June 13 – 15, 2009Washington, DC

Immediately following Endo 2009

For more information log onto www.pituitarysociety.org

The Pituitary Society presents the

The 11th InternationalPituitary Congress is

supported by:

PLATINUM LEVEL SPONSORNOVARTIS

GOLD LEVEL SPONSORIPSEN

SILVER LEVEL SPONSORPFIZER

ABSTRACT DEADLINE:Monday, April 6, 2009

ADVANCE REGISTRATION DEADLINE:Monday, April 13, 2009

STANDARD REGISTRATION DEADLINE:Friday, May 15, 2009

LATE REGISTRATION DEADLINE:After May 15, 2009

P R O G R A M A N D R E G I ST R AT I O N G U I D E

The Pituitary SocietyOfficers & Board Of Directors (2008-2009)

OFFICERS:President 2008-2009Felipe F. Casanueva, MD, PhD, Santiago de Compostela, Spain

President Elect 2009-2010Paolo Beck-Peccoz, MD, Milan, Italy

Executive DirectorMary Lee Vance, MD, Charlottesville, VA

Secretary-TreasurerDavid L. Kleinberg, MD, New York, NY

BOARD OF DIRECTORS:Felipe F. Casanueva, MD, PhD, Santiago de Compostela, SpainDavid R. Clemmons, MD, Chapel Hill, NCAnnamaria Colao, MD, Naples, ItalyLawrence A. Frohman, MD, Chicago, ILDavid L. Kleinberg, MD, New York, NYAnne Klibanski, MD, Boston, MASteven W. J. Lamberts, MD, PhD, Rotterdam, The NetherlandsShlomo Melmed, MD, Los Angeles, CAAgnes Schonbrunn, PhD, Houston, TXPaul M. Stewart, MD, Birmingham, UKBrooke Swearingen, MD, Boston, MAMary Lee Vance, MD, Charlottesville, VAJohn Wass, MD, Oxford, UK

COMMITTEE CHAIRPERSONS:Clinical InitiativesAndrea Giustina, MD, Brescia, Italy

DevelopmentDavid L. Kleinberg, MD, New York, NY

MembershipLaurence Katznelson, MD, Stanford, CA

MeetingsAnne Klibanski, MD, Boston, MAShlomo Melmed, MD, Los Angeles, CA

NominationsJohn Wass, MD, Oxford, UK

CommunicationsLawrence A. Frohman, MD, Chicago, IL

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Welcome

Dear Colleague,

The 11th International Pituitary Congress will present an exciting group of member and guest international experts in

pituitary problems. It will include distinguished clinicians and clinical researchers, fellows in training, and experts in basic

science. As usual, we will present cutting edge in-depth topics that will permit each attendee to become familiar with the

latest trends in pituitary endocrinology. The format of the meeting is intended to facilitate maximum interaction and free

exchange of ideas among the participants and speakers.

As is customary, this meeting follows the ENDO 2009 Meeting, which means that the Eleventh International Pituitary

Congress will begin on the evening of Saturday, June 13th and end the afternoon of Monday, June 15th. The meeting will be

held at The Omni Shoreham Hotel in Washington, DC. It is a lovely venue that will encourage excellent science and great fun.

Anyone who has attended one of our Congresses can attest to the beautiful and elegant surroundings, wonderful science, and

excellent entertainment.

This guide provides details of the scientific program, as well as information concerning registration, accommodations and

abstract submission. Abstracts selected for poster presentations will be published in a supplement to be distributed after

the conference. If you would like your abstract to be considered for an oral presentation in the HOT TOPICS session of the

program, please indicate with your abstract submission. In addition, a young investigator selected from those submitting

abstracts will present “The Pituitary Society Outstanding Young Investigator Presentation.”

We hope you will join us at the Eleventh International Pituitary Congress for two days of excellent science and

companionship.

