The Genetic Code

The Wobble Hypothesis:Base-Pairing Involving the Third

Base of the Codon is Less Stringent.

Base-Pairing with Inosine at the Wobble Position

In molecular biology, a wobble base pair is a non-Watson-Crick base pairing between two nucleotides in RNA molecules.The four main wobble base pairs are guanine-uracil, inosine-uracil, inosine-adenine, and inosine-cytosine (G-U, I-U, I-A and I-C).

The thermodynamic stability of a wobble base pair is comparable to that of a Watson-Crick base pair. Wobble base pairs are fundamental in RNA secondary structure and are critical for the proper translation of the genetic code.