in placental mammals

69

Baharoglu, Zeynep Indole signaling triggers a new persistence mechanism involving RaiA mediated translation slowdown in V. cholerae

70

Bailey, Mark Control of plastid ribosome biogenesis by the cytosolic ubiquitin E3 ligase NOT4

71

Barrera, Aldo hnRNPA1-induced stimulation of the HIV-1 IRES requires PRMT5-associated methylation

72

Batchelder, Jake Ribosome biogenesis during cell cycle arrest fuels the epithelial-to-mesenchymal transition

73

Beck, Heather The putative ribonucleolytic activity of elongation factor P 74

Page 19

EMBO Workshop: Protein Synthesis and Translational Control

Beckert, Bertrand The structure of the Drosophila 80S ribosome at 2.8 Å 75

Bellodi, Cristian The X-linked DDX3X RNA helicase dictates translation re-programming and metastasis in melanoma

76

Bennison, Daniel Inhibition of ribosome-associated GTPases by (p)ppGpp in Staphylococcus aureus

77

Berman, Andrea The LARP1 La-RRM module RNA-binding profile elaborates its molecular roles in the cell

78

Beznoskova, PetraCellular levels of human readthrough inducing tRNAs influence the final production of functional p53 protein from PTC-containing mRNAs

79

Bhaskar, Varun Dynamics of uS19 C-terminal tail during the translation elongation cycle in human ribosomes

80

Biffo, Stefano Translational control of fatty liver disease 81

Blagojevic, Aleksandar Presenter: Schepetilnikov, Mikhail Regulation of TOR (Target of Rapamycin) function and intracellular localization in plants

82

Boehringer, Daniel Mechanism of consecutive methylation of the 16S ribosomal RNA by the conserved dimethyltransferase KsgA

83

Boileau, Etienne The cardiac landscape of RNA translation in the mouse 84

Borg, Anneli Reconstituting mitochondrial translation in vitro 85

Page 20

Posters A-Z

Borkar, Pranita PIP4K2A: A host kinase and parasite RNA binding protein 86

Boulay, Karine Targeted clearance of senescent cells by eIF4A inhibition towards improving cancer therapy

87

Braselmann, Esther Imaging mRNA and non-coding RNA dynamics in live mammalian cells with Riboglow, a fluorescence tagging platform

88

Breitenbach-Koller, Hannelore Presenter: Friedrich, Andreas Customized translational repair of skin protein Lamb3 PTC mutation in rare disease Epidermolysis bullosa

89

Brocard, Michele Norovirus infection results in assembly of virus-specific G3BP1 granules uncoupled from eIF2 signaling

90

Büscher, Magdalena Riboregulation of mammalian autophagy by the non-coding vault RNA 1-1

91

Cairo Calzada, Albert Inhibition of protein translation is required for meiotic exit and transition to pollen development in Arabidopsis

92

Cargnello, Marie Deciphering the role of the RNA-binding protein hnRNPU in mTOR-dependent mRNA translation

93

Caruso, Marino Translational control of mitochondrial biogenesis during hepatogenic differentiation

94

Chaparro, Visnu Reprogramming of macrophage mRNA translation during infection by the protozoan parasite Leishmania donovani

95

Page 21


Chen, Liuh-yow Extrachromosomal telomere DNA triggers type I interferon response 96

Chhipi Shrestha, Jagat Splicing perturbation leads to proteotoxicity and translation inhibition 97

Chiba, Shinobu A release factor-dependent ribosome rescue mechanism in Gram-positive bacteria

98

Clayton, Christine E. Control of Trypanosoma brucei differentiation by RNA binding proteins 99

Crowe-McAuliffe, Caillan Structures of antibiotic-resistance ABCF proteins in complex with the ribosome

100

Daberger, Jan Co-translational folding of a toxin-antitoxin protein complex 101

Das, Anindhya Sundar Large ribosomal subunit protein RPL22 surveils CCL2 expression by post-transcriptional regulation in LPS-mediated inflammation

102

Das, Sarada Molecular mechanisms of stress granule assembly and disassembly 103

Dasgupta, Ananya Determining molecular signatures of cryptoccocal response to Zoloft (Sertraline) using a global approach

