The Eye in Systemic Disease.doc

7/28/2019 The Eye in Systemic Disease.doc

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The Eye in Systemic

Disease

Prepared By:

Ahmed Khamis Abu Warda

1. Diabetes mellitus

2. Acquired immunodeficiency syndrome (AIDS)

3. Graves disease

4. Sarcoidosis "Acute anterior uveitis"

5. Systemic lupus erythematosus "keratoconjunctivitis sicca and

madarosis, ulcerative keratitis and, rarely, scleritis, retinal vasculitis

or optic neuropathy"


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6. Rheumatoid Arthritis

7. Hypertension

8. Atherosclerosis

9. Sickle cell disease "vascular occlusions, anastomoses and

proliferation, vitreous haemorrhage and retinal detachment"

10.Multiple sclerosis "acute optic neuritis"

11.phosphofructokinase deficiency "cataract"

12.G6PD deficiency "cataract"

13.atopic dermatitis "cataract"

14.Neurofibromatosis-1 "eyelid neurofibromas as well as Lisch's

nodules (little nodules seen on the iris) or an optic nerve neuroma"

15.neurofibromatosis-2 "presenile cataracts; some additionally develop

ophthalmoplegia and intraocular hamartomas."

16.congenital rubella "cataract"

17.Lowe's syndrome "cataract"

18.Refsum's disease "cataract"

19.Hypoparathyroidism "cataract"

20.Behet's syndrome "Uveitis"

21.Reiter's syndrome "conjunctivitis and acute anterior uveitis "

22.Tuberculosis " grumbling uveitis or choroiditis"

23.Candidiasis "Uveitis"

24.herpes zoster "Uveitis"

25.syphilis "Uveitis , madarosis and keratitis"

26.toxoplasmosis "Uveitis"

27.toxocariasis "Uveitis"

28.pneumocystosis "Uveitis"

29.hyperlipidaemia "Central Retinal Vein Occlusion"

30.hyperviscosity states "Central Retinal Vein Occlusion,

haemorrhages, cotton wool spots "

31.thrombophilia "Central Retinal Vein Occlusion"


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32.vasculitis "Central Retinal Vein Occlusion"

33.factor V Leiden "Central Retinal Vein Occlusion"

34.myeloma "Central Retinal Vein Occlusion"

35.antiphospholipid syndrome "Central Retinal Vein Occlusion"

36.giant cell arteritis "Central Retinal Artery Occlusion"

37.polyarteritis nodosum "Central Retinal Artery Occlusion, peripheral

ulcerative keratitis and scleritis "

38.Wegener's granulomatosis "Central Retinal Artery Occlusion,

nasolacrimal duct obstruction and dacrocystitis but these patients

may also develop scleritis, peripheral ulcerative keratitis "

39.Kawasaki's disease "Central Retinal Artery Occlusion"

40.Pancreatitis "Central Retinal Artery Occlusion"

41.protein S, protein C or antithrombin deficiency "Central Retinal

Artery Occlusion"

42.leukaemia "Central Retinal Artery Occlusion, pigment changes in

the retina ('leopard spots') and spontaneous haemorrhage"

43.lymphoma "Central Retinal Artery Occlusion"

44.Horner's syndrome "ptosis, miosis and lack of sweating on that sideof the face"

45.Carotid Stenosis

46.Sjgren's syndrome"episcleritis or scleritis, keratoconjunctivitis

sicca , Adie's pupil."

47.Thyrotoxicosis

48.Migraine

49.Kaposi's sarcoma

50.Cytomegalovirus

51.Cat-scratch disease

52.Chlamydial infection

53.Leprosy "madarosis (loss of hair) and lagophthalmos"

54.Lyme disease "photophobia, pain, conjunctivitis and peri-ocular

oedema"


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55.ankylosing spondylitis "Acute anterior uveitis"

56.Crohn's disease "Acute anterior uveitis"

57.ulcerative colitis "Acute anterior uveitis"

58.juvenile idiopathic arthritis "Acute anterior uveitis"

59.Cicatricial pemphigoid "cicatrising conjunctivitis, dry eye"

60.Myasthenia gravis "fluctuating, asymmetric external

ophthalmoplegia with ptosis and weak eye closure"

61.Anaemia "haemorrhage, cotton wool spots, subconjunctival

haemorrhage and, if vitamin B12 is low, optic neuropathy may

occur"

