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5/9/16
1
The Immune SystemFourth Edition
Chapter 2Innate Immunity: The Immediate
Response to Infection
Copyright © Garland Science 2015
Peter Parham
Different type of immune responses for extra-‐and intracellular pathogens
The complement system marks pathogens for destruction
• Plasma proteins : mostly proteolic enzymes of proteases
• Complement proteins
• Complement fixation
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Activation of omplement component 3 (C3)
The alternative pathway
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iC3Bb complex
Complement receptor 1 recognizes C3b