The Program Organizing Committee

Anne Klibanski (Co-Chair) Shlomo Melmed (Co-Chair)

Program Committee:

Eduardo Arzt, ArgentinaDavid Clemmons, USAMonica Gadelha, BrazilKen Ho, AustraliaJohn Kopchick, USALynnette Nieman, USARon Rosenfeld, USAChristian Strasburger, Germany, ENEA RepresentativeMary Lee Vance, USA

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Abstract deadline Monday April 6, 2009Advance registration deadline Monday, April 13, 2009

Standard registration deadline Friday, May 15, 2009Late registration deadline after Friday, May 15, 2009

Course DescriptionThe 11th International Pituitary Congress is designed to further the knowledge of clinicians and scientists specializing in the pituitary. Single session symposia, workshops, discussions and concurrent lunch sessions on Sunday will address a broad range of pituitary research and clinical issues. The focus of this Congress is on current concepts, future strategies, and options for the investigation, diagnosis and treatment options for pituitary diseases.

WHO SHOULD ATTEND Pituitary Society members and other professionals interested in state-of-the-art clinical and basic advances in pituitary biology and disease.

Practical InformationVENUE AND DATES

The 11th International Pituitary Congress will take place from the afternoon of June 13 through the 15th at The Omni Shoreham Hotel, 2500 Calvert Street NW, Washington, DC, 20008, USA. Telephone : +202.234.0700, Fax: +202.265.7972, Website: http://www.omnishorehamhotel.com

Located in one of the most influential cities of the world, this grand luxury hotel offers a resort atmosphere and a personal taste of politics, culture, art and music at its best. The four-diamond Omni Shoreham Hotel is nestled on 11 acres in picturesque Rock Creek Park in northwest Washington, DC and is only steps away from the National Zoo.

DEADLINES

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Symposium Schedule

SATURDAY, JUNE 13, 200912:00 NOON – 6:00 PM Welcome and Registration

6:30 – 7:00 Plenary Opening Lecture Aging, Hormone Replacement and Genomics Steven W. J. Lamberts (The Netherlands)

7:00 – 8:00 Poster Presentations

8:30 OPENING RECEPTION

SUNDAY, JUNE 14, 20098:00 AM Continental Breakfast Pediatric Neuroendocrinology Chair: Ron Rosenfeld (USA)

9:00 Pituitary Transcription Factors Sally Radovick (USA)9:20 Metabolic Consequences of Primary vs. Secondary IGF Deficiency in Children and Adults Madhusmita Misra (USA) Neuroendocrinology of Body Composition Chair: Ken Ho (Australia)

9:40 Obesity and Antipsychotic Medications John Newcomer (USA)10:00 Hypothalamic Regulation of Bone Paul Baldock (Australia)10:20 Body Composition-Neuroendocrine Interrelationships in Anorexia Nervosa and Obesity Karen Miller (USA)

10:40 Coffee Break

Neuroendocrinology of Competitive Sports Chair: Christian Strasburger (Germany) 11:00 Neuroendocrine Consequences of Competitive Sports: An Overview Fabio Lanfranco (Italy)

11:20 Detection of Growth Hormone Doping by the Marker-strategy Ken Ho (Australia)11:40 Differential Immunoassays for Detection of Growth Hormone Doping by the Isoform-strategy Martin Bidlingmaier (Germany)

12:00 NOON-1:00 PM MEET THE PROFESSOR SEMINARS (Lunch Provided) MP1 Prolactinomas Janet Schlechte (USA)

MP2 Acromegaly Primary Therapy: Yes or No? Debate Chair: Marcello Bronstein (Brazil) Brooke Swearingen (USA) and Michael Sheppard (UK)

MP3 Adult GH Deficiency Michael Thorner (USA)

MP4 Pitfalls of Cortisol Replacement Paul Stewart (UK)

MP5 Approach to Pubertal Delay Ursula Kaiser (USA)

