The Hauptman-Woodward Medical Research Institute (HWI) is an independent, not-for-profit, biomedical research facility located in the heart of downtown on the Buffalo Niagara Medical Campus. We are a founding member of the BNMC, together with our neighbors Roswell Park Cancer Institute, Kaleida Health, University at Buffalo, and the Buffalo Medical Group. For more than half a century, HWI scientists have been committed to conducting life-altering research to understand the causes and potential cures of many diseases.

Working under the leadership of our new Chief Executive Officer Dr. Edward H. Snell, HWI scientists are studying a wide range of diseases which include AIDS, arthritis, breast cancer, cardiovascular disease, cystic fibrosis, prostate cancer, and many others. In addition, researchers at HWI seek to improve the methods of crystallization and data analysis used by scientists worldwide which are critical elements in drug design.

Inside … Chairman’s Message Outgoing Chief Executive Officer’s Message Vice President for Finance’s Report and Financial Highlights Research Highlights Select Publications The People of HWI Hauptman-Woodward’s Board of Directors Hauptman-Woodward’s Team Our Dedicated Donors Hauptman Society 2014

2014 ANNUAL REPORT

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Dear friends of Hauptman-Woodward,

I am very pleased to announce the selection of HWI’s new Board Officers, effective June 2015.

Judy Feldman, Board ChairPeter McCauley, Vice-ChairJohn Horn, SecretaryCharles Lannon, Finance Chair

The Board of Directors unanimously approved this slate at our Board Meeting held in June and I would like to thank the new Officers for their willingness to serve the Institute in this capacity. HWI continues with their leadership on the path toward supporting major scientific discovery and innovation, as well as greater financial strength.

2014 has been a successful year for the Institute with changes and advances in many facets of the organization. First, I would like to recognize and thank Ed Lattman for his service as HWI’s CEO for the past 7 years. Under his leadership, HWI saw the successful awarding of a prestigious National Science Foundation Science and Technology Center; a financially and scientifically advantageous relationship with IMCA-CAT; as well as the launch of HarkerBIO. Each of these is a tremendous undertaking and represents great forward momentum for the Institute. I am also more than encouraged by the Board’s selection of Edward Snell to step into the CEO role. An internation-ally recognized scientist in his own right, Ed Snell brings the scientific and administrative talents necessary to lead HWI towards a promising future. After nearly 10 years, I am officially stepping down from my own position on the HWI Board, of which 4 years were spent serving as your Chair. I would like to take this opportunity to thank each of you for the support you’ve given to the Institute and the Board during this time. Thank you for making this a very fulfilling and engaging experience. I have enjoyed the chance to serve in this capacity and to learn more about the tremendous work being done by HWI researchers. Their tenacity and commitment to the work they do, even through the most challenging of funding periods, is a testament to their dedication to contribute to future cures.

As we embark on 2016, HWI will be celebrating its 60th anniversary since Helen Woodward Rivas gave her founding gift of $3 million in 1956 to support the leading edge research of Dr. George Koepf (the equivalent of a $26 million gift in today’s economy). I am pleased to see the impact that HWI has had over this time period and how well poised it is to have significant impact in the future. It is my hope she would feel the same. I do plan to actively participate in this promising future as a friend to the Institute and it is my hope that you will continue to do the same.

My term as CEO officially ended on November 30, 2014, so I write this to you having concluded the 2014 fiscal year and having handed the reigns over to Ed Snell, a principal research scientist with HWI with a very distinguished scientific career already. In retrospect, I have seen great strides in the last 6 1/2 years with management of day-to-day operations as well as continuing efforts of long-range projects. Over-all, my time was invigorating and truly enjoyable having been a part of a remarkable institution with a tremendous legacy.

OUTGOING CHIEF EXECUTIVE OFFICER’S MESSAGE

Eaton E. Lattman, PhD

Richard A. Aubrecht, PhD

FROM THE CHAIRMAN OF THE BOARD

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HWI does still face challenges like any organization moving into the future and your support is always critical for helping the organization navigate through both the good and the bad. Chal-lenges always present opportunities and ways in which you can support HWI and poise it well for future growth I’ve suggested below.

• Consider coming in for a tour and get in touch with our team of researchers; your advocacy and knowledge of HWI in our community is a tremendous asset for the Institute

• Consider a gift to HWI; both large and small gifts enable us to support our researchers as they need funding to start new projects and collect data before they can apply for federal support

• Consider sharing your talents and perhaps volunteer at HWI; our building is vast and our team is small, we always appreciate the knowledge and expertise of friends of HWI helping us in ways that would not be feasible within a small organization

I have high hopes for the outcome of the strategic planning process that began recently, and for HWI to play a major role in the entrepreneurial and academic expansion at the BNMC. From this vantage point Ed Snell, our new CEO, is doing a wonderful, aggressive job. I am still here at HWI and leading the BioXFEL Center, and I look forward to seeing much more come to fruition.

Respectfully submitted,Eaton Lattman, PhDCEO emeritus

With sincere appreciation,Richard Aubrecht, PhDDeparting Board Chair

As I look back in a broad way at what has happened over my time at HWI I would like to mention a few of what I see are our most significant accomplishments.

• Development of new and potential revenue streams not dependent on R01-type grants • Our relationship with IMCA-CAT and their team • The establishment of HWI’s subsidiary HarkerBIO

• HWI being the primary impetus in securing the National Science Foundation BioXFEL Science and Technology Center

• The appointment of Michael Malkowski as a tenured UB professor serving as interim chair in the Department of Structural Biology situated at HWI

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Our consolidated accrual basis net loss for the year ended October 31, 2014 was $116k and was driven mainly by depreciation expense on our research facility as well as a continued reduction of our federal grant revenue base. Cash flow remained flush with the prior year positively impacted by payments on outstanding receivables. Controllable expenses were maintained within budget. Non operating gains of $536k include realized and unrealized investment performance as well as the fair value of the derivative arrangement on our outstanding debt. During the course of the year, HWI formed a for-profit subsidiary named HarkerBIO, LLC. HarkerBIO’s mission is to work with clients to improve and optimize the process of drug discovery through structural biology methods developed at the Institute. HWI invested $250k of capital into the company this year for a majority of the membership units. The establishment of HarkerBIO will enhance and expand HWI’s scientific footprint as well as generate new revenue streams for the Institute.

On the balance sheet, our total assets are approximately $26M. This includes $7.8M in investments of which our permanent endowment represents $2.3M. We have set aside another $100k in a Reserve for Replacement as required by our covenants with our lender. This effectively brings our replacement reserve up to $1M and satisfies the covenant in full. Lastly, we once again received a favorable “unqualified” report from our auditors. There were no deficiencies noted in accounting controls or major research programs.

