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A powerpoint on the Transderm Ionto the ONLY FDA approved alternative to injections.
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TransdermTransderm®®
IontoIontoThe The OnlyOnly FDA FDA
ApprovedApproved Alternative to Alternative to
InjectionsInjections
Manufactured By Manufactured By Mattioli EngineeringMattioli Engineering
Developed its first microdermabrasion Developed its first microdermabrasion system in 1991.system in 1991.
Over 6,500 microdermabrasion units Over 6,500 microdermabrasion units installed world-wide.installed world-wide.
Opened the US microdermabrasion in Opened the US microdermabrasion in 1996 when it introduced its FDA Cleared 1996 when it introduced its FDA Cleared Ultrapeel Crystal®Ultrapeel Crystal® and and Ultrapeel Pepita®Ultrapeel Pepita® microdermabrasion systems.microdermabrasion systems.
Introduced the FDA Cleared Introduced the FDA Cleared Transderm® Transderm® IontoIonto to the US market in 2003. to the US market in 2003.
FDAFDA ClearanceClearance
The Transderm® Ionto is a The Transderm® Ionto is a powered drug delivery system powered drug delivery system that is indicated for the local that is indicated for the local administration of administration of ionic drug ionic drug solutionssolutions into the body for into the body for
medical purposes and can be medical purposes and can be used as used as an alternative to an alternative to
injectionsinjections. .
The TransdermThe Transderm®® IS NOTIS NOT……
An Ultrasound DeviceAn Ultrasound Device A Muscle StimulatorA Muscle Stimulator A MassagerA Massager A Micro-Current DeviceA Micro-Current Device
……..It is a MEDICAL system for ..It is a MEDICAL system for your MEDICAL practice!your MEDICAL practice!
Limits of Pre-Existing Limits of Pre-Existing TechnologyTechnology
Traditional IonthophoresisTraditional Ionthophoresis Ineffective for heavy weight moleculesIneffective for heavy weight molecules Changes the pH of ionic drug solutionsChanges the pH of ionic drug solutions Electrolytic effect at the electrodesElectrolytic effect at the electrodes Electrolysis of the ionic solutionElectrolysis of the ionic solution
MicrodermabrasionMicrodermabrasion Low delivery rateLow delivery rate Effects limited to the skin surfaceEffects limited to the skin surface
ElectroporationElectroporation High peak currents High peak currents High risk of skin damageHigh risk of skin damage Adverse effectsAdverse effects
The TransdermThe Transderm®® Uses Uses DermoelectroporationDermoelectroporation®®
DermoelectroporationDermoelectroporation®® uses continuous uses continuous reversed polarity current pulses to deliver reversed polarity current pulses to deliver low-weight and heavy-weight molecules low-weight and heavy-weight molecules
without compromising the integrity of the without compromising the integrity of the solution.solution.
Just Two Easy StepsJust Two Easy Steps
Step One: Microdermabrasion
to Ensure Penetration and Reproducibility
Step Two: Dermoelectroporati
on®® for Transdermal Drug
Delivery
Advantages of Transdermal Advantages of Transdermal DeliveryDelivery
of Low-Weight Moleculesof Low-Weight Molecules Positive and negative ions of the drug are Positive and negative ions of the drug are
transdermally delivered at the same timetransdermally delivered at the same time No electrolytic reactions at the electrodesNo electrolytic reactions at the electrodes No change of ionic drug solution pHNo change of ionic drug solution pH No electrolysis of ionic drug solution No electrolysis of ionic drug solution Less skin irritationLess skin irritation
European European Clinical tests demonstrate advantages of Clinical tests demonstrate advantages of Dermoelectroporation® Vs. Iontophoresis for transdermal delivery of Dermoelectroporation® Vs. Iontophoresis for transdermal delivery of radioactive Lidocaineradioactive Lidocaine
Advantages of Transdermal Advantages of Transdermal DeliveryDelivery
of High-Weight Moleculesof High-Weight Molecules No skin damage due to low limited-current No skin damage due to low limited-current
pulsespulses No change in pH due to symmetrical pulse No change in pH due to symmetrical pulse
administrationadministration No adverse effects reportedNo adverse effects reported
European European Clinical tests demonstrate enhanced delivery of collagenClinical tests demonstrate enhanced delivery of collagen and a five-fold increase in transdermal delivery of Eparine and a five-fold increase in transdermal delivery of Eparine using Dermoelectroporation® Vs. application on the skinusing Dermoelectroporation® Vs. application on the skin
Advantages of Advantages of DermoelectroporationDermoelectroporation®®
OnlyOnly with the Transderm with the Transderm®®…… No NeedlesNo Needles No PainNo Pain No Bruising No Bruising No SwellingNo Swelling No DowntimeNo Downtime
...BUT ACHIEVES THE SAME RESULTS AS ...BUT ACHIEVES THE SAME RESULTS AS AN INJECTION!!!AN INJECTION!!!