104

de Boer, Ruben Eukaryotic translation initiation factor subunit eIF2B5 is involved in intestinal epithelial stemness and is potentially rate limiting in hyperproliferative conditions

105

Page 22

Posters A-Z

Denk, Sarah Impact of the c-MYC internal ribosome entry site on intestinal regeneration and colorectal tumorigenesis

106

Derylo, Kamil New alternatively spliced isoform of ribosomal uL10 protein 107

Dever, Thomas E. Ascorbate-sensing uORF Controls GDP-L-galactose phosphorylase (GGP) mRNA Translation

108

Diamond, Paige Elucidating the contribution of the cap-binding protein (eIF4E) on translation regulation in yeast

109

Djuranovic, SergejImpact of the starting amino acids, translation factors and ribosome exit channel on 5' translational ramp

110

Dmitriev, Sergey E. Ribosome profiling of mouse organs reveals translational deregulation of protein synthesis machinery during aging

111

Dong, Yihan The role of TOR in plant translation initiation control 112

Donlin-Asp, Paul Localization and dynamics of translation at the synapse 113

Draycott, Austin S.Protein output control by differential binding to eukaryotic initiation factor 4F

114

Egler, Franziska Mechanisms of selective translation stimulation and suppression by the multiple eIF4E isoforms of Trypanosoma brucei

115

Eiermann, Nina Identification of novel molecular switches regulating stress granule oscillation during HCV infection

116

Page 23


Eiler, Daniel Cryo-EM structure of the 80S ribosome from the human gastrointestinal parasite Giardia intestinalis

117

El Hachem, Najla Defining the mechanisms of selective mRNA translation regulation during resistance of melanoma to targeted therapies

118

Eliseeva, Irina Transcription factor binding sites affect mTOR translational response 119

Enam, Syed Usman Determining factor requirements and release kinetics of the 2A peptide’s StopGo activity

120

Evans, Harrison Decreased synthesis of ribosomal proteins in tauopathy revealed by non-canonical amino acid labelling

121

Farabaugh, Philip J. Presenter: Joshi, Kartikeya Translational accuracy is regulated by phosphorylation of ribosomal protein uS5 through multiple kinase pathways

122

Fatkhullin, Bulat X-ray structural studies of the complex ribosomal silencing factor S and ribosomal protein L14 from Staphylococcus aureus

123

Fenton, Darren Translation landscape of Kluyveromyces marxianus as revealed with ribosome profiling

124

Fernandez, Samantha Identifying factors that regulate start site selection in mammalian cells with CRISPRi

125

Fernández-García, Leandro Non-canonical cap-independent translation of the Dengue virus mRNA 126

Fischer, Niels Mechanism of ribosome rescue by ArfB 127

Page 24

Posters A-Z

Frydas, Alexandros Investigation of the role of GRN upstream open reading frames in frontotemporal dementia

128

Fujita, Tomoya Genome-wide probing of ribosome conformations identified bacterial translation arrests at rotated state

129

Fujiwara, Toru Genome-wide analysis of nitrogen-dependent translational regulation in sorghum

130

Fujiwara, Toshinobu Novel mechanism of ZFP36L1-mediated translation repression 131

Fusco, Claudia Can neurons spatially and temporally tune their protein synthesis machinery?

132

Gentilella, Antonio mTOR inhibition reprograms the cellular translatome to preserve the anabolic capacity of the cell

133

Goscinska, Karolina Mechanisms of global translation modulation upon dysfunctional mitochondria

134

Grela, Przemyslaw Presenter: Horbowicz-Drozdzal, Patrycja Interplay of ribosomal stalk P-proteins with ricin and trichosanthin, the plant ribosome inactivating proteins

135

Grosso, Stefano An mTOR-dependent feedforward loop that couples oxidative phosphorylation to mRNA translation, drives aberrant cell growth in malignant mesothelioma

136

Grudniewska, Magda The role of translation dynamics in ABC-transporter folding and stability 137

Page 25


Grund, Andrea The tumor suppressor gene TIP30 restricts cardiac growth and protects from heart failure by inhibiting translational elongation

