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The Optical Society, Foundation Fellowship
APPLICATION
Applicant Last or Family Name
Chen
First Name
Vincent Middle Name
Wingsang
Maiden Name (if applicable)
Phone
678 938 0285
CURRENT
Address
Home or Institution, Bldg./Room, Number/Street
Georgia Institute of Technology
Department of Chemistry and Biochemistry
901 Atlantic Drive NW
City
Atlanta State / Province
GA /
Zip (Postal) Code
30332 Country
USA
CITIZENSHIP
Country of Citizenship
USA
Current
Immigration Status
Citizen
Date Status Expires
If you are a naturalized US citizen, enter your naturalization date. Date Month/Day/Year
10/6/2006
EDUCATION HISTORY Institution Name Degree/Discipline Date Awarded (Month/Year)
1) Georgia Institute of Technology
Doctor of Philosophy - Physical Chemistry
12/2011
2) Boston College
Bachelor of Science - Chemistry
05/2003
3)
4)
EMPLOYMENT HISTORY Employer Position Inclusive Dates
1) Georgia Institute of Technology
Postdoctoral Research Fellow
02/2012 – Present
2) Georgia Institute of Technology
Graduate Research Assistant
08/ 2003 – 12/2011
3) Boston College
Undergraduate Research Assistant
05/2000 – 07/2003
HONORS AND AWARDS Honor or Award Sponsoring Organization or Institution Date Awarded (Month/Year)
1)
2)
3)
4)
REFERENCES Enter the names, titles, and professional addresses of three (3) references who will be writing a letter for you.
Reference’s Name (including title) Reference’s Complete Professional Mailing Address Reference’s E-mail Address
1) Prof. Joseph W. Perry
School of Chemistry and Biochemistry
Georgia Institute of Technology
901 Atlantic Drive, NW
Atlanta, GA 30332-0400
2) Prof. Ken H. Sandhage
School of Materials Engineering
Purdue University
West Lafayette, IN 47907
3) Dr. Joel M. Hales
Sotera Defense Solutions, Inc.
2121 Cooperative Way
Suite 400
Herndon, VA 20171
CONFIDENTIAL INFORMATION This information is used by the National Academies of Sciences, Engineering, and Medicine as well as sponsors to process awards.
Optional information on race and ethnicity is for statistical purposes. This information is not seen by reviewers or OSAF management.
APPLICANT
Date of Birth (Month/Day/Year)
Place of Birth (City, State/Province, Country)
Sex Marital Status Race Ethnicity
RESEARCH OPPORTUNITY Enter the information for the sponsor company and research opportunity to which you are applying.
Sponsoring Company Name Opportunity Title Opportunity Number
Thorlabs
High Resolution Multi-photon Imaging
OSAFF.TL.3
Dear Fellowship Selection Committee:
My research area of interest is in the development of scientific instrumentation for
photonics, lithography and imaging applications. More specifically, I’m interested in developing
research tools that are comprised of modular subsystems that can be easily customized,
integrated and upgraded in both hardware and software, which will enable researchers to focus
on and fasten the scientific research.
Obtaining this fellowship and gaining the research opportunity at Thorlabs will be ideal
for my goals because Thorlabs have successfully developed various imaging systems,
spectroscopy subsystems and educational kits. In academic laboratories, homebuilt
instrumentations are often created with a very narrow and specific goal, with homebrewed
software that are not easily translatable to other applications. At Thorlabs, I expect to gain a big-
picture understanding of how specific applications are chosen, how the targeted metrics are set,
and how to evaluate the success of a product. After this fellowship, I plan to apply for a research
position in Thorlabs or other optics related industry.
My experience in designing and building a multiphoton fabrication system has provide
me with a background in lasers, optics, optomechanics, motion control systems and detectors.
