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Dr. Eric Moore Division ChiefAdvanced and Emerging ThreatsChemical and Biological Technologies Department (J9CB)
Defense Threat Reduction Agency & USSTRATCOMCenter for Combating WMD & Standing Joint Force Headquarters-Elimination(Distribution Statement A: Approved for public release: distribution unlimited)
The Science Behind the Solutions Research and Grant Opportunities April 27, 2015
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THE DTRA/SCC MISSION
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To safeguard the US and its Allies from Weapons of Mass Destruction▪ Chemical▪ Biological▪ Radiological▪ Nuclear▪ High-Yield Explosivesby providing capabilities to reduce, eliminate and counter the threat, and mitigate its consequences.
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RESEARCH AND DEVELOPMENT OVERVIEW
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Information Sciences and Applications• 24/7 Technical Reachback• Hazard and Effects Modeling• Advanced Analytics and Situational Awareness
Nuclear Technologies• Nuclear threat detection• Nuclear forensics• System survivability
(Rad Hard, EMP)• Nuclear weapons effects• Monitoring and verification
technologies
Basic and Fundamental Research• STEM workforce development• 6.1 grants to Universities
Chemical and Biological Technologies• Medical countermeasures• Disease surveillance, threat detection,
and point of need diagnostics• Threat activity sensing and reporting• Rapid Response and Restoration S&T
Counter WMD Technologies• CWMD terrorism
technologies• Persistent ISR for WMD• Defeat concepts• Test facilities and
technology• Deployable sensors
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Diagnostics, Detection, Disease Surveillance Information and Analysis
Translational Medicine
Advanced and Emerging Threats
Physical Science and Technology
ADDRESSING KEY MISSION AREAS
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Diagnostics, Detection & Disease Surveillance
PROJECT AREASBiosurveillance Ecosystem (BSVE)
Data sources & analytic toolsChem-Bio Detection
Wearable TechnologiesHost-Based Biomarker Identification/Verification/Validation
Field Forward DiagnosticsGenetic Sequencing for Clinical Microbial/Viral Diagnostics
ADDRESSING KEY MISSION AREAS
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Translational Medicine
VACCINES & THERAPEUTICS FOCUS AREASViral: Ebola & Marburg; EEEV, VEEV, WEEV
Bacterial: Bacillus anthracis, Francisella tularensis, Burkholderia mallei & pseudomallei, C. Burnetii, Yersina pestis
Toxins: Ricin, Botulinum Neurotoxin
Platform Technologies: Animal Model Development, Ex vivo mimetics, Flexible Manufacturing, Adjuvants and Stabilization
ADDRESSING KEY MISSION AREAS
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ADDRESSING KEY MISSION AREAS
Advanced and Emerging Threats
EXAMPLE PROJECT AREASCatalytic bioscavengers of nerve agents
Centrally-acting reactivators of acetylcholinesterase, neuroprotectantsADMET Center to enhance drug discovery/development efforts
Host response to chemical toxicants, human toxicity estimates and predictive toxicologyCharacterization and predictive environmental fate of chemical and biological agents, especially particulates
Relevant understanding of routes of exposure and the blood-brain barrierAutomatic threat response, including nano- and micromotors
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THE SCIENCE BEHIND THE SOLUTIONS
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Some of our government partners include:▪ Department of Health and Human Services (HHS)▪ Food and Drug Administration (FDA) ▪ Biomedical Advanced Research and
Development Authority (BARDA)▪ U.S. Army Medical Research and
Materiel Command (USMRMC)
Our partners also include non-government entities and universities such as:▪ GlaxoSmithKline▪ George Mason University▪ Duke University
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WHERE TO FIND BUSINESS OPPORTUNITIES
https://www.fbo.gov/
http://www.grants.gov
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Carefully review BAA and Amendment
Plan ahead and allow time for peer reviews and corrections
Revolutionary advancements over existing state of technology required
Ability to achieve program milestones is critical
Partnering is encouraged
TIPS FOR STRONG PROPOSALS
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BUILDING A COMPETITIVE PROPOSAL
Concept Definition ✓ Why is the approach revolutionary? ✓ Challenges ✓ Potential solutions ✓ Risk mitigation
Supporting Technical Analysis ✓ Previous experimental evidence ✓ Technical and quantitative rationale
for ability to meet metrics
Research Plan ✓ Specific, quantitative, intermediate
milestones ✓ How will progress be assessed?
