The influence of geomagnetic and environmental factors on the
changes in autonomic regulation (based on a satellite experiment
Mars-500). Chernikova A., Zenchenko T., Baevsky R. Institute of
bio-medical problems RAS, Moscow, Russia Slide 2 The analysis of
the organism condition in cosmonauts during and after a prolonged
staying in microgravity on the OS MIR" and the ISS did not reveal
any abnormalities that prevent the gradual increase in the duration
of manned space flight. The analysis of the organism condition in
cosmonauts during and after a prolonged staying in microgravity on
the OS MIR" and the ISS did not reveal any abnormalities that
prevent the gradual increase in the duration of manned space
flight. An important precondition for the success of the
interplanetary missions is the ability of the human body to adapt
to conditions of prolonged space flight. An important precondition
for the success of the interplanetary missions is the ability of
the human body to adapt to conditions of prolonged space flight.
Slide 3 At the same time individual characteristics of an organism
(a type of regulation, age) and environmental conditions
(environmental and social conditions, the type of impact, seasonal
changes) play an important role. At the same time individual
characteristics of an organism (a type of regulation, age) and
environmental conditions (environmental and social conditions, the
type of impact, seasonal changes) play an important role. The
scientific justification of this working hypothesis in reference to
problems of Mars mission medical support together with the
development of theoretical positions on functional reserves of
human would be an important contribution to the preparation of
manned flights to Mars. Slide 4 Mars-500 project has being
conducted by the State scientific center of the Russian Federation
Institute for Bio-medical Problems of RAS under the aegis of
Roscosmos, ESA and Russian Academy of Sciences. It included a
series of experiments simulating these or those aspects of an
interplanetary manned flight. The main part was a series of
experiments on long-term isolation of the crew in conditions of the
specially built ground-based experiment facility. (web-site
http://mars500.imbp.ru) Slide 5 photo: http://mars500.imbp.ru
International crew: 6 males age 323,7 years. Work and rest schedule
of the crew is the same as in orbital flights (7-day week with two
free days). Work and rest schedule of the crew is the same as in
orbital flights (7-day week with two free days). Rations for crew
members were identical to those used on the International Space
Station. Rations for crew members were identical to those used on
the International Space Station. The crew was in an artificial
environment at normal atmospheric pressure. The crew was in an
artificial environment at normal atmospheric pressure. Slide 6 The
specificity of the project "Mars- 500" from positions the theory of
adaptation 1) The long-term adaptation processes lead to some
restructuring of the regulatory mechanisms and the establishment of
new functional relationships in the body. This can lead to
increased spending of functional reserves and substantially
increase the risk of disease. 2) experimental factors, affecting
the body, gradually become less important due to the "addiction" to
them (the factor of acclimatization). Slide 7 To solve the problem
- studying the characteristics of adaptation processes during
prolonged stay in the crew of stress conditions in the model of the
spaceship, we deemed it necessary to to conduct a parallel
experiment to compare the reactions of the organism in the
long-term isolation from the reactions of similar groups of people
living under natural conditions. Slide 8 For the scientific
analysis of changes in health status of the "Martian" crew control
experiments in which similar groups of people would be in the wild
under the influence of various environmental factors: climatic and
geographical, industrial, social and other. In this regard, control
satellite studies, which were held simultaneously in several groups
of volunteers, were organized. The reference groups were formed in
11 regions including 6 groups in Russia, one in Germany, one in
Czech, one in Belarus, one in USA and one in Canada. The reference
groups consisted of 10 to 15 essentially healthy males in the same
age range. Slide 9 CityParticipants, NInvestigations, n Moscow
(Mars-500)6120 Moscow16139 Voronej1461 Syktyvkar17232
Ekaterinburg12146 Magadan20254 Ijevsk11103 Minsk (Belorussia)10127
Berlin (Germany)1075 Prague (Czech Republic)861 Toronto(Canada)698
Poulsbo (USA)4114 Slide 10 A special website was created for
informational and technical support of research. Preliminary
individual conclusions about health status were done for every
individuals and files with the results of studies were transferred
to DataBase in analytical center via Internet connections. A
special website was created for informational and technical support
of research. Preliminary individual conclusions about health status
were done for every individuals and files with the results of
studies were transferred to DataBase in analytical center via
Internet connections. www.iki.rssi.ru/mars500 Slide 11
www.iki.rssi.ru/mars500 (Results, Weather) Slide 12
www.iki.rssi.ru/mars500 (Results, Arterial blood pressure) Slide 13
One of the hypotheses investigated in this unique experiment dealt
with the adaptation to prolonged exposure to stress factors. This
hypothesis can be stated as follows: long-term tension of
regulatory systems leads to a decrease in functional reserves,
reduced its adaptive capacity and as a result increased risk of
disease. Slide 14 Kinds of diagnostics PrenosologicalNosological
containing the name of the disease in terms of the accepted
classification and nomenclature of diseases HealthDisease
Prenosological state The human condition on the borderline between
health and disease Slide 15 Prenosological assesment of functional
deconditioning the main research method. A new methodological
approach, developed in space medicine for assessing the risk of
disease according to the HRV analysis [Baevsky, Chernikova, 2002,
2010], was used while assessing the results of studies. Adaptation
level is measured here by the parameters of the functional reserves
(FR) and the stress degree (SD) Slide 16 The space of functional
states The measure of quantifying the health risks is the
probability of prenosological and premorbid states, which differ
from normal states by significant shifts in autonomic balance. The
measure of quantifying the health risks is the probability of
prenosological and premorbid states, which differ from normal
states by significant shifts in autonomic balance. Slide 17 A
slight but significant (p