Integration of these electronic components into a functional tool required both hardware and
software development. I have explored several methods to improve the resolution of the
fabricated features, the results were published in Optics Express and a book chapter. My work
has been supported by several DoD-funded multi-university interdisciplinary research programs
where I have worked closely with researchers from various scientific and engineering fields, the
results were published in several articles in Advanced Functional Materials and Advanced Energy
Materials, with several additional manuscripts in revision.
Outside of my research activities, I have 10 years of experience in managing several
instruments in a shared user facility where I provide training and work with researchers from a
diverse background to develop new measurements. I am a self-taught Certified LabView
Associate Developer, with proficiency in various computer-aided design programs (AutoCAD and
SolidEdge) for creating custom sample holders and laser cutting of microfluidic channels, as well
as graphical rendering software (Blender) to visualize scientific concepts for presentations and as
a journal cover in Advanced Energy Materials.
I have expertise in multiphoton lithography and imaging. I am experienced in building
scientific testing platforms both in hardware and software. For my professional development, I
need to work with experienced professionals to both improve and broaden my skills in product
development, which is essential to meet the need of consumers. I believe this fellowship at
Thorlabs will provide me with the opportunity to learn these skills and to gain new insights to the
business and marketing side of this industry. In addition to the optics background, I have broad
research experience from photonics to biomedical devices, along with hands on experience in a
wide range of materials and spectroscopic tools. These experience will enable me to provide
inputs from the perspective of users and, therefore, benefit the development team at Thorlabs.
I look forward to this exciting opportunity to advance my career development.
Sincerely,
Vincent W Chen
Postdoctoral Research Associate School of Chemistry & Biochemistry Georgia Institute of Technology 901 Atlantic Dr NW, Atlanta, GA 30332 USA Office: (404) 385-6055 Fax: (404) 385-6057 Email: [email protected]
My previous and current research is primarily focused on multiphoton-based 3D
fabrication and imaging of hybrid micro components for photonics and biomedical applications,
supported by several DoD-funded multi-university interdisciplinary research programs. Working
in such collaborative environment, I successfully achieved the first sub-100 nm lateral resolution
in multiphoton lithography (Optics Express, 2007) and succeed a multiphoton-fabricated organic
microlaser that can be tailored for specific photonic design (Optical Materials Express, 2014).
Recently, I participate the research in the development of dissolvable microneedle patches for
vaccination, a program funded by Bill & Melinda Gates Foundation. I fabricated microneedle
arrays with hallow cores that could be infilled with vaccines or medications. Due to my expertise
in multiphoton lithography, I was invited to co-author a book chapter on two-photon absorption
and applications. In addition to my research activities, I am manage multiple research
instruments in a shared research facility. In this role, I have worked closely with graduate and
undergraduate students in designing and implementing their experiments, as well as provide
training and measurement support to both academic and industrial affiliates. Furthermore, I
have participated in several proposal writing and providing annual research reports to funding
agencies.
For my dissertation work under the supervision from Prof. Joseph Perry, I had
independently designed and built a multiphoton lithography system for the fabrication of
polymeric 3D photonic crystals (PC) including the automated control software to perform power
calibration, interface determination, coordinate calculation, dose array fabrication and data
logging. I was certified as a LabView® Associate Developer in 2014.
Previously, most polymer PCs fabricated using conventional systems (Ti:Sapphire laser at
800 nm in conjunction with UV photoinitiators exhibiting low two-photon absorption cross-
sections) have resolutions of ~200 nm lateral and ~600 nm axial, constricting the lower limits of
the stopband in the infrared region. To achieve better resolution, instead of using radical
quenchers or applying post-fabrication isotropic etching, we hypothesized scaling the excitation
to a shorter wavelength would result in resolution improvement with minor alterations to both
the material and the instrumentation. We had collaborated a synthetic group to synthesize a
shorter chain chromophore with two-photon absorption cross-section maximum at 500 nm, and
achieved sub-100 nm lateral resolution with the frequency-doubled Ti:Sapphire. The results from
this study was presented in a MRS meeting and a co-first author publication in Optics Express
(2007). Prof. John Fourkas, my former undergraduate research advisor, later reported two-color
multiphoton lithography and achieved further improved resolution.