138

Gu, Sohyun Balancing stoichiometry of eIF4G and PABP occurs through alternate conformations of PABP: eIF4G associates with monomeric mRNA-bound PABP, but not with dimeric RNA-free PABP

139

Gulay, Suna eIF4A and eIF4E interactions with distinct residues of the Ded1 N-terminus stimulate Ded1 function in translation initiation in vivo

140

Hanson, Johannes SeedTransNet-a network for the identification and validation of novel translational regulator in seeds

141

Hauryliuk, Vasili A role for the Saccharomyces cerevisiae ABCF protein New1 during translation termination

142

Hernández, GrecoDiversification of the AUG codon context across eukaryotes 143

Herrmannová, Anna The eIF3d subunit of the human translation initiation factor eIF3 critically promotes assembly of the pre-initiation complex

144

Hetzert, Bianca Conformational rearrangements of ABCE1 during ribosome recycling 145

Hines, Timothy Profiling transcription and translation in motor neurons from mouse models of Charcot-Marie-Tooth disease

146

Hofhuis, Julia A functional readthrough extension targets malate dehydrogenase to the peroxisome

147

Page 26

Posters A-Z

Horos, Rastislav Regulation of autophagy by RNA and vice versa 148

Hsieh, Andrew C. The androgen receptor regulates a druggable translational regulon in advanced prostate cancer

149

Hsu, Chun-Chieh Antiviral protein viperin restricts viral replication of Zika virus and Kunjin virus by inhibiting viral RNA translation

150

Hulea, Laura EIF4F links translation to energy stress response in cancer 151

Iadevaia, Valentina Regulation of RNA Granules by caliciviruses, from hijacking to novel paracrine induction

152

Ivanov, Alexander Presenter: Shuvalova, Ekaterina PDCD4 enhances translation termination in vitro 153

Ivanov, Pavel Diverse mechanisms of translation inhibition by tRNA-derived regulatory RNAs

154

Jansova, Denisa Imaging of single RNA molecule in mammalian oocyte 155

Jensen, Kirk New tools to probe mRNA translation in vivo 156

Joiret, Marc Protein translation rate modeling with extended TASEP incorporating tRNAs modifications effects

157

Karki, Prajwal Translational readthrough of the large Maf transcription factor traffic jam in Drosophila melanogaster

158

Kashiwagi, Kazuhiro Structural basis of eIF2B regulation by eIF2 phosphorylation 159

Page 27


Kaushik, Kriti Role of non-coding RNAs in regulating IGF2BP3, an oncofetal RNA binding protein

160

Khan, Yousuf Bioinformatic prediction of -1 ribosomal frameshifting sites 161

Khusainov, Iskander Role of potassium ions in structure and function of 70S ribosome as revealed by long-wavelength X-ray diffraction

162

Kiltschewskij, Dylan Functional impact of excitation-associated miRNA on posttranscriptional and translational dynamics in depolarised neurons

163

Kimura, Yusuke The gravity facilitates mitochondrial translation and ATP synthesis 164

Kiniry, Stephen J An internet portal for the exploration of ribosome profiling data 165

Kisly, Ivan The pleiotropic functions of proteins eL19 and eL24 in the eukaryotic ribosome

166

Klaas, Oliver CRISPR/Cas9-mediated deletion of upstream open reading frames (uORFs) reveals distinct patterns of endogenous and reporter-based uORF-mediated translational control

167

Knauer, Jan Felix A versatile cell-free protein production platform for the synthesis of fungal enzymes

168

Knorr, Alexandra N-terminal acetyl transferases (NATs) and the interplay of factors at the ribosomal tunnel exit

169

Page 28

Posters A-Z

König, Julian The RNA-binding ubiquitin ligase MKRN1 functions in ribosome-associated quality control of poly(A) translation

170

Krogh, Nicolai RiboMeth-seq analysis of diffuse large B-cell lymphoma cell lines and patient samples

171

Lapointe, Christopher Dynamics of translation initiation on viral mRNAs 172

Larsson, Daniel Structure of an E. coli 50S ribosome assembly intermediate, the substrate of methyltransferase RlmF

