The Thoracic Surgery Foundation

At A Glance

Thoracic Surgery Foundation

For Research and Education 401 N. Michigan Avenue Chicago, IL 60611-4267

312/644-6610 Fax No. 312/527-6635

Email: frank_kurtz@SBA.com http://www.tsfre.org

July 2001

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July 2001 To The Friends of the Foundation: The Thoracic Surgery Foundation for Research and Education had its beginning in 1984 when the Council of the Society of Thoracic Surgeons first considered the establishment of a foundation to support research and education in thoracic surgery. The need for such a foundation was based on the diminishing resources available from government and practice activities to support research and education. In 1989, The Society of Thoracic Surgeons established The Society of Thoracic Surgeons Education and Research Foundation. In 1992, with the establishment of The Nina Starr Braunwald Memorial Fund and support from the four major thoracic surgery organizations (American Association for Thoracic Surgery, The Society of Thoracic Surgeons, The Southern Thoracic Surgery Association, The Western Thoracic Surgical Association), the foundation was re-organized as The Thoracic Surgery Foundation for Research and Education, the Board of Directors being selected from individuals nominated by the four thoracic surgery organizations. Support for The Foundation’s programs in research and education, in addition to the Braunwald Memorial Fund which has now reached $2,000,000, was greatly enhanced by major gifts from Baxter Healthcare Corporation and David Sheridan. In 1993, The New Century Society was established to solicit and recognize individuals who contributed $1,000 or more in a given year. The Founders Group, of which there are 179 members, honors those who contributed $5,000 by December 1998. Life Members are those who have contributed or pledged $10,000 to The Foundation. As of December 2000, The Foundation has 124 Life Members. All Board members have committed to Life Membership. In 1999 The Foundation initiated a regional program with the objective of making every thoracic surgeon aware of The Foundation and its programs, anticipating that understanding The Foundation and its work would lead to involvement and support. This program is directed not only to surgeons, but also to friends, patients and others who may have an interest in The Foundation. In 2000, 196 surgeons in 44 regions personally contacted thoracic surgeons to acquaint them with The Foundation and solicit their support. Despite the past year being a start-up year, 333 surgeons made cash contributions, payments on pledges and new pledges totaling $696,922, a 16% increase in numbers and a 34% increase in dollars over the last year. It is anticipated that with the organization completed, the current year will prove even more successful. In 2000, The Foundation also reached a major goal. The Thoracic Surgery Foundation for Research and Education, through grants from The William J. von Liebig Foundation and Datascope Corp., and the National Heart, Lung and Blood Institute announced a program of jointly sponsored Mentored Clinical Scientist Development Awards. These awards are directed at thoracic surgeons in the early stages of their research careers in order to support the development of outstanding clinician research scientists. The program will be funded over a ten-year period by a NHLBI commitment of $5 million, which was contingent upon The Foundation securing $3.75 million in matching funds. The Foundation completed this match in 2000 with commitments of $2 million from The William J. von Liebig Foundation, $1 million from Datascope Corp., and $750,000 from The Foundation itself.

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This means that each $1,000 The Foundation contributes will be matched with an $10,666 contribution from other sources. This is an exceptional opportunity for donors who give so as to help offset the Foundation's commitment. Datascope manufactures proprietary products for clinical health care markets in interventional cardiology and radiology, anesthesiology, cardiovascular and vascular surgery, emergency medicine and critical care. The Foundation is extremely grateful to Datascope and to Mr. Lawrence Saper, President and CEO. The William J. von Liebig Foundation was established in 1975 by William J. von Liebig. An honored inventor, entrepreneur and philanthropist, Mr. von Liebig founded Meadox Medicals, Inc. in 1961. He held 33 patents for vascular prostheses, and his inventions have made significant contributions to the field of vascular surgery. Mr. von Liebig was honored with a host of achievement awards throughout his life, including the Gold Hektoen Award from the American Medical Association and the 1995 Independent Investor of the Year Award from the New Jersey Institute of Technology. "The Thoracic Surgery Foundation At A Glance" provides key information in outline form to help you understand the mission, programs and growth of The Thoracic Surgery Foundation. Thank you for your interest and support. This document is also available on the web at www.tsfre.org for your convenience. Please feel free to download it from that location or call The Foundation office for more copies.

