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Translation from mRNA to Protein

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Translation from mRNA to Protein

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  • TRANSLATION

  • What is Translation?The synthesis of polypeptides using the genetic code from RNA.

  • The Genetic CodeFive Major Features of the Genetic CodeTripletNonoverlappingCommalessDegenerateUniversal

  • The Genetic Code

  • Codon-Anticodon Pairing

  • The Wobble Hypothesis

  • Requirements for TranslationRibosomeRNAs (mRNA, tRNA, rRNA)Protein FactorsActivated Substances

  • The Ribosome

  • Phases of Translation

  • Serves as the adapter moleculeContains the anticodonCovalently bonded to aa by aminoacyl tRNA synthetase

  • INITIATION COMPLEXmRNA30S & 50 S ribosomal unitfmet-tRNAfmetGTP, Mg+2IF-1, IF-2, IF-3

  • Shine-Dalgarno sequence

  • Three Steps:aa-tRNA bindingPeptide bond formationTranslocation

  • EF-Tu recycling


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