2

The Essential Addition to Your Practice TodayWaterLase is the all-tissue laser trusted by the most dentists worldwide, with over 27,300,0001 patients treated. Its unrivaled clinical versatility – with the ability to treat hard-tissue, soft-tissue and bone – gives you unmatched results in treatment outcomes and outstanding ROI making it the essential addition for your successful practice today.

What WaterLase Can Do for Your Patients and Your PracticeWaterLase is a commitment to better care and a foundation for practice growth. WaterLase uses patented technology to provide a minimally invasive, highly precise, and an exceptionally gentle dental experience for your patients.

3

“The WaterLase iPlus has revoluntized my practice. Being able to cut bone and soft tissue with minimal trauma and none of the vibration and noise of a normal drill is unbelievable and extremely beneficial for any patient especially those with dental phobias of any sort. The addition of the laser to my treatment of gum disease has also expanded the treatment possibilities to include all the most advanced treatment methodologies which I was unable to perform before the Waterlase iPlus. I’m finding more and more uses for the WaterLase and I am using it more and more each day.”

– Dr. Howard Gluckman Cape Town, South Africa

Our Unwavering CommitmentHere at BIOLASE, our purpose is to better enable you to repair and restore your patient’s dental conditions while reducing the pain, fear and anxiety generally associated with dentistry through the use of our optimal laser technologies.

We are committed to elevating the standard of care in dentistry, while enabling you to achieve better business returns.

How will you spend your

pay raise?

of WaterLase patients recommend it to their friends and family.297%

4

Unlock Your Potential for Increased Cash Flow. Increasing the cash flow in your practice is as easy as performing just three types of procedures a month with the WaterLase iPlus, the world’s most preferred all-tissue laser.

�� Simplify the dentistry in your practice

�� Minimize chair time

�� Increase case acceptance with a patient-preferred, minimally invasive treatment option

Open a new world of clinical capabilities with the most intuitive and most versatile all-tissue laser on the market. Discover your potential for increased cash flow and enjoy the benefits that the WaterLase iPlus will bring to your practice.

PRODUCTION INCREASE MONTHLY PATIENT REFERRALS

Excerpt from A BIOLASE WaterLase Case Study: Dr. Patrick R. Ruehle, DDS, PA. Download the full case study at go.biolase.com/ROI.

“After we added the WaterLase iPlus, production went up 43% in the first six months and has never stopped growing. We now consistently do more in a day than the practice was doing in a month.”

— Dr. Patrick Ruehle, Denton, TX

5

Increasing your cash flow is easy with

Case #1 – courtesy of Dr. Bret Dyer

BEFORE 6 MONTHS POST-OP

6

P E R I O D O N T I T I S P R O T O C O L

Effectively manage your periodontal and peri-implantitis patients with the REPAIR protocols and WaterLase iPlus!REPAIR PERIO™ and REPAIR IMPLANT™ were developed to provide clinicians a scientifically advanced treatment options to assist in the management of periodontitis and peri-implantitis patients. Utilizing the WaterLase iPlus and patented Radial Firing Perio Tip™, REPAIR provides a safe, effective laser treatment protocol that patients accept.

REPAIR PERIO Benefits:�� Patient-preferred, minimally invasive, periodontal laser protocol

�� Treat site specific or full mouth cases for greater flexibility in treatment planning

�� Capable of gentle removal of subgingival calculus

�� Supported by clinical evidence and scientific research

�� Promotes cementum-mediated periodontal ligament new-attachment to the root surface in the absence of long junctional epithelium

“REPAIR is the effective protocol for managing periodontitis for it reverses the inflammatory process. The natural partner for REPAIR is the iPlus due to its ability to create a positive healing environment for soft- and hard-tissue including bone and tooth surface.”