David B. Skinner, MD President

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Table of Contents ORGANIZATIONAL INFORMATION PAGE TSF At-A-Glance: What has TSF accomplished? 5-6 How is TSF structured? 7 What are The Foundation's future plans? 8 GRANTS AND AWARDS What types of research does The Foundation fund? 9 What types of Health Care Policy Scholarships does The Foundation fund? 10 What are the Harvard Programs? 11-12 Who makes funding decisions? When are they made? 13 Who has received TSF's grants and awards? 14-20

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TSF At-A-Glance: What Has TSF Accomplished? 1. Recent Achievements

Within the last three years, The Foundation has: ♦ completed a three-year plan ♦ established a comprehensive development program through new fund-raising committees ♦ broadened and improved it's public policy training opportunities for surgeons ♦ secured a partnership with the National Heart, Lung and Blood Institute of NIH which will

broaden support for research ♦ taken the lead in moving to better coordinate the relations of the specialty with specialty-

related firms 2. Fund-Raising ♦ TSF raises funds to support awards in basic research and for education for CT surgeons in

health care policy. ♦ As of 12/31/00, 37% of all moneys raised has come from CT surgeons. ♦ In 2000, TSF raised $4,162,352 in cash, pledge payments and new pledges. 3. Award Programs ♦ As of May 2001, TSF has made 154 awards: 43 for research and 111 for health care policy

education. ♦ TSF is currently supporting 19 research scholars and three Alley-Sheridan Sabbatical

Scholars. 4. Research Awards Programs ♦ In 2001, TSF made three research awards. ♦ A total of nine Braunwald awards have been made. ♦ The Thoracic Surgery Foundation for Research and Education, through grants from The

William J. von Liebig Foundation and Datascope Corp., and the National Heart, Lung and Blood Institute is jointly sponsoring Mentored Clinical Scientist Development Awards. These awards are directed at thoracic surgeons in the early stages of their research careers in order to support the development of outstanding clinician research scientists.

The program will be funded over a ten-year period by a NHLBI commitment of $5 million, which was contingent upon The Foundation securing $3.75 million in matching funds. The Foundation completed this match in 2000 with commitments of $2 million from The William J. von Liebig Foundation, $1 million from Datascope Corp., and $750,000 from The Foundation itself.

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This means that each $1,000 The Foundation contributes will be matched with an $10,666 contribution from other sources.

Two annual awards will support young surgical scientists at the level of $175,000 per year for five years. The program provides specialized study for clinically trained professionals who are committed to a career in research and who have the potential to develop into independent investigators. The award supports a five-year period of supervised research experience that integrates didactic studies with laboratory or clinically-based research. The proposed research should have both intrinsic research importance and be a vehicle for learning the methodology, theories and conceptualizations necessary for a well-trained researcher.

5. Public Policy Training Programs ♦ The Harvard executive course, "Understanding the New World of Health Care," was

developed by The Foundation in conjunction with Harvard's Kennedy School of Government. TSF funded the development of this course.

“Understanding the New World of Health Care,” has been offered nine times since May, 1996.

♦ Five hundred fifty doctors, health care administrators and corporate officers in the health care

industry have attended.

♦ Two hundred fourteen cardiothoracic surgeons have attended.

♦ One hundred and two Alley-Sheridan scholarships have been awarded for this health care policy education.

♦ The Foundation's Education Committee and Harvard recently offered a successor course,

"Building the New World of Health Care," April 8-14, 2000, for past participants of "Understanding." Twenty-six surgeons attended “Building.”

♦ Nineteen Alley-Sheridan scholarships were awarded for cardiothoracic surgeons to attend the

successor course. ♦ The Foundation has also sponsored eight surgeons through Alley-Sheridan Sabbatical

Scholarships to attend Harvard for a year-long study of health care policy.

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How IS TSF Structured? The Thoracic Surgery Foundation for Research and Education was established in 1992 in order to support education and research in cardiothoracic surgery. The Foundation received endorsement and initial support from the American Association of Thoracic Surgery (AATS), the Society of Thoracic Surgeons (STS), the Southern Thoracic Surgical Association (STSA), and the Western Thoracic Surgery Association (WTSA). The Foundation Board of Directors, consisting of sixteen members nominated by the four sponsoring surgical organizations (AATS, STS, STSA and WTSA), is responsible for the management of The Foundation and is assisted by three full-time staff. There are four permanent committees of the Board: the Education Committee, the Research Committee, the Development Committee and the Finance Committee, which includes the treasurers of each of the four sponsoring surgical organizations. Board and committee members are not compensated. The Thoracic Surgery Foundation is a tax-exempt 501(c)(3) public foundation. Its IRS Employer Identification Number is: 36-3635910.