For my postdoctoral work, I had adapted an older two photon/confocal imaging system
to fabricate organic microlasers (OMLs). The emission spectrum and lasing threshold of the OMLs
were controlled by their geometric shapes. I adopted a step-and-scan approach, utilizing the
raster scanning parameters to control the cross-sectional dimension and z-axis translation to
create OMLs with varying edge dimensions. Whereas traditional lithographically produced
resonators require a post-fabrication under-etching to reduce loss, I utilized the advantage of the
multiphoton process to fabricate both the decoupler and resonator in a single step, achieving a
40+ fold reduction of the lasing threshold (published in Optics Express).
Another aspect of my postdoctoral work is on confocal and multiphoton imaging of
biophotonics, where we are investigating the origin of colors in butterfly scales, application of
artificial color to native butterfly scales, and enhanced two-photon excited fluorescence from
nanoparticle-decorated pollens. This is a collaborative project and I worked closely with Prof.
Ken Sandhage’s group in the School of Material Science and Engineering (MSE). To study the
green color found on Parides sesostris scales, we utilized a combination of confocal imaging and
focused ion beam milling to elucidate the structural and chemical composition of these scales.
Confocal imaging (Zeiss LSM 700-405) z-stack showed a native fluorophore distributed
throughout the scales, which are comprised of two distinct layers, a ridge-like top layer and a
polycrystalline bottom layer. My counterpart in MSE removed various parts of the scales and
found the green color disappeared when the lower layer was removed. Further analysis of the
polycrystalline layer revealed the presence of a gyroid photonic crystal, suggesting the color
originated from structural color. Spectral imaging was used in another study to spatially resolve
quantum dot coatings on Morpho rhetenor scales applied by our collaborator.
In addition to aforementioned topics, I also worked with Prof. Carson Meredith in the
School of Chemical and Biomolecular Engineering (ChBE) on the topic of tunable, adhesive
biophotonic sensing. Using multiphoton imaging (Zeiss LSM 710 NLO), I have observed
enhanced fluorescence hotspots generated by two-photon absorbing chromophores attached to
silver nanoparticle decorated ragweed pollens.
Recently, I am profoundly involved in the project of developing dissolvable microneedle
patches for drug delivery with Prof. Mark Prausnitz in ChBE. This is a collaborative research
program with Emory University and Centers for Disease Control and Prevention and is funded by
Bill & Melinda Gates Foundation. My role in this project is to develop methodology for high-
speed, large-area fabrication of microneedle skin patches using multiphoton lithography. The
success of this project will enable self-administered transdermal vaccination and medication and
minimize invasive delivery for disease treatment.
In summary, I believe my expertise in multiphoton lithography and confocal/multiphoton
imaging systems and broad research experience from photonics to biomedical devices provide
me with the necessary background in developing an improved multiphoton imaging system. I am
self-motivated and proactive in learning knowledge and skills necessary to further my research,
from learning CAD for using laser cutters to fabricate custom sample holder, to LabView® for
instrument control and data analysis. My publications and presentations demonstrate my ability
to lead and to support interdisciplinary research teams and to communicate the results of the
findings in a clearly and succinctly.
Invited Book Chapter:
Two-Photon Absorption: Concepts, Molecular Materials and Applications,” J. M. Hales, S.-H.
Chi, V. W. Chen, J. W. Perry, Eds. S. R. Marder and J. L. Brédas, (World Scientific Publishing
Company, 2015)
Publications and Presentations in Chronological Order:
1. S. P. Adhikari, Z. D. Hood, K. L. More, V. W. Chen, and A. Lachgar, "A Visible-Light-Active Heterojunction with Enhanced Photocatalytic Hydrogen Generation," ChemSusChem 9, 1869-1879 (2016).
