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  • Russian Academy of Sciences I.P.Pavlov Institute of Physiology

    Transcranial Electrostimulation Center


    Experimental and Clinical Studies

    Volume 1

    Edited by Professor Valery P.Lebedev, MD, PhD, D-r Sci

    Saint-Petersburg 1998

  • Russian Academy of Sciences I.P.Pavlov Institute of Physiology

    Transcranial Electrostimulation Center


    Experimental and Clinical Studies

    Volume 2

    Edited by Professor Valery P.Lebedev, MD, PhD, D-r Sci

    Saint-Petersburg 2003

  • Russian Academy of Sciences I.P.Pavlov Institute of Physiology

    Transcranial Electrostimulation Center


    Experimental and Clinical Studies

    Volume 3

    Edited by Professor Valery P.Lebedev, MD, PhD, D-r Sci

    Saint-Petersburg 2009

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    I. PRAC


    1. se of Transcranial lectric Stimulation and -stimulating Training in Treatment of Patients with Central Postapoplectic

    Pain Syndromes

    Chernikova L. A., Sashina M. B., Kornyukhina E. Yu., Shestakova M. V.

    There as shon that combined therapy, that includes standard ap-proved medicines together ith rehabilitation methods (transcranial elec-tric stimulation and -stimulating training) ere more effective in therapy of central postapoplectic pain syndrome as compared ith using medicines alone. Therapeutic effects of combined use of transcranial electric stimu-lation and -stimulating training have specific features depending on the location of the pathologic site as ell as severity of affective disturbances. In case the focus as located in thalamus or in the left hemisphere and tha-lamus there should be preferred to apply transcranial electric stimulation to-gether ith basic medication, as it as substantially decreasing the intensity of hyperpathia and hyperkinesia. If patient had affective disorders then treat-ment of choice should be containing -stimulating training that profoundly influences on affective pain component as ell as severity of astheno-de-pressive disorders. Prospective follo-up analysis found that 6 months after completing therapy the most stable clinical effect as observed in patients that ere given transcranial electric stimulation or -stimulating training together ith basic medication. Thus, by including rehabilitation methods into the treatment program for patients ith central postapoplectic pain syn-drome increased therapeutic effectiveness ill be definitely achieved that eventually gives rise to more steady curative effect.

    2. Impact of Transcranial lectric Stimulation on motional and Conative isorders as well as Cognitive Impairment

    in Patients with Parkinson's iseaseKornyukhina E. Yu., Chernikova L. A., Ivanova-Smolenskaya I. A.,

    Karabanov A. V., Fedin P. A.

    We eamined patients ith Parkinsons disease (PD), moderate degree, ith trembling-rigid, rigid-trembling, and akineticorigid forms. Patients of

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    both test (TES-therapy) and control (placebo) groups ere treated ith ba-sal antiparkinsonian medicines (Madopar, Mirape, Midantanum). Antide-pressants and anti-aniety medicines ere not prescribed. There as found that basal motor symptoms ere decreased in 70.3% patients of test group, hereas only 30% patients of control group had them. Moreover, level of decline as substantially bigger in the former vs. the latter group. In addi-tion, patients of test group had significantly diminished level of emotional and conative disorders. eneral level of cognitive functions increased in test group by 5.2% ( 0.05), ith no clear-cut changes in control group. Also, 77.7% patients of test group ere found to have improved attention con-centration as compared ith controls. Depression as decreased by 68.7% in test group, hereas in control group only by 23.6% aniety level de-creased by 53.1% and 26.1%, respectively. Thus, addition of transcranial electric stimulation to the comple therapy of patients ith PD is considered to be orthhile, as it leads to decreased intensity of depressive, aniety and cognitive disorders. This method has fe contra-indications, safe and easy-to-use.

    3. luvoaminc, Amitriptyline and Transcranial lectric Stimulation of the Brain in the Treatment of Chronic aily eadache

    Tarasova S. V., Amelin A. V., Skoromets A. .

    Efficacy of antidepressants fluvoamine, amitriptyline and transcranial electric stimulation of the brain in the treatment of chronic daily headache has been studied. Amitriptyline had the highest effect in dosage 50 mg daily but as not ell tolerated by patients that resulted in that only 50% of them finished the study. luvoamine had high efficacy and good tolerability in the treatment of chronic daily headache and medication overuse headache. Small dosages of amitriptyline and fluvoamine potentiated the analgesic effect of transcranial electric stimulation of the brain. The combination of antidepressants ith transcranial electric stimulation of the brain alleviated the negative effect of the ithdraal of overused analgesics and may be recommended for out-patient use.

