The entwined factors

Syndrome XSyndrome X

• hypertension

• diabetes

• heart disease

• “trunkal” obesity

• cancers of all types

Gene that lends predisposition to

Syndrome XSyndrome X

Syndrome XStudies over the last 30 years have

shown those with this family of diseases have too much insulin in

their blood.

hypertensiondiabetesheart disease“trunkal” obesitycancers

Syndrome X

“Insulin Resistance”

What’s the problem with toomuch insulin?

Insulin Resistance“hyperinsulinism”

• causes disturbances of cholesterol and triglyceride levels

VLDL increases

Triglycerides increase

HDL decreases

VLDL IDL LDL

Insulin Resistance“hyperinsulinism”

• causes damage to cell insulin receptors• causes damage to heart• affects “sodium pumps” in cell membranes• affects calcium transport into cells, forcing excess calcium into cells

Too much sodium and calcium in cells results in cell “cramping”.This vasospasm causes hypertension.

Insulin ResistanceHow Does It Work?

Cell

Receptors

Insulin

Glucose

Normal Cell

Insulin ResistanceHow Does It Work?

Cell

Receptors

Insulin

Glucose

Insulin Resistant

More Likely to Have...

• Obesity (10% or more above optimal) one out of three in U.S. at least 30 lbs. over

• Type II diabetes (5-10% of U.S. population)

• High blood pressure--one out of five

Syndrome X

It gets worse...By age 70,

• One out of four is diabetic (25%)

• One out of two is obese (50%)

• One out of two has high blood pressure

Beginning at age 20, there is an increasing insulin resistancewith each passing decade

A Flawed Rationale

Too much sodium in cells

Prescribe diuretics to reduce sodium

•Increase risk of coronary heart disease

•Increase risk of stroke

•Increase blood fat formation

•Aggravate insulin resistance

Along with beta blockers, diuretics

Dr. Norman Kaplan questions the morality of increased use of these drugs

A Typical Scenario

• Large amounts of sugar or fats

• Eight to ten hours of elevated insulin levels

• 4.5 to 6.5 lb. weight gain, due to sodium reabsorption & fluid retention

Hyperinsulinism’s Effecton the Nerves

•Causes release of norepinephrine and other stress hormones

•Speeds up pulse rate and increases blood pressure in response to “fight or flight” system activation

Hyperinsulinism and Cancer

• Insulin is a factor contributing to rapid body growth of children

• Women who have increased insulin in blood have significantly greater risk of breast cancer, regardless of body weight or fat distribution

• Pancreatic cancer is associated with insulin resistance

So, now what?

• Test for hyperinsulinism

• Blood sugar will be “normal”, insulin level will be elevated

• Cholesterol high• LDL high, HDL low• Triglycerides high

• Begin treating even without tests

• Treatment routine is the same as prevention

• Do not wait for debilitating and expensive damage to occur

Syndrome XTREATMENT ROUTINE

• Drink more water!

• Lose weight

• Total vegetarian diet

• Do not overeat

• Exercise, exercise, exercise!

Syndrome XTREATMENT ROUTINE

• Avoid refined carbohydrates & sugars• Two meals a day (nothing between)• Short-term fasting

1 or 2 days a week (not consecutively)• Stop smoking• Avoid cholesterol lowering drugs

try tocotrienols instead