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What Are The Foundation's Future Plans? In 1998, TSF developed its first three-year plan. Its central goals are summarized in the Plan's Presidential Message: Over these past seven years, The Foundation has achieved recognition as a major force in our specialty and in medicine, and has the potential to have an even greater impact. To broaden our programs and maintain cardiothoracic surgery at the forefront of medicine, it is necessary that we broaden our support. TSF has organized a regional program to personally communicate with every thoracic surgeon so that they will learn of the work of The Foundation and help us to identify sources of support. A videotape and brochure on The Foundation has been produced which will help us disseminate the purpose and work of The Foundation, through the regional program and other venues. The Foundation is now also poised to work in a mutually beneficial way with industry so that we may together introduce new innovative programs that will enhance our specialty. And, The Foundation is working with grateful patients and to seek funding from other foundations. As we look ahead, The Foundation will need greater and broader support to fulfill its considerable potential. With the Harvard programs and our own research programs, especially the jointly sponsored TSFRE and NHLBI Mentored Clinical Scientist Awards, The Foundation is becoming a true leadership institute for the specialty. Support our efforts. Our goal is to have every cardiothoracic surgeon become a Life Member in The Foundation. This will significantly improve the future of our specialty.

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What Types of Research Does The Foundation Fund?

The Foundation funds the following awards in basic research:

• The Thoracic Surgery Foundation Research Grant provides operational support of original

research projects by cardiothoracic surgeons who have completed their formal training and who are eligible by The American Board of Thoracic Surgery or its equivalent;

• The Thoracic Surgery Foundation Research Fellowship provides support to cardiothoracic

surgeons and surgical trainees who wish to acquire investigational skills;

• The Baxter Healthcare Corporation Research Fellowship provides support to cardiothoracic surgeons and surgical trainees who wish to acquire investigational skills;

• The Nina S. Braunwald Career Development Award, established by Dr. Eugene Braunwald

in memory of his wife, provides support to women in academic cardiothoracic surgery at the early stages of their faculty careers;

• The Nina S. Braunwald Research Fellowship provides support to female cardiothoracic

surgeons who wish to acquire investigational skills; and

• A research fellowship is also co-sponsored by the Cross-Jones Fund. • The Thoracic Surgery Foundation for Research and Education and the National Heart, Lung,

and Blood Institute jointly sponsor Mentored Clinical Scientist Development Awards (K08), directed at thoracic surgeons in the early stages of their research careers. The purpose of the Mentored Clinical Scientist Development Award (MCSDA) is to support the development of outstanding clinician research scientists.

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What Types of Health Care Policy Scholarships Does The Foundation Fund?

The Alley-Sheridan Fund was established within The Thoracic Surgery Foundation by Mr. David Sheridan on behalf of his life-long friend and collaborator, Dr. Ralph Alley, to provide educational opportunities, especially in health care policy matters for cardiothoracic surgeons. This fund has been used to make a generous grant from The Foundation to the Kennedy School of Government at Harvard University to develop an intensive executive course in management and health care policy. "Understanding the New World of Health Care: A Health Care Policy Program for Physicians, Trustees and Health Care Leaders." Executive Course Alley-Sheridan Fellows Through grants to Harvard, the Foundation provides scholarship support to surgeons to attend the executive courses. Alley-Sheridan Scholar-in-Residence The Foundation offers Alley-Sheridan tuition scholarships for cardiothoracic surgeons to pursue a year of study in health care policy at Harvard University.

