THE UNTAPPED POTENTIAL OF INDIAN HERBS - PFNDAI

Golden Jublee Seminar on Emerging Foods for Healthier India

THE UNTAPPED POTENTIAL OF INDIAN

HERBS NUTRACEUTICALS & FUNCTIONAL FOODS

Dr. U.V. Babu

Head-R&D- Phytochemistry

The Himalaya Drug Company,

Bengaluru

05.10.2017

PFNDAI, Mumbai

The Untapped Potential of India Herbs : Nutraceuticals & Functional Foods

Wellness in every home

through herbal healthcare

OUR VISION

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The Untapped Potential of India Herbs : Nutraceuticals & Functional Foods 05.10.2017

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Nutrition plays a central role in Ayurvedic living. Ayurveda places special

emphasis on Ahara(diet) and Anna (food) as a means to good life, health and

wellness. Healthy and wholesome Food nourishes the mind, body and soul.

Ayurveda asserts that the quality and appropriate quantity of food are necessary

for healthy life. Food taken in proper quantity provides strength,Vigor, good

complexion and nurtures the health of the tissues.

Ayurvedic Nutrition


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The diet which besides providing the basic nutrition to the body, helps to maintain

the healthy state of the body and prevents the occurrence of diseases should be

consumed

Charaka Samhita : Sutra Sthana : 5

If wholesome diet is given in a planned way, then there is no need to administer

medicines and if wholesome diet is not being used then too there is no need to give

medicine,

as this is not going to cure the disease in the absence of wholesome diet.

Vaidhya Jeevana : 1/10


Nutraceuticals & Functional Foods

WHY THERE IS GROWING DEMAND FOR THESE SUPPLEMENTS?

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DRUG DISCOVERY - TODAY

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Drug Development Costs

Average cost to develop a drug (including the cost of

failures):

• Early 2000s = $1.2 billion* (some more recent studies

estimate the costs to be even higher)

• Late 1990s = $800 million*

• Mid 1980s = $320 million*

• 1970s = $140 million*

HOW MUCH COST IS AFFORDABLE

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Consumer’s Out of pocket spend on healthcare :

Comparative split by region (world)

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NUTRACEUTICALS

FUNCTIONAL FOODS

FUNCTIONAL BEVERAGES

DIETARY SUPPLEMENTS

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Spearheading

Nations

Key Growth

Geographies

Nutraceutical

Future Focus

• United States of America

• Japan

• Israel

• Germany

• China

• India

• Brazil

Application/Disease

specific

Focus for both

functional food and

beverages as well as

dietary supplements

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Country Given Label Definition Regulatory Body

United States of

America

Dietary

supplements

Any of the following which have a

beneficial nutritional effect. 1. Vitamins 2.

Minerals

3. Botanicals and their extracts 4. Amino

acids 5. Concentrates and Extract

Foods and Drug Authority

European Union Food

supplements

1. Concentrated sources of Nutrition

2. Other substances with a beneficial

nutritional effect

European Food Safety

Authority

India Foods for special

dietary use

1. Plants/Botanicals : Whole or Extracts 2.

Minerals, Vitamins, Amino acids and

Enzymes 3. Substances of animal origin

Food Safety and Standards

Act of India

Japan Foods for specific

health use

Any food that can provide and/or

supplement any of the following 1.

Nutrition 2. Sensory Satisfaction 3.

Beneficial Physiological Effect

Japan Health and Nutrition

Food association

China Health foods

Any food that 1. Should suitable for

specific group(s) of people 2. Should also

be able to adjust body functions 3. Should

not aim at curing disease or cause acute

sub-acute or chronic harm to the body

State Food and Drug

Administration

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CUSTOMIZATION – EU & INDIA

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2009

2016

2012

2050

62 billion $

81 billion $

450 billion $

5 trillion $

2009

2012

2016

2050

816 billion $

????? $

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Medicin

al P

lan

ts a

re u

sed

by T

ribal

Communities (oral)

8000 species

Ayurveda 900 sp.

Unani 700 sp.

Siddha 600 sp.

Modern 30 sp.

Amchi 250 sp.