2. Y. Kim, M. Kathaperumal, V. W. Chen, Y. Park, C. Fuentes-Hernandez, M.-J. Pan, B. Kippelen, and J. W. Perry, "Bilayer Structure with Ultrahigh Energy/Power Density Using Hybrid Sol-Gel Dielectric and Charge-Blocking Monolayer," Advanced Energy Materials 5(2015).
3. V. W. Chen, N. Sobeshchuk, C. Lafargue, E. S. Mansfield, J. Yom, L. R. Johnstone, J. M. Hales, S. Bittner, S. Charpignon, D. Ulbricht, J. Lautru, I. Denisyuk, J. Zyss, J. W. Perry, and M. Lebental, "Three-dimensional organic microlasers with low lasing thresholds fabricated by multiphoton and UV lithography," Opt. Express 22, 12316-12326 (2014).
4. Y. N. Fang, V. W. Chen, Y. Cai, J. D. Berrigan, S. R. Marder, J. W. Perry, and K. H. Sandhage, "Biologically Enabled Syntheses of Freestanding Metallic Structures Possessing Subwavelength Pore Arrays for Extraordinary (Surface Plasmon-Mediated) Infrared Transmission," Advanced Functional Materials 22, 2550-2559 (2012).
5. V. W. Chen, "Fabrication and chemical modifications of photonic crystals produced by multiphoton lithography," in Conference on Lasers and Electro-Optics 2011 (Optical Society of America, 2011).
6. V. W. Chen, N. D. Jarnagin, and J. W. Perry, "Fabrication of Photonic Crystals with Sub-100 nm Features Using Multiphoton Lithography with Pre-Swollen Resins," in Conference on Lasers and Electro-Optics 2010, OSA Technical Digest (CD) (Optical Society of America, 2010), CThV4.
7. V. W. Chen, Y. Fang, Y. Zhang, K. J. Perry, K. H. Sandhage, and J. W. Perry, "Conformal Coating of Tailored Photonic Crystals Fabricated Using Multiphoton Lithography," in Conference on Lasers and Electro-Optics/International Quantum Electronics Conference, OSA Technical Digest (CD) (Optical Society of America, 2009), CFP3.
8. Y. Xu, X. Zhu, Y. Dan, J. H. Moon, V. W. Chen, A. T. Johnson, J. W. Perry, and S. Yang, "Electrodeposition of Three-Dimensional Titania Photonic Crystals from Holographically Patterned Microporous Polymer Templates," Chemistry of Materials 20, 1816-1823 (2008).
9. J. Perry, V. W. Chen, W. Dong, Y. Zhang, and K. J. Perry, "Fabrication of Tailored Photonic Crystals Using Multiphoton Lithography," in Conference on Lasers and Electro-Optics/Quantum Electronics and Laser Science Conference and Photonic Applications
Systems Technologies, OSA Technical Digest (CD) (Optical Society of America, 2008), CWO1.
10. M. Badieirostami, B. Momeni, A. Adibi, V. W. Chen, and J. W. Perry, "Fast and Efficient Analysis and Design of Three-Dimensional Photonic Crystal Structures for Functional Dispersive Devices," in Conference on Lasers and Electro-Optics/Quantum Electronics and Laser Science Conference and Photonic Applications Systems Technologies, OSA Technical Digest (CD) (Optical Society of America, 2008), CTuJ6.
11. J. W. Perry, V. W. Chen, W. Haske, J. M. Hales, W. T. Dong, J. Zhou, Y. D. Zhang, K. J. Perry, S. Barlow, S. R. Marder, and Ieee, Advances in Two-Photon 3D Microfabrication, 2007 Conference on Lasers & Electro-Optics/Quantum Electronics and Laser Science Conference (2007), pp. 1217-1218.