— Dr. Samuel Low, Gainesville, FL

REPAIR IMPLANT Benefits:�� Patient-preferred, minimally invasive, peri-implantitis laser protocol

�� Easy access to implant surface

�� Closed flap protocol can be used to manage early peri-implantitis

�� Treat site-specific or full-mouth therapy for flexibility in treatment planning

�� Supported by clinical evidence and scientific research

�� Laser photoacoustic properties effectively debride the implant surface3

Case #2 – courtesy of Dr. Rana Al-Falaki

BEFORE

20 MONTHS POST-OP

“The WaterLase iPlus is an integral part of every procedure I do. The results we achieve are outstanding, with so much less stress, so much more fun and so much more comfort for patients.”

— Dr. Rana Al-Falaki, London, UK

7

P E R I - I M P L A N T I T I S P R O T O C O L

Unrivaled Clinical Versatility WaterLase iPlus has over 80 different indications for soft-tissue, hard-tissue and bone — more than any other laser. As your clinical skills grow, the number and type of procedures you perform grows with you.

�� Give your patients the best possible dental experience

�� Be one of the first to offer your patients single-visit, multiple-quadrant, minimally invasive dentistry

�� Add incremental procedures to your practice to retain patients and attract new ones

�� Reduce or eliminate tooth sensitivity

INTRA-OP INTRA-OP

Root Canal Therapy Pulpotomy

PRE-OP POST-OP

Gum De-pigmentation

PRE-OP IMMEDIATE POST-OP

Implant Recovery

PRE-OP IMMEDIATE POST-OP

Subgingival Class V Cavity Preparation

PRE-OP IMMEDIATE POST-OPINTRA-OP

Posterior Osseous Crown Lengthening

PRE-OP IMMEDIATE POST-OP

Gingival Recountouring

PRE-OP IMMEDIATE POST-OP

Frenectomy

Biopsy

PRE-OP POST-OP

PRE-OP IMMEDIATE POST-OP

Class I Cavity Preparation Troughing

For a complete library of WaterLase iPlus clinical videos, visit biolase.com

8

“WaterLase may be the missing link that enables us to kill bacteria deep within the dentinal tubules. In our practice, we no longer aim to “entomb” bacteria but rather to eliminate bacteria.”

— Dr. Justin Kolnick, White Plains, NY

Simple, efficient and effective root canal therapy. Minimally invasive technique conserves remaining tooth structures for increased stability in restorations.

�� 99.7% Reduction in bacterial counts in the root canal approaches sterilization4

�� Bacteria CFUs 2.86x lower than the most effective NaOCl solution5

�� Reduces risk of reinfection6

�� Effective on most resistant bacteria – e.faecalis4

�� Only 2-3 minutes for disinfection vs. 20-30 minutes with NaOCl5

Innovative Endodontics

Canal wall after instrumentation – only dentinal tubules covered and blocked by smear layer

Canal wall after EndoLase RFT with clean, open tubules

1µm

9

Intuitive Graphic User InterfaceWaterLase iPlus has more clearances and indications than any other dental laser. As your clinical skills grow, the number and type of procedures you will perform grows with you.

�� Increase productivity and add incremental revenue with 56 pre-set procedures for select and go treatment

�� Expand your practice capabilities with the NEW REPAIR Perio and REPAIR Implant Apps to assist in the managment of periodontitis and peri-implantitis

�� Take control of tissue with adjustable settings as needed

Class I, II, III, IV, V Pocket Therapy Open or Closed Flap, Osseous Crown Lengthening Open/Closed

Gingival Recontouring, Frenectomy, Biopsy

Implant Recovery

Root Canal Therapy, Pulpotomy, Apicoectomy

Troughing,Laser Bandage

REPAIR Implant Protocol

REPAIR Perio Protocol

10

Version 2.0

11

Flexibility You DeserveThe WaterLase iPlus has the lightest, most flexible trunk fiber ever. Titanium fiber cable and an extremely small diameter give the WaterLase iPlus handpiece virtually zero resistance in your hand to help eliminate fatigue so you can easily access any treatment site. Words don’t really describe it — you have to try for yourself.