FINANCIAL REPORT AND HIGHLIGHTS

Source: The audited �nancial statements of the Hauptman Woodward Medical Research Institute, Inc.

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Respectfully submitted,

Anne M. KentVice President of Finance

Signi�cant Financial Statement Elements 10/31/2014 10/31/2013 Total Assets $ 25,704,746 $ 26,547,247 Total Liabilities $ 5,782,513 $ 6,508,659 Total Net Assets $ 19,922,233 $ 20,038,588 Total Revenues & Other Support $ 7,419,747 $ 8,385,034 Total Operating Expenses $ 8,072,587 $ 9,006,195 Net Operating Loss $ (652,840) $ (621,161) Non Operating Gains/(Losses) 536,485 621,810 Net Loss $ (116,355) $ 649

The primary focus of Dr. Cody’s research is to understand how drugs or hormones are recog-nized by their protein targets and how their interactions can be optimized to help design more effective drug treatments for diseases such as cancer, AIDS-related pneumonia, and thyroid hormone disorders.

One on-going study is aimed at finding inhibitors of dihydrofolate reductase (DHFR), a critical enzyme responsible for the synthesis of nucleic acids and proteins. This enzyme drives protein synthesis, and therefore, cell growth. The major focus of this work is to identify inhibitors that can selectively target DHFR from pathogens rather than the human enzyme, for the treatment of such diseases as Pneumocystis pneumonia, malaria, bacterial infections, and cancer. Another area of focus is on studies that will address important questions concerning the function and evolution of transthyretin (TTR), a protein that is responsible for the transport of thyroid hormone throughout the general circulation. The genetic disease, familial amyloidal polyneuropathy, is the result of a series of single mutations in the sequence of human TTR that cause the tetra-meric form of the protein to destabilize and form fibrils that make the body’s organs look like “Swiss cheese”. There is no cure for amyloid fibril damage. Researchers have focused on understanding why specific mutations result in damage to a specific organ – heart, brain, kidney, or liver. Small molecule drugs have been shown to bind tightly to the thyroid hormone binding site of TTR and stabilize the mutant form of the protein.

Dr. Cody is collaborating with a group in Australia which has designed novel compounds that can stabilize human TTR. She has determined the three dimensional crystal structure of human TTR bound with their compound. These data provide insight into the stabilization of TTR.

2014 RESEARCH HIGHLIGHTS

Dr. Vivian Cody’s Laboratory

Vivian Cody, PhD

Dr. Cody is also a Professor in the School of Medicine and Biomedical Sciences,UB and is currently Secretary of the School of Medicine Faculty Council.

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The Gewirth Lab studies the structure and mechanism of proteins involved in cancer. A major focus of this group is Hsp90 chaperones. These chap-erones are proteins, and their job is to help other proteins survive in the crowded and hostile cellular environment. They do this by helping other, newly made proteins, assume their functional folded shape, or by sequestering damaged proteins for subsequent removal. Among the ‘client’ proteins that Hsp90 acts on are many of the key proteins required for tumor growth. Inhibitors of Hsp90 are currently under intensive study because of their great potential as powerful anti-cancer drugs. Dr. Gewirth also investigates steroid and nuclear hormone receptors, in particular the androgen recep-tor and its role in the regulation of prostate cancer. Although normally slow growing and benign, in some men prostate cancer becomes aggressive and life threatening. For these patients, anti-androgens are used to counter the growth and spread of the disease. Over time, however, this treatment inevitably becomes ineffective as mutations in the androgen receptor render it insensi-tive to castration treatments. The goal of Dr. Gewirth’s research, carried out in collaboration with scientists in Minnesota and Vancouver, is to develop drugs that target new parts of the andro-gen receptor. The hope is that these inhibitors will suppress cancer cells even after the cells become resistant to the current drug treat-ments available.

2014 RESEARCH HIGHLIGHTS

Dr. Daniel T. Gewirth’s Laboratory

Daniel T. Gewirth, PhD

Andrew M. Gulick, PhD

Many pharmaceuticals, including the anti-cancer agent bleomycin and the antibiotics peni-cillin and vancomycin, are naturally produced by bacteria and fungi. The Gulick Lab is study-ing the enzymes that are involved in the production of these active natural products by a family of proteins called Non-Ribosomal Peptide Synthetases (NRPSs). The goal of this work is to understand the basic strategy of how these enzymes function, which may allow bioengi-neering approaches to produce new active compounds. Additionally, many bacteria harbor NRPSs for which the product is unknown. A better understanding of how these enzymes work could allow us to discover new natural products with new activi-ties. Finally, other NRPS proteins are responsible for the virulence of human pathogens and the Gulick lab is discovering com-pounds that block NRPS function to prevent the bacteria from making these molecules that allow them to grow. Important addi-tional studies this year led to publications with collaborators from several groups from the University at Buffalo to study important proteins in the human pathogens Klebsiella pneumoniae and Mycobacterium tuberculosis.

Dr. Andrew M. Gulick’s Laboratory

Dr. Gewirth is Chair of the HWI Scientific Governance Council and represents the faculty on the HWI Board of Directors.

Dr. Gulick was recently named HWI’s Vice President for Research.

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Joseph R. Luft

2014 RESEARCH HIGHLIGHTS

Joseph R. Luft’s Laboratory

The Luft Laboratory aims to bring scientific rigor to the means of growing protein crystals; these crystals are used to determine three-dimensional structures to see proteins and learn how they function. Crystallization conditions are identified by combining a protein with hundreds of different chemicals and then looking for indications of crystals. The high-throughput crystallization laboratory at HWI can set up 1,536 of these experiments in minutes and now has a state-of-the-art imaging system, the SONICC was aquired through a generous anonymous gift as well as with funds from Empire State Development. The SONICC can detect crystals that would otherwise be missed because they are too small to be seen with a micro-scope. The laboratory continues to improve upon technologies through collaborative scientific research and to date has screened more than 15,000 proteins for crystallization.

The Malkowski Laboratory is focused on structure-function studies of integral membrane enzymes, specifically those involved in lipid metabolism and the oxygenation of polyunsatu-rated fatty acids. One of the key families of enzymes under current study is the Cyclooxyge-nases (COX-1 and COX-2). Changes in COX-mediated prostaglandin biosynthesis are associ-ated with various disease pathologies, including inflammation, cardiovascular disease, and cancer. COX-1 and COX-2 are the targets of aspirin, ibuprofen, and other nonsteroidal anti-inflammatory drugs (NSAIDs), and COX-2 selective inhibitors (coxibs) such as Celebrex. These compounds are some of the most heavily utilized drugs in the world, used to decrease acute and chronic inflammation, protect against adverse cardiovascular events, and reduce the risk of developing certain cancers. However, NSAID and coxib use is not without risk. Over 15,000 deaths per year can be ascribed to harmful effects derived from their consumption, the molecu-lar basis of which is unknown. Dr. Malkowski’s laboratory is interested in understanding the molecular basis of how these drugs interact with the enzyme, with the ultimate goal of provid-ing a foundation for the development of new drugs and repurposing existing ones to provide maximum efficacy while minimizing risks.

