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Copyright: Lew Lim 1
The Potential ofIntranasal Light Therapyfor brain stimulationBy: Lew Lim January 2013
Presented at NAALT 2013
Copyright: Lew Lim 2
The mother: intravenous irradiation
January 2013
Blood irradiationParameters are based on
Copyright: Lew Lim 3
Why the nose
January 2013
Vascularconcentration
Copyright: Lew Lim 4January 2013
• Non-invasive blood irradiation• Small and convenient• Low cost• Idiot proof
Design opportunities
Copyright: Lew Lim 5January 2013
You can also run a truck over it!
Copyright: Lew Lim 6
It stimulates systemic homeostasis
January 2013
…and the body attempts to heal anything unprogrammed.
Copyright: Lew Lim 7January 2013
When something profound works ….
Copyright: Lew Lim 8
Present parameters
January 2013
LED model:633 nM, CW8 mW, 25 min12 J/cm²
Laser model:655mW, CW4.8 mW, 25 min7.2 J/cm²
Copyright: Lew Lim 9January 2013
Re-emphasis from blood irradiation to brain stimulation
Copyright: Lew Lim 10January 2013
Deep brain stimulation for Parkinson’s- Example of effective alternative method
It’s about stimulation
Copyright: Lew Lim 11
History of neurological evidence
January 2013
• Facial pain, 1998• Intractable headache, 1998• Cerebral thrombosis, 1999• Parkinson’s disease, 1999• Alzheimer’s disease, 1999• Mild cognitive impairment, 2000
• Insomnia, 2001• Post-stroke conditions, 2003• Migraine, 2003• Traumatic brain injury, 2003• Schizophrenia, 2000• Vascular dementia, 2005• Cerebral palsy, 2007
With present Intranasal Low Level Laser Therapy parameters
Can we still improve?
Copyright: Lew Lim 12January 2013
Before
After
Net increase
Improvement in brain blood flow
Source: Single photon emission computed photometry by Prof Xiao XC, 2005
Stroke patient. 650 nm, 4 mW, 30 min/day, 7.2 J/cm²/day, 10 days
Copyright: Lew Lim 13January 2013
Brain Cell Healing
Source: Giuliani et al. Low infra red laser light irradiation on cultured neural cells: effects on mitochondria and cell viability after oxidative stress. BMC Com Alt Med 2009, 9:8.
In vitro post-oxidative stress. 670nm, 3 mW, 20 sec/day, 5 days
Copyright: Lew Lim 14January 2013Picture source: OpimMeadow. Flickr
Intranasal:Path of low resistance to mid-brain
Limbic system
Transcranial
Copyright: Lew Lim 15January 2013
Thin ethmoid bone plate is thin
Copyright: Lew Lim 16January 2013
Opportunity for new parameters
Copyright: Lew Lim 17January 2013
Source: Barolet D. Light-emitting Diodes (LED) in Dermatology. 2008
Optical penetration depth
810nm
630nm
660nm
Copyright: Lew Lim 18January 2013
Effect of 10 hz pulsed mode
Ando et al. Comparison of Therapeutic Effects between Pulsed and Continuous Wave 810-nm Wavelength Laser Irradiation for Traumatic Brain Injury in Mice. Plos One. Oct 2011
NeurologicalSeverity Score
Area under curve
Copyright: Lew Lim 19January 2013
Deeper tissue travel may help with proximity to:• Substantia nigra for Parkinson’s• Subventricular zone for neurogenesis• Hypothalamus for homeostasis
10 Hz helps:• Greater neural response• Seratonin for depression• Alpha state 8-12 Hz entrainment for an “ordered
state”• Hippocampal theta state 5-10 Hz: resonates with
hippocampus for behavioral inhibition, attention, spatial memory
Large beam footprint for:• Systemic response• Vascular dementia and Alzheimer’s
Copyright: Lew Lim 20
The “brain-effective” model
January 2013
810 nm10 mWPulsed: 10 Hz50% duty cycle25 min7.5 J/cm² post-duty cycle
Copyright: Lew Lim 21
Initial reports
January 2013
Enhanced neural response:• Improved cognitive performance• Enhanced post-stroke conditions• Parkinson’s disease condition
better
But more clinical investigations needed
Copyright: Lew Lim 22January 2013
Presentation By: Lew [email protected]
Full paper available:http://www.mediclights.com/brain-potential
