THE EFFECTS OF 11-CIS VACCENYL ACETATE ON DROSOPHILA MELANOGASTER

By Jonathan Tam

Insect-Related Diseases

Fleas, Lice, Mosquitoes and Ticks – most responsible for infectious diseases in the United States

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Insect-Related Diseases – Malaria Malaria

Transmitted by Mosquitoes 5th Cause of the Most Deaths in the World

1.3 Million Killed in 2002

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Pheromones

Any chemical messengers that affect behavior or development of other individuals of the same species

http://upload.wikimedia.org/wikipedia/commons/8/8a/Bug_aggregation.jpg

http://upload.wikimedia.org/wikipedia/en/7/70/Nasinov_9024.JPG

Main Types of Insect Pheromones Alarm Pheromones Trail Pheromones Queen Mandibular Pheromones – (specifically in honey

bees) Sex Pheromones

http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/P/Pheromones.html#Queen_mandibular_pheromone

Pheromones in D. melanogaster 11 – Cis Vaccenyl Acetate

Only Known Pheromone in Drosophila Secreted from the Males through Ejaculation Induce Aggregation Behavior in Drosophila Known to have an Inducing Affect on Both

Males and Females

http://www.caymanchem.com/app/template/Product.vm/catalog/10010101/a/z%3Bjsessionid=4E81A18AAEBDA761F5F0F24C8343988D

Pheromone Baiting

Agricultural Technique to Lure Insects Away from Livestock and Growing Plants

Began With Moths (Indianmeal Moth) Discovery of 11 – cis vaccenyl acetate

effect on Drosophila

http://www.meojbiz.com/home/appstorage/product/0000000055/Pheromone%20trap.jpg

Sex Pheromones For Baiting

F.C. Su and M.Y. Lin Types of Traps

Delta Traps, Winged Trap or a Funnel Trap Usage of Sex Pheromones

http://www.avrdc.org/pdf/efsbtrap.pdf

Mutation and Receptionhttp://vosshall.rockefeller.edu/reprints/VosshallStensmyrNeuron05.pdf

Literature Review 1

Pingxi Xu, 2005 Reinitiate Effect of 11

– Cis Vaccenyl Acetate on Drosophila by adding Protein to Food Cultures

Insensitivity to 11 – Cis Vaccenyl Acetate

Inactivity of trichoid neurons in Drosophila

Literature Review 2

Ha and Smith, 2006 Locate the Sensilla in

the Antennae missing for 11 – Cis Vaccenyl Acetate detection

Receptors – T1Sensilla, T1 neurons responsible for sensitivity

Literature Review 3

Kruse, Zhao, Smith and Jones, 2003 Found Alcohol attraction

in Lush Flies due to Protein Binding to Alcohol

Hydroxyl group of alcohol forms hydrogen bonds to the amino acids of the Lush Protein

Bibliography

Ha, Tal Soo and Smith, Dean P. “A Pheromone Receptor Mediates 11-cis-Vaccenyl acetate-induced Responses in Drosophila. 23 August 2006. Department of Pharmacology and Center for Basic Neurosciences, University of Texas Southwestern Medical Center. 3 May 2009

"Pheromones - Types." Medindia - Medical/Health Website. 17 May 2009.

"Pheromones." RCN New York City. 17 May 2009.

ScienceDaily. "Unique Pheromone Detection System Uncovered." Science Daily. 27 June 2008. UT Southwestern Medical Center. 3 May 2009.

ScienceDaily. "One Missing Gene Leads to Fruitless Mating Rituals." Science Daily. 25 July 2008. Duke University Center. 3 May 2009.

Seybold, Steven J and Donaldson, Susan. “Pheromones in Insect Pest Management.” University of Nevada Cooperative Extension. 1995. University of Nevada 3 May 2009

Xu, Pingxi. "A Drosophila OBP Required for Pheromone Signaling." Science. 4 November 2005.Eppendorf Essays on Science and Society. 3 May 2009

Voght, RG. “Molecular Basis of Pheromone Detection in Insects.” Comprehensive Insect Physiology, Biology, Pharmacology and Molecular Biology, Volume 3, Endocrinology. 2005. Elsevier. 3 May 2009

Wagner, C Michael, Jones, Michael L, Twohey, Michael B and Sorensen, Peter W. “A field test verifies

that pheromones can be useful for sea lamprey control in the Great Lakes.” Rapid Communications. 14 January 2006. Department of Fisheries and Wildlife. 3 May 2009

"Wake Up and Smell The Pheromones." The Rockefeller University - Laboratory of Neurogenetics and Behavior. 20 Jan. 2005. 17 May 2009.