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What Are the Harvard Programs? Executive Course The executive course, "Understanding the New World of Health Care," was developed by The Foundation in conjunction with Harvard's Kennedy School of Government. The program covers the following topics: health economics; the political environment and the media; hospital and physician reimbursement schemes; the structure of Medicare and Medicaid; the inner workings of managed care; the role of information technology; the relevant aspects of anti-trust; professional and corporate liability; and the nature and extent of health care fraud. The course has been offered nine times since early 1996, and continues to receive superlative ratings from participants. It is the most highly rated course of its type at Harvard. Since its inception, nearly five hundred fifty doctors, health care administrators, government officials, and corporate officers in the health care industry have attended including one hundred and two cardiothoracic surgeons who received Alley-Sheridan Scholarships from The Foundation. A total of two hundred and fourteen cardiothoracic surgeons have attended. The attendees include seven STS and two AATS Presidents, twelve other former or current STS officers, four STS Councilors, fifteen STS Committee Chairs, thirty-five former or current Committee members and four principal administrative staff. And, The Foundation's Education Committee and Harvard offered a successor course, "Building the New World of Health Care," April 8-14, 2000, for past participants of "Understanding." Year-Long Sabbatical Scholarships for a yearlong sabbatical to study health care policy at the Kennedy School are awarded to board certified cardiothoracic surgeons. The program focuses on problems and solutions in health care management, the role of government in health care, bioethics, standards of care, and the scientific assessment of outcomes. The program also seeks to cultivate cardiothoracic surgeons who can provide the specialty with strong leadership in the future. Seven sabbatical awards have been made, including a current Alley-Sheridan Scholar-in-Residence who is pursuing an MPH at Harvard. Participants in the sabbatical program can elect to structure their coursework to lead to a Masters Degree in Public Administration, or conduct a year of social science research on a specific topic under the supervision of a faculty member. The five Alley-Sheridan Scholars-in-Residence who have completed this program have had a direct impact on public policy related to health care. For example, one Alley-Sheridan Scholar-in-Residence authored “Accountable Health Care: Letting Patients Lead the Way: Transforming Medicare for the 21st Century”, on behalf of the Health Policy Development Group of the AATS and STS. This set of recommendations was presented to the National Bipartisan Commission on the Future of Medicare. The Foundation also supports surgeons to pursue the MPH, and other forms of policy training.

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If we define politics more broadly as public action to address public problems, then the effect of the Kennedy School experience is even broader. Two of the sabbatical scholars have become intimately involved in developing programs in their communities to provide healthcare to all and shelter to those without sanctuary. A third has become a Robert Wood Johnson Fellow and is a Senior Legislative staffer in Senator Kennedy's office, assigned to the Health, Education Labor and Pension Committee. And, a fourth has become the Director of a surgical program and is involved with research on quality issues.

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Who Makes Funding Decisions? When Are They Made? Research Awards The Research Committee of The Thoracic Surgery Foundation for Research and Education consists of 14 research-oriented cardiac and thoracic surgeons. The members of this committee meet annually, in conjunction with the STS Annual Meeting, to discuss and rank applications submitted for possible funding by The Foundation. Each application received by the fall deadline is reviewed by members of the Committee according to current review standards. The names and mean scores of the first 20 applicants are presented by the Committee Chairman to the Board of Directors.

At the STS Annual Meeting, The Board of Directors of TSF then reviews these applications and approves for funding as many of the most highly ranked application as current allocations allow. Alley-Sheridan Scholarships The Education Committee reviews applications for year-long Alley-Sheridan scholarships, and recommends applications for funding to the Board of Directors. At the STS Annual Meeting, the TSF Board reviews and approves those recommendations as current allocations allow.

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Who Has Received TSF's Grants and Awards?

Alley-Sheridan Scholarships to Attend the Harvard Executive Course

Alley-Sheridan Fellows One hundred and two surgeons have received scholarship support totaling $286,150 to attend the Harvard executive course during the period from May 1996 through November 2000.

Alley-Sheridan Scholarships for a Harvard Year Long Sabbatical MPA Program Alley-Sheridan Scholars-in-Residence

Nine surgeons have received Alley-Sheridan Sabbatical Scholarships for a total of $315,000. 1996 Paul Uhlig 1997 Peter McKeown

Jud McNamara 1998 Edward Dunn

Edgar Feinberg 1999 Edward Dunn (MPH Program) 2000 Juan Sanchez 2001 William R. Berry, MD

