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TNFTNF--αα
Activated Macrophage
Tumor Necrosis Factor: TNFα
Inflammation Proliferation Apoptosis Immune Response
Somatic cells&
Endothelium
TNFα Diseases and Treatments
1. Alzheimer2. Parkinson’s3. Stroke-Neuoroinflammation-mediated cell death
Suspected of playing a role:
Anti-TNFα therapy for Crohn’s disease, rheumatoid arthritis, asthma
Anti-TNF antibody Soluble TNFRII-human Fc fusion
2. Infliximab1. Adalimumab Etanercept
Local vs Systemic Infection (Sepsis)TNFα activation
Local Liver&
spleen
EdemaLocal activity
DeathCleared infection
Phagocytosis Organ failure
NF- κB Family of Transcription Factors
5’-NNNNNNNNNGGRNWYYCCNNNNNNNNNNNN-3’
Bind as dimers to κB DNA sites
W:A or TY: C or T