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Tissues,OrgansandPhysiologyModeling
CurrentAreaofResearchInterest• Vision,VisualSystemFunc:on,VisualProsthesis• DynamicNeuroimagingofBrainFunc:onMEG,fMRI,Op:calImaging,neuralcurrentMRISourcecharacteriza:on,mul:‐modalityintegra:on• UnderstandingNeuralComputa:on
ChallengesthatMaybeAddressedwithAdvancedCompu<ngandMathema<csCapabili<es• LargescaleBiophysicalModelingMRIfunc:onalContrast,NeuralS:mula:on
• Synthe:cCogni:on,SensoryInforma:onProcessing
• Neuromime:candNeuromorphicComputerSystems
JohnS.GeorgeTechnicalStaffMemberLosAlamosNa:onalLaboratory
DOE/OfficeofScience ExtremeBiology August17‐19
Tissues,OrgansandPhysiologyModeling
CurrentAreaofResearchInterest• Simula(on‐basedresearchinneuroscience• biologicallydetailed,physiologicalmodeling• learning&plas(city,large‐scalenetworkdynamics
ChallengesthatMaybeAddressedwithAdvancedCompu@ngandMathema@csCapabili@es
• large‐scaletheoriesofbrainfunc(on&dysfunc(on• predic(vemodelsfordrugdesign• informa(onprocessinginbraincircuitry
SeanHill(PhD)ProjectManager‐Computa(onalNeuroscienceBlueBrain/EPFL
Opportuni(esinBiologyattheextremescaleofcompu(ng Aug17‐19,2009
Tissues,Organs,andPhysiologyModelling
NeuralNetworksimula9onmethods
Challengespresentedbyavailabilityofverylargeparallelcomputers• Loadbalancewhenlargestneuronismuchlargerthanaveragecomputa9onalloadperprocessor• Overlappingcomputa9onandspikeexchange:avoidingcommunica9onbandwidthlimita9ons
MichaelHinesSr.ResearchScien9stComputerScienceYaleUniversity
Opportuni9esinBiologyattheextremeScaleofCompu9ng:May11‐12
Tissues,Organs,andPhysiologyMul4scaleModelingofArterialTrees
Computa4onalChallenges: Solu4onoflinearsystemson1000sProcessors Couplingheterogeneouscodes:
atomis4c‐con4nuum
GeorgeEmKarniadakisProfessorofAppliedMathema4csBrownUniversity
Opportuni4esinBiologyattheextremeScaleofCompu4ng:May11‐12
Tissues,Organs,andPhysiologyModeling
ResearchInterest:HighPerformanceI/O• NovelapproachestoparallelI/Oso;ware• Data‐intensivecompu@ng• I/OInterfacesforHPCApplica@ons
ChallengesaddressedwithAdvancedCompu>ng• Mee@ngtheI/OperformancerequirementsofBiologyApplica@ons• Providingefficient,usableinterfacestoI/OandstorageforBiology• Furthereduca@onofbestprac@cesI/Otechniques
SamLangPVFSTechnicalLeadArgonne/MCS
ExtremeScaleBiology August17,2009
Tissues,Organs,andPhysiologyModeling
CurrentAreaofResearchInterest• ExperimentalandComputa:onalsimula:onofbiologicalflows• Hemodynamicsofthecaro:dbifurca:onandvasculargraBs.• Hydrodynamicsofcerbrospinalfluidmo:oninthespinalcanal
ChallengesthatMaybeAddressed• Fluidsdynamicssimula:onsofmanypa:entspecificgeometriesandflowsforcorrela:onbetweenmechanicalforces(shearstressandpressure)withbiologicalmarkerssuchasdiseasepresenceand/orprogression.
FrancisLothAssociateProfessorUniversityofAkron
Opportunities in Biology at the Extreme Scale of Computing August 17-19, 2009
Tissues,OrgansandPhysiologyModeling
CurrentAreaofResearchInterest[Includegraphic]• BiomedicalModelingatmul8scales• BiomedicalAnalysis• BiomedicalDatamanagement
ChallengesthatMaybeAddressedwithAdvancedCompu>ngandMathema>csCapabili>es
• Limitstowhatunderlyingmechanis8calgorithmsarecomputable• Limitstowhatunderlyingmechanis8calgorithmscanbevalidatedwiththeoryordata•
PeterLyster DrNa8onalIns8tutesofHealth
DOE/OfficeofScienceGraphic NameofWorkshop Date
Op8onalphotoofworkshoppar8cipant
Illustra8vefigurethatdescribesresearcheffort
CurrentAreaofResearchInterest• Simula(on‐basedresearchinneuroscience• high‐performancecompu(ngandsimula(on‐steering• integra(vecompu(ngworkflows
ChallengesthatMaybeAddressedwithAdvancedCompu<ngandMathema<csCapabili<es
• hypothesis‐drivendrugdevelopment• personalizedmedicine• reducinganimalexperimenta(on
Dr.FelixSchürmannGeneralProjectManagerBlueBrain/EPFL
Opportuni(esinBiologyattheextremescaleofcompu(ng Aug17‐19,2009
Tissues,OrgansandPhysiologyModeling
Woloschak Lab • Current Research: (janus.northwestern.edu/wololab): -Studies of radiation on late tissue toxicities including cancer—DOE -Development of nanoparticles for imaging and therapy of cancer—
NCI
• Challenges/Other areas: -modeling radiation toxicity at the tissue/organism level
(applications to RadOnc) -modeling effects of different radiation qualities (low LET, p+ for
RadOnc; p+, HZE for NASA); modeling interactions of different radiation qualities
-modeling interaction of radiation with other toxicities (chemo for cancer therapy; heavy metals for environmental concerns; others)
-modeling toxicities of various nanoparticles (different materials, sizes, molecules bound, shapes) on tissues, organisms; modeling toxicities of nanoparticles coupled with other materials (applications to nanotech, cancer, therapies, environmental concerns)
-modeling which nanoparticles will be able to accumulate in tissues/tumors due to EPR (enhanced permeability and retention)—(applications to cancer therapy and imaging)