Alan J. Spotnitz, MD

Alley Sheridan Award Totals Total Number of Scholarships: 111

Total Funds Awarded: $601,150

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TSF Research Awards 1993 Julie Glasson, MD Thoracic Surgery Foundation Research Fellowship The Importance of Preservation of the Chordae Tendineae During Mitral Valve Replacement Stanford University Jennifer Walker, MD 2 year Nina S. Braunwald Research Fellowship The Direct Effects of Acute Administration of 3, 5, 3’Triiodo-L-Thyronine on Isolated Myocyte Function Medical University of South Carolina 1995 Margaret Allen, MD 2 year Nina S. Braunwald Career Development Award To Expand the Scope of Research on Adhesion Molecules University of Washington School of Medicine Richard Embrey, MD 1 year Thoracic Surgery Foundation Research Grant Mechanisms of Coronary Microvascular Abnormalities Due to Cardiopulmonary Bypass and Cardioplegia Medical College of Virginia Joseph Gorman, MD 1 year Thoracic Surgery Foundation Research Fellowship Pathogenesis and Repair of Ischemic Mitral Regurgitation Hospital of the University of Pennsylvania Joren Madsen, MD 1 year Thoracic Surgery Foundation Research Grant Cardiac Allograft Vasculopathy in Miniature Swine Massachusetts General Hospital John Mannion, MD 1 year Thoracic Surgery Foundation Research Grant Basic Fibroblast Growth Factor Protects Ischemic Skeletal Muscle During Long-term Electrical Stimulation Thomas Jefferson University Elanie Tseng, MD 2 year Nina S. Braunwald Research Fellowship The Role of Nitric Oxide in Mediating Neurologic Injury in a Canine Model of Hypothermic Circulatory Arrest Johns Hopkins Hospital

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1996 Mary Mancini, MD 2 year Nina S. Braunwald Career Development Award The Role of Platelet Derived Growth Factor in Allograft Vascular Disease Louisiana State University Si M. Pham, MD 1 year Thoracic Surgery Foundation Research Grant Nitric Oxide in Allograft Vasculopathy University of Pittsburgh Robert Poston, Jr., MD 1 year Thoracic Surgery Foundation Research Fellowship Generation of Allograft Specific Tolerance with Combination Ex Vivo Antisense ICAM-1 and Systematic Anti-LFA MAB Stanford University Medical Center Andrew Sherman, MD 1 year Thoracic Surgery Foundation Research Fellowship Gene Expression of Sarcoplasmic Reticular Regulatory Proteins in Myocardial Hibernation Northwestern University Medical School 1997 Edward Boyle, MD 1 year Thoracic Surgery Foundation Research Fellowship The Role of Tissue Factor in Ischemia-Reperfusion Injury University of Washington Seth Force, MD 2 year Thoracic Surgery Foundation Research Fellowship Role of p53 Tumor Suppressor Gene in Malignant Mesothelioma Pathogenesis University of Pennsylvania Si M. Pham, MD 1 year Thoracic Surgery Foundation Research Grant Nitric Oxide in Allograft Vasculopathy University of Pittsburgh Todd Rosengart, MD 2 year Thoracic Surgery Foundation Research Grant Growth Factors and Angiogenesis: Implications for Biologic Revascularization of Ischemic Tissues Cornell University Medical College

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David Schrump, MD 6 months Thoracic Surgery Foundation Research Grant Molecular Analysis of Esophageal Adenocarcinogenesis University of Texas, Anderson Cancer Center Patricia Thistlethwaite, MD 2 year Nina S. Braunwald Career Development Award Expression of Angiogenesis Factors in the Heart by Adenovirus Mediated Gene Therapy University of Pittsburgh 1998 Daniel Kreisel, MD 2 year Thoracic Surgery Foundation Research Fellowship Allorecognition Pathways in Murine Cardiac Transplantaton University of Pennsylvania Paul Lee, MD 1.5 year Thoracic Surgery Foundation Research Fellowship Angiogenic Effects of VEGF and iNOS Gene Therapy in Ischemic Heart University of Pittsburgh Elizabeth Northrop Morgan, MD 2 year Nina S. Braunwald Research Fellowship The Role of NF-kB in Myocardial Ischemia-Reperfusion Injury University of Washington Michael Smith, MD 1 year Thoracic Surgery Foundation Research Fellowship Immune Mechanisms of Bronchiolitis Obliterans Syndrome Washington University Vinod Thourani, MD 1 year Thoracic Surgery Foundation Research Fellowship Myocardial Protectioin Using a Novel Adenosine A3-Receptor Approach Emory University School of Medicine Tomasz Timek, MD 2 year Thoracic Surgery Foundation Research Fellowship Mitral Valvular-Subvalvular Complex in Tachycardia-Induced Cardiomyopathy Stanford University School of Medicine Melina Kibbe, MD 1 year Nina S. Braunwald Research Fellowship Prevention of Intimal Hyperplasia With iNOS Gene Therapy University of Pittsburgh