Dr. Michael G. Malkowski’s Laboratory

Michael G. Malkowski, PhD

The Luft lab is playing an integral role in the launch of HWI’s HarkerBIO. Dr. Malkowski was recently named Interim Chairman for the Deparment of Structural Biology at the University at Buffalo School of Medicine and Biological Sciences which is housed at HWI.

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Edward H. Snell, PhD

Crystallography is the dominant technique for visualizing biological macromolecules and understanding how they work. The existence of high-quality crystals is a key requirement. However, the growth of such crystals is often a major obstacle. Therefore, one of the major goals of the Snell laboratory is to develop greater understanding of the crystallization process and to improve the methodology for elucidating the structure, function and dynamics of large biological molecules. Complementary techniques are also being developed where crystalliza-tion is not successful or to add additional information to the crystallographic structure.

The Snell laboratory is situated adjacent to HWI’s high-throughput crystalli-zation screening labora-tory, directed by Joseph Luft; the two labs work together to develop practi-cal approaches for initial crystallization screening, to examine different methods of evaluating experimental outcome, and to make use of the crystals that result. More often than not, crystallization attempts initially fail or samples remain recalcitrant to crystallization. In cases like these where satisfactory crystallographic work is not possible, the Snell lab has developed algo-rithms and techniques in Small-Angle X-ray Scattering (SAXS), to extend the information that can be derived from this complementary technique.

The Snell lab has multiple collaborations in combining complementary methods: for example, they have made use of neutron scattering to study enzymes, SAXS as a tool to validate basic shape information, and Nuclear Magnetic Resonance (NMR) in combination with computa-tional modeling to understand structure. Of particular importance is the combination of crystal-lography, SAXS, and molecular dynamics to provide structural and mechanistic information.

2014 RESEARCH HIGHLIGHTS

Dr. Edward H. Snell’s Laboratory Dr. Timothy C. Umland’s Laboratory

Timothy C. Umland, PhD

Dr. Timothy Umland explores how animal viruses mutate to gain the ability to productively infect human cells through evasion of the innate immune system. Many viruses have evolved responses that allow them to either remain undetected by, or to disable a host’s first-line innate immune responses. Discovering how animal viruses mutate to “match” with key innate immu-nity proteins present in a new host cell may eventually lead to antiviral drugs or the ability to enhance surveillance for emerging pathogenic viruses. The Umland Lab, in collaboration with Thomas Russo, M.D (University of Buffalo and VA Medical Center), has also identified proteins that are essential during infection for the growth and survival of Acinetobacter baumannii, a bacterium that exhibits extreme-drug resistance that primarily affects medical health center patients. This is a first step in an effort to develop new antibiotics capable of combating multi-, and extreme drug-resistant bacteria.

Dr. Snell was recently named Chief Executive Officer of HWI.

Dr. Umland hopes to lay the groundwork for developing new antibiotics to treat drug-resistant bacteria.

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2014 PUBLICATIONS

Acbas G, Niessen KA, Snell EH, Markelz AG. Optical measurements of long-range protein vibrations. Nat Commun. 2014 Jan 16;5:3076. PMID: 24430203

Allen CL, Gulick AM. Structural and bioinformatic characterization of an Acinetobacter baumannii type II carrier protein. Acta Crystallogr D Biol Crystallogr. 2014 Jun;70(Pt 6):1718-25. Epub 2014 May 30. PMID: 24914982 Blessing RH. Phasing in Crystallography: A Modern Perspective. (Book review) Acta Crystal-logr A Found Adv. 2014 Sep;70(Pt 5):518-9. Epub 2014 Jul 17. PMID: 25176999

Bruno AE, Ruby AM, Luft JR, Grant TD, Seetharaman J, Montelione GT, Hunt JF, Snell EH. Comparing chemistry to outcome: the development of a chemical distance metric, coupled with clustering and hierarchal visualization applied to macromolecular crystallography. PLoS One. 2014 Jun 27;9(6):e100782. eCollection 2014. PMID: 24971458 Calero G, Cohen AE, Luft JR, Newman J, Snell EH. Identifying, studying and making good use of macromolecular crystals. Acta Crystallogr F Struct Biol Commun. 2014 Aug;70(Pt 8):993-1008. Epub 2014 Jul 25. PMID: 2508437 Fusco D, Barnum TJ, Bruno AE, Luft JR, Snell EH, Mukherjee S, Charbonneau P. Statistical analysis of crystallization database links protein physico-chemical features with crystallization mechanisms. PLoS One. 2014 Jul 2;9(7):e101123. eCollection 2014. PMID: 24988076 Grant T, and 35 others. Time-resolved serial crystallography captures high-resolution interme-diates of photoactive yellow protein. Science. 2014 Dec 5;346(6214):1242-6. PMID: 25477465

Greenberg SM, Ferrara AM, Nicholas ES, Dumitrescu AM, Cody V, Weiss RE, Refetoff S. A novel mutation in the albumin gene (R218S) causing familial dysalbuminemic hyperthyroxine-mia in a family of Bangladeshi extraction. Thyroid. 2014 Jun;24(6):945-50. Epub 2014 Mar 21. PMID: 24494774 Jones MM, Johnson A, Koszelak-Rosenblum M, Kirkham C, Brauer AL, Malkowski MG, Murphy TF. Role of the oligopeptide permease ABC transporter of Moraxella catarrhalis in nutrient acquisition and persistence in the respiratory tract. Infect Immun. 2014 Nov;82(11):4758-66. Epub 2014 Aug 25. PMID: 25156736 Kholodar SA, Tombline G, Liu J, Tan Z, Allen CL, Gulick AM, Murkin AS. Alteration of the flexible loop in 1-deoxy-D-xylulose-5-phosphate reductoisomerase boosts enthalpy-driven inhibition by fosmidomycin. Biochemistry. 2014 Jun 3;53(21):3423-31. Epub 2014 May 22. PMID: 24825256

Luft JR, Grant TD, Wolfley JR, Snell EH. A new view on crystal harvesting. J Appl Crystallogr. 2014 May 29;47(Pt 3):1158-1161. eCollection 2014 Jun 1. PMID: 24904250 Luft JR, Newman J, Snell EH. Crystallization screening: the influence of history on current practice. Acta Crystallogr F Struct Biol Commun. 2014 Jul;70(Pt 7):835-53. Epub 2014 Jun 27. PMID: 25005076