12. W. Haske*, V. W. Chen*, J. M. Hales, W. Dong, S. Barlow, S. R. Marder, and J. W. Perry, "65 nm feature sizes using visible wavelength 3-D multiphoton lithography," Opt. Express 15, 3426-3436 (2007). (*co-first author)
13. W. Dong, V. Chen, J. Zhou, S. M. Kuebler, K. L. Braun, Y. Wang, U. Perry, S. R. Marder, and J. Perry, "Two-Photon 3D Micro-Fabrication with Polymer, Metal Nanocomposite and Hybrid Materials," in Conference on Lasers and Electro-Optics/Quantum Electronics and Laser Science Conference and Photonic Applications Systems Technologies, Technical Digest (CD) (Optical Society of America, 2006), CThQ7.
14. R. A. Farrer, F. L. Butterfield, V. W. Chen, and J. T. Fourkas, "Highly efficient multiphoton-absorption-induced luminescence from gold nanoparticles," Nano Letters 5, 1139-1142 (2005).
15. B. J. Taft, C. LaFratta, M. O'Keefe, V. W. Chen, J. Moser, M. J. Naughton, J. T. Fourkas, and S. O. Kelley, "Electrical DNA sensing at nanoelectrode arrays," Abstracts of Papers American Chemical Society 224, 147-ANYL 147 (2002).
Manuscripts Under Revision/In Preparation:
1. L. R. Johnstone, I. J. Gomez, H. Lin, O. O. Fadiran, V. W. Chen, J. C. Meredith, and J. W.
Perry, " Ag and Ag@SiO2 Nanoparticle Decorated Ragweed Pollen: An Adhesive,
Broadband Near-IR SERS Micro-Particle Sensor,” ACS Applied Materials and Interfaces
(Under revision).
2. S. P. Adhikari, Z. D. Hood, H. Wang, R. Peng, H.Li, V. W. Chen, K. L. More, Z. Wu, S. Geyer
and A. Lachgar, “Enhanced Visible Light Photocatalytic Water Reduction of a g-
C3N4/SrTa2O6 heterojunction,” Advanced Function Material (In preparation).
Joseph W. Perry School of Chemistry & Biochemistry Georgia Institute of Technology 901 Atlantic Drive, NW Atlanta, GA 30332-0400 404-385-6046 (Fax: 6057) [email protected]
August 29, 2016 National Academies of Science, Engineering and Medicine RE: OSA Foundation Fellowship
Dear OSA Foundation Fellowship Committee, It is my pleasure to recommend Dr. Vincent W Chen for the position in High Resolution Multi-
photon Imaging (RO Number: OSAFF.TL.3). During my years of as a faculty member, I have worked with and personally trained more than 55 graduate students and postdocs in laboratories at the Jet Propulsion Laboratory, University of Arizona, and, currently, at Georgia Institute of Technology. In my opinion, Vince is among the top 10 percent of the researchers to emerge from my lab.
The focus of Vince’s work is on the fabrication of micro-scaled optical and medical devices based on multiphoton initiated polymerization. Vince has built a lithography system from scratch, starting with designing the optical layout, to integrating the optics, optomechanic and electronic components, as well as writing the control software in LabView. Vince has presented the results of his research in several CLEO conference talks, as well as first author publications in Optics Express. He has prepared annual review presentations and progress reports for our funded projects, as well as preparing literature reviews, modelling and graphics for proposals.
Vince has made highly significant contributions to other research projects in the group and collaborations in multi-disciplinary teams. He is leading our group’s effort in confocal and multiphoton imaging of bio-derived photonics, where we are investigating the origin of colors in butterfly scales, application of artificial color to native butterfly scales, and enhanced two-photon excited fluorescence from nanoparticle-decorated pollens. His expertise in LabView programming has aided the automation of various home-built measurement systems. He works closely with the primary users to develop methods of data acquisition and analysis. He is also in charge of maintaining and training new users on our infrared spectrometer and fluorimeter, as well as performing measurements and analysis for academic and industrial collaborators.
Vince is a self-starter and has quickly picked up new skills to tackle a broad range of research interests in my group. His ability to communicate and collaborate with fellow scientists and engineers will make him a valuable addition to your team. I can be contacted by email or by phone should you need more information or have questions.