Continued on page 4

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Symposium Schedule Continued from page 3

Neuroendocrinology & Cardiovascular Disease Chair: David Clemmons (USA)

1:00 PM Changes in Insulin Sensitivity and Glucose Sensing in GHRelin Receptor Knockout Mice Roy Smith (USA)1:20 GHRelin and the Regulation of Peripheral Metabolic Function Ezio Ghigo (Italy)

GH Axis Chair: John Kopchick (USA)

1:40 The Breast as a GH Axis Target David L. Kleinberg (USA)2:00 Pituitary Somatotrophic Cell Networks Iain Robinson (UK)2:20 GH and Cancer: Animal Models Steve Swanson (USA)2:40 GH and Cancer Risk: Epidemiologic Update Michael Pollak (Canada)

3:00 Coffee Break

ACTH Axis Chair: Lynnette Nieman (USA)

3:20 Vasopressin Antagonists Joseph Verbalis (USA)3:40 Pathogenesis of Cushing’s Disease Jacques Drouin (Canada)4:00 Nelson’s Syndrome Xavier Bertagna (France)

4:30 Poster Presentations

7:30 GALA DINNER

MONDAY, JUNE 15, 20098:00 AM Continental Breakfast

Genetic Syndromes Chair: Monica Gadelha (Brazil)

8:30 Central Precocious Puberty: The Roles of Kisspeptin and GPR-54 Protein Ana Claudia Latronico (Brazil)8:50 Carney Complex: Pathogenesis of GH and Prolactin Hypersecretion Lawrence Kirschner (USA)9:10 Familial Isolated Pituitary Adenomas: Clinical and Genetic Features Lawrence A. Frohman (USA)

9:30 Coffee Break Pituitary Tumor Biology Chair: Eduardo Arzt (Argentina)

9:50 Regulation of the Number of Somatotropes Clara Alvarez (Spain)10:10 Epigenetically Silenced Genes in Pituitary Tumors William Farrell (UK)10:30 Cytokine Regulation of Pituitary Growth Günter Stalla (Germany) Hypopituitarism Chair: Mary Lee Vance (USA)

10:50 Congenital Hypopituitarism Simon J. Rhodes (USA)11:10 Treatment of Hypopituitarism: Is Growth Hormone Really Necessary for Adults? Christian Strasburger (Germany) and Ariel Barkan (USA)

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11:30 Treatment of Hypopituitarism: What is an Optimal Glucocorticoid Regimen for Bone and Heart Protection? John Newell-Price (UK)

Luncheon and Awards Presentations Chair: David L. Kleinberg (USA)

12:00 Noon Presidential Address 12:15 Travel Grant Awards and Poster Prizes12:30 The Novartis Pituitary Society Lifetime Achievement Award

The Pituitary Society Outstanding Young Investigator Award Chairs: Paolo Beck-Peccoz (Italy) and David Clemmons (USA)

1:30 The Pituitary Society Outstanding Young Investigator Award and Presentation

Hot Topics Chairs: Paolo Beck-Peccoz (Italy) and David Clemmons (USA)

2:00 Four Hot Topics (to be announced)3:00 Congress Adjourns

RegistrationPAYMENT INSTRUCTIONS Payment can be made by credit card on-line at www.pituitarysociety.org or by mailing the registration form, with a check in US dollars (drawn on a US bank) or credit card details. Please make checks payable to The Pituitary Society and send to the Congress Secretariat.

CANCELLATION AND REFUNDS Cancellation of registration must be sent in writing to the Congress Secretariat by April 15, 2009. The registration fee, less a $50 processing fee, will be refunded following the Congress. We regret that no refunds can be made for cancellations received after April 15, 2009.

CERTIFICATE OF ATTENDANCE A certificate of attendance will be given to all attendees upon registration in Washington.