Miller BR, Sundlov JA, Drake EJ, Makin TA, Gulick AM. Analysis of the linker region joining the adenylation and carrier protein domains of the modular non-ribosomal peptide synthetases. Proteins. 2014 Oct;82(10):2691-702. Epub 2014 Jul 5. PMID: 24975514

Munshi P, Snell EH, van der Woerd MJ, Judge RA, Myles DA, Ren Z, Meilleur F. Neutron struc-ture of the cyclic glucose-bound xylose isomerase E186Q mutant. Acta Crystallogr D Biol Crys-tallogr. 2014 Feb;70(Pt 2):414-20. Epub 2014 Jan 29. PMID: 24531475

Orlando BJ, McDougle DR, Lucido MJ, Eng ET, Graham LA, Schneider C, Stokes DL, Das A, Malkowski MG. Cyclooxygenase-2 catalysis and inhibition in lipid bilayer nanodiscs. Arch Biochem Biophys. 2014 Mar 15;546:33-40. Epub 2014 Feb 3. PMID: 24503478

Rossi P, Shi L, Liu G, Barbieri CM, Lee H, Grant TD, Luft JR, Xiao R, Acton TB, Snell EH, Mon-telione GT, Baker D, Lange OF, Sgourakis NG. A hybrid NMR/SAXS-based approach for discriminating oligomeric protein interfaces using Rosetta. Proteins. Proteins. 2015 Feb;83(2):309-17. Epub 2014 Dec 19. PMID: 25388768 Russo TA, Olson R, Macdonald U, Metzger D, Maltese LM, Drake EJ, Gulick AM. Aerobactin mediates virulence and accounts for the increased siderophore production under iron limiting conditions by hypervirulent (hypermucoviscous) Klebsiella pneumoniae. Infect Immun. 2014 Jun;82(6):2356-67. Epub 2014 Mar 24. PMID: 24664504 Seidler PM, Shinsky SA, Hong F, Li Z, Cosgrove MS, Gewirth DT. Characterization of the Grp94/OS-9 chaperone-lectin complex. J Mol Biol. 2014 Oct 23;426(21):3590-605. Epub 2014 Sep 3. PMID: 25193139 Umland TC, Schultz LW, Russo TA. Re-evaluating the approach to drug target discovery in multidrug-resistant Gram-negative bacilli. Future Microbiol. 2014;9(10):1113-6. doi: 10.2217/fmb.14.72. PMID: 25405880 Wurst JM, Drake EJ, Theriault JR, Jewett IT, VerPlank L, Perez JR, Dandapani S, Palmer MA, Moskowitz SM, Schreiber SL, Munoz B, Gulick AM. Identification of inhibitors of Pseudomo-nas aeruginosa PvdQ acylase, an enzyme involved in the synthesis of the siderophore pyover-dine. ACS Chem Biol. 2014 Jul 18;9(7):1536-44. Epub 2014 May 21. PMID: 24824984

The nonsteroidal anti-inflammatory drug Ibuprofen bound to Cyclooxygenase-2.

Solved by the Malkowski Laboratory

Our greatest assets are our people. Hauptman-Woodward is fortunate to be home to some of the most creative minds in science today and has the distinction of offering an investigator-initiated approach that allows our scientists to translate their passion for their work into their everyday experiences. The scientific team is supported daily by talented individuals who serve on our boards and a staff which includes individuals with a wide range of talents and experiences. Each employee at Hauptman-Woodward plays a role in ensuring the organization’s current and future successes.

Board of Directors and OfficersRichard A. Aubrecht, PhD Chair of the Board

Judith A. Feldman Vice-Chair of the Board

Edward H. Snell, PhD Chief Executive Officer

Andrew M. Gulick, PhD Vice President of Research

Jill M. Szczesek Chief Operating Officer

Anne M. Kent Vice President of Finance

Mary Engler Roche, Esq. Secretary

Michele O. Heffernan, Esq. Counsel

Daniel T. Gewirth, PhD Chairman, Scientific Governance Council

Charles E. Lannon Chairman, Finance Committee

Richard Mueller Chairman, Audit Committee

Anthony P. Pandolfi, CFP, CLU Chairman, Development Committee

Stuart H. AngertJane F. Griffin, PhD Co-Chairs, Governance Committee

James R. Biltekoff Chairman, Hauptman-Woodward Foundation

Frederick G. Attea, Esq.Emily Constantine DorenChristopher G. Gibas, CFP

Emeritus DirectorsAlan P. BagleyThomas R. Beecher Jr., Esq.Norbert A. Bennett, CPAJames R. BiltekoffConstance S. ConstantineChristopher T. Greene, Esq.L. Nelson Hopkins, III, MDRobert J. A. IrwinJames R. Kanski, MDCharles A. Martin, Jr.Lewis D. McCauleyElizabeth S. MitchellDonald F. NewmanPeter T. Ostrow, MD, PhDPamela VogtAlbert J. Wright, III

Scientific Advisory BoardDavid C. Hohn, MD - ChairmanMarvin Cassman, PhDAngela Gronenborn, PhDGeorge N. Phillips Jr., PhDF. Raymond Salemme, PhDWalter F. Stafford, III, PhD

Scientific Governance CouncilDaniel T. Gewirth, PhD - ChairmanJoseph R. Luft - Vice ChairmanVivian Cody, PhD - SecretaryWilliam L. Duax, PhDAndrew M. Gulick, PhDTimothy C. Umland, PhD

Cynthia R. HeximerJohn G. Horn, Esq.Peter McCauleyThomas McMahonSheri Mooney, EsqDavid SchneeweissJoseph A. Voelkl