173

Lee, Jung A Effects of Combretum quadrangulare on 2,4-Dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in BALB/c mice

174

Lee, Ying-Hue The role of RPL-24 isoforms in response to food deprivation stress in tissues of C. elegans

175

Li, Xin Ribosomes guide initial piRNA processing on long single strand precursor RNAs

176

Liendl, Lisa Nsun5 in ribosome function and mammalian healthy lifespan 177

Lilleorg, Silva On the importance of bacterial ribosome heterogeneity 178

Lorent, Julie Presenter: Furic, Luc Estrogen receptor alpha controls gene expression via translational offsetting

179

Lorenzo Orts, Laura Concerted expression of a cell-cycle regulator and a metabolic enzyme from a polycistronic transcript in plants

180

Page 29


Loughran, Gary Roadblock properties of ribosome stalling in AMD1 mRNA and its effect on protein stability

181

Lu, Jian Function and adaptive evolution of uORFs in Drosophila 182

Makeeva, Desislava S. Sequestration of termination and recycling factors to stress granules contributes to elevated stop-codon readthrough and translation reinitiation rates upon stress

183

Mangano, Kyle Analysis of the in vivo action of antimicrobials targeting protein synthesis 184

Mariotti, Marco Translational recoding: comparative genomics of selenocysteine, the 21st amino acid

185

Martin, Franck Deciphering the Repeat Associated non-AUG (RAN) translation initiation mechanism from C9ORF72 transcripts in ALS/FTD patients

186

Martinez-Salas, Encarna A novel dimerization module in Gemin5 is critical for protein recruitment and translation control

187

Marzi, Stefano S. aureus S1 is an RNA chaperone which promotes translation of secreted virulence factors by modulating mRNA structures

188

Matcovitch Natan, Orit PSM: a novel technology for monitoring translation in mammalian cells 189

May, Gemma Presenter: McManus, Joel Analysis of uORF functions using a massively parallel reporter assay 190

Page 30

Posters A-Z

Meffert, Mollie Shaping plasticity with growth regulatory MiRNAs 191

Merker, Dorina The nascent interactome of the ribosome associated factor NAC studied by selective ribosome profiling

192

Mikhaylova, Maria S. MIR transposition engendered dual coding capacity in POLG encoding mitochondrial DNA polymerase

193

Mishima, Yuichiro Defining codon-mediated mRNA decay and No-go decay in zebrafish embryos

194

Mohammad, Mahabub Pasha Scaffolder (eIF4G) in translation re-initiation 195

Moll, Isabella Expanding the bacterial proteome 196

Müller, Christine Ablation of uORF-dependent translation into C/EBPß-LIP extends health- and lifespan in mice

197

Müller, Claudia Structural insights into bacterial ribosome rescue of non-stop complexes

198

Nadimpalli, Hima-Priyanka Presenters: Coll, Olga; Guitart, Tanit Dicer-2 targets and complexes in translational control 199

Naito, Satoshi Reverse genetics-based biochemical studies of the ribosomal exit tunnel constriction region on eukaryotic programed ribosome stalling systems

200

Namy, Olivier The importance of RNA modifications in translation fidelity 201

Page 31


Nedialkova, Danny D. Presenters: Nedialkova, Danny D.; Behrens, Drew

High-resolution quantitative profiling of tRNA pools by mim-tRNAseq 202

Nevado, Rosa M Impaired protein synthesis as a contributor to accelerated cardiovascular disease in Hutchinson-Gilford progeria syndrome

203

Nicholson, David The action of ribosome-targeting antibiotics in pathogenic bacteria 204

Niederer, Rachel Direct analysis of ribosome targeting illuminates thousand-fold regulation of translation initiation

205

Nieuwkoop, Thijs Improved protein production and codon optimization analyses in Escherichia coli by bicistronic design

206

Nikolay, Rainer Functionalization of pre-50S subunits by ObgE 207

Noble, Michelle MDH2 meets RNA: A study into the mechanisms and functions of this interaction

208

Nürenberg-Goloub, Elina Structure, function and dynamics of ABCE1 in ribosome recycling 209