Sincerely,
Joseph W. Perry Professor of Chemistry and Biochemistry
Joel McCajah Hales 21 Peabody St. Newton, MA. 02458 Ph: 404-735-0754 [email protected]
The National Academies of Sciences-Engineering-Medicine Optical Society Foundation Fellowship Thorlabs Inc. Re: High Resolution Multiphoton Imaging (OSAFF.TL3) Dear Fellowship Awards Committee,
My name is Joel Hales and I am writing to you on behalf of Vincent Chen concerning his application for the Optical Society Foundation Fellowship at Thorlabs Inc. for High Resolution Multiphoton Imaging (OSAFF.TL3). I am a research scientist working with the Naval Research Laboratory and have over 15 years of experience in the fields of optics and photonics with a focus in nonlinear optics and ultrafast spectroscopy. I have known Vincent for over 10 years, mainly during our time overlapping in the same research group in the chemistry and biochemistry department at Georgia Tech. During this tenure, my relationship with Vincent was both as a project supervisor and a collaborator on a number of different scientific studies. This relationship has given me a unique ability to gauge Vincent’s qualifications and I believe his ingenuity, capability to traverse different scientific and engineering disciplines, and strong work ethic make him an excellent candidate for this position.
During his time at Georgia Tech, Vincent has developed and taken ownership of a major research thrust in the group: multiphoton lithography (MPL). This technique involves the use of multiphoton absorption to enable three-dimensional (3D) fabrication of micro- and nanostructures. Through the use of novel and complex materials systems, Vincent has applied this technique toward the study of bioinspired synthetic structures, photonic structures for signal processing, and lasing-based microstructures. What is most impressive is that, with only minor supervision, Vincent has effectively piloted this research from the initial stages of system development, through device design and fabrication, to the final stages of optical and materials characterization. A significant amount of Vincent’s initial efforts were focused on the engineering, testing and automation of the apparatus used for MPL. These efforts involved designing the optical layout including beam delivery and shaping as well as automating various aspects of the system including 3D stage movement, laser-power control, and dosing modulation. The end result was an agile, rapid fabrication platform that could be exploited for the development of arbitrarily-shaped structures through numerous adjustable design parameters. The flexibility of the system enabled a myriad of devices/structures to be fabricated, each which required its own unique resin system. Therefore, Vincent devoted substantial materials chemistry
efforts towards the identification of the optimal resin system for each structure. Furthermore, the specific topologies of those structures required consideration of aspects involving surface modification, material infiltration, and kinetic control. Finally, Vincent utilized a variety of optical (FTIR, Raman, optical profilometry, optical microscopy, etc.) and materials (SEM, FIB, TEM, etc.) characterization techniques to interrogate the resulting structures. Overall, Vince’s experiences make him ideally-equipped to participate in the design and decision making processes that occur during the stages of prototype to production.
Clearly, Vince’s experience and expertise would be directly applicable to the High Resolution Multiphoton Imaging position. The apparatus that Vince has developed and utilized for MPL shares extensive similarities with a typical instrument used for multiphoton imaging (e.g. beam delivery and shaping, high-NA focusing objectives, galvanometer-based beam scanning, 3D stage movement, etc) and he is intimately familiar with the related hardware and software control. He has extensive experience developing optical and materials approaches aimed at achieving smaller structural features which correlates to modifying the point-spread function for improved imaging resolution. He has utilized a variety of optical imaging techniques for characterizing his structures including multiphoton absorption-based imaging, SHG imaging, laser confocal microscopy, and epi-fluorescence imaging. Vincent’s ability to apply concepts from diverse science and engineering areas towards the development of functional devices suggests that he would not only readily transition into an interdisciplinary team of engineers and scientist but would excel there.
I have had the pleasure of working with and supervising Vincent for nearly a decade and can say unequivocally that his strong scientific versatility would make him an ideal candidate for the High Resolution Multiphoton Imaging position. I hope you have found this information helpful and please do not hesitate to contact me if you have any further questions.
Sincerely,
Joel Hales