The People of the Hauptman-Woodward Medical Research Institute

BOARD OF DIRECTORS AND OFFICERS HAUPTMAN-WOODWARD TEAM

Daniel Bailey Graduate Student

Kevin Battaile, PhD* Research Scientist

William Bauer, PhD Associate Education and Diversity Director of BioXFEL

Robert H. Blessing, PhD Senior Research Scientist

Jennifer B. Breen Research Associate

Vivian Cody, PhD Principal Research Scientist

Gloria J. Del Bel Director of Creative Services

Joseph Digilio* System Administrator

Eric J. Drake Staff Scientist

William L. Duax, PhD Principal Research Scientist

Eleanor Cook Franks Research Associate

Daniel T. Gewirth, PhD Principal Research Scientist

Jessica L. Graham Research Associate

Jane F. Griffin, PhD Principal Research Scientist

Andrew M. Gulick, PhD Vice President for Research

Dongyao Guo, PhD Emeritus Scientist

Elijah Harvey Facilities Aide

Fiacre Kabayiza Facilities Aide

Lisa J. Keefe, PhD* CAT Director & Senior Research Scientist

Anne M. Kent Vice President of Finance

David A. Langs, PhD Emeritus Scientist

Eaton E. Lattman, PhD Principal Research Scientist

Angela M. Lauricella Research Associate

Geoffrey Lippa, PhD Postdoctoral Associate

Michael Lucido Graduate Student

Joseph R. Luft Senior Research Scientist

Michael G. Malkowski, PhD Principal Research Scientist

Marc Messerschmidt Research Scientist for BioXFEL

Nathaniel R. Michals System Administrator

Bradley Miller Graduate Student

John Lewis Muir* Software Developer

Anne Mulichak, PhD* Research Scientist

Raymond M. Nagel Software Developer

Ben Orlando Graduate Student

*HWI’s staff at IMCA-CAT As of April 2015 As of April 2015

Stephen A. Potter Director of Information Technology

Nanette L. S. Que, PhD Staff Scientist

Michael J. Rhodes Assistant Controller

Rick Roberts Graduate Student

Mary E. Rosenblum, PhD Staff Scientist

G. David Smith, PhD Emeritus Scientist

Edward H. Snell, PhD Chief Executive Officer

Mary Elizabeth Snell Research Associate

Jill Szczesek Chief Operating Officer

Timothy C. Umland, PhD Research Scientist

Erin Uppington Program Manager for BioXFEL

Deena Grom Vanderbosch Special Projects

Charles M. Weeks, PhD Senior Research Scientist

Brianne Williams Development Administrator

Jennifer R. Wolfley Research Associate

Guangyu Zhu, PhD Staff Scientist

Eric Zoellner* Beamline Technician

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$50,000 - $99,999Richard W. and Mae Stone Goode Trust

$10,000 - $24,999E.J. and Martha J. BurkeCommunity Foundation for Greater Bu�aloDr. Edith M. FlanigenGeorgetown Square Wine & Liquor M&T BankMrs. Gilbert J. Yager

$5,000 - $9,99919/19 Investment CounselAmici CellarsMitch and Lura Hess BechtelMr. and Mrs. William BlanchardMrs. Charles E. Dowdell and The Dowdell FamilyJohn J. Cordes & Michele O. He�ernanKeyBankDr. Eaton E. LattmanMr. and Mrs. Peter L. McCauleyMontgomery Family Foundation Mr. and Mrs. David PietrowskiMr. and Mrs. Theodore RichDr. and Mrs. Walter F. Sta�ord, III The Bu�alo News $2,500 - $4,999Abino Mills GlassworksBu�alo Niagara Medical Campus and Renaissance Fellowship Grant ProgramBu�alo PharmaciesBu�alo Spree PublishingThe Marjorie and John Buyers Foundation Inc.Computer Task Group, Inc.Mr. and Mrs. Walter E. Constantine, Jr.Jesse and Emily Constantine DorenMr. Joseph ErvolinaFirst Niagara BankMr. Richard E. GarmanGelia, Inc. Hodgson Russ, LLPImagine Sta�ng Technology, Inc.Louis S. & Molly B. Wolk FoundationPhillips Lytle, LLPRoswell Park Cancer InstituteMs. Joan Schechtman Sovran Self Storage, Inc.Kevin LoVullo Spiel the WineThe Fatta Foundation Try-It DistributingMr. Kevin Van SplunderWest Herr Auto GroupZeptoMetrix Corp.

$1,500 - $2,499Mr. Bradford H. Banks Mr. and Mrs. Norbert A. BennettDr. and Mrs. Robert H. Blessing

We would like to thank and acknowledge the following donorsGifts received between

January 1, 2014 and December 31, 2014

Mr. and Mrs. Robert M. ChurColumbia ManagementDr. and Mrs. Matthew CywinskiMr. Andrew P DurfeeMs. Judith A. Feldman and Mr. Ed SchunkGEMCORMr. and Mrs. Richard F. Gri�nHorace B. Pomeroy FundJohn W. Danforth CompanyMr. David KimelbergLippes Mathias Wexler Friedman LLPMr. and Mrs. David ManginoMr. and Mrs. E. Dennis McCarthy McGard, LLCMr. and Mrs. John A. Mitchell and Mitchell Family Philanthropic Fund at the CFGBPlanned Futures Financial GroupMs. Cynthia SchwartzSiemensDr. and Mrs. John SlivkaTherese M. VitaWalsh Du�eld InsuranceMr. and Mrs. Peter WilsonDr. and Mrs. C. Richard Zobel $1,000 - $1,499The Joyce and Stuart Angert Fund at the Community Foundation for Greater Bu�aloMr. and Mrs. Bruce C. BairdMr. Henry H. BaxterMr. and Mrs. George F. BellowsMr. and Mrs. James R. Bilteko�Mr. and Mrs. Bruce BuyersDavis-Ulmer Sprinkler Co. Inc.Thomas C. and Mary S. Detwiler FundDon Davis Auto World and Donald Davis FoundationMrs. Jeanne C. EatonDr. Edward G. EberlEmployees of Northrup Grumman Political Action Com mitteeEnergy Mark LLCMr. Brian FotiMr. and Mrs. Christopher T. GreeneIndependent Health Association Mr. Robert J. A. IrwinJaeckle Fleischmann & Mugel, LLPDrs. James and Genevieve Kanski Mr. and Mrs. Peter G. KleinMrs. Mary M. Koessler Ms. Lorinda J. LaubMr. and Mrs. Lewis D. McCauleyNew Era CapMr. and Mrs. Reginald B. Newman, IIDrs. Dean & Donna OrmanDr. and Mrs. Peter T. OstrowPeter J. Ferraro Memorial FundMr. Joseph Priselac, Jr.Mr. and Mrs. Patrick ReillyMr. David Rice

Rich Products CorporationRobert D. Flickinger Charitable FoundationDr. and Mrs. Paul SargeantSevenson Environmental ServicesStrategic Advisory, Inc.The New York Palace Ms. Patricia A. Toole Mr. and Mrs. Wm. Dennis TooleUniversity Orthopedic Services, Inc.Mr. and Mrs. Joseph A. VoelklMr. and Mrs. Albert J. Wright, III