TH

E IN

DIA

N F

LO

RA

(c

a 1

75

00

sp

ec

ies

)

IND

IAN

SY

ST

EM

S O

F M

ED

ICIN

E

India’s strength in Herbal Technology

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ESTABLISHING AUTHENTICITY

Morphologically

Microscopic

DNA Fingerprinting

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• Pharmacognosy-

–Adulterations & Substitutes - Unintentional

• Traditional Literature describes more than one

species

–Bala

»Sida rhomboidea Sida spinosa

»Sida retusa Abutilon indicum

»Sida cordifolia Urena lobata

»Sida acuta Urena sinuata

»Sida rhombifolia Pavonia odorata

»Sida veronicaefolia Pavonia zeylanica 05.10.2017

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Mucuna deerigiana M. utilis M. cochinshinensis Canavalia virosa Canavalia ensiformis

Mucuna pruriens

L-Dopa

Active constituent

Formulary vs. Market Samples: Mucuna pruriens

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DNA BARCODING

THE NEXT TOUGH TEST FOR

AUTHENTICITY

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https://www.google.co.in/url?url=http://theaphidroom.wordpress.com/tag/dna-barcoding/&rct=j&sa=U&ei=U-3OUrerOOu8iAeQwYGIAw&ved=0CDIQ9QEwBA&q=dna+barcoding+in+plants&usg=AFQjCNGy0csrjIKxSaGz3XP4kZejtLi0Rg


Authenticity, Herb-Extract Ratio & GACP

Manufacturing facilities & Reproducibility

Bioactive/Analytical markers & Standardization

Contaminants, Heavy metals, Pesticides, Aflatoxins &

Solvent Residues

Safety & Efficacy

The Quality of Medicinal Plants & Products

A

M

B

C

S

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//upload.wikimedia.org/wikipedia/commons/6/67/Tetrahedron-2-3D-balls.png


Geographical Seasonal Authenticity Finger printing Assay markers

HPTLC LC-MS Pharmacognosy

DNA Barcode

Herb:Extract

Ratio Group

Assays

Contaminants

Heavy metals

Pesticides

Microbial

Aflatoxins

HP

Choice of

Solvent

Population studies

Sustainable

Cultivation Practices

Total Spectrum

HPLC

Safety profile

Total Quality : Full Spectrum

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Tissue culture of Ratna Purush, an endangered herb, at Himalaya’s Lab and successful field trial

TISSUE CULTURE

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BIOACTIVE

MARKER

ANALYTICAL

MARKER

BIOAVAILABILITY

ENHANCER

BINDER/

LUBRICANT

SELF

PRESERVATIVE

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Molecule

Fraction

Herb

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Multiple herbs

Multiple compound

s

Multiple targets

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Single Herbs Phytopharmaceutic

als

Classical Ayurvedic

formulations

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Active

Ingredients

Preservatives

Excipients

& Additives

Consumer Expectations : Win-Win Strategy

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O%

DISCHAR

GE

SOLVENT

FREE

PRESERV

ATIVE/EX

CIPIENT

FREE

NATURAL/

ORGANIC BIODEGR

ADABLE

BIODIVER

SITY

CONCER

N


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Novel extraction technologies :

Supercritical Fluid Extraction (SCFE)

Microwave Assisted Extraction (MAE)

Accelerated Solvent Extraction (ASE)

Ultrasound Extraction (USE)

Subcritical Fluid Extraction (SFE)

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http://www.google.co.in/url?sa=i&rct=j&q=&esrc=s&frm=1&source=images&cd=&cad=rja&docid=okMuq7m64MrUmM&tbnid=OI96UYi-4WEqAM:&ved=0CAUQjRw&url=http://www.healthybusiness.co.za/GNLD Products Guide/herbal/h2.html&ei=-AwWU9mtOuWQigfhvYCoBg&bvm=bv.62286460,d.aGc&psig=AFQjCNGcoq16q6pW9WCjhgmHRnzx46lCrg&ust=1394040416685670


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http://www.google.co.in/url?sa=i&rct=j&q=&esrc=s&frm=1&source=images&cd=&cad=rja&docid=8f0NCF1oMoaSGM&tbnid=_8qB6t-DpiIGgM:&ved=0CAUQjRw&url=http://www.pharmainfo.net/tablet-ruling-dosage-form-years/operations-involved-tablet-manufacturing&ei=yAsWU8DKMsjpiAfg24HYCw&bvm=bv.62286460,d.aGc&psig=AFQjCNG8UNBPjuUoUDxsveDuW-eCKKYYhw&ust=1394039972608094


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https://www.google.co.in/imgres?imgurl=http://curcumin-turmeric.net/img/diagram_curcuminoids.gif&imgrefurl=http://curcumin-turmeric.net/&docid=NX7JLrHne-E3VM&tbnid=NPC4tc3WiI7IHM:&w=290&h=322&ei=ReYVU-63N6LoiAeo1YCYBw&ved=0CAIQxiAwAA&iact=c


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TURMERIC -- SCFE --TURMERONES -- CURCUMINOIDS

