THE EVOLUTION OF GENETIC MATERIAL ON THE Y CHROMOSOME

AND ITS ROLE IN GENDER DETERMINATION

 

Sam Taylor and Lauren RussellBiology 101HDr. Jean DeSaixDr. Moriah BeckApril 15, 2009 

http://www.youtube.com/watch?v=nlOAnL9xI74

SEX DETERMINATION

Women are XX Men are XY Primary vs. Secondary sex characteristics

EVOLUTION OF Y CHROMOSOME

EVOLUTION OF Y AND SRY

SRY AND SOX’S(SOX9 AND SOX3)

SRY ENABLES SOX9 EXPRESSION

http://www.youtube.com/watch?v=5yia5MmDXFw

XX MALE SEX REVERSAL SYNDROME

Human genetic disorder characterized by male physical characteristics and XX chromosomal karyotype

In case study, tested to determine why self-identified male is infertile and has undescended testicles

Gel electrophoresis compared subject’s DNA with normal male and normal female DNA

SRS PATIENT NORMAL MALE

XX SEX REVERSAL SYNDROME CASE STUDY CONCLUSION

• This subject’s SRS syndromes caused by translocation of father’s SRY gene from Y to X chromosome during meiosis

• Confirmed SRY is required for physical male characteristics to be expressed

• Strengthened hypothesis that SRY silences SOX3 and enhances SOX9 on male X chromosomes

BIBLIOGRAPHY Delbridge, M. L. & Marshall Graves, J. A. (1999).

Mammalian Y Chromosome Evolution and the male-specific functions of Y chromosome-borne genes. Journals of Reproduction and Fertility, 4(2), 101-109.

 

Waters, P. D., Wallis, M. C., & Marshall Graves, J. A. (2007).

Mammalian sex-Origin and evolution of the Y Chromosome and SRY. Seminars in Cell & Developmental Biology, 18(3), 389-400.

 

Schartl, M. (2004). Sex Chromosome evolution in non-mammalian vertebrates.

Current Opinion in Genetics and Development, 14(6), 634-641.

 

Wang, T., Liu, J. H., Yang, J., Chen, J. & Ye, Z. Q.(2009).

XX Male Sex Reversal Syndrome: A Case Report and Review of the Genetic Basis.

First International Journal of Andrology: Andrologia, 41(1), 59-62.

 

Campbell, Neil A. and Reece, Jane B. (2008). Biology (Eighth Edition). New York, NY: Pearson Benjamin Cummings. Pearson Education.

 

secondary sex character. (2009). In Encyclopædia Britannica. Retrieved March 23, 2009,

from Encyclopædia Britannica Online: http://www.britannica.com/EBchecked/topic/531812/secondary-sex-character