TRAVEL GRANTS Twenty travel grants of $500 each will be awarded to the best abstracts, as judged by the Abstract Review Committee, submitted by fellows-in-training. Those applying for a travel grant must be BOTH the first author and presenting author. Eligible individuals are those who are currently enrolled in an endocrine-related training program as a clinical fellow or postdoctoral fellow. Winners will also receive one year of free membership to The Pituitary Society. When submitting your abstract, please indicate if you would like to be considered for a travel grant. Abstracts should be submitted on-line at www.pituitarysociety.org.

THE PITUITARY SOCIETY OUTSTANDING YOUNG INVESTIGATOR AWARD This award will be chosen from the submitted abstracts by a selection committee. A first author who is 45 years old or younger will be chosen for the excellence of the abstract and will be asked to give a 30-minute presentation to the group. This award is sponsored by an unrestricted educational grant from Eli Lilly and Company. The selection committee will notify the winner.

Neuroendocrinology & Cardiovascular Disease Chair: David Clemmons (USA)

1:00 PM Changes in Insulin Sensitivity and Glucose Sensing in GHRelin Receptor Knockout Mice Roy Smith (USA)1:20 GHRelin and the Regulation of Peripheral Metabolic Function Ezio Ghigo (Italy)

GH Axis Chair: John Kopchick (USA)

1:40 The Breast as a GH Axis Target David L. Kleinberg (USA)2:00 Pituitary Somatotrophic Cell Networks Iain Robinson (UK)2:20 GH and Cancer: Animal Models Steve Swanson (USA)2:40 GH and Cancer Risk: Epidemiologic Update Michael Pollak (Canada)

3:00 Coffee Break

ACTH Axis Chair: Lynnette Nieman (USA)

3:20 Vasopressin Antagonists Joseph Verbalis (USA)3:40 Pathogenesis of Cushing’s Disease Jacques Drouin (Canada)4:00 Nelson’s Syndrome Xavier Bertagna (France)

4:30 Poster Presentations

7:30 GALA DINNER

MONDAY, JUNE 15, 20098:00 AM Continental Breakfast

Genetic Syndromes Chair: Monica Gadelha (Brazil)

8:30 Central Precocious Puberty: The Roles of Kisspeptin and GPR-54 Protein Ana Claudia Latronico (Brazil)8:50 Carney Complex: Pathogenesis of GH and Prolactin Hypersecretion Lawrence Kirschner (USA)9:10 Familial Isolated Pituitary Adenomas: Clinical and Genetic Features Lawrence A. Frohman (USA)

9:30 Coffee Break Pituitary Tumor Biology Chair: Eduardo Arzt (Argentina)

9:50 Regulation of the Number of Somatotropes Clara Alvarez (Spain)10:10 Epigenetically Silenced Genes in Pituitary Tumors William Farrell (UK)10:30 Cytokine Regulation of Pituitary Growth Günter Stalla (Germany) Hypopituitarism Chair: Mary Lee Vance (USA)

10:50 Congenital Hypopituitarism Simon J. Rhodes (USA)11:10 Treatment of Hypopituitarism: Is Growth Hormone Really Necessary for Adults? Christian Strasburger (Germany) and Ariel Barkan (USA)

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Registration FormPlease register on-line at www.pituitarysociety.org. If you do not have access to the web, please complete the registration form:

ADVANCE REGISTRATION DEADLINE: APRIL 13, 2009STANDARD REGISTRATION DEADLINE: MAY 15, 2009LATE AND ON-SITE REGISTRATION DEADLINE: AFTER MAY 15, 2009Please note the number of delegates is limited and it is strongly advised to register prior to the event Title: First name: Family/Last Name:

Institutional affiliation:

Department:

Mailing address:

City/Region:

State/Province: Zip/Post code: Country:

Is this your home address? Yes No

Email:

Speciality Please mark the items which apply to you: Clinical Practice Academic Industry Administration

Reason for attendance Please mark the items which apply to you: Clinical update Scientific update Technical update