62.Albinism "the lack of pigmentation to the eye"

63.Ehlers-Danlos syndrome "susceptible to trauma, blue sclerae and a

microcornea"

64.Marfan's syndrome "ectopia lentis, myopia, retinal detachment and

anomalies with the iridocorneal angle and pupil function"

65.Myotonic dystrophy "early cataracts and ptosis"

66.Tuberous sclerosis "retinal astrocytomas occur in 50% of these

patients"

67.Acromegaly "bitemporal hemianopia and optic atrophy, nystagmus"

68.Cushing's syndrome "Glucoma"

69.Homocystinuria "ectopia lentis and may also be prone to high

myopia and retinal detachment"

70.Dermatomyositis "purple coloration and oedema of the eyelids with

oedema of the conjunctiva"

71.Kearns-Sayre syndrome "symmetrical ptosis and externalophthalmoplegia as well as pigmentary retinopathy"

72.Idiopathic intracranial hypertension "frequent transient visual

obscurations (up to 30 a day) diplopia, visual field defects and disc

swelling which is usually bilateral"

73.Psoriatic arthritis "uveitis, conjunctivitis, keratitis or

keratoconjunctivitis sicca"

74.Rosacea "chronic blepharitis and recurrent meibomian cysts, also

severe conjunctivitis and keratitis"


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75.Steele-Richardson-Olszewski syndrome "progressive

ophthalmoplegia associated with progressive dementia"

76.Stevens-Johnson syndrome "transient membranous conjunctivitis,

anterior uveitis, superficial punctate keratopathy"

77.Systemic Sclerosis "eyelid tightening and telangiectasia ,

keratoconjunctivitis sicca"

78.Vogt-Koyanagi-Harada syndrome (VKH) "anterior uveitis"

79.von Hippel-Lindau syndrome "capillary haemangiomas of the retina

or the optic nerve head"

80.Wilson's disease "Kayser-Fleischer ring that is a copper-coloured

ring at the periphery of the cornea"

81.Metabolic syndrome

82.Yunis-Varon syndrome "Sparse eyebrows , Sparse eyelashes"

83.hay fever "conjunctival swelling and erythema, eyelid swelling,

lower eyelid venous stasis"

84.Asthma "

85.Epidermolysis bullosa

86.Gorlin-Goltz syndrome

87.LouisBar syndrome "Ocular apraxia, Telangiectasias of the eyes"

88.WyburnMason syndrome

89.Scleroderma

90.Rubella "conjunctivitis, Cataract"

91.Infectious mononucleosis "Photophobia"

92.Gonorrhea "Neonatal conjunctivitis"

93.Candidiasis

94.Patau's syndrome

95.Edwards' syndrome

96.Down's syndrome "Cataract"

97.Osler-Weber-Rendu disease

98.Addisons disease

99.Hyperthyroidis


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100. Hypothyroidism

101. Whipple's disease

102. Amyloidosis

103. Fabry disease "Cataract"

104. Gaucher's disease

105. NiemannPick disease "supranuclear gaze palsy"

106. Alport's Syndrome

107. Weil's syndrome "Red Eye"

108. Besnier-Boeck-Schaumann disease" Vision difficulty, Scleral

nodules , Chorioretinitis"

109. Rieger Syndrome

110. Molluscum Contagiosum

111. Hypercholesterolaemia "Xanthelasmas"

112. Basal Cell Carcinoma

113. Squamous Cell Carcinoma

114. Galactosaemia "Cataract"

115. Hypocalcemia "Cataract"

116. Relapsing polychondritis

117. Cri-du chat syndrome

118. Schmid-Fraccaro syndrome

119. Turner's syndrome

120. Ring-D chromosome

121. Monosomy-G syndrome

122. Pre-eclampsia

123. Thromboangiitis obliterans

124. Hyperparathyroidism

125. Hypoparathyroidism

126. Vitamin A deficiency

127. Vitamin B deficiency


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128. Vitamin C deficiency

129. Hemochromatosis

130. Albright's disease

131. Apert's disease

132. Conradi's syndrome

133. Craniofacial syndromes

134. Osteogenesis imperfecta

135. Pneumonias

136. acute and chronic pyelonephritis

137. Nephrotic syndrome

138. Wilms' tumor

139. Cystinosis

140. Endocarditis

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The Eye in Systemic Disease.doc