The four units of the Ca2+ signalling network

Nature Rev. Mol. Cell Biol. 1, 11-21 (2000)

Speed

Amplitude

Spatio-temporal pattern

Spatial aspects of Ca2+ signalling

Nature 395, 645 - 648 (1998)

Nature 395, 645 - 648 (1998)

Basic Mechanisms of Ca2+ Signalling

Elements of the Ca2+ signalling toolkit

Nature Rev. Mol. Cell Biol. 1, 11-21 (2000)

quarks/sparksblips/puffs

[IP3] and lumenal Ca2+ modulate the shape of the bell-shaped curve

Current Biology 1999, 9:R876-R878

The steps leading to activation or inactivation

of IP3 receptors

Current Biology 1999, 9:R876-R878

Ca2+ signalling by conformational coupling using macromolecular complexes

Nature Rev. Mol. Cell Biol. 1, 11-21 (2000)

1s

Application of the Ca2+ signalling toolkit to regulate different cellular processes

Nature Rev. Mol. Cell Biol. 1, 11-21 (2000)

The spatial organization of Ca2+ release from internal stores

Nature Rev. Mol. Cell Biol. 1, 11-21 (2000)

Schematic representation of the mitochondrial Ca2+ transport pathways in energized mitochondria

3-D imaging of mitochondrial and ER structure in living HeLa cells

M

ER

Structural Organization of

the Endoplasmic Reticulum in Neurons

Neuron, 21, 13–26, (1998)

Binary Membrane System of Neural Calcium Signaling

Neuron, 21, 13–26, (1998)

Proposed Role of Ca2+ Signaling in Neuronal Gene Transcription

Neuron, 21, 13–26, (1998)

Compartmentalization of Ca2+ signals in neurons

Nature 395, 645 - 648 (1998)

A Ca2+ nexus — crosstalk between signalling pathways  

L-VDCC IP3R

Nature Rev. Mol. Cell Biol. 1, 11-21 (2000)

Schematic structures and sequences of cameleons

Nature (1997) 388, 882-887

Nature Reviews Neuroscience (2002) 3, 175-190

Nature Reviews Neuroscience (2002) 3, 175-190

Nature Reviews Neuroscience (2002) 3, 175-190

Immobilization and superfusion of CaM kinase II

Science 279, 227-230 (1998)

Properties of immobilized CaM kinase II

Science 279, 227-230 (1998)

Stimulation of CaM kinase II by pulse flow

Science 279, 227-230 (1998)

Modulation of the frequency response of CaM kinase II

Science 279, 227-230 (1998)

Calcium rollercoaster

Science 279, 191-192 (1998)