Other (specify):

Tel: Intl. code/Area code: Number:

Mobile: Intl. code/Area code: Number:

Congress FeesAll registration fees include admission to the scientific meeting, program and abstract book, continental breakfasts, coffee breaks, lunches, Reception, and the Gala Dinner. The registration fee includes accommodation at the Omni Shoreham for two nights, June 13th & June 14th. Spouse/guest registrations are inclusive of accommodation in the room of the registered delegate on this form, admission to the Reception and the Gala Dinner. IF YOU NEED A RESERVATION FOR ADDITIONAL NIGHTS AT THE OMNI SHOREHAM, PLEASE CONTACT THE CONGRESS SECRETARIAT AT PITUITARYCONGRESS@CSHS.ORG. You will be responsible for paying the hotel for any additional nights.

Advance Registration Standard Registration Late Registration Total $ (By April 13) (April 14 - May 15) (After May 15)

Pituitary Society members: $900 $1050 $1150

Non-members: $1200 $1350 $1450

Fellow-in-training: $750 $900 $1000

Spouses/Guests:* $300 $450 $550

Name of spouse/guest:

Members sharing a room:** $450 $600 $700

Name of person sharing room:(This person must also be registered separately)

Fellow-in-training sharing a room:** $375 $525 $625

Name of person sharing room:(This person must also be registered separately)

*Spouse/guest registrations are inclusive of accommodation in the room of the registered delegate on this form, admission to the Reception and the Gala Dinner.** The number of rooms for members and fellows-in-training to share are limited. Please register as soon as possible if you wish to share a room. Residents of Washington, DC who do not require hotel accommodations should contact the Congress Secretariat at PituitaryCongress@cshs.org to discuss registration.

Home Tel: Intl. code/Area code: Number:

Fax: Intl. code/Area code: Number:

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Meet the Professor Lunch SeminarsThe five Meet the Professor lunch seminars take place concurrently on Sunday, June 14th between 12:00 Noon and 1:00 pm. Attendance is limited so please indicate your first and second choice of seminar. Lunch will be provided for Congress attendees at the seminars.

I would like to attend the seminar on:

(Please indicate your first and second choice for June 14th. Admission to the requested seminars will be on a first–come, first–served basis.)

June 14

Seminar 1: Prolactinomas

Seminar 2: Acromegaly Primary Therapy: Yes or No?

Seminar 3: Adult GH Deficiency

Seminar 4: Pitfalls of Cortisol Replacement

Seminar 5: Approach to Pubertal Delay

Catering RequirementsPlease indicate your attendance at each event and dietary requirements for yourself or your spouse/guest

I will be attending: (please circle below): Delegate Guest

June 13th, Reception: YES / NO YES / NO

June 14th, Gala Dinner: YES / NO YES / NO

I require vegetarian meals: YES / NO YES / NO

Other special dietary requirements:

We encourage participation by all individuals. If you have any special needs, advanced notification will help us better serve you. Please contact the Congress Secretariat at PituitaryCongress@cshs.org.

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Payment DetailsTo register on-line please visit www.pituitarysociety.org

Payment may be made by credit card on-line on the secure site at www.pituitarysociety.org or by mailing this registration form, with a check (drawn on a US bank) or credit card details. Please make checks payable to The Pituitary Society.

Payment can be made using the following credit cards: Visa, Mastercard and American Express. Credit card details submitted in hard-copy will be input on-line by the Congress Secretariat.

Cancellation of registration must be sent in writing to the Congress Secretariat by April 15, 2009. The registration fee, less a $50 processing fee, will be refunded following the Congress. We regret that no refunds can be made for cancellations received after April 15, 2009.