$500 - $999Mr. Stephen C. AmesAuburn WatsonBalbach Family FoundationBennett, Schecter, Arcuri & WillBraman Pomeroy TrustCoca-Cola Bottling Co. of Bu�alo, Inc.Dr. Vivian CodyCommercial Pipe & Supply CorpMr. and Mrs. W. Edwin Constantine, IIIMr. Mark Czarnecki Gloria J. Del BelMs. Cynthia W. DoolittleDouble Cross VodkaMr. and Mrs. Jim EaganMr. and Mrs. Thomas R. FlickingerDr. Samuel Goodloe, Jr.Mr. and Mrs. Don GrennonDr. Kenneth W. GrossMr. and Mrs. Timothy GrotzMr. and Mrs. Harold HeximerDr. and Mrs. L. Nelson Hopkins, IIIJet Blue AirwaysMr. Charles G. Jones, Jr.Keller Technology Corp.Mr. and Mrs. Sarah Heximer KlompstraMs. Sandra Johnston LaubMr. Mark MandersMr. William J. McDermottDr. and Mrs. Herman S. Mogavero, Jr.National Fuel Gas Company FoundationMr. Anthony Pandol� Mr. and Mrs. David S. QuackenbushMrs. Wayne R. ReillyMr. and Mrs. C. Anthony RiderMr. and Mrs. Vincent RinaldoMr. and Mrs. David Rogers and Sovran Foundation For A Better WNY at the CFGB Mr. and Mrs. Jason SmithMr. and Mrs. Robert G. Spampata, Jr.The Strauss GroupMr. Robert TockerVino AromaMr. David WagnerWegmans Food Markets, Inc.Mr. and Mrs. Brian WellsMr. and Mrs. Wayne D. Wisbaum

$250 - $499Mr. and Mrs. Joe ArmbrustMr. Jack ArmstrongMr. and Mrs. Corey AuerbachMs. Margot BantaMr. and Mrs. Dennis BlackBlack Stallion Estate WineryBloom FloralBlueCross BlueShield of Western New York and Health NowMr. and Mrs. Donald BoydBrighton LiquorBu�alo Bills Alumni AssociationMr. and Mrs. William K. Buscaglia, Jr.Caderet, Grant & Co.Mr. and Mrs. Dan CastleMs. Alicia CheneyMr. and Mrs. Arthur W. CryerMrs. Jim DegenDeSpirt Foundation Inc.Mr. Dennis DeTittaMr. and Mrs. John B. DrenningMr. and Mrs. Anthony DuddyMr. and Mrs. Frank L. EberlDr. and Mrs. Edmund EganEric Javits FB Displays & Designs, Inc.Ferguson Electric FoundationDr. and Mrs. Thomas D. Flanagan Mrs. Fay FriedmanMr. Richard L. FriendGotham Bar and GrillHallwallsMiss Deanna Hefner Evelyn HermanMr. and Mrs. John HornMs. Mary HurleyMr. and Mrs. William Baird Irwin Kevin Karn Mr. & Dr. Joel KrenisMs. Lisa LaTrovatoMr. and Mrs. Robert LaughlinLawley InsuranceMs. Grace D. LawrenceMr. and Mrs. Robert C. Leighton Dr. Michael G. Malkowski and Lisa Foti-MalkowskiMarc JacobsMr. James MarkovichMs. Linda Buerk MattMr. and Mrs. John McGrathMr. and Mrs. Richard MinekimeMs. Sheri MooneyMr. Richard MuellerMUSEjarMr. and Mrs. Michael R. OrtmanDr. and Mrs. Walter A. Pangborn Passport Wine & SpiritsDr. and Mrs. John H. PetersonDr. George N. Phillips, Jr.Mr. and Mrs. Ted PyrakMr. and Mrs. Marc RachieleMr. and Mrs. Edward B. RighterWilliam SamsonMr. David Serra

Drs. Stuart & Caren ShapiroMr. and Mrs. Robert G. ShawSilverado VineyardsDr. and Mrs. John B. SimpsonSir Francis Drake Hotel (San Francisco)Dr. and Mrs. Edward H. SnellMr. Don SpasianoDr. Richard A. Stockton, Jr.Mr. Michael StraeckMs. Melda TugacUBS Foundation USA Matching Gift ProgramMs. Katie WagnerMr. Gary WiencekWNY Stem Cell SymposiumZh Racine JewelryMr. and Mrs. Charles Zukoski

$100 - $249Dr. and Mrs. Mark W. AckleyMr. and Mrs. Robert J. AdamsAdam's Mark HotelMs. Susan AdelmanMrs. Stephanie ArgentineAUI Fine FoodsMr. and Mrs. Judson AungstMr. and Mrs. Virgil J. AustinMrs. Wavel H. Barber Mr. and Mrs. Vincent B. BarrettMs. Ellen W. Baxter & Mr. Robert KavashMr. and Mrs. Christopher R. BechtelDr. and Mrs. Howard W. BenatovichBing's Mr. and Mrs. Paul BonaroMr. and Mrs. Harvey J. BrevermanBu�alo Philharmonic OrchestraBurch�eld-Penney Art CenterMr. and Mrs. Tim BurkeMrs. Mary Ann Byers Mr. Philip CelnikerChemMet LLCMrs. Robert C. CummingsMr. and Mrs. Joel DamianiMr. and Mrs. Frank Dedomenico Mr. and Mrs. David H. DesmonMr. Brian DonaghyMr. and Mrs. Andrew W. Dorn, Jr. Mr. and Mrs. Kenneth DrakeMr. and Mrs. Kevin DriscollMs. Eleanor DruryDr. and Mrs. William L. DuaxMr. John ElieElm Street BakeryMr. and Mrs. Larry F. EnsmingerMr. and Mrs. John C. FarmeloMs. Courtney FasolinoMrs. Helen T. FoleyMs. Patricia P. GalboGates Circle Wine & LiquorMs. Lillian GerstmanMr. and Mrs. Irwin E. GinsbergDr. James E. GlogowskiMr. and Mrs. Peter GlorMr. and Mrs. Peter M GondekMr. and Mrs. Roger Gray