    4. ffectiveness of anual Therapy used Together with TS-procedures in Patients with ri-Barr-iou Syndrome

    Gorokhov B. N., Gorokhov S. B., Enatstki S. Yu., Yurov A. F.

    Therapeutic effectiveness of patients ith confirmed Nri-Barr-Liou syndrome as estimated by comparing manual therapy alone or together ith TES-procedures. By using combined therapy curative effect as de-veloping 1.52 fold faster.

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    5. Transcranial lectric Stimulation as an Approach to Potentiate Anti-nociceptive ffect licited

    by Sanatorium-resort Therapy in Patients with Cervical orsopathy

    Kazakova M.S., Karakulova Yu.V.

    Transcranial electric stimulation (TES-therapy) potentiates effect of curative balneal and bog factors found at the resort Klyuchi, and facilitates achievement of far better therapeutic effectiveness ithin shorter period of time. There as found that 2 eek courses of balneal and bog therapy com-bined ith TES-therapy ere as effective as 3 eek course of basic therapy. Moreover, such shortened courses ere more affordable to patients as ell as sanatorium-resort compounds due to obviously reduced stay in the re-sort.

    6. ffectiveness of Brain Transcranial lectric Stimulation in Correction of Pain Syndromes and Psycho-vegetative Status

    uring Treatment of Patients with umbar orsopathy

    Panasyuk I.Ya., Shutov A.A., Karakulova Yu.V.

    Addition of TES-therapy as a part of comple therapy in patients ith vertebragenous chronic lo back pain potentiates therapeutic effect of cura-tive balneal and bog factors provided at the resort Klyuchi. Altogether, it facilitates achievement of more advanced therapeutic effectiveness signif-icant decrease of pain intensity, reduction of aniety and depression, magni-tude of vegetative disorders, substantially improving parameters of patients life quality. By including shortened balneal and bog therapy combined ith TES-therapy for treatment of such patients they ere found to be more supe-rior in terms of direct clinical effectiveness as compared ith basic therapy courses. The results of combined therapy validate a reason to include it as routine service at balneal and bog resorts.

    7. Immediate Influence of Transcranial lectric Stimulation on Pain and -endorphin Blood evels.

    An Active Placebo-controlled Study

    Gabis L., Shklar B., Geva D.

    Methods: We conducted a randomized, double-blind, placebo-control-led study on 20 chronic back pain patients. They ere treated ith either transcranial electric stimulation (TES) or an active placebo device. Pain level and serum -endorphin levels ere measured before and after treat-ment. Results: -Endorphin level increased in seven of the ten patients from the treatment group and did not change in eight of ten patients from control group (P 0.057 beteen groups). Pain level decreased in eight treated patients and seven control patients (significant decrease for each group, no

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    significant difference beteen groups). Conclusions: ranscranial electric stimulation is a nonpharmacologic method of pain relief accompanied or mediated by -endorphin release. The comparable degree of the initial clini-cal response emphasizes the poerful placebo effect on reported pain not mediated by endorphin release. This preliminary study shos that nonin-vasive electrical stimulation is a safe treatment ith a positive effect on -endorphin blood levels.

    8. Comple Rehabilitation of motional-affective isorders by Applying Transcranial lectric Stimulation and Binaural Rhythms

    Urazaeva F. H., Urazaev K. F.

    In this study e ere interested in checking if it is possible to use a comple approach that involves transcranial electric stimulation and binau-ral rhythms to perform psychocorrection of emotional-affective disorders. There as found that such comple therapy is effective in reducing frequen-cy of depressive states, aniety, computer addiction, ecessive gambling, and age-related deviations of mental development. Curative effect as ac-companied not only ith improved clinical picture and psycho-physiolog-ic parameters of these patients, but also ith remarked positive effect on mental health. Aniety level as profoundly reduced (Spielberger-Hanin and Taylor tests), subjective test on sense of health, activity and mood ere improved (by SAM questioner: state of health-activity-mood).


    9. Application of Transcranial lectric Stimulation (TS-therapy) in Therapy of gastroesophageal Reflu isease

    Berest D. G., Shiman A. G., Tkachenko E. I., Lebedev V. P.


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