Please indicate below which means of payment you are using:

VISA Mastercard American Express I enclose a check

Name and address of card holder:

Last Name First Name

Street City State Postal Code County

Credit card no:

Expiration date: Security digits: (last 3 digits printed on signature strip on reverse of card)

My signature confirms that I have read and am fully aware of the above registration payment conditions. I hereby authorize The Pituitary

Society to debit this credit card account for the total amount due. I also consent to The Pituitary Society debiting or crediting my credit

card account with the amount of any subsequent change(s) to the items booked.

Date: Signature:

Please return this form and payment to:

11th International Pituitary Congress SecretariatATTN: Bari Laner8797 Beverly Blvd., Ste. 250

Los Angeles, CA 90048

USA

Tel: +310.423.2937

Fax: +310.423.0309

Email: pituitarycongress@cshs.org

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Abstract Submission DetailsAbstracts are warmly invited for submission to this meeting. Abstracts can be submitted on-line at www.pituitarysociety.org . The abstract deadline for the meeting is Monday April 6, 2009. Abstracts accepted for the meeting will either be presented orally as part of the Hot Topics session or as a poster. If you would like to be considered for the Hot Topics session, please indicate when submitting your abstract.

If you are unable to submit your abstract online, please submit your abstract on a blank sheet of paper to the Congress Secretariat with a copy on disk in text format. Your abstract must contain 300 words or fewer, including numbers and symbols.

Abstracts arriving after April 6, 2009, will not be considered. Please note that faxed abstracts cannot be accepted.

Please read the following guidelines thoroughly before preparing your abstract. The scoring committee will not consider abstracts which have not been prepared in accordance with these instructions:

1) Abstracts must be submitted in English

2) The abstract should be as informative as possible:a. State the specific objective of the studyb. State the methods used, including statistical analysis. If pertinent, state whether experiments were in vivo or in vitro; if in vivo,

state whether animal was anaesthetized or unanaesthetizedc. Summarize results obtained in sufficient detail to enable review and classification of the abstractd. State conclusions reached based on the results as they appear in the abstracte. When experiments were performed on human subjects and local Ethical Committee approval was obtained, please indicate

this in the abstractf. Statements such as ‘results will be discussed’, or ‘data will be presented’ cannot be accepted

3) Abstracts will be reproduced exactly as submitted. Any typing error will be visible on publication

Poster PresentationsPosters will be on display throughout the meeting and should be setup between 3:00 pm and 7:00 pm on Saturday, June 13th. Posters should be dismantled by 4:00 pm on Monday, June 15th.

INSTRUCTIONS FOR POSTER PRESENTATIONSPosters should be prepared in advance, should strictly adhere to the submitted abstract and should be brought in person by the participants. The dimensions of the poster boards are 8’ wide and 4’ high. Posters should be legible from 3’. Therefore the title of your poster, which should be the same as your abstract, should use letters at least 1” high. The names of the author(s), institutions, city, state (if relevant) and country should be clearly indicated. It is advisable to organize the posters into sections: introduction, methods, results and conclusions. The use of color is recommended. Materials for assembling posters will be provided (push pins and velcro).

Social EventsHOSPITALITY WELCOME DESKAfter you register, join your colleagues for a soft drink and snack to refresh yourself following your journey.

Saturday, June 13thRECEPTIONThe opening reception will provide attendees with a large selection of passed hors d’oeuvres in addition to hot and cold appetizer stations. The meal and entertainment are included in the registration fee for the Congress.

Sunday, June 14thGALA DINNERThe dinner will be held in the Blue Room of the Omni Shoreham. As the only nightclub in Washington offering top-name performers along with the “Big Band” sound, the Blue Room was the social gathering place for the diplomatic corps, the Capitol Hill crowd and K Street movers and shakers. Band-leader Barnee Breeskin knew the names and faces of every Senator and Representative and never failed to introduce them to the rest of his audience. An evening in the celebrity-studded Blue Room was always a night to remember. This night promises to be festive and entertaining continuing our tradition of gala celebrations. Attendance is included in the registration fee for the Congress.

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