Oh, Joa Sub Anti-hyperlipidemic activity of Amomum tsao-ko Crevost et Lemarie extract in C57BL/6 mice fed a high-carbohydrate diet

210

Osterman, Ilya Tetracenomycin – new inhibitor of the bacterial translation, which binds in peptide tunnel close to macrolide binding site

211

Pareja Sánchez, Yerma Regulation of translation upon oxidative stress in yeast 212

Page 32

Posters A-Z

Pavlikova, Zuzana The role of glutamine tRNA primary sequence in recognition of the stop codon and its influence on the readthrough efficiency

213

Perez-Martinez, Xochitl Defects on translation of the mitochondrial COX1 mRNA are bypassed by a nuclear suppressor

214

Pilpel, Yitzhak Presenter: Dahan, Orna Systematic detection of amino acid substitutions in proteome reveals a mechanistic basis of ribosome errors

215

Pospisek, Martin Messenger RNAs of the yeast cytoplasmic DNA virus-like elements contain uncapped non-templated 5' poly(A) leaders and their expression is independent of eIF4E and Pab1

216

Postovit, Lynne-Marie Translational regulation of cancer cell plasticity 217

Poulis, Panagiotis Accumulation of late translocation intermediates correlates with spontaneous frameshifting

218

Pradhan, Swagat Characterizing molecular mechanisms in infantile mitochondrial cardiomyopathy

219

Prilepskaja, TerezieInvestigating the role of human eIF3c and eIF3d in translation initiation 220

Quintas, Ana Presenter: Marini, Alberto Elevated expression of eIF4B in Diffuse Large B-Cell Lymphoma results in remodelling of eIF4B-containing complexes and increased binding to 5’UTRs and coding regions

221

Rae, Christopher The movement of transfer-messenger RNA through the ribosome 222

Page 33


Ranjan, Namit Presenters: Ranjan, Namit; Blanchet, Sandra

The function of fungal-specific elongation factor eEF3 223

Rapino, FrancescaUncovering the U34 tRNA modifying enzymes target proteome and its impact in human disease

224

Ravi, VenkatramanSirtuin 6 controls global protein synthesis through transcriptional regulation of mTOR signaling

225

Reier, Kaspar Ribosomal proteins in Escherichia coli’s proteome in the stationary growth phase

226

Relier, Sébastien Presenter: Bastide, Amandine FTO/m6Am axis controls cancer stem-like properties in colorectal cancer by fine-tuning translation process

227

Relton, Emily Novel human iPSCs derived models to understand the regulation of RNA granules in neurodegeneration

228

Renard, Eva Biophysical investigation of antibiotics targeting multi-drug resistant pathogens

229

Rendleman, JustinA 5’ UTR hexamer motif interacts with ribosomes to modulate gene expression in key stress response factors

230

Ricciardi, Sara Tight translational control of glycolysis and fatty acid metabolism regulates the transition of CD4+ T cells from quiescence to metabolic remodelling

231

Ristau, Johannes RITA requires eIF2alpha-dependent modulation of mRNA translation for its anti-cancer activity

232

Page 34

Posters A-Z

Roghanian, Mohammad The allosteric pppGpp binding site of Escherichia coli stringent factor RelA

233

Rol Moreno, Javier Characterization of the 5’ IRES elements regulating the translation of mRNAs encoding cancer-related factors

234

Roncero Sanchez, Ana-Maria Novel U34-tRNA modification targets highlight a new therapeutic approach in triple negative breast cancer

235

Rothamel, Katherine The RNA-binding protein ELAVL1 determines the efficacy of an IRF3 induced innate immune response

236

Rundlet, Emily Mechanistic analysis of human tRNA selection by smFRET 237

Sajeev, Nikita Translational control of seed germination: Role of mRNA binding proteins

238

Samsonova, Anastasiia Structural and functional insights into the activity of mammalian cold-shock proteins

239

Sattlegger, Evelyn Presenter: Shanmugam, Renuka Towards the Gcn1 interactome. Evidence that Xrn1 is in complex with Gcn1, and is required for full activation of Gcn2