Management Plan ✓ Plan for coordination and roles of
all members ✓ Risk management approaches
Clarity is Key
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Questions
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?For more information visit:http://www.dtra.mil/Home.aspxhttp://www.acq.osd.mil/cp/http://www.dtra.mil/Missions/ChemicalBiologicalDefense/ChemicalBiologicalDefenseHome.aspx
To read more about some of our current scientific progress:http://www.dvidshub.net/publication/538/jsto-in-the-news
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BACKUPS
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J9 CB BASIC RESEARCH FOCUS AREAS
Approaches to predict or trigger technological surprise
BUILDING THE FOUNDATION FOR TOMORROW’S CBDP
Novel countermeasures
Understanding and characterizing threat agents
Novel approaches to sensing
Innovative materials
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Diagnostics, Detection & Disease Surveillance
MISSION Deliver cutting edge Integrated Early Warning, Information Management and Applied Analytic capabilities to the warfighter; virtually connect them to these capabilities and other system users for rapid situational awareness, course of action (CoA) analysis and decision support.
ADDRESSING KEY MISSION AREAS
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Translational Medicine
MISSION Develop vaccines and therapeutics to mitigate
the threat of biological warfare agents
ADDRESSING KEY MISSION AREAS
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• MISSION • Deliver novel concepts and • technologies to address current and
emerging chemical and biological threats to protect the lives of our warfighters
Advanced and Emerging Threats
ADDRESSING KEY MISSION AREAS
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• MISSION • Provide and use Chemical Biological • Radiological Nuclear information
and analysis capabilities to enable and support operational & programmatic decision-making.
Information & Analysis
ADDRESSING KEY MISSION AREAS
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Information & Analysis
PROJECT AREASCollective Protection System Performance Model
Individual Protection System Performance ModelDecontamination System Performance Model
ADDRESSING KEY MISSION AREAS
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• MISSION • Providing tomorrow’s solutions today • to build next generation chemical and
biological defense capabilities for decontamination and protective materials, and ensuring transition of prototypes to advanced developers serving warfighter needs through advanced demonstrations and exercises.
Physical Science & Technology
ADDRESSING KEY MISSION AREAS
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Physical Science & Technology
FOCUS AREASProtective Materials – e.g. Second Skin and Ammonia Breakthrough Filters
Hazard Mitigation – e.g. Material and Equipment Restoration (HaMMER) decontamination system (DFoS)Demonstrations – e.g. Consequence Management Bioresiliency (TaCBRD)
Materials and Imaging Sciences – e.g. Better Biosensors, Nanomaterials for drug delivery, Robust Biomimetic Materials & Devices
ADDRESSING KEY MISSION AREAS
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DTRA RDT&E Summary
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• Responds to top national and DOD priorities in CWMD• Supports the strategic deterrent by enhancing system
survivability, nuclear forensics, and targeting effectiveness• Provides DoD’s primary support to USSOCOM for WMD-T
Future Capabilities• Leverages DTRA’s combat support role to provide unique WMD
expertise directly to our warfighters• Infuses WMD-related research into over 100 of our top
universities• Well connected to DoD, Interagency and international partners
DTRA’s steady-state S&T efforts create the expertise and capabilities required for agile responses to urgent operational needs
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THE THREATS ARE REAL
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Chemical ▪ Traditional Chemical Warfare Agents ▪ Toxic Industrial Materials and Toxic
Industrial Chemicals ▪ Emerging and Non-traditional Agents Biological
▪ Traditional Biological Threat Agents ▪ Emerging Diseases ▪ Enhanced Threats
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J9CB APPROACH
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Science & TechnologyInvestment Strategies SENSE
SHAPE
SHIELD
SUSTAIN
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DRIVERS OF SUCCESS
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Collaboration We work with other agencies, academia
and the science community.
Innovation
Performance
Product
Strategy
Warfighter
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Lead DoD science and technology to anticipate, defend, and safeguard against chemical and
biological threats for the warfighter and the nation
DTRA J9CB Mission
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Warfighter Driven Innovation Driven Strategy Driven Product Driven Performance Driven
Collaboration Driven
Warfighter Delivered
MISSION