Mr. and Mrs. F. Robert Greene, III Dr. and Mrs. Andrew M. GulickMrs. Halim J. HabibMr. and Mrs. Calvin J. HallerDr. and Mrs. Bruce HauptmanMrs. Dorothy C. HausleMr. and Mrs. John HenrichMr. and Mrs. Sherlock A. Herrick, Jr.Mr. William N. Hudson, Jr.Integrity O�ce SupplyIvanka Trump HandbagsMr. Christopher L. JacobsMs. Alison C. JohanssonMr. and Mrs. Douglas Kirkpatrick Mr. and Mrs. G. David KoepfDr. Joseph KrasnerMr. Charles F. Kreiner, Sr.Mr. and Mrs. Patrick LahrMr. and Mrs. Frederick D. LaubMr. and Mrs. Frank LauricellaMr. and Mrs. Sheldon T. Lenahan Dr. and Mrs. Murray LevineLinda A. & Kenneth R. Kahn Fund at the Community Foundation for Greater Bu�aloMr. and Mrs. Joel LippesDr. Michael MankaMr. and Mrs. Gary MarchioriMr. and Mrs. Charles A. Martin, Jr.Mrs. Sarah G. MetzgerMilitello's LuggageMr. and Mrs. Glen MillerMr. Anthony Miranda Ms. Robyn NixonMr. and Mrs. Sanford M. NobelNYS Center of ExcellenceMr. David Oestreicher Mr. and Mrs. John O'KeefeMr. and Mrs. Erik O'NeillMr. William O'Sullivan Dr. Greta PangbornMr. and Mrs. Kenneth R. PaslaquaMr. and Mrs. Michael PattersonMrs. Gloria PembletonSusan Pfei�erMr. and Mrs. George F. Phillips, Jr.Mrs. Phyllis Wendt PierceMrs. Marjorie M. PlumbMr. and Mrs. Je�rey M. PorcelliDr. Paul H. PotterPraxair Matching Gifts ProgramDr. Theodore C. PrenticeMr. and Mrs. Eric L. ReimannMs. Mary RossMr. John M. RyanMs. Nancy L. SadeghianMr. and Mrs. Scott K. Saperston Mr. and Mrs. Robert SaudaRichard W. Schevitz and Rosemary J. ErvinMr. and Mrs. Tom SchratzMrs. Kenneth F. SeagraveDrs. James Shi�ner and Cathy CarterDr. Douglas SillartMrs. Jacqueline SimonSolomon R. Guggenheim MuseumMr. and Mrs. Edward Steinfeld

continued on page 181716

$100 - $249Steve Madden, Ltd. Mr. and Mrs. Robert W StockmasterMr. and Mrs. Malcolm StrachanMr. and Mrs. Je�ery R. SullivanMs. Mimi SwadosSynergetic Sales, Inc. Dr. Hiroshi TakitaTony WalkerUB BiochemistryMrs. Constance S. UmlandDr. Timothy Umland & Ms. Carleen PopeVerizon FoundationMr. and Mrs. Richard VienneMs. Margit WeinmannMiss Gail S. WeymouthMs. Camille WicherWine Spectator/Cigar A�cionadoMs. Sharon WinerMr. and Mrs. Frederick A. WolfMr. Arthur J. Zi�er

Under $100800 Maple Mr. and Mrs. Morton AbramsonMr. and Mrs. Thomas A. Alberalla Albright-Knox Art GalleryAlethea's ChocolatesMr. and Mrs. Joseph Al�eriMrs. Katherine Allen Anderson's Custard Aquarium of Niagara Ms. Jeanne ArcherMr. and Mrs. Wyatt ArthursMr. John C. Bailey, Esq.Mr. Ted Banfalvi Mr. and Mrs. Irving A. Barrett, Jr.Dr. Ralph T. BehlingMr. Ron Benczkowski Mr. Gary BensleyMr. and Mrs. Tom BericalBetty's Mr. and Mrs. Michael BradleyMs. Rebecca BremillerMs. Joan BrickellMs. Nellie BrownMr. and Mrs. Michael BrunnerBu�alo ChophouseBu�alo Harbor CruisesBu�alo Museum of ScienceBu�alo SabresMiss Maureen ByrneMr. James CampbellMs. Rose CarhartMr. David ChamberlainMs. Patricia Ciccarelli Dr. and Mrs. Harold L. CohenMs. Nancy M. Conley Mrs. Kelly Cultrara Dr. Kelly CyconD'arcy McGee'sMr. and Mrs. Joseph A. DeckDelta SonicMr. and Mrs. Pat DesiderioMiss TinaMarie DeVineMs. Angela DiBiase Ms. Irene DiMaria

James DiPernoMr. and Mrs. Marwin L. Feldman Dr. and Mrs. Ronald FemiaMr. and Mrs. Marvin FrankelMr. and Mrs. Richard L. Freeman Ms. Candace A. Frerk Ms. Michelle Gerace Dr. and Mrs. A. Donald GildenDr. and Mrs. Je�rey GoldbergMelanie GooldyMr. and Mrs. Michael N. Grasso Mr. and Mrs. Richard F. GreenGreen Spa Reverend and Mrs. James D. HakesMary, Elizabeth, & David HandleyMr. and Mrs. Charles E. HarterMr. and Mrs. A. Allan HayesMr. and Mrs. Thomas J. Haykel Mr. Alex Herlovitch Herschell Carrousel Factory MuseumMrs. Sheila M. Hess Mr. and Mrs. Peter HilmeyMs. Sandra Hoehn Mr. and Mrs. James S. Howell Mr. and Mrs. David HughesHurwitz & Fine, P.C. Mr. and Mrs. Hartley Frank HutchinsInitially YoursIrish Classical Theatre Company Mr. and Mrs. William G. IrrMr. and Mrs. Patrick R. JanigaMr. and Mrs. James JohnsonMr. and Mrs. Mark KarlinMr. and Mrs. Roger KarlinskiMs. Heather KellerMr. and Mrs. Steve KempfMs. Anne KentMs. Justine KrasuskiMr. Tony KuberaChris LamannaDr. and Mrs. Harold J. LevyMr. Robert LightfootLombardo Ristorante Loughran'sLucy Desi Center For ComedyMr. and Mrs. Joseph R. LuftMs. Heidi L. MahoneyMr. Stephen ManesMr. and Mrs. William MangusMs. Barbara MarkelDr. and Mrs. Paul V. MarroneMattel Consumer ServicesMr. Ed McKennaMiss Katie McKennaMr. and Mrs. Thomas McMahonMr. Stuart C. MeyerDr. and Mrs. Enrico MihichMr. and Mrs. Robert Lang MillerMrs. Naomi K. MintzerJean MyersMr. and Mrs. David OestreicherPaint On TapDr. Edwin V. PatricolaMrs. Alice PearsonMr. and Mrs. David M. PecynskiPeg's HardwareMr. Daniel Penberthy

Mrs. Carrie PetersonMr. and Mrs. Robert PhillipsMr. and Mrs. Richard M. PirsonMr. and Mrs. Harvey PodolskyMs. Patty PokrackiMr. Paul PowellMr. and Mrs. Louis PozarnyPrima OlivaMr. Raymond ReichertRenaissance Charitable FoundationMrs. Lois F. RenzResearch and DesignMs. Mary Ann Rogers Mr. and Mrs. Brian D. RuskRussell'sDrs. L. Wayne & Kennedy Schultz Mr. and Mrs. Joseph G. ScullyMr. and Mrs. Cisco SenecaMr. Eugene M. SetelDr. and Mrs. Russell N. ShefrinMs. Mary B. SippelMr. Rick SmithMs. Geraldine SonnessoMrs. Nicole SpauldingAngel SwannMr. Christopher SzmaniaTempo The Boris & Renee Jo�ee FoundationThe Bu�alo History MuseumThe Massage Suite & SpaThe Melting PotTheatre of YouthMs. Catherine TojekMr. and Mrs. TomaselloMr. and Mrs. Peter TraboldUnited Way of Bu�alo & Erie CountyMr. and Mrs. Jonathan Vesneske Vogue SalonMs. Kate Wehrmeyer Mr. John WerelyMr. and Mrs. Martin S. WrightMr. Carlos Zuniga