BIOAVAILABILITY ENHANCER

HOLISTIC APPROACH

BINDER & LUBRICANT BIOACTIVE

Hardness 2-3 kg. DT =5 min and

Friability < 1%

Global Patent, 2009


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http://www.google.co.in/url?sa=i&rct=j&q=&esrc=s&frm=1&source=images&cd=&cad=rja&docid=wXfrgkH2m9jx2M&tbnid=L2Sb09iZ2NS1-M:&ved=0CAUQjRw&url=http://www.iherb.com/Himalaya-Herbal-Healthcare-Turmeric-60-Capsules/3744/&ei=5ukVU76cL8e4iQfwtYHgBQ&bvm=bv.62286460,d.aGc&psig=AFQjCNEncjGu-YBSrWttKSI7R0vPei1oqQ&ust=1394031432106671


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Range of 22 organic Pure Herbs in

tablet form

100% USDA certified organic products

Excipient & preservative free

Advanced super critical fluid extraction

Highly enriched active markers

Global patent filed

ORGANIC PURE

HERBS

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Fiber &

Prebiotic

s

Probiotic

s

&

Botanica

ls

Anti-

oxidants

Omega-

3

Proteins

&

Amino

Acids

Vitamin

s &

Mineral

s

Consumer Desirability Low High

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The Untapped Potential of India Herbs : Nutraceuticals & Functional

Foods

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CARDIOVASCULAR

DISEASES

ARJUNA,GARLIC,GUGGUL, FENUGREEK, SAWPALMITO, GINSENG & GINKGO

PLANT STEROLS, FENUGREEK

OMEGA

EPA & DHA CoQ 10

LYCOPENE

POLYCOSANOL

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WEIGHT

MANAGEMENT &

OBESITY

SALACIA, NIGELLA, LICORICE

FIBRES, PROTEINS, FATTY ACIDS

GARCINIA GREEN TEA

FORSKOLINE

BITTER ORANGE

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COGNITIVE &

SLEEP

ASHWAGANDHA, BRAHMI, VALERIANA

OMEGA

EPA & DHA ANTIOXIDANTS MELATONIN

AMINO ACIDS

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BONE & JOINTS

TURMERIC, BOSWELLIA, HADJOD

ANTIOXIDANTS

OMEGA-3 MINERALS

PROTEIN

AMINO ACIDS

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DIABETES

BITTER MELON, GYMNEMA, FENUGREEK, PTEROCARPUS

GREEN TEA, AMLA

OMEGA-3 CHROMIUM

CINNAMON

MAGNESIUM

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CANCER

TURMERIC, GARLIC, ECHINACEA, WHEAT GRASS

GREEN TEA, AMLA

GINSENG CO Q 10

LYCOPENE

SELENIUM

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Increasing Cost of Health

Care

Ageing Population

Increasing Consumer Health

Awareness

Increase in Disposable

Income

Natural Sourcing

USA EU INDIA MARKET DRIVERS – NUTRACEUTICALS

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Slow pace of Regulatory

approval

High cost of Product Develop-

ment and maturing market

Lack of Regulatory frame work

to validate health claims

Inadequate investment in Nutra-

ceutical and Food Research

USA EU INDIA RESTRAINTS– NUTRACEUTICALS

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STRENGTHS Huge Opportunity for growth driven

by changing urban life style.

Younger Indian population with

significant nutritional deficiency.

There is history of Ayurveda and

health enhancing products in

natural way.

GMP practices and experience base

in Pharma, food and beverage

industry.

WEAKNESSES Nature of market fragmented both from

demand and supply perspective.

A kind of niche market.

Lack of will to reinvent already existing

rituals/practices which could develop into

big brand.

Lack of information to prove

efficacy/benefit. OPPORTUNITIES To position local remedies to fully

branded.

Consumer & Stake holder opinion

education through communication.

Ease of doing business index.

Sports related nutraceuticals will

have major impact on consumer

health as fitness enthusiasts

growing.

THREATS

Spurious Products & Brands.

Most nutraceutical products branded as

premium so limits its scope to Urban

market.

Lack of stake holders support.

Adulteration.

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ACADEMIA AND INDUSTRY COLLABORATION – A MUST

Agriculture

Plant biotechnology

Chemical engineering

Extraction technology

Food technology & preservation

Fermentation technology

Microbial technology

Enzyme technology

Delivery systems & biodegradable packaging

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Good Product

Requirement

Active Ingredient

s

Therapeutic Claims

Artwork

Aesthetics

Packaging

Excipients

Cost


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Thank you and keep well!

Costus (Kushtha) – The essential oil of roots has strong antiseptic, disinfectant and

anti-inflammatory properties. Used in Purim


If any queries, mail me:

[email protected]

05.10.2017

PFNDAI, Mumbai

Documents

THE UNTAPPED POTENTIAL OF INDIAN HERBS - PFNDAI