The Complete SystemThe Complete System
Included:Included: Mattioli Mattioli
Microdermabrasion Microdermabrasion SystemSystem
Two Probes for the Two Probes for the Face and BodyFace and Body
Precision Liquid Precision Liquid DispenserDispenser
Initial SuppliesInitial Supplies
Other ConfigurationsOther Configurations
Face and Body ApplicationsMicrodermabrasion System Not Included
Face Application OnlyMicrodermabrasion System Not
Included
Precision Liquid Dispenser and
Disposable Caps
Probe for Face
Probe for Body
Disposable Accessories
A Sterile SystemA Sterile System
All of the accessories for the Transderm®
come pre-sterilized and individually
wrapped
Physician’s IndicationsPhysician’s Indications
IontocaineIontocaine (lidocaine hydrochloride 2% and epinephrine (lidocaine hydrochloride 2% and epinephrine
1:1000,000)1:1000,000) and other anesthetics prior to and other anesthetics prior to laser procedureslaser procedures
Needle Free MesotherapyNeedle Free Mesotherapy – – Cellulite, Body Cellulite, Body Sculpting, Fat PadsSculpting, Fat Pads
Hyaluronic AcidHyaluronic Acid – – Facial RhytidsFacial Rhytids
Collagen, Elastin, Vitamins and Minerals Collagen, Elastin, Vitamins and Minerals - - Facial RejuvenationFacial Rejuvenation
And More!!!!!And More!!!!!
TransdermTransderm®® ResultsResults
4.33.4
6.7
7.6
0
1
2
3
4
5
6
7
8
10 patients
LMX 5 Ionto + 2% lidocaine Ionto + water Nothing
Pilot clinical study to evaluate the efficacy of the Transdermal Ionto device to minimize pain and
discomfort associated with dermatological cosmetic procedures
Mark Nestor, MD, PhD and Alex CazzanigaCenter for Cosmetic Enhancement, Aventura, Florida
Before
TransdermTransderm®® ResultsResults
After
© Saratoga Aesthetics • 2006 • All rights reserved
Before
TransdermTransderm®® ResultsResults
After
© Saratoga Aesthetics • 2006 • All rights reserved
Before
TransdermTransderm®® ResultsResults
After
© Saratoga Aesthetics • 2006 • All rights reserved
Before
TransdermTransderm®® ResultsResults
After
© Saratoga Aesthetics • 2006 • All rights reserved
Before
TransdermTransderm®® ResultsResults
After
© Saratoga Aesthetics • 2006 • All rights reserved
Before
TransdermTransderm®® ResultsResults
After
© Saratoga Aesthetics • 2006 • All rights reserved
Before
TransdermTransderm®® ResultsResults
After
© Saratoga Aesthetics • 2006 • All rights reserved
Frequently Asked QuestionsFrequently Asked Questions Q: What is the difference between the various Transdermal Delivery Devices Q: What is the difference between the various Transdermal Delivery Devices
available in the available in the USA?USA?A: The Transderm® is the ONLY system to be FDA Cleared as an alternative to A: The Transderm® is the ONLY system to be FDA Cleared as an alternative to injections. Other systems will be ultrasound devices, muscle stimulators, micro-injections. Other systems will be ultrasound devices, muscle stimulators, micro-current devices, etc. The Transderm® is a medical device, and all medical devices current devices, etc. The Transderm® is a medical device, and all medical devices must have FDA Clearance.must have FDA Clearance.
Q: How deep can we deliver ionic drug solutions with the Transderm®?Q: How deep can we deliver ionic drug solutions with the Transderm®?A: Based on the weight of the molecule, the Transderm® can deliver as deep as A: Based on the weight of the molecule, the Transderm® can deliver as deep as the muscle membranethe muscle membrane
Q: Is the Transderm® only sold to physicians?Q: Is the Transderm® only sold to physicians?A: Yes. The Transderm® has the same clearance as an injection and is only A: Yes. The Transderm® has the same clearance as an injection and is only distributed to physicians.distributed to physicians.
Q: Is the Transderm® painful for the patient?Q: Is the Transderm® painful for the patient?A: No. The Transderm® has a vibration mode which significantly minimizes the A: No. The Transderm® has a vibration mode which significantly minimizes the sensation of the electrical pulses.sensation of the electrical pulses.
Q: Will my patient have any bruising or swelling?Q: Will my patient have any bruising or swelling?A: No. Because there are no needles, there is no pain, bruising or swelling with the A: No. Because there are no needles, there is no pain, bruising or swelling with the Transderm®.Transderm®.
The Transderm IontoThe Transderm Ionto
Manufactured by Mattioli EngineeringManufactured by Mattioli Engineering
Distributed by:Distributed by:
1.888.785.75461.888.785.7546
www.SaratogaAesthetics.comwww.SaratogaAesthetics.com