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The new age GastroprotectantThe new age GastroprotectantThe new age GastroprotectantThe new age Gastroprotectant
Zinc CarnosineZinc CarnosineZinc CarnosineZinc CarnosineZinc Carnosine
ZINC CARNOSINE
Effect of Zinc Carnosine on epigastric pain
Night
Fasting
After meals
Disappearance rates of pain (%)
53.3
76.9
90.9
0 20 40 60 80 100
1
1.http://www.lef.org/magazine/mag2006/dec2006_report_stomach_02.htm 2.A natural approach to ulcer treatment, In Ulcer free by Halpern GM. 2004, 145-166
Clinical efficacy
Zinc Carnosine has been used widely in human
clinical trials for over a decade. In clinical trials
enrolling a total of 691patients, 70% experienced
remarkable improvement in symptoms and 65%
of patients demonstrated evidence of healing on
gastrointestinal imaging tests after eight weeks
of using Zinc Carnosine. There were remarkable
improvements in objective outcomes as well as subjective symptoms such as heartburn, 1nausea,vomiting, belching and bloating.
In a meta-analysis of studies done on Zinc Carnosine, there were no adverse effects from the
supplement. None of the patients with side effects required further evaluation or treatment.
Zinc Carnosine, offers an ideal supplement to be added with proton pump inhibitors and NSAIDs. PPIs
have been demonstrated to be effective in symptom relief and prevention of relapse of peptic ulcers by
reducing the acid secretion. On the other hand, Zinc Carnosine produces visible changes in stomach
integrity.
Clinical safety of Zinc Carnosine
Combination therapy with Zinc Carnosine
The Mark of Innovative Chemistry
Puneet Laboratories Pvt. Ltd.605 Raheja Plaza-B, L.B.S Marg, Ghatkopar (W), Mumbai 400086, INDIA.
Tel : +91-22-61367000 Fax : +91-22-61367067 Email : [email protected] Web : www.puneetlabs.com
The Mark of Innovative Chemistry
ZINC CARNOSINE ZINC CARNOSINE THE NEW AGE GASTROPROTECTANT
Zinc Carnosine
Zinc Carnosine offers a new dimension to the treatment of acid
peptic disorders due to its ability to strengthen the gastric
mucosa and protecting the stomach lining against acid 1 damage. Zinc Carnosine is a chelate of zinc and L- carnosine;
having powerful antioxidant, tissue-healing and mucosal-1supportive functions.
Component of various enzymes required in the
maintenance of structural integrity of proteins
Zinc
l
Common causes of mucosal
destruction
Excessive acid secretion
NSAID usage
Helicobacter pylori
Smoking
Alcohol
l
l
l
l
l
This causes gastritis and eventual ulcerations.The common diseases in which the gastrointestinal
mucosa is damaged are peptic ulcer and gastritis.
The primary goal of acid peptic disorders would be to reduce the acid secretion which can reduce
gastritis and bring about healing of the ulcers. But little attention has been paid towards the protection of
the gastric mucosa, primarily due to lack of options for the same. In this regard, PPIs have dominated the
treatment course due to their excellent clinical efficacy in reducing hypersecretion of acid. However, the
improvement of gastrointestinal lesions would be much better and faster if the PPIs are combined with a
drug which will heal the lesions.
N
N
ZnN
NH
H
H2
0
0
0n
ZINC CARNOSINE
Gastric mucosal barrier and gastrointestinal
health
Gastrointestinal mucosal damage
The gastrointestinal mucosa :
Offers protection from digestive acid, pepsin, bile
acids, and proteolytic enzymes
Ensures healthy gastric function
Prevents irritation and auto-digestion of mucosa by
gastric secretion
Breakdown and disruption of the gastric mucosa may be
caused by gastric stress due to:
Excessive acid secretion,
NSAID usage,
Infection with Helicobacter pylori
l
l
l
l
l
l
l
l
l
l
l
l
l
l
l
l
l
l
l
l
l
l
l
Catalytic, structural or regulatory roles in more than 200 metalloenzymes.
Composed of the amino acids histidine and B-alanine
Found in relatively high concentrations in the skeletal muscle, heart muscle, and in the brain.
When zinc and L-carnosine are linked by chemical bond in a single molecule, or chelated, their tissue-
healing effects become even more remarkable.
Successful pharmaceutical product in Japan since 1994 for the treatment of stomach and
gastrointestinal disorders
Large body of animal safety and efficacy/mechanism of action research
Supports the inhibition of Helicobacter pylori (H. pylori)
Numerous research studies and more than 12 years of human experience
US FDA approved as dietary ingredient
Increases production of insulin-like growth factor-1 (IGF-1)
Promotes gastric epithelial wound repair
Inhibits production of pro-inflammatory interleukin-8
Prevents inflammatory white blood cells from adhering to epithelial cells
Minimises gastric stress due to free radicals
Being a chelate, Zinc Carnosine is not destroyed in the acidic pH of stomach. On oral administration,
Zinc Carnosine adheres and bind to gastric ulcer site.
L-carnosine, which has wound healing ability is released on the ulcer lesion.
Simultaneously, Zinc, which has a protective effect on membranes, penetrates into the ulcer to ease
inflammation.
Zinc carnosine has a slow dissociation rate because of which it is not easily removed form the ulcer
site of stomach.
The slow dissociation rate of Zinc Carnosine in gastric juice due to the polymeric character is
essentially important because the prolonged existence in the stomach maintains the healing effect 2for a long time.
L-carnosine
Accelerates healing of ulcers
Anti-inflammatory effect
Antioxidant effect
1Zinc-Carnosine - The new age gastroprotectant
2Mechanism of action
Penetration of Zinc Carnosine inside gastric tissue