�� Redesigned optics efficiently deliver precise laser energy to cut enamel, dentin, and bone for increased precision and less destruction

�� Optimized to provide more uptime with a replaceable, disposable shield for better dependability

�� Decrease your treatment fatigue with the most flexible, tension free delivery system available

�� Improved clinical access and comfort with the SureFireTM exclusive contra-angle handpiece, navigate subgingivally with ease

Access You NeedThe WaterLase iPlus features the only illuminated contra-angle handpiece on any dental laser. BIOLASE’s patented contra-angle design allows you to easily and precisely move the laser tip around the treatment site, giving you access to those difficult to reach posterior cases, while the illumination of the handpiece provides the visibility you need.

The iPlus handpiece is also the smallest handpiece, an important consideration for pediatric patients and working in the back of the mouth.

The WaterLase contra-angle handpiece is the sleekest and most ergonomic of any dental laser.

The WaterLase contra-angle The WaterLase contra-angle handpiece is the sleekest handpiece is the sleekest and most ergonomic of any and most ergonomic of any dental laser.

“The use of the WaterLase iPlus in combination with diode 940 nm, in my daily clinical practice, has allowed me to optimize cosmetic designs, performing surgeries and minimally invasive procedures, with precise cuts without

bleeding, rarely needing anesthesia and very fast tissue recovery with great comfort for patients and for our team.

The handling of hard-tissues, enamel, dentin and bone, is greatly facilitated by the laser energy of the iPlus, providing versatility to our work; in the same intervention I can work hard- and soft-tissues allowing superior cosmetic finish with high comfort for our patients.”

— Dr. Pilar Martin Santa Cruz de Tenerife, Spain

12

World-Class TrainingBIOLASE is a World Leader in Laser Education and TrainingWith more than 14,000 global members, it is the largest dental and medical laser education organization in the world. WCLI symposiums are held frequently around the world.

Choose from a wide range of learning tools and educational solutions to meet your learning style. To ensure that you feel comfortable and confident with this exciting technology, we encourage you take advantage of some of the following educational solutions we have to offer:

�� Group or in-office certification training

�� Advanced laser training courses

�� On-demand online training

�� Full schedule of live and online CE events

�� Comprehensive library of published clinical articles and videos from laser researchers and experts worldwide

Certified Training Courses (CTC)Combining lecture and hands-on exercises, CTC teaches you essential soft-tissue, hard-tissue, perio (including REPAIR) and endo procedures that you can immediately provide your patients with new or enhanced treatment techniques that will improve their experiences in your practice. As you hone your skills, move on to Advanced Training Courses or even Master Level courses offered frequently in locations worldwide by WCLI or other laser organizations with associations with WCLI.

Advanced Training Courses (ATC)Develop your clinical skills with in-depth training on a particular technique or treatment. Advanced training courses offered for pediatrics and periodontics.

International Educational Partners

13

14

Clinical IndicationsSoft-Tissue (Including Pulpal Tissue)*

Incision, excision, vaporization, ablation and coagulation of oral soft-tissues, including:�� Excisional and incisional biopsies

�� Exposure of unerupted teeth

�� Fibroma removal

�� Flap preparation – incision of soft-tissue to prepare a flap and expose the bone

�� Flap preparation – incision of soft-tissue to prepare a flap and expose unerupted teeth (hard- and soft-tissue impactions)

�� Frenectomy and frenotomy

�� Gingival troughing for crown impressions

�� Gingivectomy

�� Gingivoplasty

�� Gingival incision and excision

�� Hemostasis

�� Implant recovery

�� Incision and drainage of abscesses

�� Laser soft-tissue curettage of the post-extraction tooth sockets and the periapical area during apical surgery