MEMORIALSIn memory ofDrs . A. Aaron, E. Melch & L. Berman Mr. and Mrs. Michael N. GrassoHobson W. Archer, Sr. Ms. Jeanne ArcherDorothy Aubrecht Jane and Richard Gri�nVal Bartowski Ms. Candace A. FrekNan Boneberg Mr. and Mrs. Charles E. HarterWendy H. Bourgeois Mr. and Mrs. Donald BoydBeth Burrows Ms. Sharon WinerBill Castle Mr. and Mrs. Dan CastleMichelle Cress Mr. and Mrs. James JohnsonJim Degen Mrs. Jim DegenDorothy Detlef Ms. Candace A. Frerk

David DiGasparro Dr. Vivian CodyCharles Dowdell Mrs. Charles Dowdell Employees of Northrup GrummanCarol J. Drzymala Miss TinaMarie DeVineAlice Duax Mrs. Marjorie M. PlumbL. Matt Duggan Mrs. Naomi K. MintzerAppleton Fryer Dr. and Mrs. William L. DuaxClara Gondek Mr. and Mrs. Peter M. GondekFinley Greene Mr. and Mrs. F. Robert Greene Charles J. Hahn Dr. and Mrs. William L. DuaxDr. Herbert A. and Edith Hauptman Mr. and Mrs. Marvin Frankel Dr. and Mrs. Bruce Hauptman Mr. Arthur Zi�er Dorothy and Henry Hefner Miss Deanna HefnerMargaret Krenis andMary Louise Herendeen Mr. and Dr. Joel KrenisDonald and Victoria Hess Mr. and Mrs. Christopher R. Bechtel Mrs. Charles Dowdell Dr. Kenneth W. Gross Mr. and Mrs. Robert G. Shaw Employees of Northrup GrummanSusan Hill Dr. and Mrs. Paul SargeantAlla Hillyard Ms. Jeanne Archer Miss Deanna HefnerJoseph Jason Ms. Margit WeinmannSteven Kabak Mrs. Naomi K. MintzerDr. George F. Koepf Mr. and Mrs. Albert J. Wright, IIIDr. George F. and Kathryn Koepf Mr. and Mrs. G. David Koepf Richard Krzyzanowski Ms. Candace A. Frerk

Bob Kulpit Miss TinaMarie DeVineDennis Landesman Mr. and Mrs. G. David KoepfHonorable Sam Maislin Mr. and Mrs. Marvin Frankel Carolyn McClure Mary, Elizabeth, & David HandleyMary Meyer Ms. Sharon Winer Eugenia Miranda Mr. Anthony MirandaRichard Murray Mr. and Mrs. Dan CastleRichard Naylon Ms. Mary B SippelIda Newlin Ms. Gail S. WeymouthLouis Reif Mrs. Robert C. Cummings Mr. and Mrs. Sheldon T. Lenahan Emmett Reilly Mrs. Wayne R. ReillyEmmett and Neil Reilly Mr. and Mrs. Patrick ReillyNeil Reilly Ms. Mary Hurley Mrs. Wayne R. Reilly Wayne R. Reilly Jane and Richard Gri�n Mrs. Dorothy C. Hausle Mr. William O’Sullivan Mrs. Wayne R. Reilly Rosa and Nora Sabetti Ms. Patricia CiccarelliNina Sawrischenski Ms. Jeanne Archer Miss Deanna HefnerBud and Connie Sta�ord Ms. Cynthia W. DoolittleMr. Brian Townson Ms. Sandra Johnston LaubLouis E. Wagner Mrs. Robert C. CummingsDr. Paul L. Weinmann Ms. Margit WeinmannHelen Woodward-Rivas Mr. and Mrs. Walter E. Constantine, Jr.Barbara Ziembiec Mr. and Mrs. Eric L. Reimann

SPECIAL OCCASIONSIn Honor of Dr. Don Donius Ms. Margit WeinmannErnst Both Ms. Sandra HoehnDr. Vivian Cody Mrs. Katherine AllenConstance Constantine Mr. and Mrs. Christopher T. GreeneEmily Constantine Doren Mr. and Mrs. Michael R. Ortman Mr. Robert Tocker Beverly Gilden Dr. and Mrs. A. Donald GildenDr. Jane F. Gri�n Ms. Nancy M. Conley Ms. Lillian Gerstman Mr. and Mrs. Joseph G. Scully Mr. and Mrs. Wayne D. Wisbaum Ralph Halpern Ms. Margit WeinmannCynthia R. Heximer Mr. and Mrs. Don GrennonThe International Year of Crystallography Dr. George N. Phillips, Jr.Dr. Eaton E. Lattman Mr. and Mrs. Irving A. Barrett, Jr. Ms. Eleanor Drury Ms. Cynthia Schwartz Mr. and Mrs. Edward SteinfeldLaura Hopkins and John Farmelo Dr. Eaton E. LattmanMr. Ronald Meer Ms. Barbara Markei Ms. Sharon WinerKaaren Norman Ms. Sharon WinerMadeline Stevens Ms. Sharon WinerThe Heart Donor Mr. and Mrs. Hartley Frank HutchinsWarren Whitford Mr. and Mrs. Michael Brunner

1918

continued from page 17

20

2014 HAUPTMAN-SOCIETY

The sixth annual Hauptman Society gathering took place on April 16, 2015. The Hauptman Society was created in 2008 to honor Corporate or Individual donors who contribute leadership unrestricted gifts of $1,000 or more annually. These gifts support HWI’s mission and the pursuit of life-altering research.

“Hauptman-Woodward is honored to receive these important donations which allow HWI scientists to contribute to cures to the diseases that plague our friends and families,” 2015 Chairman Joe Voelkl said.

“Four hundred years ago, no one could possibly have anticipated the enormous strides that science and

technology were destined to make in the ensuing centuries. Even as recently as one hundred years ago,

who would have predicted the great revolutions in these two areas that the twentieth century held in

store for us? Thus the theories of relativity and quantum mechanics, the nature of the structure of

matter, molecular biology, and our new understanding of life processes changed forever the way we look

at the world around us, and at the same time have irrevocably established the rational mode of inquiry,

the quintessential element of the scientific method, as preferred above all others.”

Herbert A. Hauptman, PhDNobel Prize in Chemistry, 1985