240

Saurer, Martin Biogenesis of mitochondrial ribosomes in trypanosomes involves formation of large assembly intermediates

241

Schenckbecher, Emma Macrolides binding on bacterial ribosome : thermodynamic studies 242

Page 35


Schloßhauer, Jeffrey Qualifying a mutually orthogonal pyrrolysyl-tRNA synthetase-tRNA(Pyl) pair for fluorescent labeling of membrane proteins in eukaryotic cell-free systems

243

Schmidt, Stefanie A MYC/GCN2/eIF2a negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer

244

Schmidt, Tobias Distinct functions of DEAD-box helicases DDX6 and eIF4A2 in mRNA deadenylation

245

Schosserer, Markus Two specific m5C-modifications of ribosomal RNA distinctly modulate healthy lifespan and development

246

Schwarzl, Thomas Improved RNA-binding site analysis for ENCODE eCLIP data sets using htseq-clip and DEWSeq

247

Sehrawat, Urmila EIF1A regulates translation of cell cycle genes 248

Sfakianos, Aristeidis eIF5A as a target for anti-cancer drug development 249

Sharma, Sandeep Presenter: Kaji, Akira Appearance of 40S particles containing 16S ribosomal RNA as a possible reason for lethal effect of denatured Ts-RRF at lag Phase

250

Shields, Kathryn Presenter: Yap, M.-N. Frances Functional consequences of methylated bacterial ribosomes 251

Shih, Ming-Che The dynamic translational regulation in Arabidopsis under submergence 252

Shuvalov, Alexey Activity of human eRF1 isoforms in translation termination 253

Page 36

Posters A-Z

Silva, Joana The role of RNA translation in intestinal stem cells 254

Sinnadurai, Samantha Translation dysregulation is linked to epithelial-mesenchymal transition (EMT) in primary human tumour tissues

255

Smirnova, Anna Deciphering the mechanics of translation control of ATF4 under stress 256

Smit, Wouter The intestinal epithelial global translational capacity is governed by driver mutations of the adenoma-carcinoma sequence of colorectal cancer

257

So, Lomon Regulatory T cells impose translational remodeling in effector CD4 T cells

258

Sotta, Naoyuki Genome-wide analysis of boron-dependent translational regulation in plants

259

Stilinovic, Martina Ribonuclease Inhibitor (RNH1) regulates hematopoietic cell specific translation

260

Stoneley, Mark Ribosomes stalled during genotoxic stress are resolved by a novel RNA binding protein complex

261

Sur, Debpali Investigating enhanced expression of LINE-1 retrotransposon encoded proteins in early onset of Oral squamous cell carcinoma

262

Swain, Kendra A global landscape of post-transcriptional regulators in Saccharomyces cerevisiae

263

Page 37


Swirski, Michal Detection and quantification of protein variants with N-terminal extensions containing mitochondrial targeting signals

264

Szaflarski, Witold The anticancer drug mitoxantrone is a protein biosynthesis inhibitor 265

Szkop, Krzysztof J.Bolstered eIF4E-dependent mRNA translation in patients with Autism Spectrum Disorder

266

Takada, Hiraku TGS and Helical domains are crucial for tRNA-dependent locking of Rel on the ribosome to drive processive (p)ppGpp synthesis

267

Tamm, Tiina Protein domains responsible for evolutionary success of eukaryotic ribosomes

268

Tchorzewski, Marek Presenter: Grela, Przemyslaw Mode of interaction of ribosomal stalk proteins with translational factors 269

Thoms, Sven Functional translational readthrough 270

Ting, Michael uORF mediated translational regulation of the plant circadian clock 271

Turnbull, Kathryn Structural basis for ribosomal protection by the Listeria monocytogenes ABCF ATPase Lmo0919

272

Vadivel Gnanasundram, Sivakumar HDM2 regulates E2F1 synthesis upon EBNA1 induced mRNA translation stress.

