The effect of angular extent on reconstructed image quality in

tomosynthesisA tissue sample example

Tissue Imaging Example• Lumpectomy, embedded in agar

– 47F, node negative– 3.5 cm dia.; IDC, grade III

67 mm

Whole Mount Histology Slide

Lumpectomy

Tomosynthesis (P=11, 22°)300μm × 300 μm × 600 μm voxels

Relative Dose: 1

Constant Exposure/Projection

CT (P=93, 186°)300μm × 300 μm × 600 μm voxels

Relative Dose: 10

Tissue Imaging

0 50 100 150 2000

0.01

0.02

0.03

0.04

0.05

0.06

0.07

0.08

Angular Extent ()

Con

tras

t

0 50 100 150 2000

0.2

0.4

0.6

0.8

1

Angular Extent ()

SD

NR

(no

rmal

ized

)

Angular Spacing, Δθ=2°

0 50 100 150 2000

0.2

0.4

0.6

0.8

1

Angular Extent ()

SD

NR

(no

rmal

ized

)

Less clutter in background, better contrast

More artifacts, Background tissue partly suppressed

Phantom Development

• Background complexity phantom

• 6 acetate beads (1.5-8 mm)

• Natural sea sponge (including coral pieces) in corn oil

Evaluating the Effect of Dose on Reconstructed Image Quality in Digital Breast Tomosynthesis, M. P. Kempston et al., IWDM 2006 Poster Session

Phantom Development