�� Leukoplakia

�� Operculectomy

�� Oral papillectomies

�� Pulpotomy

�� Pulp extirpation

�� Pulpotomy as an adjunct to root canal therapy

�� Root canal debridement and cleaning

�� Reduction of gingival hypertrophy

�� Soft-tissue crown lengthening

�� Treatment of canker sores, herpetic and aphthous ulcers of the oral mucosa

�� Vestibuloplasty

Hard-TissueGeneral Indications*�� Class I, II, III, IV and V cavity preparation

�� Caries removal

�� Hard-tissue surface roughening or etching

�� Enameloplasty, excavation of pits and fissures for placement of sealants

Laser Periodontal Procedures�� REPAIR Protocol: WaterLase

Er,Cr:YSGG assisted new attachment procedure (cementum-mediated periodontal ligament new attachment to the root surface in the absence of long junctional epithelium)

�� Removal of subgingival calculi in periodontal pockets with periodontitis by closed or open curettage

�� Removal of highly inflamed edematous tissue affected by bacteria penetration of the pocket lining and junctional epithelium

�� Full thickness flap

�� Partial thickness flap

�� Split thickness flap

�� Laser soft-tissue curettage

�� Laser removal of diseased, infected, inflamed and necrosed soft-tissue within the periodontal pocket

�� Removal of granulation tissue from bony defects

�� Sulcular debridement (removal of diseased, infected, inflamed or necrosed soft-tissue in the periodontal pocket to improve clinical indices including gingival index, gingival bleeding index, probe depth, attachment loss and tooth mobility)

�� Osteoplasty and osseous recontouring (removal of bone to correct osseous defects and create physiologic osseous contours)

�� Ostectomy (resection of bone to restore bony architecture, resection of bone for grafting, etc.)

�� Osseous crown lengthening

Endodontic Surgery (Amputation)�� Flap preparation – incision of soft-tissue

to prepare a flap and expose the bone

�� Cutting bone to prepare a window access to the apex (apices) of the root(s)

�� Apicoectomy – amputation of the root end

�� Root end preparation for retrofill amalgam or composite

�� Removal of pathological tissues (i.e. cysts, neoplasm or abscess) and hyperplastic tissues (i.e., granulation tissue) from around the apex

Root Canal Hard-Tissue�� Tooth preparation to obtain access to

root canal

�� Root canal preparation including enlargement

�� Root canal debridement and cleaning

�� Laser root canal disinfection after endodontic instrumentation

Bone/Surgical�� Cutting, shaving, contouring and

resection of oral osseous tissues (bone)

�� Osteotomy

*For use on adult and pediatric patients. IMPORTANT: Review all Contraindications, Warnings and Precautions presented in the User Manual before proceeding with using a laser device on patients. NOTE: Any tissue growth (i.e., cyst, neoplasm or other lesions) must be submitted to a qualified laboratoryfor histopathological evaluation.

15

Technical SpecificationsDimensionsUnit (W x L x H): 11.0 x 18.9 x 35.5 in (27.9 x 48.0 x 85.1 cm)With Fiber (W x L x H): 11.0 x 18.9 x 53.3 in (27.9 x 48.0 x 135.4 cm)Weight: 75 lb (34 kg)

ElectricalClass I Medical Electrical (ME) EquipmentOperating voltage: 100 VAC ± 10% / 230 VAC ± 10%Frequency: 50 / 60 HzCurrent rating: 5.0 A / 8 AMain control: Circuit breakerOn / Off control: KeyswitchRemote interruption: Remote interlock connnector

Water SprayWater type: Distilled, De-ionized, or SterileExternal air source: 80 – 120 psi. (5.5 - 8.2 bar)Water: 0 – 100%Air: 0 – 100%Interaction zone: 0.5 – 5.0 mm from handpiece tip to target

OpticalLaser classification: IV (4)Medium: Er,Cr:YSGG (Erbium, Chromium: Yttrium,

