Title Chronic vascular complications in diabetes Author(s) Jia, W; Xu, A; Chen… · 2016. 6. 4. · Title Chronic vascular complications in diabetes Author(s) Jia, W; Xu, A; Chen,

Title Chronic vascular complications in diabetes

Author(s) Jia, W; Xu, A; Chen, A; Wu, J; Ye, J

Citation Journal of diabetes research, 2013, v. 2013, p. 858746

Issued Date 2013

URL http://hdl.handle.net/10722/189246

Rights Creative Commons: Attribution 3.0 Hong Kong License

Hindawi Publishing CorporationJournal of Diabetes ResearchVolume 2013, Article ID 858746, 1 pagehttp://dx.doi.org/10.1155/2013/858746

EditorialChronic Vascular Complications in Diabetes

Weiping Jia,1 Aimin Xu,2 Alex Chen,3 Jiarui Wu,4 and Jianping Ye5

1 Department of Endocrinology and Metabolism, Shanghai Diabetes Institute,Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China

2The University of Hong Kong, Pokfulam, Hong Kong3University of Pittsburg, Pittsburgh, PA 15261, USA4Chinese Academy of Science, Shanghai 200031, China5 Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA

Correspondence should be addressed to Weiping Jia; [email protected]

Received 14 May 2013; Accepted 14 May 2013

Copyright © 2013 Weiping Jia et al. This is an open access article distributed under the Creative Commons Attribution License,which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

With high prevalence of type 2 diabetes worldwide, diabeticcomplications have been a major health problem, whichreduce life quality and induce premature death in adults. Theprevalence of type 2 diabetes is closely related to obesity andaging, two major risk factors for metabolic disorders. Thediabetic complications, including retinopathy, nephropathy,neuropathy, skin ulcer, and atherosclerosis, are risk factorsfor mortality of patients. Retinopathy, nephropathy, and skinulcer are representatives of microvascular complications,which often happen in insulin-deficient diabetic conditions,such as type 1 diabetic patients and some late-stage type2 diabetic patients when 𝛽-cells completely lose function.Atherosclerosis that is often found in type 2 diabetes is acomplication of macrovascular disease that increases the riskfor myocardial infarction and strokes. However, atheroscle-rosis is receiving more and more appreciation in type 1diabetes. Endothelial cells that line the inner vessel have beenextensively studied in the mechanism of the diabetic com-plications. Impaired endothelial cell function is a commoncellular mechanism for most of the diabetic complications(retinopathy, nephropathy, skin ulcer, and atherosclerosis).The cells are exposed to the high level of glucose in diabeticcondition and subjected to glucose-induced stresses. Thestress may cause overproliferation and deficiency in prolif-eration of endothelial cells, which contribute to dysfunctionof microcirculation. Prevention and treatment of the com-plications are dependent on protection of the endothelialcell functions in most cases. In this issue, the mechanism

of endothelial cell dysfunction was investigated in severalstudies to understand the molecular events by which theendothelial cells are impaired by hyperglycemia. This topic isenhancedwith another group of studies about intervention ofthe endothelial complications with antioxidant compoundsand new drug candidates. These studies will help readers tounderstand the current status and gain new insights into thediabetic complications.

Weiping JiaAimin XuAlex ChenJiarui Wu

Jianping Ye

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Title Chronic vascular complications in diabetes Author(s) Jia, W; Xu, A; Chen… · 2016. 6. 4. · Title Chronic vascular complications in diabetes Author(s) Jia, W; Xu, A; Chen,