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Objectives
Explain how hormones work
Outline the role of the pancreas as an endocrinegland
Explain how blood glucose concentration is regulated with reference to insulin, glucagon and adrenaline
Hormone Regulation Hormones are
regulated by negative feedback.
Regulation of blood sugar is a good example of this.
How do hormones work?
Hormones are proteins that are produced in (endocrine) glands and secreted into the blood
Carried in the blood plasma to target cells
These cells have complementary receptors to the specific hormone
Adrenaline and glucagon follow the second messenger model of action
The pancreas Is both an endocrine
and exocrine gland Exocrine function -
secretes digestive enzymes into the pancreatic duct
Endocrine function - secretes hormones (insulin and glucagon) directly into the blood
Secretion of enzymes (exocrine function)
Pancreatic cells surround small tubules which drain into the pancreatic duct
Pancreatic cells produce pancreatic juice which is made up of; Amylase (a
carbohydrase) Trypsinogen (an inactive
protease) Lipase
Secretion of hormones (endocrine function)
Hormones are secreted from the cells in the islets of Langerhans
α cells manufacture and secrete the hormone glucagon
βcells manufacture and secrete the hormone insulin
These are released directly into the blood
Control of blood glucose The natural sources of blood glucose are:
1. Directly from the diet – glucose enters blood when carbohydrates are broken down
2. Breakdown of glycogen (Glycogenolysis )
3. Gluconeogenesis – production of new glucose from sources other than carbohydrates
Control of blood glucose
Is a negative feedback process
The normal blood glucose level is 90mg per 100ml of blood
If the blood glucose levels get too high or too low, then the changes are detected by the α and βcells in the islets of Langerhans
Insulin and the β cells of the pancreas
*Act as Receptors that detect rise in blood glucose level
*When rise is detected they secrete insulin into the blood plasma
*Insulin binds to glycoprotein receptors on cell surface of most body cells (notably excluding Red Blood Cells)
http://www.medbio.info/horn/time%203-4/insulin's%20mechanism%20of%20action.htm
When bound the following can happen:1) Modifies the tertiary structure of glucose carrier protein channels so that they allow more glucose into cells 2) Increase number of glucose carrier proteins in cell -surface membrane3) Activate enzymes that convert glucose to glycogen and fat
This results in:
1)More glucose absorbed into cells
2)Increases respiratory rate of cells so more glucose is used up so more glucose is absorbed
3)Increasing rate of conversion of glucose to glycogen (glycogenesis) in the liver and muscles
4)Increasing conversion of glucose to fat
http://www.youtube.com/watch?v=X0ezy1t6N08
Glucagon and the α cells of the pancreas
*Act as Receptors that detect fall in blood glucose level
*When fall is detected they secrete hormone glucagon into the blood plasma
*glucagon binds to glycoprotein receptors on LIVER cells only
When bound the following happens:a)An enzyme is activated that converts glycogen to glucose
b)There is an increase in the conversion of amino acids and glycerol into glucose GLUCONEOGENESIS)
This results in:An increase in blood glucose levels
The role of adrenalineThere are a number of other hormones that increase blood sugar levels. The most well known is adrenaline
• Produced in adrenal glands (above kidneys)
•It raises blood glucose by:
Activating an enzyme that causes breakdown of glycogen to glucose in the liver
Inactivating an enzyme that synthesises glycogen from glucose
Hormone interaction in regulating blood glucose
Uses negative feedback as both hormones work to keep blood glucose at around 90mg per 100ml of blood.
They are said to work antagonistically
Task
The exam questions