Scandium, Gallium, Garnet)Wavelength: 2.78 µm (2780 nm)Frequency: 5 – 100 HzAverage power: 0.1 – 10.0 WPower accuracy: ± 20%Pulse energy: 0 – 600 mJPulse duration “H” mode: 60 µsPulse duration “S” mode: 700 µsHandpiece head angles: 70° contra-angleGold HP Tip diameter range: 200 – 1200 µmTurbo Tip focal diameter range: 500 – 1100 µmOutput divergence: ≥ 8° per sideMode: MultimodeAiming beam: 635 nm (red) laser, 1 mW max (safety classification 1)Water level sensor beam: 635 nm laser, 1 mW max (safety classification 1)Nominal Ocular Hazard Distance (NOHD): 5 cmMaximum Permissible Exposure (MPE): 3.5 x 105 W/m2

635 nm (red) laser, 1 mW max (safety classification 1)

Find your local distributor at biolase.com

1 BIOLASE analysis based on global WaterLase systems and average patients treated with per clinician2 BIOLASE Brand Development Research; Final Report Rev. Aug. 20053 Kusek, Edward R. “Immediate implant placement into infected sites: bacterial studies of the Hydroacoustic effects of the YSGG laser.” Journal

of Oral Implantology 37.sp1 (2011): 205-211.4 The antimicrobial efficacy of the erbium, chromium:yttrium-scandium-gallium-garnet laser with radial emitting tips on root canal dentin

walls infected with Enterococcus faecalis: Wanda Gordon, DMD, Vahid A. Atabakhsh, DDS, Fernando Meza, DMD, Aaron Doms, DDS, Roni Nissan, DMD, Ioana Rizoiu, MS and Roy H. Stevens, DDS, MS JADA 2007; 138(7): 992-1002.

5 The impact of an erbium, chromium: yttrium-scandium-gallium-garnet laser with radial-firing tips on endodontic treatment: U. Schoop, A. Barylyak, K. Goharkhay, F. Beer, J. Wernisch, A. Georgopoulos,W. Sperr, A. Moritz Lasers in Medical Science; DOI 10.1007/s10103-007-0520-4.

6 The use of the erbium, chromium:yttrium-scandium-gallium-garnet laser in endodontic treatment. The results of an in vitro study: Ulrich Schoop, DDS, MD, Kawe Goharkhay, DMD, MD, Johannes Klimscha, DMD, MD, Manuela Zagler, DMD, Johann Wernisch, TD, PhD, Apostolos Georgopoulos, MD, PhD, Wolfgang Sperr, DDS, MD, PhD and Andreas Moritz, DMD, MD, PhD JADA 2007;138(7): 949-955.

©2016 BIOLASE, Inc. All rights reserved. MCD#305-02-007-D

4 Cromwell Irvine, CA 92618 USA +1 949.361.1200

BIOLASE Europe GmbH Paintweg 10A, 92685 Floss, Germany +0049 9603 8080

BIOLASE Technology India Pvt. Ltd.404, Agarwal Golden ChambersFun Republic Road, Off New Link RoadAndheri (W), Mumbai – 400 053+91 22 6195 3400

biolase.com

PlatinumPN7200854-09

Racing Red PN7200854-02

Gloss Black PN7200854-03

Pearl White PN7200854-01

Midnight Blue PN7200854-04

Bright Lime PN7200854-05

Burnt Orange PN7200854-07

PinkPN7200854-08

Aquarium PN7200854-13

Fish PN7200854-15

Jungle PN7200854-14

Zebra PN7200854-16

Yellow PN7200854-12

Purple PN7200854-11

“For the past 13 years the WaterLase has drastically changed my surgical procedures and protocols. It has helped me to set-up new paradigms in implantology, periodontology and oral surgery treatment. WaterLase has opened a new window to regenerative techniques, avoiding the use of some unpredictable biomaterials. I cannot imagine daily surgeries without the help of my WaterLase.”

— Dr. Gilles Chaumanet Villeneuve Loubet, France