273

Valadon, CharlèneImportance of RNA modifications on translational regulations 274

Page 38

Posters A-Z

van der Horst, Sjors Novel pipeline identifies new uORFs and non-AUG main ORFs using sequence conservation

275

Vanselow, Sven Stepwise assembly of eIF2 by the ATP-Grasp protein Cdc123 276

Vieira, Carlos Regulatory roles of SERBP1 Ser330 phosphorylation identified by funSILAC – an unbiased proteome-wide functional screening for protein post-translationally modified sites

277

Vincent, Theresa Presenter: Blanchard, Scott C. Ribosome biogenesis during cell cycle arrest fuels EMT in development and disease

278

Voigt, Franka Quantifying gene expression noise via single mRNA imaging in living cells

279

Waldron, Joseph Global mRNA Structure-Seq yields insights into the helicase activity of eIF4A during translation initiation

280

Wallace, Edward Start codon context controls translation initiation in the fungal kingdom 281

Wang, Jia The role of mRNA looping in regulating translational initiation efficiency 282

Wang, Zefeng Pervasive translation of circular RNAs driven by short IRES-like elements

283

Weigand, Julia E. Muscleblind-like 2 controls the hypoxia response of cancer cells 284

Wells, Jennifer Protection factors Lso2, CCDC124 and EBP1 bound to yeast and human 80S ribosomes

285

Page 39


Wethmar, Klaus Somatic mutations alter canonical and alternative upstream translational initiation and termination codons in acute myeloid leukemia

286

Wieden, Hans-Joachim One design to guide them all: High Resolution structure and biochemical characterization of the conserved ATPase YchF bound to the Plasmodium falciparum ribosome

287

Willmer, Moritz W. R. Ribosome recycling in a natural translation termination context 288

Wohlgemuth, IngoAminoglycosides induce miscoding clusters in cellular proteins 289

Woodvine, Bethany Reprogramming translation in mammalian cells by tRNA pool modifications

290

Xu, Fu SSD1 suppresses phenotypes induced by the lack of Elongator-dependent tRNA modifications

291

Yamashita, Yui In vivo status of S-adenosyl-L-methionine-induced translation arrest on Arabidopsis CGS1 mRNA

292

Yan, Shuling Slam RNA localization and translation are regulated by FMRP in early Drosophila embryos

293

Yang, Yun Global identification of cap-independent translation initiation sites in human transcriptome

294

Yang-Yen, Hsin-Fang TCTP promotes mRNA translation during T cell activation 295

Yi, Sung-Hui Reconstitution of human translation initiation system 296

Page 40

Posters A-Z

Yordanova, Martina Translation of a conserved ORF in the AMD1 3’ trailer: exploring the effects on initiation

297

Young, David Presenter: Guydosh, Nicholas Recycling of 40S ribosomes and translation of ORFs internal to coding sequences revealed by small-subunit ribosome profiling

298

Young-Baird, SaraSuppression of a MEHMO syndrome mutation in eIF2 by small molecule ISRIB

299

Zaher, Hani The ribosome and quality control of chemically-damaged mRNA 300

Zeman, Jakub eIF3: A Structural Odyssey. An epic drama of exploring the yeast eIF3 structure

301

Zemella, Anne Site-specific modification of erythropoietin produced in cell-free extracts 302

Zhang, Yujie High-throughput 5PSeq for ribosome dynamics analysis 303

Zheng, Alice Studies on EBNA1 and its GAr domain shed light on a novel translation control pathway

304

Zhou, Fujun mRNA Recruitment Sequencing (RecSeq), a deep-sequencing based high-throughput approach for studying mRNA recruitment by 43S PICs in vitro

305

Zinshteyn, Boris Identification of factors that suppress protein output from a splicing-independent NMD reporter

306

Page 41


Zuccotti, Alessandro Eukaryotic Elongation Factor 2 kinase, activated in the response to ribosomal stress, is a novel target of the oncogenic PIM1 kinase

307

Zuidhof, Hidde R. Translational regulation and oncogenic functions of C/EBPß-LIP in breast cancer

308

Page 42

Documents

TRC19 Abstract Book 19 Aug v10 - EMBL Heidelberg · Diverse mechanisms of translation inhibition by tRNA-derived regulatory RNAs 154 Jansova, Denisa Imaging of single RNA molecule