POSTER PRESENTATION Open Access

The association between bone age advancementand insulin in prepubertal children with obesityHae Sang Lee*, Hwal Rim Jeong, Eunbyul Kwon, Jin Soon Hwang

From 8th APPES Biennial Scientific MeetingDarwin, Australia. 29 October 1 November 2014

AimsObesity is associated with bone age (BA) advancementof unclear etiology. In animal study, insulin may directlymodulate skeletal growth. Our objective was to investi-gate the association with BA maturation and insulinlevels in children with overweight and obesity.

MethodsIn this cross-sectional study of 103 prepubertal children,anthropometric data and hormonal values during oralglucose tolerance test were measured. Subjects weredivided into two groups by the difference between BAand chronological age (CA) (noted as BA-CA).

ResultsThe study population included 49 (47.6%) males and 54(52.4%) females with a mean age of 7.6 1.6 years. Theadvanced bone age group defined as BA-CA>1 year(n=53) had significantly higher HOMA-IR, fasting insu-lin levels and lower quantitative insulin sensitivity checkindex (QUICKI). Also, BA-CA was significantly corre-lated with fasting insulin (r=0.315, P /AntiAliasGrayImages false /CropGrayImages true /GrayImageMinResolution 300 /GrayImageMinResolutionPolicy /Warning /DownsampleGrayImages true /GrayImageDownsampleType /Bicubic /GrayImageResolution 500 /GrayImageDepth -1 /GrayImageMinDownsampleDepth 2 /GrayImageDownsampleThreshold 1.50000 /EncodeGrayImages true /GrayImageFilter /DCTEncode /AutoFilterGrayImages true /GrayImageAutoFilterStrategy /JPEG /GrayACSImageDict > /GrayImageDict > /JPEG2000GrayACSImageDict > /JPEG2000GrayImageDict > /AntiAliasMonoImages false /CropMonoImages true /MonoImageMinResolution 1200 /MonoImageMinResolutionPolicy /Warning /DownsampleMonoImages true /MonoImageDownsampleType /Bicubic /MonoImageResolution 1200 /MonoImageDepth -1 /MonoImageDownsampleThreshold 1.50000 /EncodeMonoImages true /MonoImageFilter /CCITTFaxEncode /MonoImageDict > /AllowPSXObjects false /CheckCompliance [ /None ] /PDFX1aCheck false /PDFX3Check false /PDFXCompliantPDFOnly false /PDFXNoTrimBoxError true /PDFXTrimBoxToMediaBoxOffset [ 0.00000 0.00000 0.00000 0.00000 ] /PDFXSetBleedBoxToMediaBox true /PDFXBleedBoxToTrimBoxOffset [ 0.00000 0.00000 0.00000 0.00000 ] /PDFXOutputIntentProfile (None) /PDFXOutputConditionIdentifier () /PDFXOutputCondition () /PDFXRegistryName () /PDFXTrapped /False

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