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1999 James S. Allan, MD 2 year Thoracic Surgery Foundation Research Grant The Effect of Nitric Oxide on the Development of Obliterative Bronchiolitis in MHC-Defined Miniature Swine Massachusetts General Hospital Kathryn Quadracci Flores, MD 2 year Nina S. Braunwald Research Fellowship Upregulation of Angiogenic Growth Factors and Their Receptors as a Mechanism for TMR Brigham and Women’s Hospital Richard W. Kim, MD 2 year Baxter Healthcare Corporation Research Fellowship In Vivo Effects of Bcl-2 and Survivin Gene Transfer Yale University School of Medicine Baiya Krishnadasan, MD 2 year Thoracic Surgery Foundation Research Fellowship Endothelial Cell Signal Transduction Pathways Activated by Oxidant Stress University of Washington Sang Lee, MD 2 year Thoracic Surgery Foundation Research Fellowship Myocardial Angiogenesis Using VEGF, FGF, and Their Receptors University of California, San Diego Kenneth McCurry, MD 2 year Thoracic Surgery Foundation Career Development Award Alloresponse to Aerosolized iNOS Gene in Lung Transplants University of Pittsburgh Christopher L. Skelly, MD 2 year Thoracic Surgery Foundation Research Fellowship Attenuation of Vein Graft Intimal Hyperplasia Through Gene Transfer University of Chicago Edward Yiming Woo, MD 2 year Thoracic Surgery Foundation Research Fellowship Augmentation of HSV-based Oncolytic Therapy by Producer Cells University of Pennsylvania

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2000 Paul M. Kirshbom, MD 1 year Thoracic Surgery Foundation Research Grant Matrix Metalloproteinases and Pulmonary Vascular Remodeling Children’s Hospital of Pennsylvania Raja S. Mahidhara, MD 2 year Thoracic Surgery Foundation Research Fellowship Nitric Oxide Prevents Cardiac Allograft Vasculopathy University of Pittsburgh Steffen Pfeiffer, MD 2 year Thoracic Surgery Foundation Research Fellowship Anti-CD40L Therapy for hDAF+ Pig-to-Primate Cardiac Xenotransplantation Vanderbilt University Medical Center Lynne A. Skaryak, MD 2 year Nina S. Braunwald Career Development Award Tissue Engineered Trachea University of Massachusetts Medical Center Wilson Y. Szeto, MD 2 year Thoracic Surgery Foundation Research Fellowship The Immunologic Mechanism of Cardiac Allograft Vasculopathy in Rat Chimeric Organ Transplantation Hospital of the University of Pennsylvania Mohan Thanikachalam, MD 2 year Thoracic Surgery Foundation Research Fellowship The Role of p53 in the Nitric Oxide Synthase (iNOS)-Mediated Inhibition of Cardiac Allograft Vasculopathy (CAV) University of Miami Thomas K. Waddell, Ph.D., MD 2 year Thoracic Surgery Foundation Research Grant The Role of Bcl-2 Family Proteins in TNF-mediated NF-kB Activation Toronto General Hospital and the University of Toronto 2001 Richard G. Battafarano, MD 2 year Thoracic Surgery Foundation Research Grant Cell Cycle Mutations in Esophageal Cancer Washington University School of Medicine Marc R. Moon, MD 2 year Thoracic Surgery Foundation Research Grant Pathophysiology and Treatment of Chronic Pulmonary Hypertension Washington University School of Medicine

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Meena Nathan, MBBS, FRCS (Edin), FRCS (Glas) 2 year Braunwald Research Fellowship The Stunned Heart and Cardiac Surgery; Apoptosis/Necrosis Brigham and Women's Hospital Alfred C. Nicolosi, MD 2 year Thoracic Surgery Research Grant Effects of Stretch on the Myopathic Heart Medical College of Wisconsin

TSFRE Research Award Totals Total Number of Awards: 44

Total Funds Awarded: $2,517,500

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