Digital

Reconstruc0onand

Simula0onofthe

Brain

TheBlueBrainProjectDigitalReconstruc0onandSimula0onof

theBrain

HenryMarkram

BlueBrainProject,EPFL

BrainForum,2016

Biology Reconstruc5on

Reconstruc5on

Invitro-like(Regenera5veState)

Invivo-like(Non-Regenera5veState)

ASpectrumofStates

epilepsy

Regenera0ve

State

Non-Regenera0ve

State

DigitalReconstruc5onoftheGlialandVascularSystem

Reconstruc5ngtheNeocortex

Simula5ngSomatosensoryCortex

Reconstruc5ngotherbrainregions(egthehippocampus)

Reconstruc5ngtheWholeMouseBrain

Simula5ngtheMouseBrain

DigitalRobo5cs

DigitalBehavior

TheHumanBrainProject

InfrastructureforCollabora0on

CollaboratorsHenryMarkram,1,2,19,*EilifMuller,1,19SrikanthRamaswamy,1,19MichaelW.Reimann,1,19MarwanAbdellah,1CarlosAguadoSanchez,1AnastasiaAilamaki,16LidiaAlonso-Nanclares,6,7NicolasAn5lle,1SelimArsever,1GuyAntoineAtenekengKahou,1ThomasK.Berger,1AhmetBilgili,1NenadBuncic,1AthanassiaChalimourda,1GiuseppeChindemi,1Jean-DenisCourcol,1FabienDelalondre,1VincentDela[re,2ShaulDruckmann,5RaphaelDumusc,1JamesDynes,1StefanEilemann,1EyalGal,4MichaelEmielGevaert,1Jean-PierreGhobril,2AlbertGidon,3JoeW.Graham,1AnirudhGupta,2Valen5nHaenel,1EtayHay,3,4ThomasHeinis,1,16,17JuanB.Hernando,8MichaelHines,12LidaKanari,1DanielKeller,1JohnKenyon,1GeorgesKhazen,1YihwaKim,1JamesG.King,1ZoltanKisvarday,13PramodKumbhar,1Sébas5enLasserre,1,15Jean-VincentLeBé,2BrunoR.C.Magalhães,1AngelMerchán-Pérez,6,7JulieMeystre,2BenjaminRoyMorrice,1JeffreyMuller,1AlbertoMuñoz-Céspedes,6,7Shru5Muralidhar,2KeerthanMuthurasa,1DanielNachbaur,1TaylorH.Newton,1MaxNolte,1AleksandrOvcharenko,1JuanPalacios,1LuisPastor,9RodrigoPerin,2RajnishRanjan,1,2ImadRiachi,1José-RodrigoRodríguez,6,7JuanLuisRiquelme,1Chris5anRössert,1Konstan5nosSfyrakis,1YingShi,2JulianC.Shillcock,1GiladSilberberg,18RicardoSilva,1FarhanTauheed,1,16Mar5nTelefont,1MariaToledo-Rodriguez,14ThomasTränkler,1WernerVanGeit,1JafetVillafrancaDíaz,1RichardWalker,1YunWang,10,11StefanoM.Zanine[a,1JavierDeFelipe,6,7,20SeanL.Hill,1,20IdanSegev,3,4,20andFelixSchürmann1,20